HONGKUI contact ZENG

Summary

Affiliation: Allen Institute for Brain Science
Country: USA

Publications

  1. pmc Phenotypic analysis of mice deficient in the type 2 galanin receptor (GALR2)
    Michelle L Gottsch
    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    Mol Cell Biol 25:4804-11. 2005
  2. ncbi request reprint Thyrotropin-releasing hormone receptor 1-deficient mice display increased depression and anxiety-like behavior
    Hongkui Zeng
    Omeros Corporation, 1420 Fifth Avenue, Suite 2600, Seattle, Washington 98101, USA
    Mol Endocrinol 21:2795-804. 2007
  3. ncbi request reprint The role of kisspeptin-GPR54 signaling in the tonic regulation and surge release of gonadotropin-releasing hormone/luteinizing hormone
    Heather M Dungan
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 27:12088-95. 2007
  4. pmc A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing
    Linda Madisen
    Allen Institute for Brain Science, Seattle, Washington, USA
    Nat Neurosci 15:793-802. 2012
  5. pmc Large-scale cellular-resolution gene profiling in human neocortex reveals species-specific molecular signatures
    Hongkui Zeng
    Allen Institute for Brain Science, Seattle, WA 98103, USA
    Cell 149:483-96. 2012
  6. pmc Mouse transgenic approaches in optogenetics
    Hongkui Zeng
    Allen Institute for Brain Science, Seattle, WA, USA
    Prog Brain Res 196:193-213. 2012
  7. pmc Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia
    Tsuyoshi Miyakawa
    Howard Hughes Medical Institute, The Picower Center for Learning and Memory and RIKEN Massachusetts Institute of Technology Neuroscience Research Center, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:8987-92. 2003
  8. pmc Neuromedin U receptor 2-deficient mice display differential responses in sensory perception, stress, and feeding
    Hongkui Zeng
    Nura, Inc, Seattle, WA 98104, USA
    Mol Cell Biol 26:9352-63. 2006
  9. pmc Large-scale, saturating insertional mutagenesis of the mouse genome
    Alexander Gragerov
    Omeros Corporation, 1420 Fifth Avenue, Suite 2600, Seattle, WA 98101, USA
    Proc Natl Acad Sci U S A 104:14406-11. 2007

Collaborators

  • Jan Marino Ramirez
  • Alfredo J Garcia
  • Xue Han
  • Edward S Boyden
  • Gyorgy Buzsaki
  • Eric E Turner
  • Susan M Sunkin
  • DAVID contact WEINSHENKER
  • R R Gainetdinov
  • Linda Madisen
  • Alexander Gragerov
  • Michelle L Gottsch
  • Heather M Dungan
  • Demetrios K Vassilatis
  • Donald K Clifton
  • Robert A Steiner
  • Tsuyoshi Miyakawa
  • Yun Wei A Hsu
  • Shigeyoshi Fujisawa
  • Karel Svoboda
  • Antal Berenyi
  • Hong Gu
  • Allan R Jones
  • Henner Koch
  • Jolene Kidney
  • Tianyi Mao
  • Sebastien Zanella
  • Yimei Mao
  • Jia Min Zhuo
  • Xuan Gu
  • Bryan M Hooks
  • Alex Rhode
  • Galina Gragerova
  • Io Dolka
  • Maria Pavlova
  • John E Bergmann
  • George N Pavlakis
  • George A Gaitanaris
  • Eric Finn
  • Kyoji Horie
  • Amanda Ebbert
  • John Bergmann
  • Patricia Roth
  • Stephanie Moe
  • Christopher Navas
  • John G Hohmann
  • Susumu Tonegawa
  • Tatyana D Sotnikova
  • David J Gerber
  • Lorene M Leiter
  • Marc G Caron

Detail Information

Publications9

  1. pmc Phenotypic analysis of mice deficient in the type 2 galanin receptor (GALR2)
    Michelle L Gottsch
    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    Mol Cell Biol 25:4804-11. 2005
    ..It is also conceivable that GALR2 plays only a subtle role in some of these functions and that the impact of its loss could not be detected by the analytical procedures used here...
  2. ncbi request reprint Thyrotropin-releasing hormone receptor 1-deficient mice display increased depression and anxiety-like behavior
    Hongkui Zeng
    Omeros Corporation, 1420 Fifth Avenue, Suite 2600, Seattle, Washington 98101, USA
    Mol Endocrinol 21:2795-804. 2007
    ..These results provide the first direct evidence that the endogenous TRH system is involved in mood regulation, and this function is carried out through TRH-R1-mediated neural pathways...
  3. ncbi request reprint The role of kisspeptin-GPR54 signaling in the tonic regulation and surge release of gonadotropin-releasing hormone/luteinizing hormone
    Heather M Dungan
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 27:12088-95. 2007
    ..Thus, in mice, kisspeptin-GPR54 signaling is required for the tonic stimulation of GnRH/LH secretion but is not required for generating the E-induced GnRH/LH surge...
  4. pmc A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing
    Linda Madisen
    Allen Institute for Brain Science, Seattle, Washington, USA
    Nat Neurosci 15:793-802. 2012
    ..When combined with the hundreds of available Cre driver lines, this optimized toolbox of reporter mice will enable widespread investigations of neural circuit function with unprecedented reliability and accuracy...
  5. pmc Large-scale cellular-resolution gene profiling in human neocortex reveals species-specific molecular signatures
    Hongkui Zeng
    Allen Institute for Brain Science, Seattle, WA 98103, USA
    Cell 149:483-96. 2012
    ....
  6. pmc Mouse transgenic approaches in optogenetics
    Hongkui Zeng
    Allen Institute for Brain Science, Seattle, WA, USA
    Prog Brain Res 196:193-213. 2012
    ..In this chapter, we review the state of these efforts and consider aspects of the current technology that would benefit from additional improvement...
  7. pmc Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia
    Tsuyoshi Miyakawa
    Howard Hughes Medical Institute, The Picower Center for Learning and Memory and RIKEN Massachusetts Institute of Technology Neuroscience Research Center, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:8987-92. 2003
    ..Collectively, the abnormalities of CN mutant mice are strikingly similar to those described for schizophrenia. We propose that alterations affecting CN signaling could comprise a contributing factor in schizophrenia pathogenesis...
  8. pmc Neuromedin U receptor 2-deficient mice display differential responses in sensory perception, stress, and feeding
    Hongkui Zeng
    Nura, Inc, Seattle, WA 98104, USA
    Mol Cell Biol 26:9352-63. 2006
    ..They suggest that NMUR2 plays a more significant role in central pain processing than other brain functions including stress/anxiety and regulation of feeding...
  9. pmc Large-scale, saturating insertional mutagenesis of the mouse genome
    Alexander Gragerov
    Omeros Corporation, 1420 Fifth Avenue, Suite 2600, Seattle, WA 98101, USA
    Proc Natl Acad Sci U S A 104:14406-11. 2007
    ..The method also allows for increased scale and automation for the large-scale production of mutant mice, which could substantially expedite the functional characterization of the mouse genome...

Research Grants6

  1. A transgenic platform to produce genetic tools for monitoring & manipulating plas
    Hongkui Zeng; Fiscal Year: 2010
    ....
  2. G-Protein-Coupled Receptors As Drug Targets for Anxiety
    Hongkui Zeng; Fiscal Year: 2004
    ..The genes and eventually, the proteins they code for may be useful drug targets for discovery of new drugs to treat the disruptive behavioral disorders. ..
  3. Generation and characterization of novel and highly specific neruonal subtype tra
    Hongkui Zeng; Fiscal Year: 2009
    ..Both of these tools will have major impact on the broad neuroscience community, from molecular to systems neuroscience, from development to behavior studies, from studies of normal brain physiology to disease mechanisms. ..
  4. A transgenic platform to produce genetic tools for monitoring & manipulating plas
    Hongkui Zeng; Fiscal Year: 2009
    ....
  5. Generation and characterization of novel and highly specific neruonal subtype tra
    HONGKUI contact ZENG; Fiscal Year: 2010
    ..Both of these tools will have major impact on the broad neuroscience community, from molecular to systems neuroscience, from development to behavior studies, from studies of normal brain physiology to disease mechanisms. ..