David E Skoner

Summary

Affiliation: Allegheny General Hospital
Country: USA

Publications

  1. doi request reprint Effects of inhaled mometasone furoate on growth velocity and adrenal function: a placebo-controlled trial in children 4-9 years old with mild persistent asthma
    David P Skoner
    Allegheny General Hospital, Pittsburgh, PA 15212, USA
    J Asthma 48:848-59. 2011
  2. doi request reprint Effect of therapeutic doses of mometasone furoate on cortisol levels in children with mild asthma
    David P Skoner
    Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212, USA
    Allergy Asthma Proc 31:10-9. 2010
  3. doi request reprint Sublingual immunotherapy in patients with allergic rhinoconjunctivitis caused by ragweed pollen
    David Skoner
    Drexel University College of Medicine, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    J Allergy Clin Immunol 125:660-6, 666.e1-666.e4. 2010
  4. doi request reprint Effect on growth of long-term treatment with intranasal triamcinolone acetonide aqueous in children with allergic rhinitis
    David P Skoner
    Division of Allergy, Asthma, and Immunology, Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Ann Allergy Asthma Immunol 101:431-6. 2008
  5. ncbi request reprint Therapeutic margin of budesonide in patients with mild to severe asthma
    David E Skoner
    Department of Pediatrics, Division of Allergy, Asthma and Immunology, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Clin Ther 25:C61-74. 2003
  6. ncbi request reprint Assessment of the long-term safety of inhaled ciclesonide on growth in children with asthma
    David P Skoner
    Allegheny General Hospital, Department of Pediatrics, 320 E North Ave, South Tower, Seventh Floor, Pittsburgh, PA 15212, USA
    Pediatrics 121:e1-14. 2008
  7. ncbi request reprint Association between TNF-alpha and TGF-beta genotypes in infants and parental history of allergic rhinitis and asthma
    Deborah A Gentile
    Department of Pediatrics, Allegheny General Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA 15212, USA
    Hum Immunol 65:347-51. 2004
  8. ncbi request reprint Diminished dendritic cell interleukin 10 production in atopic children
    Deborah A Gentile
    Division of Allergy, Asthma and Immunology, Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Ann Allergy Asthma Immunol 92:538-44. 2004
  9. ncbi request reprint Childhood socioeconomic status and host resistance to infectious illness in adulthood
    Sheldon Cohen
    Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Psychosom Med 66:553-8. 2004
  10. ncbi request reprint Evaluation of the safety and efficacy of levalbuterol in 2-5-year-old patients with asthma
    David P Skoner
    Allegheny General Hospital, Division of Allergy, Asthma and Immunology, Pittsburgh, Pennsylvania, USA
    Pediatr Pulmonol 40:477-86. 2005

Research Grants

  1. IMMUNE MECHANISMS OF MIDDLE EAR DISEASE
    David Skoner; Fiscal Year: 2006

Detail Information

Publications36

  1. doi request reprint Effects of inhaled mometasone furoate on growth velocity and adrenal function: a placebo-controlled trial in children 4-9 years old with mild persistent asthma
    David P Skoner
    Allegheny General Hospital, Pittsburgh, PA 15212, USA
    J Asthma 48:848-59. 2011
    ..To assess the effects of long-term mometasone furoate delivered via a dry powder inhaler (MF-DPI) on growth velocity and hypothalamic-pituitary-adrenal axis function in children with asthma...
  2. doi request reprint Effect of therapeutic doses of mometasone furoate on cortisol levels in children with mild asthma
    David P Skoner
    Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212, USA
    Allergy Asthma Proc 31:10-9. 2010
    ..All regimens were well tolerated. MF-DPI did not have a significant effect on plasma or urinary cortisol levels at doses up to 200 micrograms b.i.d. in children with mild asthma. Higher MF-DPI doses may potentially suppress the HPA axis...
  3. doi request reprint Sublingual immunotherapy in patients with allergic rhinoconjunctivitis caused by ragweed pollen
    David Skoner
    Drexel University College of Medicine, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    J Allergy Clin Immunol 125:660-6, 666.e1-666.e4. 2010
    ..Specific allergen immunotherapy is most often delivered subcutaneously, but sublingual immunotherapy may confer greater benefit in terms of tolerability and safety, accessibility, and improved antigen delivery...
  4. doi request reprint Effect on growth of long-term treatment with intranasal triamcinolone acetonide aqueous in children with allergic rhinitis
    David P Skoner
    Division of Allergy, Asthma, and Immunology, Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Ann Allergy Asthma Immunol 101:431-6. 2008
    ..Guidelines recommend treatment with intranasal corticosteroids for patients with allergic rhinitis (AR), but concerns remain about possible adverse effects...
  5. ncbi request reprint Therapeutic margin of budesonide in patients with mild to severe asthma
    David E Skoner
    Department of Pediatrics, Division of Allergy, Asthma and Immunology, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Clin Ther 25:C61-74. 2003
    ....
  6. ncbi request reprint Assessment of the long-term safety of inhaled ciclesonide on growth in children with asthma
    David P Skoner
    Allegheny General Hospital, Department of Pediatrics, 320 E North Ave, South Tower, Seventh Floor, Pittsburgh, PA 15212, USA
    Pediatrics 121:e1-14. 2008
    ..To assess the effects of the new inhaled corticosteroid ciclesonide on growth in children with asthma...
  7. ncbi request reprint Association between TNF-alpha and TGF-beta genotypes in infants and parental history of allergic rhinitis and asthma
    Deborah A Gentile
    Department of Pediatrics, Allegheny General Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA 15212, USA
    Hum Immunol 65:347-51. 2004
    ..If confirmed by future studies, cytokine genotyping may be a useful tool for identifying at-risk infants who may benefit from the selective use of preventative and/or early intervention treatments for these disorders...
  8. ncbi request reprint Diminished dendritic cell interleukin 10 production in atopic children
    Deborah A Gentile
    Division of Allergy, Asthma and Immunology, Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Ann Allergy Asthma Immunol 92:538-44. 2004
    ..Diminished interleukin 10 (IL-10) and/or IL-12 production may contribute to the pathogenesis of asthma and atopy. Dendritic cells (DCs) produce these cytokines and have been implicated in the pathogenesis of these disorders...
  9. ncbi request reprint Childhood socioeconomic status and host resistance to infectious illness in adulthood
    Sheldon Cohen
    Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Psychosom Med 66:553-8. 2004
    ....
  10. ncbi request reprint Evaluation of the safety and efficacy of levalbuterol in 2-5-year-old patients with asthma
    David P Skoner
    Allegheny General Hospital, Division of Allergy, Asthma and Immunology, Pittsburgh, Pennsylvania, USA
    Pediatr Pulmonol 40:477-86. 2005
    ..In this study of levalbuterol in children aged 2-5 years with asthma, LEV was generally well-tolerated, and in children able to perform PEF, led to significant bronchodilation compared with placebo...
  11. ncbi request reprint Concerns about intranasal corticosteroids for over-the-counter use: position statement of the Joint Task Force for the American Academy of Allergy, Asthma and Immunology and the American College of Allergy, Asthma and Immunology
    Leonard Bielory
    Department of Medicine, UMDNJ New Jersey Medical School, Newark, USA
    Ann Allergy Asthma Immunol 96:514-25. 2006
    ..Thus, as stated, we recommend that intranasal corticosteroids remain prescription-only drugs...
  12. ncbi request reprint Allergy skin test responses during experimental infection with respiratory syncytial virus
    David P Skoner
    Department of Pediatrics, Allegheny Singer Research Institute, Pittsburgh, Pennsylvania 15212, USA
    Ann Allergy Asthma Immunol 96:834-9. 2006
    ..False-positive allergen skin test results are known to occur; however, contributing factors are not well understood...
  13. ncbi request reprint Evaluation of levalbuterol metered dose inhaler in pediatric patients with asthma: a double-blind, randomized, placebo- and active-controlled trial
    William E Berger
    Allergy and Asthma Associates of Southern California, Mission Viejo, CA, USA
    Curr Med Res Opin 22:1217-26. 2006
    ..To evaluate the efficacy and safety of levalbuterol metered dose inhaler (MDI) in children aged 4-11 years (n = 173)...
  14. doi request reprint The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5-year follow-up: effectiveness of early intervention with budesonide in mild persistent asthma
    William W Busse
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, J5 219 CSC, Box 2454, 600 Highland Ave, Madison, WI 53792, USA
    J Allergy Clin Immunol 121:1167-74. 2008
    ....
  15. ncbi request reprint Elevations of local leukotriene C4 levels during viral upper respiratory tract infections
    Deborah A Gentile
    Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Ann Allergy Asthma Immunol 91:270-4. 2003
    ..One potential mechanism by which respiratory viruses trigger illness and complications is via the local elaboration of inflammatory mediators...
  16. ncbi request reprint Growth effects of asthma and asthma therapy
    David P Skoner
    Pediatrics and Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 2583, USA
    Curr Opin Pulm Med 8:45-9. 2002
    ..Ultimately, no child whose disease severity warrants ICS therapy should be denied the tremendous benefits that this therapy can provide because of relatively minor concerns about growth effects...
  17. ncbi request reprint Balancing safety and efficacy in pediatric asthma management
    David P Skoner
    Section of Allergy and Immunology, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Pediatrics 109:381-92. 2002
    ..Physicians must evaluate and compare the balance of safety and efficacy for each agent to determine the appropriate asthma therapy for individual patients...
  18. ncbi request reprint Nasal and otologic effects of experimental respiratory syncytial virus infection in adults
    Craig A Buchman
    Department of Otolaryngology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA
    Am J Otolaryngol 23:70-5. 2002
    ..This study was conducted to more clearly define the extent and frequency of nasal and otologic effects of respiratory syncytial virus infection in healthy adult volunteers...
  19. ncbi request reprint Cytokine gene polymorphisms moderate responses to respiratory syncytial virus in adults
    Deborah A Gentile
    Department of Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Hum Immunol 64:93-8. 2003
    ..These results suggest that certain cytokine gene polymorphisms moderate immune responses and illness severity in adults experimentally exposed to RSV...
  20. ncbi request reprint The effects of intranasal triamcinolone acetonide and intranasal fluticasone propionate on short-term bone growth and HPA axis in children with allergic rhinitis
    David P Skoner
    Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Ann Allergy Asthma Immunol 90:56-62. 2003
    ....
  21. ncbi request reprint Cytokine gene polymorphisms moderate illness severity in infants with respiratory syncytial virus infection
    Deborah A Gentile
    Department of Pediatrics, Children s Hospital of Pittsburgh, PA 15213, USA
    Hum Immunol 64:338-44. 2003
    ..If future prospective studies confirm these observations, cytokine genotyping may be a useful tool for identifying "at risk" infants who may benefit from the selective use of preventive or early intervention treatments for RSV...
  22. ncbi request reprint Emotional style and susceptibility to the common cold
    Sheldon Cohen
    Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213 3890, USA
    Psychosom Med 65:652-7. 2003
    ..We tested these hypotheses for host resistance to the common cold...
  23. ncbi request reprint State and trait affect as predictors of salivary cortisol in healthy adults
    Deborah E Polk
    Psychology Department, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
    Psychoneuroendocrinology 30:261-72. 2005
    ..Differences in rhythmicity found here are noteworthy given the possible role of cortisol dysregulation in disease incidence, morbidity, mortality, and severity...
  24. ncbi request reprint Inhaled steroids and the risk of adrenal suppression in children
    Jamar D Robinson
    Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Expert Opin Drug Saf 1:237-44. 2002
    ..This review will discuss adrenal suppression found with common ICS...
  25. ncbi request reprint Outcome measures in childhood asthma
    David P Skoner
    Sections of Allergy and Immunology, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Pediatrics 109:393-8. 2002
    ..Whether 1 or more of these outcome measures will prove useful clinically in improving the diagnosis and management of childhood asthma remains uncertain, although early research results are encouraging...
  26. ncbi request reprint Nasal and oral nitric oxide levels during experimental respiratory syncytial virus infection of adults
    Deborah A Gentile
    Department of Pediatrics, Children s Hospital of Pittsburgh and the University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Acta Otolaryngol 122:61-6. 2002
    ..These results do not support the hypothesis of increased NO production during RSV infection and complement earlier studies that reported a lack of change in nasal NO concentration during experimental influenza and rhinovirus infections...
  27. doi request reprint The diagnosis and management of rhinitis: an updated practice parameter
    Dana V Wallace
    J Allergy Clin Immunol 122:S1-84. 2008
  28. doi request reprint A randomized, double-blind, parallel-group, multicenter, placebo-controlled study of the safety and efficacy of extended-release guaifenesin/pseudoephedrine hydrochloride for symptom relief as an adjunctive therapy to antibiotic treatment of acute respira
    Craig LaForce
    North Carolina Clinical Research Inc, Raleigh, NC, USA
    Postgrad Med 120:53-9. 2008
    ....
  29. ncbi request reprint Use of intranasal cromolyn sodium for allergic rhinitis
    Paul H Ratner
    Sylvana Research Associates and Department of Pediatrics, University of Texas Health Science Center, San Antonio, USA
    Mayo Clin Proc 77:350-4. 2002
    ..Intranasal cromolyn has an excellent safety record, is available as an over-the-counter medication, and has been proved to be efficacious in patients with allergic rhinitis...
  30. ncbi request reprint Viral and bacterial rhinitis
    William J Doyle
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Allergy Immunol 19:177-95. 2007
    ....
  31. ncbi request reprint Viral infection and allergy: lower airway
    David P Skoner
    Department of Pediatrics and Otolaryngology, University of Pittsburgh School of Medicine, Department of Allergy and Immunology, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Allergy Asthma Proc 23:229-32. 2002
    ..Undoubtedly, future efforts will be aimed at the prevention of asthma exacerbations via well-targeted and well-conceived strategies for prevention and/or treatment of upper respiratory infections...
  32. ncbi request reprint Comparison of subject-reported allergy versus skin test results in a common cold trial
    Jason S Krahnke
    Department of Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Rhinol 17:159-62. 2003
    ..The objective of this study was to compare the results of self-reported allergy via verbal questioning with the results of allergy skin testing by the puncture method in 237 healthy adult subjects enrolled in a common cold study...
  33. ncbi request reprint Effect of respiratory syncytial virus infection during early infancy on the ontogeny of cytokine immune responses
    Deborah A Gentile
    Department of Pediatrics, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Allergy Asthma Proc 23:399-405. 2002
    ..Such strategies may include administration of IL-12 or manipulation of DC maturation or function...
  34. ncbi request reprint Nasal cytokines as mediators of illness during the common cold
    William J Doyle
    Allegheny Hospital, 320 East North Avenue, Pittsburgh, PA 15212, USA
    Curr Allergy Asthma Rep 5:173-81. 2005
    ..The available evidence for mediation of the common cold is the subject of this manuscript...
  35. ncbi request reprint Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents
    David P Skoner
    Pediatrics 115:512; author reply 512-3. 2005
  36. ncbi request reprint Sociability and susceptibility to the common cold
    Sheldon Cohen
    Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Psychol Sci 14:389-95. 2003
    ..The association between sociability and disease was also independent of baseline immunity (virus-specific antibody), demographics, emotional styles, stress hormones, and health practices...

Research Grants4

  1. IMMUNE MECHANISMS OF MIDDLE EAR DISEASE
    David Skoner; Fiscal Year: 2006
    ..The primary hypothesis is that cytokine genotype is predictive of illness expression and of OM incidence during a documented RSV infection in young children. ..