Research Topics
| J C PostSummaryAffiliation: Allegheny General Hospital Country: USA Publications
Research Grants
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Detail Information
Publications
Preliminary study: treatment with intramuscular interferon beta-1a results in increased levels of IL-12R?2+ and decreased levels of IL23R+ CD4+ T - Lymphocytes in multiple sclerosisJennifer M Kress-Bennett
Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
BMC Neurol 11:155. 2011....- Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strainsJustin S Hogg
Allegheny General Hospital, Allegheny Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania 15212, USA
Genome Biol 8:R103. 2007..Studies based on random sequencing of multiple strain libraries suggested that free-living bacterial species possess a supragenome that is much larger than the genome of any single bacterium... - Multiple displacement amplification as an adjunct to PCR-based detection of Staphylococcus aureus in synovial fluidSandeep Kathju
Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA, USA
BMC Res Notes 3:259. 2010..aureus DNA as well as on clinical samples known to contain S. aureus nucleic acids... - Characterization of biofilm matrix, degradation by DNase treatment and evidence of capsule downregulation in Streptococcus pneumoniae clinical isolatesLuanne Hall-Stoodley
Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
BMC Microbiol 8:173. 2008..To better understand pneumococcal biofilm formation six low-passage encapsulated nasopharyngeal isolates of S. pneumoniae were assessed over a six-eight day period in vitro... - Virulence phenotypes of low-passage clinical isolates of nontypeable Haemophilus influenzae assessed using the chinchilla laniger model of otitis mediaFarrel J Buchinsky
Center for Genomic Sciences, Allegheny Singer Research Institute Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
BMC Microbiol 7:56. 2007..These diverse clinical and genotypic findings suggest that each NTHi strain possesses a unique set of virulence factors that contributes to the course of the disease... - Comparative supragenomic analyses among the pathogens Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae using a modification of the finite supragenome modelRobert Boissy
Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
BMC Genomics 12:187. 2011.... - Direct evidence of bacterial biofilms in otitis mediaJ C Post
Department of Pediatric Otolaryngology, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212 4722, USA
Laryngoscope 111:2083-94. 2001..The objective of this study was to collect visual evidence of the formation of bacterial biofilms in these situations... - The role of biofilms in otolaryngologic infections: update 2007J Christopher Post
Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, Pennsylvania, USA
Curr Opin Otolaryngol Head Neck Surg 15:347-51. 2007..Biofilms have been shown to play a role in otitis media, sinusitis, cholesteatoma, tonsillitis, adenoiditis, and device infections. This article is written to review recent advances in the field... - Genetics of otitis mediaJ Christopher Post
Pediatric Otolaryngology, and Center for Genomic Sciences, Allegheny General Hospital, Pittsburgh, PA, USA
Adv Otorhinolaryngol 70:135-40. 2011..Existing data do not support routine genetic testing to determine a child's susceptibility to OM; however, given the advances in whole genome sequencing, such testing may someday play a role in the management of the OM patient... - Genetics of pediatric gastroesophageal refluxJ Christopher Post
Center for Genomic Sciences, Allegheny Singer Research Institute, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
Curr Opin Allergy Clin Immunol 5:5-9. 2005..The results of family and twin studies have identified an inherited tendency toward developing the disease, and a locus common to multiple families with severe GERD has been found on 13q14, known as GERD1... - Mapping of a gene for severe pediatric gastroesophageal reflux to chromosome 13q14F Z Hu
Center for Genomic Sciences, Room 1030, Allegheny General Hospital, 320 E North Ave, Pittsburgh, PA 15212, USA
JAMA 284:325-34. 2000..A few reports have suggested, however, that a genetic component may contribute to the incidence of GER, especially in its severe or chronic forms... - Direct detection of bacterial biofilms on the middle-ear mucosa of children with chronic otitis mediaLuanne Hall-Stoodley
Center for Genomic Sciences, Allegheny-Singer Research Institute, Pittsburgh, PA 15212, USA
JAMA 296:202-11. 2006..CONCLUSION: Direct detection of biofilms on MEM biopsy specimens from children with OME and recurrent OM supports the hypothesis that these chronic middle-ear disorders are biofilm-related... - Chronic surgical site infection due to suture-associated polymicrobial biofilmSandeep Kathju
Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
Surg Infect (Larchmt) 10:457-61. 2009..Surgical site infection (SSI) is a common surgical complication; culture-negative SSI presents a particular problem in management... - Human susceptibility to viral infection: the search for HIV-protective alleles among Africans by means of genome-wide studiesJoseph Donfack
Center for Genomic Sciences, Allegheny Singer Research Institute, Drexel University College of Medicine, Pittsburgh, Pennsylvania 15212, USA
AIDS Res Hum Retroviruses 22:925-30. 2006.... - Identification of differentially expressed genes in scarless wound healing utilizing polymerase chain reaction-suppression subtractive hybridizationSandeep Kathju
Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212 4772, USA
Wound Repair Regen 14:413-20. 2006..With this approach, we have also identified novel genes potentially involved in scarless wound healing... - Biofilms in nephrologyRichard J Marcus
Division of Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, PA 15212, USA
Expert Opin Biol Ther 8:1159-66. 2008..Biofilms also play critical roles in persistent and resistant renal and urinary tract infections... - Multicenter initiative seeking critical genes in respiratory papillomatosisFarrel J Buchinsky
Center for Genomic Sciences, Allegheny Singer Research Institute, 320 E North Avenue, Pittsburgh, PA 15212 4772, USA
Laryngoscope 114:349-57. 2004..Genetically encoded host susceptibility is postulated. Determining the host genes that govern susceptibility will enhance our understanding not only of RRP but also of host-viral interaction in general... - Mucosal biofilm formation on middle-ear mucosa in the chinchilla model of otitis mediaGarth D Ehrlich
Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
JAMA 287:1710-5. 2002.... - Outpatient treatment suite: a safe and cost-effective venue to perform myringotomy and tubes placement in childrenJames M Compliment
Allegheny General Hospital, 320 East North Ave, Pittsburgh, PA 15212, USA
Int J Pediatr Otorhinolaryngol 67:1159-68. 2003..Non-traditional settings for children requiring bilateral myringotomy and tube (BMT) placement for ear disease have the potential to offer the same degree of patient safety and improved efficiency but at lower cost... - Development and characterization of a pooled Haemophilus influenzae genomic library for the evaluation of gene expression changes associated with mucosal biofilm formation in otitis mediaGeza Erdos
Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, 320 E North Ave, Pittsburgh, PA 15212, USA
Int J Pediatr Otorhinolaryngol 67:749-55. 2003..It has been etiologically associated with otitis media, otorrhea, and chronic obstructive pulmonary disease. Identification of new genomic elements will provide novel targets to fight chronic infections caused by this organism... - Adenoid reservoir for pathogenic biofilm bacteriaL Nistico
Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA
J Clin Microbiol 49:1411-20. 2011.... - Expression of receptor for activated C kinase 1 in healing skin and mucosal woundsLatha Satish
Wound Healing Program, Center for Genomic Sciences, Allegheny Singer Research Institute, 320 East North Ave, Pittsburgh, PA 15212, USA
Ann Plast Surg 64:238-41. 2010..These observations suggest that RACK1 may play an important role in distinguishing scarless fetal wound healing from its scirrhous counterpart in adults... - Strain-specific virulence phenotypes of Streptococcus pneumoniae assessed using the Chinchilla laniger model of otitis mediaMichael L Forbes
Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 3:e1969. 2008.... - Differential expression of chaperonin containing T-complex polypeptide (CCT) subunits during fetal and adult skin wound healingLatha Satish
Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA 15212, USA
Cell Stress Chaperones 13:527-33. 2008..We also confirm that quantitative evaluation of CCT-alpha and CCT-zeta mRNA expression shows no change in healing fetal wounds... - Fine mapping a gene for pediatric gastroesophageal reflux on human chromosome 13q14Fen Ze Hu
Center for Genomic Sciences, Allegheny Singer Research Institute, 320 East North Ave, Pittsburgh, PA 15212, USA
Hum Genet 114:562-72. 2004..The results suggest that the GERD1 gene might be located near SNP160 or SNP168... - Medical treatment of craniosynostosis: recombinant Noggin inhibits coronal suture closure in the rat craniosynostosis modelK Shen
Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
Orthod Craniofac Res 12:254-62. 2009..Topical application of rhNoggin protein prevents craniosynostosis in the weanling nude rat xenotransplantation model of syndromic craniosynostosis... - Gene expression changes in peripheral blood mononuclear cells from multiple sclerosis patients undergoing beta-interferon therapyM K Singh
Center for Genomic Sciences, Allegheny Singer Research Institute, 320 E North Avenue, Pittsburgh, PA 15212, USA
J Neurol Sci 258:52-9. 2007..We studied the gene expression patterns in peripheral blood mononuclear cells from relapsing-remitting MS patients undergoing weekly beta IFN-1a therapy (Avonex; 30 mg intramuscular) to identify biomarkers for beta IFN responsiveness... - Comparative genomic analyses of seventeen Streptococcus pneumoniae strains: insights into the pneumococcal supragenomeN Luisa Hiller
Allegheny General Hospital, Allegheny Singer Research Institute, Center for Genomic Sciences, Pittsburgh, PA 15212, USA
J Bacteriol 189:8186-95. 2007.... - Identification, distribution, and expression of novel genes in 10 clinical isolates of nontypeable Haemophilus influenzaeKai Shen
Center for Genomic Sciences, Allegheny-Singer Research Institute, Allegheny General Hospital, 320 East North Ave, 11th Floor South Tower, Pittsburgh, PA 15212, USA
Infect Immun 73:3479-91. 2005..These genic distribution analyses were more effective as a strain discrimination tool than either multilocus sequence typing or 23S ribosomal gene typing methods... - Extensive genomic plasticity in Pseudomonas aeruginosa revealed by identification and distribution studies of novel genes among clinical isolatesKai Shen
Center for Genomic Sciences, Allegheny-Singer Research Institute, Allegheny General Hospital, 320 East North Ave, 11th Floor South Tower, Pittsburgh, PA 15212, USA
Infect Immun 74:5272-83. 2006..Expression profiling revealed that a vast majority of these sequences are expressed, strongly suggesting they encode functional proteins... - Codon usage comparison of novel genes in clinical isolates of Haemophilus influenzaeJohn Gladitz
Center for Genomic Sciences, Allegheny-Singer Research Institute Pittsburgh, PA, USA
Nucleic Acids Res 33:3644-58. 2005..The remaining novel sequences produced similarity statistics closer to one of the other reference genomes thereby suggesting that these sequences may have entered the H.influenzae gene pool more recently via horizontal transfer... - Construction and characterization of a highly redundant Pseudomonas aeruginosa genomic library prepared from 12 clinical isolates: application to studies of gene distribution among populationsGeza Erdos
Center for Genomic Sciences, Allegheny-Singer Research Institute, 320 E. North Avenue, Pittsburgh, PA 15212, United States
Int J Pediatr Otorhinolaryngol 70:1891-900. 2006..aeruginosa population-based supra-genome... - Characterization, distribution, and expression of novel genes among eight clinical isolates of Streptococcus pneumoniaeKai Shen
Center for Genomic Sciences, Allegheny-Singer Research Institute, Allegheny General Hospital, 320 East North Avenue, 11th Floor South Tower, Pittsburgh, PA 15212, USA
Infect Immun 74:321-30. 2006..Sixty-five percent (38/58) of these sequences were found in 50% or less of the clinical strains, indicating a significant degree of genomic plasticity among natural isolates... - The distributed genome hypothesis as a rubric for understanding evolution in situ during chronic bacterial biofilm infectious processesGarth D Ehrlich
Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA, USA
FEMS Immunol Med Microbiol 59:269-79. 2010.... - Adenotonsillectomy in children with von Willebrand diseaseG C Allen
Department of Pediatric Otolaryngology, Children s Hospital of Pittsburgh, PA, USA
Arch Otolaryngol Head Neck Surg 125:547-51. 1999..To review the effectiveness of a perioperative management protocol and our experience with a large population of patients with von Willebrand disease (vWD) who require adenotonsillar surgery (T&A)... - Mapping of an autosomal dominant gene for Dupuytren's contracture to chromosome 16q in a Swedish familyF Z Hu
Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
Clin Genet 68:424-9. 2005..A maximal two-point logarithm of odds (LOD) score of 3.18 was achieved at microsatellite marker D16S415 with four other markers in the region producing LODs of >1.5... - The genetics of otitis mediaJoseph H Goodwin
Allegheny General Hospital, Pediatric Otolaryngology, MCP-Hahnemann School of Medicine, 320 East North Avenue, 7th Floor, South Tower, Pittsburgh, PA 15212, USA
Curr Allergy Asthma Rep 2:304-8. 2002..Delineating the OM genes not only provides a deeper understanding of the pathophysiology of this common disease, but also of acute and chronic bacterial disease in general... - Age of child, more than HPV type, is associated with clinical course in recurrent respiratory papillomatosisFarrel J Buchinsky
Allegheny General Hospital, Allegheny Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 3:e2263. 2008..These data suggest that there are factors other than HPV type and age of the patient that determine disease course... - The role of biofilms in otolaryngologic infectionsJ Christopher Post
Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, Pennsylvania 15212, USA
Curr Opin Otolaryngol Head Neck Surg 12:185-90. 2004..Understanding that many of the infections that affect structures of the head and neck are actually biofilm related is fundamental to developing rational strategies for treatment and prevention... - Four mutations in Epidermodysplasia verruciformis 1 (EVER1) gene are not contributors to susceptibility in RRPJoseph Donfack
Allegheny General Hospital, Allegheny Singer Research Institute, 320 East North Avenue, 11th Floor, South Tower, Room 1171, Pittsburgh, PA 15212 4772, USA
Int J Pediatr Otorhinolaryngol 70:1235-40. 2006.... - Research education and training in otolaryngology: meeting summary and research opportunitiesJennifer R Grandis
Departments of Otolaryngology and Pharmacology, Eye and Ear Institute Building, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Otolaryngol Head Neck Surg 135:361-7. 2006 - Role of biofilms in neurosurgical device-related infectionsErnest E Braxton
Department of Neurosurgery, Allegheny General Hospital, Pittsburgh, PA, USA
Neurosurg Rev 28:249-55. 2005..Understanding how these biofilm infections affect patients with neurosurgical devices is a prerequisite to developing strategies for their treatment and prevention... - Unique challenges of obtaining regulatory approval for a multicenter protocol to study the genetics of RRP and suggested remediesMylaina L Sherwood
Center for Genomic Sciences at Allegheny Singer Research Institute, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212-4772, USA
Otolaryngol Head Neck Surg 135:189-96. 2006..For multicenter studies, investigators should seriously consider the establishment of cooperative authorization agreements. On a simpler level, a standardized format for applications needs to be adopted nationwide. EBM rating: B-3b... - Phenotypic characterization of Streptococcus pneumoniae biofilm developmentMagee Allegrucci
State University of New York at Binghamton, Department of Biological Sciences, 104 Science III, Vestal Parkway East, Binghamton, NY 13902, USA
J Bacteriol 188:2325-35. 2006..Protein identification revealed that proteins involved in virulence, adhesion, and resistance were more abundant under biofilm growth conditions. A possible role of the identified proteins in biofilm formation is discussed... - Mucin gene cDNA sequence characterization in chinchilla middle ear epitheliumJoseph E Kerschner
Division of Pediatric Otolaryngology, Medical College of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53226, USA
Int J Pediatr Otorhinolaryngol 70:1449-56. 2006.... - Tonsilloliths a common finding in pediatric patientsNicole E Myers
Chatham College PA program in Pittsburgh, USA
Nurse Pract 31:53-4. 2006
Research Grants
- MOLECULAR GENETICS OF A SYNDROME WITH HEARING IMPAIRMENTJ Post; Fiscal Year: 2004..The delineation of the panoply of genes involved in causing craniosynostosis will enhance our understanding of these diseases and suggest new therapeutic strategies. ..
- Pneumococcal Biofilms in Otitis MediaJames Post; Fiscal Year: 2007..Delineating the molecular basis of biofilms will not only advance our understanding of OM, but of chronic infectious disease in general. ..