Sandeep Kathju

Summary

Affiliation: Allegheny General Hospital
Country: USA

Publications

  1. ncbi Identification of differentially expressed genes in scarless wound healing utilizing polymerase chain reaction-suppression subtractive hybridization
    Sandeep Kathju
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212 4772, USA
    Wound Repair Regen 14:413-20. 2006
  2. ncbi Increased expression of Ero1L-alpha in healing fetal wounds
    Phillip H Gallo
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    BMC Res Notes 4:175. 2011
  3. ncbi Multiple displacement amplification as an adjunct to PCR-based detection of Staphylococcus aureus in synovial fluid
    Sandeep Kathju
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA, USA
    BMC Res Notes 3:259. 2010
  4. ncbi Bacterial biofilm on monofilament suture and porcine xenograft after inguinal herniorrhaphy
    Sandeep Kathju
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA, USA
    FEMS Immunol Med Microbiol 59:405-9. 2010
  5. ncbi Perineal hernia repair with acellular dermal graft and suture anchor fixation
    S Kathju
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212, USA
    Hernia 15:357-60. 2011
  6. ncbi Chronic surgical site infection due to suture-associated polymicrobial biofilm
    Sandeep Kathju
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Surg Infect (Larchmt) 10:457-61. 2009
  7. ncbi Cutaneous fistula from the gastric remnant resulting from a chronic suture-associated biofilm infection
    Sandeep Kathju
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA, USA
    Obes Surg 20:251-6. 2010
  8. ncbi Pseudogout of the temporomandibular joint: immediate reconstruction with total joint arthroplasty
    Sandeep Kathju
    Division of Oral Maxillofacial Surgery, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA
    Head Neck 32:406-10. 2010
  9. ncbi Chaperonin containing T-complex polypeptide subunit eta (CCT-eta) is a specific regulator of fibroblast motility and contractility
    Latha Satish
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 5:e10063. 2010
  10. ncbi Chaperonin containing T-complex polypeptide (CCT) subunit expression in oral mucosal wounds and fibroblasts
    Latha Satish
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    Cell Stress Chaperones 16:675-80. 2011

Research Grants

  1. Molecular Analysis of Scarless Fetal Wound Healing
    Sandeep Kathju; Fiscal Year: 2007

Collaborators

Detail Information

Publications26

  1. ncbi Identification of differentially expressed genes in scarless wound healing utilizing polymerase chain reaction-suppression subtractive hybridization
    Sandeep Kathju
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212 4772, USA
    Wound Repair Regen 14:413-20. 2006
    ..With this approach, we have also identified novel genes potentially involved in scarless wound healing...
  2. ncbi Increased expression of Ero1L-alpha in healing fetal wounds
    Phillip H Gallo
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    BMC Res Notes 4:175. 2011
    ..abstract:..
  3. ncbi Multiple displacement amplification as an adjunct to PCR-based detection of Staphylococcus aureus in synovial fluid
    Sandeep Kathju
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA, USA
    BMC Res Notes 3:259. 2010
    ..aureus DNA as well as on clinical samples known to contain S. aureus nucleic acids...
  4. ncbi Bacterial biofilm on monofilament suture and porcine xenograft after inguinal herniorrhaphy
    Sandeep Kathju
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA, USA
    FEMS Immunol Med Microbiol 59:405-9. 2010
    ..These results demonstrate that implanted monofilament suture and xenograft material can provide the substratum for a chronic biofilm infection...
  5. ncbi Perineal hernia repair with acellular dermal graft and suture anchor fixation
    S Kathju
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212, USA
    Hernia 15:357-60. 2011
    ..We report a case wherein a large perineal hernia was reduced via an abdominal approach, and then repaired by the placement of an acellular dermal graft (DermaMatrix) fixated anteriorly directly to the pubis with Mitek suture anchors...
  6. ncbi Chronic surgical site infection due to suture-associated polymicrobial biofilm
    Sandeep Kathju
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Surg Infect (Larchmt) 10:457-61. 2009
    ..Surgical site infection (SSI) is a common surgical complication; culture-negative SSI presents a particular problem in management...
  7. ncbi Cutaneous fistula from the gastric remnant resulting from a chronic suture-associated biofilm infection
    Sandeep Kathju
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA, USA
    Obes Surg 20:251-6. 2010
    ..The patient has subsequently been free of complaint or finding for over 3 years...
  8. ncbi Pseudogout of the temporomandibular joint: immediate reconstruction with total joint arthroplasty
    Sandeep Kathju
    Division of Oral Maxillofacial Surgery, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA
    Head Neck 32:406-10. 2010
    ..Pseudogout of the temporomandibular joint (TMJ) is a rare disorder with <40 reported cases in the English-language literature. It is usually treated with surgical resection and condylectomy alone...
  9. ncbi Chaperonin containing T-complex polypeptide subunit eta (CCT-eta) is a specific regulator of fibroblast motility and contractility
    Latha Satish
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 5:e10063. 2010
    ..These results indicate that CCT-eta is a specific regulator of fibroblast motility and contractility and may be a key determinant of the scarless wound healing phenotype by means of its specific regulation of alpha-SMA expression...
  10. ncbi Chaperonin containing T-complex polypeptide (CCT) subunit expression in oral mucosal wounds and fibroblasts
    Latha Satish
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    Cell Stress Chaperones 16:675-80. 2011
    ..These differences may contribute to the reported difference in healing outcomes between these two tissue types...
  11. ncbi Expression of receptor for activated C kinase 1 in healing skin and mucosal wounds
    Latha Satish
    Wound Healing Program, Center for Genomic Sciences, Allegheny Singer Research Institute, 320 East North Ave, Pittsburgh, PA 15212, USA
    Ann Plast Surg 64:238-41. 2010
    ..These observations suggest that RACK1 may play an important role in distinguishing scarless fetal wound healing from its scirrhous counterpart in adults...
  12. ncbi Cloning and expression of rabbit CCT subunits eta and beta in healing cutaneous wounds
    Latha Satish
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    Cell Stress Chaperones 15:819-26. 2010
    ..smooth muscle actin (-SMA), a recognized substrate of CCT known to be important in integumentary wound healing, was also measured over the course of wound healing, and both mRNA and protein levels were elevated throughout the 28 days...
  13. ncbi Differential expression of chaperonin containing T-complex polypeptide (CCT) subunits during fetal and adult skin wound healing
    Latha Satish
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    Cell Stress Chaperones 13:527-33. 2008
    ..We also confirm that quantitative evaluation of CCT-alpha and CCT-zeta mRNA expression shows no change in healing fetal wounds...
  14. ncbi Direct demonstration of Staphylococcus biofilm in an external ventricular drain in a patient with a history of recurrent ventriculoperitoneal shunt failure
    Paul Stoodley
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212 4772, USA
    Pediatr Neurosurg 46:127-32. 2010
    ..Undetected biofilm may pose a latent risk on EVD and other neurosurgical catheters...
  15. ncbi Characterization of a mixed MRSA/MRSE biofilm in an explanted total ankle arthroplasty
    Paul Stoodley
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA, USA
    FEMS Immunol Med Microbiol 62:66-74. 2011
    ..These observations suggest that molecular methods, particularly the new Ibis methodology, may be a useful adjunct to routine cultures in the detection of biofilm bacteria in prosthetic joint infection...
  16. ncbi Direct demonstration of viable Staphylococcus aureus biofilms in an infected total joint arthroplasty. A case report
    Paul Stoodley
    Center for Genomic Sciences, Allegheny-Singer Research Institute, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212-4772, USA
    J Bone Joint Surg Am 90:1751-8. 2008
  17. ncbi New methods for the detection of orthopedic and other biofilm infections
    John William Costerton
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA, USA
    FEMS Immunol Med Microbiol 61:133-40. 2011
    ....
  18. ncbi Considering hidradenitis suppurativa as a bacterial biofilm disease
    Sandeep Kathju
    Division of Plastic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    FEMS Immunol Med Microbiol 65:385-9. 2012
    ..The paradigmatic clinical features of HS, coupled with the adherent bacterial communities we observe here, suggest that HS should be considered in the expanding spectrum of bacterial biofilm-based disorders...
  19. ncbi Fibroblasts from phenotypically normal palmar fascia exhibit molecular profiles highly similar to fibroblasts from active disease in Dupuytren's Contracture
    Latha Satish
    Department of Surgery, Division of Plastic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    BMC Med Genomics 5:15. 2012
    ....
  20. ncbi Reversal of TGF-β1 stimulation of α-smooth muscle actin and extracellular matrix components by cyclic AMP in Dupuytren's-derived fibroblasts
    Latha Satish
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
    BMC Musculoskelet Disord 12:113. 2011
    ....
  21. ncbi Mechanical effects, antimicrobial efficacy and cytotoxicity of usnic acid as a biofilm prophylaxis in PMMA
    Sunghwan Kim
    Allegheny General Hospital, Pittsburgh, PA, USA
    J Mater Sci Mater Med 22:2773-80. 2011
    ..Diminished biofilm formation on usnic-containing coupons indicated that usnic can be an effective anti-microbial agent...
  22. ncbi Molecular analysis of coronal perisutural tissues in a craniosynostotic rabbit model using polymerase chain reaction suppression subtractive hybridization
    James J Cray
    Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Pittsburgh and Pediatric Craniofacial Biology Laboratory, Children s Hospital of Pittsburgh, Pittsburgh, PA 15224, USA
    Plast Reconstr Surg 128:95-103. 2011
    ..To understand the pathogenesis of craniosynostosis, the authors compared gene expression in perisutural tissues between wild-type and craniosynostotic rabbits using polymerase chain reaction suppression subtractive hybridization...
  23. ncbi Scarless integumentary wound healing in the mammalian fetus: Molecular basis and therapeutic implications
    Sandeep Kathju
    Department of Surgery, Division of Plastic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania
    Birth Defects Res C Embryo Today 96:223-36. 2012
    ..Birth Defects Research (Part C) 96:223-236, 2012. © 2012 Wiley Periodicals, Inc...
  24. ncbi Secondary surgery for cicatricial complications of facial injury
    Irene Tower
    Department of Surgery, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    J Oral Maxillofac Surg 68:751-5. 2010
    ..To investigate the nature of surgical revision procedures necessitated by cicatricial complications of facial injury...
  25. ncbi Comparative supragenomic analyses among the pathogens Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae using a modification of the finite supragenome model
    Robert Boissy
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
    BMC Genomics 12:187. 2011
    ....
  26. ncbi Cellular and Molecular Characteristics of Scarless versus Fibrotic Wound Healing
    Latha Satish
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212, USA
    Dermatol Res Pract 2010:790234. 2010
    ..Understanding the molecular and cellular events during regenerative healing may provide clues that one day enable us to modulate adult wound healing and consequently reduce scarring...

Research Grants1

  1. Molecular Analysis of Scarless Fetal Wound Healing
    Sandeep Kathju; Fiscal Year: 2007
    ..With these complementary approaches we hope to thereby arrive at a broad understanding of the gene patterns controlling both fetal and adult wound healing, and identify gene products/pathways critical to both. ..