Research Topics
| Thomas B JulianSummaryAffiliation: Allegheny General Hospital Country: USA Publications
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Publications
Sentinel node biopsy after neoadjuvant chemotherapy for breast cancerThomas B Julian
Department of Human Oncology, Allegheny General Hospital, Pittsburgh, PA 15212, USA
Am J Surg 184:315-7. 2002....
Novel intraoperative molecular test for sentinel lymph node metastases in patients with early-stage breast cancerThomas B Julian
Allegheny Breast Care Center, Allegheny General Hospital, 320 E North Ave, Pittsburgh, PA 15212, USA
J Clin Oncol 26:3338-45. 2008..We present the results from a large, prospective evaluation of the first rapid molecular SLN test, the Breast Lymph Node (BLN) Assay...
Is sentinel node biopsy necessary in conservatively treated DCIS?Thomas B Julian
National Surgical Adjuvant Breast and Bowel Project Operations Office and Biostatistical Center, Pittsburgh, Pennsylvania, USA
Ann Surg Oncol 14:2202-8. 2007..Its use in patients with DCIS versus local excision (LE), observation, and/or breast irradiation remains in question...
Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trialDavid N Krag
National Surgical Adjuvant Breast and Bowel Project NSABP, Pittsburgh, PA, USA
Lancet Oncol 11:927-33. 2010....
Patient-reported outcomes in sentinel node-negative adjuvant breast cancer patients receiving sentinel-node biopsy or axillary dissection: National Surgical Adjuvant Breast and Bowel Project phase III protocol B-32Stephanie R Land
National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistics Center, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Clin Oncol 28:3929-36. 2010..We report the definitive patient-reported outcomes (PRO) comparisons...
Reduction in radiation-induced morbidity by use of an intercurrent boost in the management of early-stage breast cancerMark Trombetta
Department of Radiation Oncology, Allegheny General Hospital, Pittsburgh, PA 15212, USA
Int J Radiat Oncol Biol Phys 77:1303-8. 2010..Herein, we compare patients treated with whole-breast irradiation followed by boost compared with a cohort with a planned intercurrent radiation boost...
The half century of clinical trials of the National Surgical Adjuvant Breast And Bowel ProjectD Lawrence Wickerham
NSABP Operations Office, Biostatistical Center and Graduate School of Public Health, University of Pittsburgh, and Department of Human Oncology, Allegheny General Hospital, Pittsburgh, PA 15212, USA
Semin Oncol 35:522-9. 2008....
Sentinel lymph node biopsy and management of the axilla in ductal carcinoma in situHilary M Shapiro-Wright
Department of Human Oncology, Allegheny General Hospital, Pittsburgh, PA 15212, USA
J Natl Cancer Inst Monogr 2010:145-9. 2010..Routine use of sentinel node biopsy for DCIS is not supported...
The need for axillary dissection in patients with positive axillary sentinel lymph nodesRandal L Croshaw
Department of Human Oncology, Drexel University College of Medicine, Philadelphia, PA, USA
Curr Oncol Rep 13:5-10. 2011..The surgical approach to the treatment of breast cancer continues to move away from the traditional Halstedian concept...
Long-term cosmesis after lumpectomy and brachytherapy in the management of carcinoma of the previously irradiated breastMark Trombetta
Department of Radiation Oncology, Allegheny General Hospital, Pittsburgh, PA 15212, USA
Am J Clin Oncol 32:314-8. 2009..To evaluate the cosmetic outcome of brachytherapy after lumpectomy in the management of carcinoma of the previously irradiated breast...
Axillary recurrences following positive sentinel lymph node biopsy with individual tumor cells or micrometastases and no axillary dissectionKathleen M Erb
Department of Human Oncology, Allegheny General Hospital, Pittsburgh, PA 15212, USA
Breast Dis 31:83-90. 2010..One should consider the tumor characteristics, findings within the SLN, and a multidisciplinary treatment plan. Clinical trial results may help to resolve the dilemma. There appears to be a low risk for axillary recurrence...
Completion of axillary dissection for a positive sentinel node: necessary or not?Kathleen M Erb
Allegheny General Hospital, Pittsburgh, PA 15213, USA
Curr Oncol Rep 11:15-20. 2009..In selected patients, it may be appropriate to forgo an axillary node dissection, although there are no randomized clinical trial data to support or refute this suggestion...
Mammary fat necrosis following radiotherapy in the conservative management of localized breast cancer: does it matter?Mark Trombetta
Department of Radiation Oncology, Allegheny General Hospital, Pittsburgh, PA 15212, USA
Radiother Oncol 97:92-4. 2010..We wish to assess the clinical significance of fat necrosis resulting from post-lumpectomy breast irradiation...
The landmark surgical trials of the National Surgical Adjuvant Breast and Bowel ProjectD Lawrence Wickerham
National Surgical Adjuvant Breast and Bowel Project NSABP, Pittsburgh, Pennsylvania 15212, USA
World J Surg 30:1138-46. 2006....
Technical limitations of sentinel node biopsy in breast cancer: a single surgeon's experienceNilesh A Patel
Department of Human Oncology, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
Am Surg 69:111-6. 2003..In the present study SNB detection by both isotope and blue dye has been shown to be superior to blue dye alone. This finding demonstrates that these limitations may be overcome with the standardization of the technique used...
Comparison of conservative management techniques in the re-treatment of ipsilateral breast tumor recurrenceMark Trombetta
Department of Radiation Oncology, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212, USA
Brachytherapy 10:74-80. 2011..To compare brachytherapy and three-dimensional (3-D) conformal external beam radiotherapy for breast cancer presenting in the previously irradiated breast...
Correlation of the use of axillary ultrasound and lymph node needle biopsy with surgical lymph node pathology in patients with invasive breast cancerMichael S Cowher
Department of Surgery, Allegheny General Hospital, Pittsburgh, PA, USA
Am J Surg 196:756-9. 2008..Results vary regarding the utility of perioperative axillary ultrasound (AUS) and biopsy for detecting axillary metastases...
Neo-adjuvant hormonal therapyMarcia Valenzuela
Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
Breast J 14:279-83. 2008..Biomarker findings of improved response in tumors that are both estrogen receptor positive and HER-2 positive as well as progesterone receptor positivity only will be important for planning future selective treatment and clinical trials...
Compliance with patient-reported outcomes in multicenter clinical trials: methodologic and practical approachesStephanie R Land
National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Centers, Pittsburgh, PA 15213, USA
J Clin Oncol 25:5113-20. 2007..We describe the effectiveness of several interventions and of observational factors...
Ductal carcinoma in situ: biology, diagnosis, and new therapiesMarcia Valenzuela
Allegheny General Hospital, Pittsburgh, PA 15212, USA
Clin Breast Cancer 7:676-81. 2007..Genome-wide microarray-based gene expression analyses are now providing new opportunities to discover genes that are specifically activated or inactivated during the course of breast cancer progression...
The allegheny general modification of the Harvard Breast Cosmesis Scale for the retreated breastMark Trombetta
Department of Radiation Oncology, Allegheny General Hospital, 320 East North Ave, Pittsburgh, PA 15212, USA
Oncology (Williston Park) 23:954-6. 2009..We propose a modification of the scale for patients who undergo retreatment--the Allegheny General Modification of the Harvard/NSABP/RTOG scoring scale...
Prophylactic and Therapeutic Breast Conservation in BRCA1/2 Mutation CarriersRandal L Croshaw
Allegheny General Hospital, 320 E North Avenue, Pittsburgh, PA 15212 4746, USA
Int J Breast Cancer 2011:481563. 2011..This paper reviews the available literature for breast conservation and surgical decision making in BRCA1/2 mutation carriers...
Detection of occult sentinel lymph node micrometastases by immunohistochemistry in breast cancer. An NSABP protocol B-32 quality assurance studyDonald L Weaver
Department of Pathology, College of Medicine, University of Vermont, Burlington, Vermont 05405 0068, USA
Cancer 107:661-7. 2006..2 mm but not larger than 2.0 mm) or isolated tumor cell clusters (< or = 0.2 mm). This study defines the rate at which pathologists miss metastases on CK IHC of sentinel lymph nodes (SLN)...
Practice patterns of sentinel node biopsy at five comprehensive cancer centersDavid N Krag
J Natl Cancer Inst 95:1498-9. 2003
NSABP-32: Phase III, randomized trial comparing axillary resection with sentinal lymph node dissection: a description of the trialDavid N Krag
Department of Surgery, University of Vermont, Burlington, Vermont, USA
Ann Surg Oncol 11:208S-10S. 2004..A secondary aim of the B32 trial is to evaluate whether patients with "occult" metastases in the SNs have worse survival. Accrual is taking place at 73 institutions in North America, and 217 surgeons are enrolling patients...
Accelerated partial breast irradiation after conservative surgery for breast cancerHenry M Kuerer
Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Ann Surg 239:338-51. 2004..To critically review the theoretical and actual risks and benefits of accelerated partial breast irradiation (APBI) after breast-conserving surgery...
Prerandomization Surgical Training for the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-32 trial: a randomized phase III clinical trial to compare sentinel node resection to conventional axillary dissection in clinically node-negative breSeth P Harlow
Department of Surgery, University of Vermont College of Medicine and the Vermont Cancer Center, Burlington 05405, USA
Ann Surg 241:48-54. 2005..To train surgeons in a standardized technique of sentinel lymph node biopsy and to prepare them for the requirements of a prospective randomized surgical trial...
Mammographic density and breast cancer after ductal carcinoma in situLaurel A Habel
Division of Research, Kaiser Permanente Medical Care Program, Oakland, CA 94612, USA
J Natl Cancer Inst 96:1467-72. 2004..Our results provide initial evidence that the risk of second breast cancers may be increased among DCIS patients with highly dense breasts...
Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trialDavid N Krag
University of Vermont, College of Medicine, Burlington, VT 05405 0068, USA
Lancet Oncol 8:881-8. 2007..The aim of this paper is to report the technical success and accuracy of SLN resection plus ALND versus SLN resection alone...
Image-detected breast cancer: state of the art diagnosis and treatmentMelvin J Silverstein
USC-Norris Cancer Center, Los Angeles 90033, USA
J Am Coll Surg 201:586-97. 2005
Report of the Working Groups on Breast MRI: report of the Breast Cancer Staging GroupSteven E Harms
University of Arkansas for Medical Sciences, Little Rock 72205, USA
Breast J 10:S3-8. 2004
Added cancer yield of MRI in screening the contralateral breast of women recently diagnosed with breast cancer: results from the International Breast Magnetic Resonance Consortium (IBMC) trialConstance D Lehman
Department of Radiology, University of Washington, Seattle Cancer Care Alliance, Seattle, Washington 98109, USA
J Surg Oncol 92:9-15; discussion 15-6. 2005..To estimate the added cancer yield of magnetic resonance imaging (MRI) over mammography in the contralateral breast of patients with a recent diagnosis of breast cancer...
MRI evaluation of the contralateral breast in women with recently diagnosed breast cancerConstance D Lehman
University of Washington Medical Center, Seattle, WA 98109, USA
N Engl J Med 356:1295-303. 2007....
Report of the Working Groups on Breast MRI: report of the Biopsy and Intervention Working GroupV Suzanne Klimberg
University of Arkansas for Medical Sciences, Little Rock 72205-12191, USA
Breast J 10:S13-6. 2004
