Fen Ze Hu

Summary

Affiliation: Allegheny General Hospital
Country: USA

Publications

  1. pmc The microbiome of chronic rhinosinusitis: culture, molecular diagnostics and biofilm detection
    Sam Boase
    Department of Surgery Otorhinolaryngology, Head and Neck Surgery, University of Adelaide, Adelaide, Australia
    BMC Infect Dis 13:210. 2013
  2. pmc Design and validation of a supragenome array for determination of the genomic content of Haemophilus influenzae isolates
    Rory A Eutsey
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    BMC Genomics 14:484. 2013
  3. pmc Preliminary study: treatment with intramuscular interferon beta-1a results in increased levels of IL-12Rβ2+ and decreased levels of IL23R+ CD4+ T - Lymphocytes in multiple sclerosis
    Jennifer M Kress-Bennett
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
    BMC Neurol 11:155. 2011
  4. pmc Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species
    Claudio Donati
    Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy
    Genome Biol 11:R107. 2010
  5. pmc Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains
    Justin S Hogg
    Allegheny General Hospital, Allegheny Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania 15212, USA
    Genome Biol 8:R103. 2007
  6. pmc Comparative supragenomic analyses among the pathogens Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae using a modification of the finite supragenome model
    Robert Boissy
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
    BMC Genomics 12:187. 2011
  7. pmc Comparative analysis and supragenome modeling of twelve Moraxella catarrhalis clinical isolates
    Jeremiah J Davie
    Department of Microbiology and Immunology, University at Buffalo, Buffalo, New York, USA
    BMC Genomics 12:70. 2011
  8. doi request reprint Population-level virulence factors amongst pathogenic bacteria: relation to infection outcome
    Fen Ze Hu
    Center for Genomic Sciences, Allegheny Singer Research Institute Allegheny General Hospital, USA
    Future Microbiol 3:31-42. 2008
  9. pmc Construction and characterization of a highly redundant Pseudomonas aeruginosa genomic library prepared from 12 clinical isolates: application to studies of gene distribution among populations
    Geza Erdos
    Center for Genomic Sciences, Allegheny Singer Research Institute, 320 E North Avenue, Pittsburgh, PA 15212, United States
    Int J Pediatr Otorhinolaryngol 70:1891-900. 2006
  10. pmc The distributed genome hypothesis as a rubric for understanding evolution in situ during chronic bacterial biofilm infectious processes
    Garth D Ehrlich
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA, USA
    FEMS Immunol Med Microbiol 59:269-79. 2010

Collaborators

Detail Information

Publications22

  1. pmc The microbiome of chronic rhinosinusitis: culture, molecular diagnostics and biofilm detection
    Sam Boase
    Department of Surgery Otorhinolaryngology, Head and Neck Surgery, University of Adelaide, Adelaide, Australia
    BMC Infect Dis 13:210. 2013
    ..This study used multiple detection methods to compare microbial diversity and microbial abundance in healthy and diseased sinonasal mucosa. The utility of contemporary detection methods is also examined...
  2. pmc Design and validation of a supragenome array for determination of the genomic content of Haemophilus influenzae isolates
    Rory A Eutsey
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    BMC Genomics 14:484. 2013
    ..influenzae display extensive genomic diversity and plasticity. The development of strategies to successfully prevent, diagnose and treat H. influenzae infections depends on tools to ascertain the gene content of individual isolates...
  3. pmc Preliminary study: treatment with intramuscular interferon beta-1a results in increased levels of IL-12Rβ2+ and decreased levels of IL23R+ CD4+ T - Lymphocytes in multiple sclerosis
    Jennifer M Kress-Bennett
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
    BMC Neurol 11:155. 2011
    ....
  4. pmc Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species
    Claudio Donati
    Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy
    Genome Biol 11:R107. 2010
    ..Streptococcus pneumoniae is one of the most important causes of microbial diseases in humans. The genomes of 44 diverse strains of S. pneumoniae were analyzed and compared with strains of non-pathogenic streptococci of the Mitis group...
  5. pmc Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains
    Justin S Hogg
    Allegheny General Hospital, Allegheny Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania 15212, USA
    Genome Biol 8:R103. 2007
    ..Studies based on random sequencing of multiple strain libraries suggested that free-living bacterial species possess a supragenome that is much larger than the genome of any single bacterium...
  6. pmc Comparative supragenomic analyses among the pathogens Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae using a modification of the finite supragenome model
    Robert Boissy
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
    BMC Genomics 12:187. 2011
    ....
  7. pmc Comparative analysis and supragenome modeling of twelve Moraxella catarrhalis clinical isolates
    Jeremiah J Davie
    Department of Microbiology and Immunology, University at Buffalo, Buffalo, New York, USA
    BMC Genomics 12:70. 2011
    ..catarrhalis clinical isolates, a greater understanding of this pathogen's genome and its variability among isolates is needed...
  8. doi request reprint Population-level virulence factors amongst pathogenic bacteria: relation to infection outcome
    Fen Ze Hu
    Center for Genomic Sciences, Allegheny Singer Research Institute Allegheny General Hospital, USA
    Future Microbiol 3:31-42. 2008
    ..The recent recognition of multicellularity among chronic bacterial pathogens will lead the way towards new multimodality therapies...
  9. pmc Construction and characterization of a highly redundant Pseudomonas aeruginosa genomic library prepared from 12 clinical isolates: application to studies of gene distribution among populations
    Geza Erdos
    Center for Genomic Sciences, Allegheny Singer Research Institute, 320 E North Avenue, Pittsburgh, PA 15212, United States
    Int J Pediatr Otorhinolaryngol 70:1891-900. 2006
    ....
  10. pmc The distributed genome hypothesis as a rubric for understanding evolution in situ during chronic bacterial biofilm infectious processes
    Garth D Ehrlich
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA, USA
    FEMS Immunol Med Microbiol 59:269-79. 2010
    ....
  11. pmc Virulence phenotypes of low-passage clinical isolates of nontypeable Haemophilus influenzae assessed using the chinchilla laniger model of otitis media
    Farrel J Buchinsky
    Center for Genomic Sciences, Allegheny Singer Research Institute Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    BMC Microbiol 7:56. 2007
    ..These diverse clinical and genotypic findings suggest that each NTHi strain possesses a unique set of virulence factors that contributes to the course of the disease...
  12. pmc Strain-specific virulence phenotypes of Streptococcus pneumoniae assessed using the Chinchilla laniger model of otitis media
    Michael L Forbes
    Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 3:e1969. 2008
    ....
  13. pmc Differential expression of chaperonin containing T-complex polypeptide (CCT) subunits during fetal and adult skin wound healing
    Latha Satish
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    Cell Stress Chaperones 13:527-33. 2008
    ..We also confirm that quantitative evaluation of CCT-alpha and CCT-zeta mRNA expression shows no change in healing fetal wounds...
  14. pmc Characterization of biofilm matrix, degradation by DNase treatment and evidence of capsule downregulation in Streptococcus pneumoniae clinical isolates
    Luanne Hall-Stoodley
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
    BMC Microbiol 8:173. 2008
    ..To better understand pneumococcal biofilm formation six low-passage encapsulated nasopharyngeal isolates of S. pneumoniae were assessed over a six-eight day period in vitro...
  15. pmc Direct detection of bacterial biofilms on the middle-ear mucosa of children with chronic otitis media
    Luanne Hall-Stoodley
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
    JAMA 296:202-11. 2006
    ....
  16. ncbi request reprint Development and characterization of a pooled Haemophilus influenzae genomic library for the evaluation of gene expression changes associated with mucosal biofilm formation in otitis media
    Geza Erdos
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, 320 E North Ave, Pittsburgh, PA 15212, USA
    Int J Pediatr Otorhinolaryngol 67:749-55. 2003
    ..It has been etiologically associated with otitis media, otorrhea, and chronic obstructive pulmonary disease. Identification of new genomic elements will provide novel targets to fight chronic infections caused by this organism...
  17. pmc Codon usage comparison of novel genes in clinical isolates of Haemophilus influenzae
    John Gladitz
    Center for Genomic Sciences, Allegheny Singer Research Institute Pittsburgh, PA, USA
    Nucleic Acids Res 33:3644-58. 2005
    ..The remaining novel sequences produced similarity statistics closer to one of the other reference genomes thereby suggesting that these sequences may have entered the H.influenzae gene pool more recently via horizontal transfer...
  18. ncbi request reprint Identification of differentially expressed genes in scarless wound healing utilizing polymerase chain reaction-suppression subtractive hybridization
    Sandeep Kathju
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212 4772, USA
    Wound Repair Regen 14:413-20. 2006
    ..With this approach, we have also identified novel genes potentially involved in scarless wound healing...
  19. pmc What makes pathogens pathogenic
    Garth D Ehrlich
    Center for Genomic Sciences, Allegheny General Hospital, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
    Genome Biol 9:225. 2008
    ..This transition is likely to depend both on the prevailing environmental conditions and on specific gene-gene interactions placed within the context of the entire ecosystem...
  20. ncbi request reprint Fine mapping a gene for pediatric gastroesophageal reflux on human chromosome 13q14
    Fen Ze Hu
    Center for Genomic Sciences, Allegheny Singer Research Institute, 320 East North Ave, Pittsburgh, PA 15212, USA
    Hum Genet 114:562-72. 2004
    ..The results suggest that the GERD1 gene might be located near SNP160 or SNP168...
  21. ncbi request reprint Mucosal biofilm formation on middle-ear mucosa in the chinchilla model of otitis media
    Garth D Ehrlich
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
    JAMA 287:1710-5. 2002
    ....
  22. ncbi request reprint Lack of major involvement of human uroplakin genes in vesicoureteral reflux: implications for disease heterogeneity
    Songshan Jiang
    Epithelial Biology Unit, Ronald O Perelman Department of Dermatology, Kaplan Comprehensive Cancer Center, New York University Medical School, New York, New York, USA
    Kidney Int 66:10-9. 2004
    ..Recent studies indicate that genetic ablation of mouse uroplakin (UP) III gene, which encodes a 47 kD urothelial-specific integral membrane protein forming urothelial plaques, causes VUR and hydronephrosis...