Deborah A Gentile

Summary

Affiliation: Allegheny General Hospital
Country: USA

Publications

  1. ncbi request reprint Effect of tetanus immunization on t-helper cytokine production in adults with and without allergic rhinitis
    Deborah Gentile
    Dept of Pediatrics, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Allergy Asthma Proc 27:197-201. 2006
  2. doi request reprint Sublingual immunotherapy in patients with allergic rhinoconjunctivitis
    Deborah Gentile
    Division of Allergy, Asthma, and Immunology, Department of Internal Medicine, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212, USA
    Curr Allergy Asthma Rep 11:131-8. 2011
  3. ncbi request reprint Evolving role of leukotrienes in the pathogenesis of viral infections, including otitis media
    Deborah Gentile
    Division of Allergy, Asthma and Immunology, Allegheny General Hospital, 320 E North Avenue, Pittsburgh, PA 15212, USA
    Curr Allergy Asthma Rep 6:316-20. 2006
  4. ncbi request reprint Diminished dendritic cell interleukin 10 production in atopic children
    Deborah A Gentile
    Division of Allergy, Asthma and Immunology, Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Ann Allergy Asthma Immunol 92:538-44. 2004
  5. ncbi request reprint Association between TNF-alpha and TGF-beta genotypes in infants and parental history of allergic rhinitis and asthma
    Deborah A Gentile
    Department of Pediatrics, Allegheny General Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA 15212, USA
    Hum Immunol 65:347-51. 2004
  6. ncbi request reprint Elevations of local leukotriene C4 levels during viral upper respiratory tract infections
    Deborah A Gentile
    Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Ann Allergy Asthma Immunol 91:270-4. 2003
  7. ncbi request reprint Association between environmental tobacco smoke and diminished dendritic cell interleukin 10 production during infancy
    Deborah Gentile
    Division of Allergy, Asthma and Immunology, Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Ann Allergy Asthma Immunol 92:433-7. 2004
  8. ncbi request reprint Cytokine gene polymorphisms moderate illness severity in infants with respiratory syncytial virus infection
    Deborah A Gentile
    Department of Pediatrics, Children s Hospital of Pittsburgh, PA 15213, USA
    Hum Immunol 64:338-44. 2003
  9. ncbi request reprint Cytokine gene polymorphisms moderate responses to respiratory syncytial virus in adults
    Deborah A Gentile
    Department of Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Hum Immunol 64:93-8. 2003
  10. ncbi request reprint Cytokine levels during symptomatic viral upper respiratory tract infection
    Deborah A Gentile
    Department of Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15212, USA
    Ann Allergy Asthma Immunol 91:362-7. 2003

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Effect of tetanus immunization on t-helper cytokine production in adults with and without allergic rhinitis
    Deborah Gentile
    Dept of Pediatrics, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Allergy Asthma Proc 27:197-201. 2006
    ..Future studies are warranted and may result in the identification of potential prevention/treatment strategies for atopy/asthma...
  2. doi request reprint Sublingual immunotherapy in patients with allergic rhinoconjunctivitis
    Deborah Gentile
    Division of Allergy, Asthma, and Immunology, Department of Internal Medicine, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212, USA
    Curr Allergy Asthma Rep 11:131-8. 2011
    ..Results of recent US studies document the safety and efficacy of SLIT and have started to yield insight into the mechanisms of SLIT...
  3. ncbi request reprint Evolving role of leukotrienes in the pathogenesis of viral infections, including otitis media
    Deborah Gentile
    Division of Allergy, Asthma and Immunology, Allegheny General Hospital, 320 E North Avenue, Pittsburgh, PA 15212, USA
    Curr Allergy Asthma Rep 6:316-20. 2006
    ..If proven effective, this drug's safety/convenience profiles and indication for children as young as 6 months of age would make it suitable for treatment of OM, and perhaps even prophylaxis of OM in at-risk populations...
  4. ncbi request reprint Diminished dendritic cell interleukin 10 production in atopic children
    Deborah A Gentile
    Division of Allergy, Asthma and Immunology, Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Ann Allergy Asthma Immunol 92:538-44. 2004
    ..Diminished interleukin 10 (IL-10) and/or IL-12 production may contribute to the pathogenesis of asthma and atopy. Dendritic cells (DCs) produce these cytokines and have been implicated in the pathogenesis of these disorders...
  5. ncbi request reprint Association between TNF-alpha and TGF-beta genotypes in infants and parental history of allergic rhinitis and asthma
    Deborah A Gentile
    Department of Pediatrics, Allegheny General Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA 15212, USA
    Hum Immunol 65:347-51. 2004
    ..If confirmed by future studies, cytokine genotyping may be a useful tool for identifying at-risk infants who may benefit from the selective use of preventative and/or early intervention treatments for these disorders...
  6. ncbi request reprint Elevations of local leukotriene C4 levels during viral upper respiratory tract infections
    Deborah A Gentile
    Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Ann Allergy Asthma Immunol 91:270-4. 2003
    ..One potential mechanism by which respiratory viruses trigger illness and complications is via the local elaboration of inflammatory mediators...
  7. ncbi request reprint Association between environmental tobacco smoke and diminished dendritic cell interleukin 10 production during infancy
    Deborah Gentile
    Division of Allergy, Asthma and Immunology, Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Ann Allergy Asthma Immunol 92:433-7. 2004
    ..Diminished interleukin 10 (IL-10) production has been documented in children and adults with asthma and atopy. Environmental tobacco smoke (ETS) is recognized as a risk factor for the development of childhood asthma...
  8. ncbi request reprint Cytokine gene polymorphisms moderate illness severity in infants with respiratory syncytial virus infection
    Deborah A Gentile
    Department of Pediatrics, Children s Hospital of Pittsburgh, PA 15213, USA
    Hum Immunol 64:338-44. 2003
    ..If future prospective studies confirm these observations, cytokine genotyping may be a useful tool for identifying "at risk" infants who may benefit from the selective use of preventive or early intervention treatments for RSV...
  9. ncbi request reprint Cytokine gene polymorphisms moderate responses to respiratory syncytial virus in adults
    Deborah A Gentile
    Department of Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Hum Immunol 64:93-8. 2003
    ..These results suggest that certain cytokine gene polymorphisms moderate immune responses and illness severity in adults experimentally exposed to RSV...
  10. ncbi request reprint Cytokine levels during symptomatic viral upper respiratory tract infection
    Deborah A Gentile
    Department of Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15212, USA
    Ann Allergy Asthma Immunol 91:362-7. 2003
    ..However, most of these studies fail to make comparisons between symptomatic and asymptomatic infected subjects...
  11. ncbi request reprint Emotional style, nasal cytokines, and illness expression after experimental rhinovirus exposure
    William J Doyle
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain Behav Immun 20:175-81. 2006
    ..These results are consistent with the hypothesis that IL-6 acts as a biological mediator in linking positive emotional style to illness expression during rhinovirus infection...
  12. ncbi request reprint Allergy skin test responses during experimental infection with respiratory syncytial virus
    David P Skoner
    Department of Pediatrics, Allegheny Singer Research Institute, Pittsburgh, Pennsylvania 15212, USA
    Ann Allergy Asthma Immunol 96:834-9. 2006
    ..False-positive allergen skin test results are known to occur; however, contributing factors are not well understood...
  13. doi request reprint New asthma drugs: small molecule inhaled corticosteroids
    Deborah A Gentile
    Division of Allergy, Asthma and Immunology, Department of Pediatrics, Allegheny General Hospital, Pittsburgh, PA, United States
    Curr Opin Pharmacol 10:260-5. 2010
    ....
  14. ncbi request reprint Viral and bacterial rhinitis
    William J Doyle
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Allergy Immunol 19:177-95. 2007
    ....
  15. ncbi request reprint Effect of respiratory syncytial virus infection during early infancy on the ontogeny of cytokine immune responses
    Deborah A Gentile
    Department of Pediatrics, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Allergy Asthma Proc 23:399-405. 2002
    ..Such strategies may include administration of IL-12 or manipulation of DC maturation or function...
  16. ncbi request reprint Nasal and oral nitric oxide levels during experimental respiratory syncytial virus infection of adults
    Deborah A Gentile
    Department of Pediatrics, Children s Hospital of Pittsburgh and the University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Acta Otolaryngol 122:61-6. 2002
    ..These results do not support the hypothesis of increased NO production during RSV infection and complement earlier studies that reported a lack of change in nasal NO concentration during experimental influenza and rhinovirus infections...
  17. doi request reprint Sublingual immunotherapy in patients with allergic rhinoconjunctivitis caused by ragweed pollen
    David Skoner
    Drexel University College of Medicine, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    J Allergy Clin Immunol 125:660-6, 666.e1-666.e4. 2010
    ..Specific allergen immunotherapy is most often delivered subcutaneously, but sublingual immunotherapy may confer greater benefit in terms of tolerability and safety, accessibility, and improved antigen delivery...
  18. ncbi request reprint An asthma sports camp series to identify children with possible asthma and cardiovascular risk factors
    Jennifer Padden Elliott
    Duquesne University, Mylan School of Pharmacy, Pittsburgh, PA, USA
    J Asthma 51:267-74. 2014
    ..In response to known disparities in asthma prevalence and morbidity, along with barriers to diagnosis, assessment and education, a comprehensive asthma sports camp series was developed and implemented...
  19. doi request reprint Effect of therapeutic doses of mometasone furoate on cortisol levels in children with mild asthma
    David P Skoner
    Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212, USA
    Allergy Asthma Proc 31:10-9. 2010
    ..All regimens were well tolerated. MF-DPI did not have a significant effect on plasma or urinary cortisol levels at doses up to 200 micrograms b.i.d. in children with mild asthma. Higher MF-DPI doses may potentially suppress the HPA axis...
  20. doi request reprint Effect on growth of long-term treatment with intranasal triamcinolone acetonide aqueous in children with allergic rhinitis
    David P Skoner
    Division of Allergy, Asthma, and Immunology, Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Ann Allergy Asthma Immunol 101:431-6. 2008
    ..Guidelines recommend treatment with intranasal corticosteroids for patients with allergic rhinitis (AR), but concerns remain about possible adverse effects...
  21. ncbi request reprint Comparison of subject-reported allergy versus skin test results in a common cold trial
    Jason S Krahnke
    Department of Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Rhinol 17:159-62. 2003
    ..The objective of this study was to compare the results of self-reported allergy via verbal questioning with the results of allergy skin testing by the puncture method in 237 healthy adult subjects enrolled in a common cold study...
  22. ncbi request reprint The effects of intranasal triamcinolone acetonide and intranasal fluticasone propionate on short-term bone growth and HPA axis in children with allergic rhinitis
    David P Skoner
    Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Ann Allergy Asthma Immunol 90:56-62. 2003
    ....
  23. ncbi request reprint Comparison of objective and subjective measurements of cough frequency in patients with seasonal allergic rhinitis
    Jason Krahnke
    Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Ann Allergy Asthma Immunol 93:259-64. 2004
    ..However, it is not known whether subjective reports of cough from patients with SAR are accurate...
  24. ncbi request reprint Nasal and otologic effects of experimental respiratory syncytial virus infection in adults
    Craig A Buchman
    Department of Otolaryngology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA
    Am J Otolaryngol 23:70-5. 2002
    ..This study was conducted to more clearly define the extent and frequency of nasal and otologic effects of respiratory syncytial virus infection in healthy adult volunteers...
  25. doi request reprint A randomized, double-blind, parallel-group, multicenter, placebo-controlled study of the safety and efficacy of extended-release guaifenesin/pseudoephedrine hydrochloride for symptom relief as an adjunctive therapy to antibiotic treatment of acute respira
    Craig LaForce
    North Carolina Clinical Research Inc, Raleigh, NC, USA
    Postgrad Med 120:53-9. 2008
    ....