Garth Ehrlich

Summary

Affiliation: Allegheny General Hospital
Country: USA

Publications

  1. pmc The microbiome of chronic rhinosinusitis: culture, molecular diagnostics and biofilm detection
    Sam Boase
    Department of Surgery Otorhinolaryngology, Head and Neck Surgery, University of Adelaide, Adelaide, Australia
    BMC Infect Dis 13:210. 2013
  2. pmc Comparison of PCR/electron spray ionization-time-of-flight-mass spectrometry versus traditional clinical microbiology for active surveillance of organisms contaminating high-use surfaces in a burn intensive care unit, an orthopedic ward and healthcare wor
    Heather C Yun
    San Antonio Military Medical Center, San Antonio, TX, USA
    BMC Infect Dis 12:252. 2012
  3. pmc Design and validation of a supragenome array for determination of the genomic content of Haemophilus influenzae isolates
    Rory A Eutsey
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    BMC Genomics 14:484. 2013
  4. pmc Preliminary study: treatment with intramuscular interferon beta-1a results in increased levels of IL-12Rβ2+ and decreased levels of IL23R+ CD4+ T - Lymphocytes in multiple sclerosis
    Jennifer M Kress-Bennett
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
    BMC Neurol 11:155. 2011
  5. pmc Fibroblasts from phenotypically normal palmar fascia exhibit molecular profiles highly similar to fibroblasts from active disease in Dupuytren's Contracture
    Latha Satish
    Department of Surgery, Division of Plastic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    BMC Med Genomics 5:15. 2012
  6. pmc Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species
    Claudio Donati
    Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy
    Genome Biol 11:R107. 2010
  7. pmc Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains
    Justin S Hogg
    Allegheny General Hospital, Allegheny Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania 15212, USA
    Genome Biol 8:R103. 2007
  8. pmc Multiple displacement amplification as an adjunct to PCR-based detection of Staphylococcus aureus in synovial fluid
    Sandeep Kathju
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA, USA
    BMC Res Notes 3:259. 2010
  9. pmc Physiology of Pseudomonas aeruginosa in biofilms as revealed by transcriptome analysis
    James P Folsom
    Center for Biofilm Engineering and Department of Chemical and Biological Engineering, PO Box 173980, Montana State University Bozeman, Bozeman, Montana 59717 3980, USA
    BMC Microbiol 10:294. 2010
  10. pmc Characterization of biofilm matrix, degradation by DNase treatment and evidence of capsule downregulation in Streptococcus pneumoniae clinical isolates
    Luanne Hall-Stoodley
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
    BMC Microbiol 8:173. 2008

Collaborators

Detail Information

Publications55

  1. pmc The microbiome of chronic rhinosinusitis: culture, molecular diagnostics and biofilm detection
    Sam Boase
    Department of Surgery Otorhinolaryngology, Head and Neck Surgery, University of Adelaide, Adelaide, Australia
    BMC Infect Dis 13:210. 2013
    ..This study used multiple detection methods to compare microbial diversity and microbial abundance in healthy and diseased sinonasal mucosa. The utility of contemporary detection methods is also examined...
  2. pmc Comparison of PCR/electron spray ionization-time-of-flight-mass spectrometry versus traditional clinical microbiology for active surveillance of organisms contaminating high-use surfaces in a burn intensive care unit, an orthopedic ward and healthcare wor
    Heather C Yun
    San Antonio Military Medical Center, San Antonio, TX, USA
    BMC Infect Dis 12:252. 2012
    ..Understanding nosocomial pathogen transmission is restricted by culture limitations. Novel platforms, such as PCR-based electron spray ionization-time-of-flight-mass spectrometry (ESI-TOF-MS), may be useful as investigational tools...
  3. pmc Design and validation of a supragenome array for determination of the genomic content of Haemophilus influenzae isolates
    Rory A Eutsey
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    BMC Genomics 14:484. 2013
    ..influenzae display extensive genomic diversity and plasticity. The development of strategies to successfully prevent, diagnose and treat H. influenzae infections depends on tools to ascertain the gene content of individual isolates...
  4. pmc Preliminary study: treatment with intramuscular interferon beta-1a results in increased levels of IL-12Rβ2+ and decreased levels of IL23R+ CD4+ T - Lymphocytes in multiple sclerosis
    Jennifer M Kress-Bennett
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
    BMC Neurol 11:155. 2011
    ....
  5. pmc Fibroblasts from phenotypically normal palmar fascia exhibit molecular profiles highly similar to fibroblasts from active disease in Dupuytren's Contracture
    Latha Satish
    Department of Surgery, Division of Plastic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    BMC Med Genomics 5:15. 2012
    ....
  6. pmc Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species
    Claudio Donati
    Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy
    Genome Biol 11:R107. 2010
    ..Streptococcus pneumoniae is one of the most important causes of microbial diseases in humans. The genomes of 44 diverse strains of S. pneumoniae were analyzed and compared with strains of non-pathogenic streptococci of the Mitis group...
  7. pmc Characterization and modeling of the Haemophilus influenzae core and supragenomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains
    Justin S Hogg
    Allegheny General Hospital, Allegheny Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania 15212, USA
    Genome Biol 8:R103. 2007
    ..Studies based on random sequencing of multiple strain libraries suggested that free-living bacterial species possess a supragenome that is much larger than the genome of any single bacterium...
  8. pmc Multiple displacement amplification as an adjunct to PCR-based detection of Staphylococcus aureus in synovial fluid
    Sandeep Kathju
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA, USA
    BMC Res Notes 3:259. 2010
    ..aureus DNA as well as on clinical samples known to contain S. aureus nucleic acids...
  9. pmc Physiology of Pseudomonas aeruginosa in biofilms as revealed by transcriptome analysis
    James P Folsom
    Center for Biofilm Engineering and Department of Chemical and Biological Engineering, PO Box 173980, Montana State University Bozeman, Bozeman, Montana 59717 3980, USA
    BMC Microbiol 10:294. 2010
    ....
  10. pmc Characterization of biofilm matrix, degradation by DNase treatment and evidence of capsule downregulation in Streptococcus pneumoniae clinical isolates
    Luanne Hall-Stoodley
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
    BMC Microbiol 8:173. 2008
    ..To better understand pneumococcal biofilm formation six low-passage encapsulated nasopharyngeal isolates of S. pneumoniae were assessed over a six-eight day period in vitro...
  11. pmc Virulence phenotypes of low-passage clinical isolates of nontypeable Haemophilus influenzae assessed using the chinchilla laniger model of otitis media
    Farrel J Buchinsky
    Center for Genomic Sciences, Allegheny Singer Research Institute Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    BMC Microbiol 7:56. 2007
    ..These diverse clinical and genotypic findings suggest that each NTHi strain possesses a unique set of virulence factors that contributes to the course of the disease...
  12. pmc Comparative supragenomic analyses among the pathogens Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae using a modification of the finite supragenome model
    Robert Boissy
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
    BMC Genomics 12:187. 2011
    ....
  13. pmc Comparative analysis and supragenome modeling of twelve Moraxella catarrhalis clinical isolates
    Jeremiah J Davie
    Department of Microbiology and Immunology, University at Buffalo, Buffalo, New York, USA
    BMC Genomics 12:70. 2011
    ..catarrhalis clinical isolates, a greater understanding of this pathogen's genome and its variability among isolates is needed...
  14. pmc What makes pathogens pathogenic
    Garth D Ehrlich
    Center for Genomic Sciences, Allegheny General Hospital, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
    Genome Biol 9:225. 2008
    ..This transition is likely to depend both on the prevailing environmental conditions and on specific gene-gene interactions placed within the context of the entire ecosystem...
  15. ncbi request reprint Mucosal biofilm formation on middle-ear mucosa in the chinchilla model of otitis media
    Garth D Ehrlich
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
    JAMA 287:1710-5. 2002
    ....
  16. pmc Direct detection of bacterial biofilms on the middle-ear mucosa of children with chronic otitis media
    Luanne Hall-Stoodley
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
    JAMA 296:202-11. 2006
    ....
  17. ncbi request reprint Identification of differentially expressed genes in scarless wound healing utilizing polymerase chain reaction-suppression subtractive hybridization
    Sandeep Kathju
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212 4772, USA
    Wound Repair Regen 14:413-20. 2006
    ..With this approach, we have also identified novel genes potentially involved in scarless wound healing...
  18. ncbi request reprint Human susceptibility to viral infection: the search for HIV-protective alleles among Africans by means of genome-wide studies
    Joseph Donfack
    Center for Genomic Sciences, Allegheny Singer Research Institute, Drexel University College of Medicine, Pittsburgh, Pennsylvania 15212, USA
    AIDS Res Hum Retroviruses 22:925-30. 2006
    ....
  19. pmc Strain-specific virulence phenotypes of Streptococcus pneumoniae assessed using the Chinchilla laniger model of otitis media
    Michael L Forbes
    Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 3:e1969. 2008
    ....
  20. doi request reprint Population-level virulence factors amongst pathogenic bacteria: relation to infection outcome
    Fen Ze Hu
    Center for Genomic Sciences, Allegheny Singer Research Institute Allegheny General Hospital, USA
    Future Microbiol 3:31-42. 2008
    ..The recent recognition of multicellularity among chronic bacterial pathogens will lead the way towards new multimodality therapies...
  21. pmc Chronic surgical site infection due to suture-associated polymicrobial biofilm
    Sandeep Kathju
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Surg Infect (Larchmt) 10:457-61. 2009
    ..Surgical site infection (SSI) is a common surgical complication; culture-negative SSI presents a particular problem in management...
  22. ncbi request reprint The role of biofilms in otolaryngologic infections: update 2007
    J Christopher Post
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, Pennsylvania, USA
    Curr Opin Otolaryngol Head Neck Surg 15:347-51. 2007
    ..Biofilms have been shown to play a role in otitis media, sinusitis, cholesteatoma, tonsillitis, adenoiditis, and device infections. This article is written to review recent advances in the field...
  23. ncbi request reprint Genetics of pediatric gastroesophageal reflux
    J Christopher Post
    Center for Genomic Sciences, Allegheny Singer Research Institute, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    Curr Opin Allergy Clin Immunol 5:5-9. 2005
    ..The results of family and twin studies have identified an inherited tendency toward developing the disease, and a locus common to multiple families with severe GERD has been found on 13q14, known as GERD1...
  24. ncbi request reprint Multicenter initiative seeking critical genes in respiratory papillomatosis
    Farrel J Buchinsky
    Center for Genomic Sciences, Allegheny Singer Research Institute, 320 E North Avenue, Pittsburgh, PA 15212 4772, USA
    Laryngoscope 114:349-57. 2004
    ..Genetically encoded host susceptibility is postulated. Determining the host genes that govern susceptibility will enhance our understanding not only of RRP but also of host-viral interaction in general...
  25. ncbi request reprint Development and characterization of a pooled Haemophilus influenzae genomic library for the evaluation of gene expression changes associated with mucosal biofilm formation in otitis media
    Geza Erdos
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, 320 E North Ave, Pittsburgh, PA 15212, USA
    Int J Pediatr Otorhinolaryngol 67:749-55. 2003
    ..It has been etiologically associated with otitis media, otorrhea, and chronic obstructive pulmonary disease. Identification of new genomic elements will provide novel targets to fight chronic infections caused by this organism...
  26. doi request reprint Fluorescence "in situ" hybridization for the detection of biofilm in the middle ear and upper respiratory tract mucosa
    Laura Nistico
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA, USA
    Methods Mol Biol 493:191-213. 2009
    ....
  27. doi request reprint New methods for the detection of orthopedic and other biofilm infections
    John William Costerton
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA, USA
    FEMS Immunol Med Microbiol 61:133-40. 2011
    ....
  28. pmc The distributed genome hypothesis as a rubric for understanding evolution in situ during chronic bacterial biofilm infectious processes
    Garth D Ehrlich
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA, USA
    FEMS Immunol Med Microbiol 59:269-79. 2010
    ....
  29. doi request reprint Expression of receptor for activated C kinase 1 in healing skin and mucosal wounds
    Latha Satish
    Wound Healing Program, Center for Genomic Sciences, Allegheny Singer Research Institute, 320 East North Ave, Pittsburgh, PA 15212, USA
    Ann Plast Surg 64:238-41. 2010
    ..These observations suggest that RACK1 may play an important role in distinguishing scarless fetal wound healing from its scirrhous counterpart in adults...
  30. pmc Identification, distribution, and expression of novel genes in 10 clinical isolates of nontypeable Haemophilus influenzae
    Kai Shen
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, 320 East North Ave, 11th Floor South Tower, Pittsburgh, PA 15212, USA
    Infect Immun 73:3479-91. 2005
    ..These genic distribution analyses were more effective as a strain discrimination tool than either multilocus sequence typing or 23S ribosomal gene typing methods...
  31. ncbi request reprint Fine mapping a gene for pediatric gastroesophageal reflux on human chromosome 13q14
    Fen Ze Hu
    Center for Genomic Sciences, Allegheny Singer Research Institute, 320 East North Ave, Pittsburgh, PA 15212, USA
    Hum Genet 114:562-72. 2004
    ..The results suggest that the GERD1 gene might be located near SNP160 or SNP168...
  32. pmc Characterization, distribution, and expression of novel genes among eight clinical isolates of Streptococcus pneumoniae
    Kai Shen
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, 320 East North Avenue, 11th Floor South Tower, Pittsburgh, PA 15212, USA
    Infect Immun 74:321-30. 2006
    ..Sixty-five percent (38/58) of these sequences were found in 50% or less of the clinical strains, indicating a significant degree of genomic plasticity among natural isolates...
  33. pmc Differential expression of chaperonin containing T-complex polypeptide (CCT) subunits during fetal and adult skin wound healing
    Latha Satish
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    Cell Stress Chaperones 13:527-33. 2008
    ..We also confirm that quantitative evaluation of CCT-alpha and CCT-zeta mRNA expression shows no change in healing fetal wounds...
  34. pmc Extensive genomic plasticity in Pseudomonas aeruginosa revealed by identification and distribution studies of novel genes among clinical isolates
    Kai Shen
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, 320 East North Ave, 11th Floor South Tower, Pittsburgh, PA 15212, USA
    Infect Immun 74:5272-83. 2006
    ..Expression profiling revealed that a vast majority of these sequences are expressed, strongly suggesting they encode functional proteins...
  35. pmc Comparative genomic analyses of seventeen Streptococcus pneumoniae strains: insights into the pneumococcal supragenome
    N Luisa Hiller
    Allegheny General Hospital, Allegheny Singer Research Institute, Center for Genomic Sciences, Pittsburgh, PA 15212, USA
    J Bacteriol 189:8186-95. 2007
    ....
  36. ncbi request reprint The role of biofilms in otolaryngologic infections
    J Christopher Post
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, Pennsylvania 15212, USA
    Curr Opin Otolaryngol Head Neck Surg 12:185-90. 2004
    ....
  37. pmc Codon usage comparison of novel genes in clinical isolates of Haemophilus influenzae
    John Gladitz
    Center for Genomic Sciences, Allegheny Singer Research Institute Pittsburgh, PA, USA
    Nucleic Acids Res 33:3644-58. 2005
    ..The remaining novel sequences produced similarity statistics closer to one of the other reference genomes thereby suggesting that these sequences may have entered the H.influenzae gene pool more recently via horizontal transfer...
  38. ncbi request reprint Mucosal biofilm formation on middle-ear mucosa in a nonhuman primate model of chronic suppurative otitis media
    Joseph E Dohar
    Department of Pediatric Otolaryngology, Children s Hospital of Pittsburgh, 3705 5th Avenue, Pittsburgh, PA 15213, USA
    Laryngoscope 115:1469-72. 2005
    ..Perhaps the best studied pathogen for its propensity toward biofilm formation is Pseudomonas aeruginosa, also the primary pathogen in chronic suppurative otitis media (CSOM)...
  39. pmc Direct demonstration of viable Staphylococcus aureus biofilms in an infected total joint arthroplasty. A case report
    Paul Stoodley
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212 4772, USA
    J Bone Joint Surg Am 90:1751-8. 2008
  40. pmc Construction and characterization of a highly redundant Pseudomonas aeruginosa genomic library prepared from 12 clinical isolates: application to studies of gene distribution among populations
    Geza Erdos
    Center for Genomic Sciences, Allegheny Singer Research Institute, 320 E North Avenue, Pittsburgh, PA 15212, United States
    Int J Pediatr Otorhinolaryngol 70:1891-900. 2006
    ....
  41. ncbi request reprint Four mutations in Epidermodysplasia verruciformis 1 (EVER1) gene are not contributors to susceptibility in RRP
    Joseph Donfack
    Allegheny General Hospital, Allegheny Singer Research Institute, 320 East North Avenue, 11th Floor, South Tower, Room 1171, Pittsburgh, PA 15212 4772, USA
    Int J Pediatr Otorhinolaryngol 70:1235-40. 2006
    ....
  42. doi request reprint Biofilm formation by ica-positive and ica-negative strains of Staphylococcus epidermidis in vitro
    Bethany Dice
    Center for Genomic Sciences, Allegheny Singer Research Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA
    Biofouling 25:367-75. 2009
    ..It was concluded that ica is not required for biofilm formation, nor is the 24-h CV assay generalizable for predicting the 6-day biofilm-forming ability for all S. epidermidis strains...
  43. pmc Age of child, more than HPV type, is associated with clinical course in recurrent respiratory papillomatosis
    Farrel J Buchinsky
    Allegheny General Hospital, Allegheny Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 3:e2263. 2008
    ..Patients undergo multiple surgeries to maintain a patent airway and in order to communicate vocally. Several small studies have been published in which most have noted that HPV 11 is associated with a more aggressive course...
  44. ncbi request reprint Role of biofilms in neurosurgical device-related infections
    Ernest E Braxton
    Department of Neurosurgery, Allegheny General Hospital, Pittsburgh, PA, USA
    Neurosurg Rev 28:249-55. 2005
    ..Understanding how these biofilm infections affect patients with neurosurgical devices is a prerequisite to developing strategies for their treatment and prevention...
  45. ncbi request reprint Unique challenges of obtaining regulatory approval for a multicenter protocol to study the genetics of RRP and suggested remedies
    Mylaina L Sherwood
    Center for Genomic Sciences at Allegheny Singer Research Institute, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212 4772, USA
    Otolaryngol Head Neck Surg 135:189-96. 2006
    ..This study describes the process of obtaining regulatory approval for a minimal risk genetic study in a multi-center setting as undertaken by the Recurrent Respiratory Papillomatosis (RRP) Task Force...
  46. ncbi request reprint Lack of major involvement of human uroplakin genes in vesicoureteral reflux: implications for disease heterogeneity
    Songshan Jiang
    Epithelial Biology Unit, Ronald O Perelman Department of Dermatology, Kaplan Comprehensive Cancer Center, New York University Medical School, New York, New York, USA
    Kidney Int 66:10-9. 2004
    ..Recent studies indicate that genetic ablation of mouse uroplakin (UP) III gene, which encodes a 47 kD urothelial-specific integral membrane protein forming urothelial plaques, causes VUR and hydronephrosis...
  47. pmc Phenotypic characterization of Streptococcus pneumoniae biofilm development
    Magee Allegrucci
    State University of New York at Binghamton, Department of Biological Sciences, 104 Science III, Vestal Parkway East, Binghamton, NY 13902, USA
    J Bacteriol 188:2325-35. 2006
    ..Protein identification revealed that proteins involved in virulence, adhesion, and resistance were more abundant under biofilm growth conditions. A possible role of the identified proteins in biofilm formation is discussed...
  48. ncbi request reprint Recent advances in otitis media. 4A. Molecular biology
    Allen F Ryan
    Division of Otolaryngology, University of California, San Diego, La Jolla, USA
    Ann Otol Rhinol Laryngol Suppl 194:42-9. 2005
  49. pmc Oxygen limitation contributes to antibiotic tolerance of Pseudomonas aeruginosa in biofilms
    Giorgia Borriello
    Center for Biofilm Engineering and Department of Chemical Engineering, Montana State University Bozeman, Bozeman, MT 59717 3980, USA
    Antimicrob Agents Chemother 48:2659-64. 2004
    ..Local oxygen limitation and the presence of nitrate may contribute to the reduced susceptibilities of P. aeruginosa biofilms causing infections in vivo...
  50. pmc Efficacy of single-dose azithromycin in treatment of acute otitis media in children after a baseline tympanocentesis
    Michael W Dunne
    Pfizer Global Research and Development, New London, Connecticut 06320, USA
    Antimicrob Agents Chemother 47:2663-5. 2003
    ..Clinical cure rates for patients infected with Streptococcus pneumoniae (67 of 76; 88%) and Haemophilus influenzae (28 of 44; 64%) were consistent with historical rates for the 5-day dosing regimen...
  51. ncbi request reprint Recent advances in otitis media. 4C. Interaction between middle ear and inner ear in otitis media
    Allen F Ryan
    Division of Otolaryngology, University of California, San Diego, La Jolla, USA
    Ann Otol Rhinol Laryngol Suppl 194:56-9. 2005
  52. pmc Pseudomonas aeruginosa displays multiple phenotypes during development as a biofilm
    Karin Sauer
    Center for Biofilm Engineering, Montana State University Bozeman, Bozeman, Montana, USA
    J Bacteriol 184:1140-54. 2002
    ..These results demonstrate that P. aeruginosa displays multiple phenotypes during biofilm development and that knowledge of stage-specific physiology may be important in detecting and controlling biofilm growth...
  53. doi request reprint Biofilms and chronic infections
    Randall D Wolcott
    Medical Biofilm Research Institute, 2002 Oxford Ave, Lubbock, TX 79410, USA
    JAMA 299:2682-4. 2008
  54. pmc Arginine or nitrate enhances antibiotic susceptibility of Pseudomonas aeruginosa in biofilms
    Giorgia Borriello
    Center for Biofilm Engineering and Department of Clinical Engineering, Montana State University Bozeman, 409 Cobleigh Hall, Bozeman, Montana 59717 3980, USA
    Antimicrob Agents Chemother 50:382-4. 2006
    ..Arginine or nitrate also enhanced the killing by these antibiotics in mature biofilms, reducing viable cell counts by a factor of 10 to 100 beyond that achieved by antibiotics alone...
  55. pmc Insights into the genome of large sulfur bacteria revealed by analysis of single filaments
    Marc Mussmann
    Max Planck Institute for Marine Microbiology, Bremen, Germany
    PLoS Biol 5:e230. 2007
    ..The first look into the genome of these filamentous sulfur-oxidizing bacteria substantially deepens the understanding of their evolution and their contribution to sulfur and nitrogen cycling in marine sediments...

Research Grants25

  1. The Role of Biofilms in the Pathogenesis of Otorrhea
    Garth Ehrlich; Fiscal Year: 2007
    ..A discovery that has immediate clinical relevancy is that biofilm antibiotic resistance is mediated largely by bacterial metabolic resistance owing to limiting nutrient conditions within the core of the biofilms. ..
  2. Impact of Antibiotics and Vaccines on the in vivo Evolution of S. pneumoniae
    Garth Ehrlich; Fiscal Year: 2009
    ..pneumoniae. The research program described at Allegheny Singer Research Institute (ASRI) headed by Garth Ehrlich, Roche 454 LifeSciences Titanium platform...
  3. Impact of Antibiotics and Vaccines on the in vivo Evolution of S. pneumoniae
    Garth D Ehrlich; Fiscal Year: 2010
    ..WGS will be used to test if the emergence of these strains from minority to majority status in the nasopharynx and from colonizers to disease causing strains is accompanied by changes in genetic makeup ..
  4. GENETICS OF SEVERE PEDIATRIC GASTROESOPHAGEAL REFLUX
    Garth Ehrlich; Fiscal Year: 2003
    ....
  5. MOLECULAR ANALYSIS OF PATHOGENS IN OTITIS MEDIA BY PCR
    Garth Ehrlich; Fiscal Year: 2002
    ..A combined final series of experiments will attempt to determine the mechanism(s) that regulate or trigger the formation of biofilms and to correlate different models of mutational2 induction with the consequences of antibiotic therapy. ..
  6. THE ROLE OF BIOFILMS IN THE PATHOGENESIS OF OTORRHEA
    Garth Ehrlich; Fiscal Year: 2002
    ....
  7. MOLECULAR ANALYSIS OF PATHOGENS IN OTITIS MEDIA BY PCR
    Garth Ehrlich; Fiscal Year: 2009
    ..These findings shed light on many aspects of OM, including disease persistence in the fact of antibiotic treatment, and provide an explanation for the success of adenoidectomy in the management of OM. ..