GARY WILLIAM LITMAN

Summary

Affiliation: All Children's Hospital
Country: USA

Publications

  1. pmc Novel genes dramatically alter regulatory network topology in amphioxus
    Qing Zhang
    Burnham Institute for Medical Research, North Torrey Pines Road, La Jolla, CA 92037, USA
    Genome Biol 9:R123. 2008
  2. pmc Genomic complexity of the variable region-containing chitin-binding proteins in amphioxus
    Larry J Dishaw
    All Children s Hospital, Department of Molecular Genetics, 801 Sixth Street South, St, Petersburg, FL 33701, USA
    BMC Genet 9:78. 2008
  3. pmc The medaka novel immune-type receptor (NITR) gene clusters reveal an extraordinary degree of divergence in variable domains
    Salil Desai
    Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    BMC Evol Biol 8:177. 2008
  4. pmc Reconstructing immune phylogeny: new perspectives
    Gary W Litman
    Department of Pediatrics, University of South Florida College of Medicine, All Children s Hospital Children s Research Institute, 830 First Street South, Saint Petersburg, Florida 33701, USA
    Nat Rev Immunol 5:866-79. 2005
  5. pmc Alternative mechanisms of immune receptor diversity
    Gary W Litman
    Department of Molecular Genetics, All Children s Hospital, 801 Sixth Street South, St Petersburg, FL 33701, United States
    Curr Opin Immunol 19:526-34. 2007
  6. pmc Immunoglobulin variable regions in molecules exhibiting characteristics of innate and adaptive immune receptors
    Gary W Litman
    Department of Pediatrics, University of South Florida College of Medicine, USF ACH Children s Research Institute, 830 First Street South, St Petersburg, FL 33701, USA
    Immunol Res 38:294-304. 2007
  7. ncbi request reprint Evolution of antigen binding receptors
    G W Litman
    Department of Pediatrics, University of South Florida College of Medicine, All Children s Hospital, St Petersburg 33701, USA
    Annu Rev Immunol 17:109-47. 1999
  8. pmc The origins of vertebrate adaptive immunity
    Gary W Litman
    Department of Molecular Genetics, All Children s Hospital, St Petersburg, Florida 33701, USA
    Nat Rev Immunol 10:543-53. 2010
  9. ncbi request reprint Novel immune-type receptor genes
    G W Litman
    University of South Florida All Children s Hospital, Children s Research Institute, St Petersburg 33701, USA
    Immunol Rev 181:250-9. 2001
  10. ncbi request reprint New insights into alternative mechanisms of immune receptor diversification
    Gary W Litman
    Department of Pediatrics, University of South Florida College of Medicine, USF ACH Children s Research Institute, St Petersburg, Florida 33701, USA
    Adv Immunol 87:209-36. 2005

Research Grants

  1. EVOLUTIONARY ORIGINS OF IMMUNE-TYPE GENES
    GARY WILLIAM LITMAN; Fiscal Year: 2010
  2. Novel Innate Immune Receptors in Zebrafish
    GARY WILLIAM LITMAN; Fiscal Year: 2010
  3. Novel Innate Immune Receptors in Zebrafish
    GARY LITMAN; Fiscal Year: 2009
  4. EVOLUTIONARY ORIGINS OF IMMUNE-TYPE GENES
    GARY LITMAN; Fiscal Year: 2007
  5. EARLY EVOLUTIONARY ORIGIN OF IMMUNOGLOBULIN GENES
    GARY LITMAN; Fiscal Year: 1993
  6. EVOLUTIONARY ORIGINS OF IMMUNE-TYPE GENES
    GARY WILLIAM LITMAN; Fiscal Year: 2011

Collaborators

Detail Information

Publications38

  1. pmc Novel genes dramatically alter regulatory network topology in amphioxus
    Qing Zhang
    Burnham Institute for Medical Research, North Torrey Pines Road, La Jolla, CA 92037, USA
    Genome Biol 9:R123. 2008
    ....
  2. pmc Genomic complexity of the variable region-containing chitin-binding proteins in amphioxus
    Larry J Dishaw
    All Children s Hospital, Department of Molecular Genetics, 801 Sixth Street South, St, Petersburg, FL 33701, USA
    BMC Genet 9:78. 2008
    ..In this report, we describe VCBP genomic organization and characterize adjacent and intervening genetic features which may influence both their polymorphism and complex transcriptional repertoire...
  3. pmc The medaka novel immune-type receptor (NITR) gene clusters reveal an extraordinary degree of divergence in variable domains
    Salil Desai
    Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    BMC Evol Biol 8:177. 2008
    ....
  4. pmc Reconstructing immune phylogeny: new perspectives
    Gary W Litman
    Department of Pediatrics, University of South Florida College of Medicine, All Children s Hospital Children s Research Institute, 830 First Street South, Saint Petersburg, Florida 33701, USA
    Nat Rev Immunol 5:866-79. 2005
    ....
  5. pmc Alternative mechanisms of immune receptor diversity
    Gary W Litman
    Department of Molecular Genetics, All Children s Hospital, 801 Sixth Street South, St Petersburg, FL 33701, United States
    Curr Opin Immunol 19:526-34. 2007
    ....
  6. pmc Immunoglobulin variable regions in molecules exhibiting characteristics of innate and adaptive immune receptors
    Gary W Litman
    Department of Pediatrics, University of South Florida College of Medicine, USF ACH Children s Research Institute, 830 First Street South, St Petersburg, FL 33701, USA
    Immunol Res 38:294-304. 2007
    ..Both families of molecules encode V domains that share some characteristics of adaptive immune receptors but likely mediate innate functions...
  7. ncbi request reprint Evolution of antigen binding receptors
    G W Litman
    Department of Pediatrics, University of South Florida College of Medicine, All Children s Hospital, St Petersburg 33701, USA
    Annu Rev Immunol 17:109-47. 1999
    ....
  8. pmc The origins of vertebrate adaptive immunity
    Gary W Litman
    Department of Molecular Genetics, All Children s Hospital, St Petersburg, Florida 33701, USA
    Nat Rev Immunol 10:543-53. 2010
    ..We combine evidence from a wide range of organisms to obtain an integrated view of the origins and patterns of divergence in adaptive immunity...
  9. ncbi request reprint Novel immune-type receptor genes
    G W Litman
    University of South Florida All Children s Hospital, Children s Research Institute, St Petersburg 33701, USA
    Immunol Rev 181:250-9. 2001
    ....
  10. ncbi request reprint New insights into alternative mechanisms of immune receptor diversification
    Gary W Litman
    Department of Pediatrics, University of South Florida College of Medicine, USF ACH Children s Research Institute, St Petersburg, Florida 33701, USA
    Adv Immunol 87:209-36. 2005
    ..Unusual genetic mechanisms for diversifying recognition proteins may be a widespread characteristic of animal immunity...
  11. ncbi request reprint Mechanisms of antigen receptor evolution
    Donna D Eason
    Department of Pediatrics, Children s Research Institute, University of South Florida College of Medicine, 830 First Street South, St Petersburg, FL 33701, USA
    Semin Immunol 16:215-26. 2004
    ..Such studies have uncovered previously unknown mechanisms of generating receptor diversity...
  12. pmc The basis for haplotype complexity in VCBPs, an immune-type receptor in amphioxus
    Larry J Dishaw
    Department of Molecular Genetics, All Children s Hospital, St Petersburg, FL, USA
    Immunogenetics 62:623-31. 2010
    ..The collective observations suggest that mechanisms were in place at the time of divergence of the cephalochordates that could selectively hyperdiversify immune-type receptors within a multigene family...
  13. pmc Ancient divergence of a complex family of immune-type receptor genes
    John P Cannon
    Department of Pediatrics, University of South Florida College of Medicine, and USF ACH Children s Research Institute, 830 First Street South, St Petersburg, FL, 33701, USA
    Immunogenetics 58:362-73. 2006
    ....
  14. ncbi request reprint The phylogenetic origins of the antigen-binding receptors and somatic diversification mechanisms
    John P Cannon
    Department of Molecular Genetics, All Children s Hospital, St Petersburg, FL, USA
    Immunol Rev 200:12-22. 2004
    ..Such studies have the potential for uncovering previously unknown mechanisms of generating receptor diversity...
  15. pmc Variable domains and a VpreB-like molecule are present in a jawless vertebrate
    John P Cannon
    Department of Molecular Genetics, All Children s Hospital, 801 Sixth Street South, St Petersburg, FL 33701, USA
    Immunogenetics 56:924-9. 2005
    ..This is the first indication of a molecule related to the B cell receptor (BCR) complex in a species that diverged prior to the jawed vertebrates in which RAG-mediated adaptive immunity is first encountered...
  16. ncbi request reprint Structure and diversity of T-lymphocyte antigen receptors alpha and gamma in Xenopus
    Robert N Haire
    Department of Pediatrics, University of South Florida, Children s Research Institute, 140 Seventh Avenue South, St Petersburg 33701, USA
    Immunogenetics 54:431-8. 2002
    ..This process produces a translatable cDNA that is not readily predictable from the genomic locus utilizing normal recombination and splicing mechanisms...
  17. ncbi request reprint Haplotype exclusion: the unique case presented by multiple immunoglobulin gene loci in cartilaginous fish
    Donna D Eason
    Department of Molecular Genetics, All Children s Hospital, St Petersburg, FL 33701, USA
    Semin Immunol 14:145-52; discussion 220. 2002
    ....
  18. pmc Recognition of additional roles for immunoglobulin domains in immune function
    John P Cannon
    University of South Florida, Department of Pediatrics, USF ACH Children s Research Institute, 140 Seventh Avenue South, St Petersburg, FL 33701, USA
    Semin Immunol 22:17-24. 2010
    ....
  19. ncbi request reprint Expression of individual immunoglobulin genes occurs in an unusual system consisting of multiple independent loci
    Donna D Eason
    Department of Molecular Genetics, All Children s Hospital, St Petersburg, FL, USA
    Eur J Immunol 34:2551-8. 2004
    ..Taken together, these findings suggest that a mechanism for haplotype exclusion arose early in the evolution of antibody diversity and is independent of a single genetic locus...
  20. pmc A bony fish immunological receptor of the NITR multigene family mediates allogeneic recognition
    John P Cannon
    Department of Pediatrics, University of South Florida College of Medicine, St Petersburg, FL 33701, USA
    Immunity 29:228-37. 2008
    ....
  21. ncbi request reprint BIVM, a novel gene widely distributed among deuterostomes, shares a core sequence with an unusual gene in Giardia lamblia
    Jeffrey A Yoder
    Department of Pediatrics, University of South Florida, Children s Research Institute, St Petersburg, FL 33701, USA
    Genomics 79:750-5. 2002
    ..However, an unusual gene has been identified in the protozoan pathogen Giardia lamblia that is similar to the core sequence of BIVM, suggesting the possibility of a horizontal gene transfer...
  22. ncbi request reprint Identification of diversified genes that contain immunoglobulin-like variable regions in a protochordate
    John P Cannon
    Immunology Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Avenue, Tampa, FL 33612, USA
    Nat Immunol 3:1200-7. 2002
    ..Thus, multigenic families encoding diversified V regions exist in a species lacking an adaptive immune response...
  23. pmc The amphioxus genome illuminates vertebrate origins and cephalochordate biology
    Linda Z Holland
    Marine Biology Research Division, Scripps Institution of Oceanography, La Jolla, California 92093 0202, USA
    Genome Res 18:1100-11. 2008
    ..Our results indicate that the amphioxus genome is elemental to an understanding of the biology and evolution of nonchordate deuterostomes, invertebrate chordates, and vertebrates...
  24. pmc Structural characteristics of zebrafish orthologs of adaptor molecules that associate with transmembrane immune receptors
    Jeffrey A Yoder
    Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Gene 401:154-64. 2007
    ..Their genomic organizations have been characterized, cDNA transcripts have been recovered, phylogenetic relationships have been defined and their cell lineage-specific expression patterns have been established...
  25. pmc Genomic insights into the immune system of the sea urchin
    Jonathan P Rast
    Sunnybrook Research Institute and Department of Medical Biophysics, University of Toronto, 2075 Bayview Avenue, Room S 126B, Toronto, Ontario M4N 3M5, Canada
    Science 314:952-6. 2006
    ..The findings serve to underscore the dynamic utilization of receptors and the complexity of immune recognition that may be basal for deuterostomes and predicts features of the ancestral bilaterian form...
  26. pmc Lineage-restricted retention of a primitive immunoglobulin heavy chain isotype within the Dipnoi reveals an evolutionary paradox
    Tatsuya Ota
    Department of Biosystems Science, The Graduate University for Advanced Studies Sokendai, Hayama, Kanagawa 240 0193, Japan
    Proc Natl Acad Sci U S A 100:2501-6. 2003
    ..Moreover, its absence in other gnathostome lineages implies paradoxically that the IgW-type genes were lost from teleost and tetrapod lineages...
  27. pmc Ancient evolutionary origin of diversified variable regions demonstrated by crystal structures of an immune-type receptor in amphioxus
    Jose A Hernandez Prada
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Nat Immunol 7:875-82. 2006
    ....
  28. ncbi request reprint Individual protochordates have unique immune-type receptor repertoires
    John P Cannon
    Curr Biol 14:R465-6. 2004
  29. pmc Resolution of the novel immune-type receptor gene cluster in zebrafish
    Jeffrey A Yoder
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Proc Natl Acad Sci U S A 101:15706-11. 2004
    ..These studies resolve a complete immune gene cluster in zebrafish and indicate that the NITRs represent the most complex family of activating/inhibitory surface receptors thus far described...
  30. ncbi request reprint Crystallization and preliminary X-ray analysis of VCBP3 from Branchiostoma floridae
    Jose A Hernandez Prada
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Acta Crystallogr D Biol Crystallogr 60:2022-4. 2004
    ..Unit-cell parameters are a = b = 58.99, c = 79.21 A, alpha = beta = 90, gamma = 120 degrees . Two distinct crystallization conditions yielded crystals with similar morphologies and these crystals are isomorphous to each other...
  31. ncbi request reprint On the origins of adaptive immunity: innate immune receptors join the tale
    Timo K van den Berg
    Department of Molecular Cell Biology, VU Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Trends Immunol 25:11-6. 2004
    ..We propose the existence of an evolutionary and functional link between innate and adaptive immune receptors that sheds light on the nature of the antigen receptor predecessor(s)...
  32. ncbi request reprint Terminal deoxynucleotidyl transferases from elasmobranchs reveal structural conservation within vertebrates
    Simona Bartl
    Moss Landing Marine Laboratories, 8272 Moss Landing Road, CA 95039, Moss Landing, USA
    Immunogenetics 55:594-604. 2003
    ..Thus, unlike other molecules of adaptive immunity, TdT is a member of an ancient gene family with a clear gene phylogeny and a high degree of similarity, which implies the existence of TdT ancestors in jawless fishes and invertebrates...
  33. ncbi request reprint Zebrafish as an immunological model system
    Jeffrey A Yoder
    Department of Biology, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620, USA
    Microbes Infect 4:1469-78. 2002
    ..Recent advances in mutation screening, the creation of genomic resources, including the Zebrafish Genome Project and the development of efficient transgenesis procedures, make this model increasingly attractive for immunological study...
  34. ncbi request reprint Histocompatibility: colonial match and mismatch
    Gary W Litman
    Nature 438:437-9. 2005
  35. pmc Evidence for a transposition event in a second NITR gene cluster in zebrafish
    Jeffrey A Yoder
    Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Immunogenetics 60:257-65. 2008
    ..Sequence features of the chromosomal region encoding nitr13 suggest that this gene arose via retrotransposition...
  36. pmc Crystallization and X-ray diffraction analysis of a novel immune-type receptor from Ictalurus punctatus and phasing by selenium anomalous dispersion methods
    David A Ostrov
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 63:1035-7. 2007
    ..77 by SAD methods and experimental electron-density maps were calculated to 1.65 A. Five NITR10 molecules are predicted to be present in the asymmetric unit based on the Matthews coefficient...
  37. ncbi request reprint Cloning novel immune-type inhibitory receptors from the rainbow trout, Oncorhynchus mykiss
    Jeffrey A Yoder
    Immunology Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Immunogenetics 54:662-70. 2002
    ..Several probable scenarios that explain the origins of variant forms of NITRs are described...
  38. ncbi request reprint Evolutionary origins of lymphocytes: ensembles of T cell and B cell transcriptional regulators in a cartilaginous fish
    Michele K Anderson
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Immunol 172:5851-60. 2004
    ..However, certain factors relevant to the B lineage differ in their tissue-specific expression patterns from their mouse counterparts, suggesting expanded or divergent B lineage characteristics or tissue specificity in these animals...

Research Grants18

  1. EVOLUTIONARY ORIGINS OF IMMUNE-TYPE GENES
    GARY WILLIAM LITMAN; Fiscal Year: 2010
    ....
  2. Novel Innate Immune Receptors in Zebrafish
    GARY WILLIAM LITMAN; Fiscal Year: 2010
    ....
  3. Novel Innate Immune Receptors in Zebrafish
    GARY LITMAN; Fiscal Year: 2009
    ..Understanding this relationship has broad health consequences in terms of mechanisms of resistance to infection and susceptibility to malignancy. ..
  4. EVOLUTIONARY ORIGINS OF IMMUNE-TYPE GENES
    GARY LITMAN; Fiscal Year: 2007
    ..Such information is fundamental to understanding the basis for self-nonself discrimination and how structural diversification relates to immune specificity. ..
  5. EARLY EVOLUTIONARY ORIGIN OF IMMUNOGLOBULIN GENES
    GARY LITMAN; Fiscal Year: 1993
    ....
  6. EVOLUTIONARY ORIGINS OF IMMUNE-TYPE GENES
    GARY WILLIAM LITMAN; Fiscal Year: 2011
    ....