Thomas H Shaffer

Summary

Affiliation: Alfred I. duPont Hospital for Children
Country: USA

Publications

  1. pmc Neonatal non-invasive respiratory support: physiological implications
    Thomas H Shaffer
    Nemours Center for Pediatric Lung Research, Nemours Alfred I duPont Hospital for Children, Wilmington, DE 19803, USA
    Pediatr Pulmonol 47:837-47. 2012
  2. doi request reprint Recombinant human Clara cell secretory protein treatment increases lung mRNA expression of surfactant proteins and vascular endothelial growth factor in a premature lamb model of respiratory distress syndrome
    Marla R Wolfson
    Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Am J Perinatol 25:637-45. 2008
  3. ncbi request reprint Effects of recombinant Clara cell secretory protein (rhCC10) on inflammatory-related matrix metalloproteinase activity in a preterm lamb model of neonatal respiratory distress
    Thomas L Miller
    Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA
    Pediatr Crit Care Med 8:40-6. 2007
  4. ncbi request reprint Protective ventilation to reduce inflammatory injury from one lung ventilation in a piglet model
    Mary C Theroux
    Department of Anesthesiology and Critical Care Medicine, Alfred I duPont Hospital for Children, Wilmington, DE 19803, USA
    Paediatr Anaesth 20:356-64. 2010
  5. ncbi request reprint Correlation of tracheal smooth muscle function with structure and protein expression during early development
    Aaron B Cullen
    Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Pediatr Pulmonol 42:421-32. 2007
  6. pmc Hyperoxia during one lung ventilation: inflammatory and oxidative responses
    Alicia Olivant Fisher
    Nemours Biomedical Research, Nemours Alfred I duPont Hospital for Children, Wilmington, DE19803, USA
    Pediatr Pulmonol 47:979-86. 2012
  7. ncbi request reprint Sequential alterations of tracheal mechanical properties in the neonatal lamb: effect of mechanical ventilation
    Thomas L Miller
    Nemours Research Lung Center, Alfred I duPont Hospital for Children, Wilmington, Delaware 19803, USA
    Pediatr Pulmonol 42:141-9. 2007
  8. ncbi request reprint Matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase expression profiles in tracheal aspirates do not adequately reflect tracheal or lung tissue profiles in neonatal respiratory distress: observations from an animal model
    Thomas L Miller
    Nemours Research Lung Center, Nemours Biomedical Research, Alfred I duPont Hospital for Children, Wilmington, DE, USA
    Pediatr Crit Care Med 7:63-9. 2006
  9. doi request reprint Airway injury resulting from repeated endotracheal intubation: Possible prevention strategies
    Adebayo Oshodi
    Nemours Research Lung Center, Alfred I duPont Hospital for Children, Wilmington, DE, USA
    Pediatr Crit Care Med 12:e34-9. 2011
  10. ncbi request reprint Recombinant human Clara cell secretory protein in acute lung injury of the rabbit: effect of route of administration
    Thomas L Miller
    Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA
    Pediatr Crit Care Med 6:698-706. 2005

Research Grants

  1. Center for Pediatric Research
    Thomas Shaffer; Fiscal Year: 2007

Collaborators

Detail Information

Publications61

  1. pmc Neonatal non-invasive respiratory support: physiological implications
    Thomas H Shaffer
    Nemours Center for Pediatric Lung Research, Nemours Alfred I duPont Hospital for Children, Wilmington, DE 19803, USA
    Pediatr Pulmonol 47:837-47. 2012
    ..The purpose of this article is to review non-invasive respiratory support methodologies to address the physiologic mechanisms by which these methods may prevent the pathophysiologic effects of invasive mechanical ventilation...
  2. doi request reprint Recombinant human Clara cell secretory protein treatment increases lung mRNA expression of surfactant proteins and vascular endothelial growth factor in a premature lamb model of respiratory distress syndrome
    Marla R Wolfson
    Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Am J Perinatol 25:637-45. 2008
    ..These data demonstrate that early intervention with rhCC10 up-regulates surfactant protein and VEGF expression, supporting the role of CC10 to protect against hyperoxia and mechanical ventilation in the immature lung...
  3. ncbi request reprint Effects of recombinant Clara cell secretory protein (rhCC10) on inflammatory-related matrix metalloproteinase activity in a preterm lamb model of neonatal respiratory distress
    Thomas L Miller
    Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA
    Pediatr Crit Care Med 8:40-6. 2007
    ....
  4. ncbi request reprint Protective ventilation to reduce inflammatory injury from one lung ventilation in a piglet model
    Mary C Theroux
    Department of Anesthesiology and Critical Care Medicine, Alfred I duPont Hospital for Children, Wilmington, DE 19803, USA
    Paediatr Anaesth 20:356-64. 2010
    ....
  5. ncbi request reprint Correlation of tracheal smooth muscle function with structure and protein expression during early development
    Aaron B Cullen
    Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Pediatr Pulmonol 42:421-32. 2007
    ..In conclusion, the developmental alterations in tracheal function appear due, in part, to enhanced smooth muscle myosin heavy chain expression...
  6. pmc Hyperoxia during one lung ventilation: inflammatory and oxidative responses
    Alicia Olivant Fisher
    Nemours Biomedical Research, Nemours Alfred I duPont Hospital for Children, Wilmington, DE19803, USA
    Pediatr Pulmonol 47:979-86. 2012
    ..We hypothesized that lower oxygen (FiO(2) ) during OLV will result in less inflammatory and oxidative lung injury and improved lung function...
  7. ncbi request reprint Sequential alterations of tracheal mechanical properties in the neonatal lamb: effect of mechanical ventilation
    Thomas L Miller
    Nemours Research Lung Center, Alfred I duPont Hospital for Children, Wilmington, Delaware 19803, USA
    Pediatr Pulmonol 42:141-9. 2007
    ..05) and dynamic (elastic modulus; 282 %; P < 0.05) conditions, indicating a significant alteration in elastic components. No time dependent changes were identified in dimensions or mechanical properties in the SHAM group...
  8. ncbi request reprint Matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase expression profiles in tracheal aspirates do not adequately reflect tracheal or lung tissue profiles in neonatal respiratory distress: observations from an animal model
    Thomas L Miller
    Nemours Research Lung Center, Nemours Biomedical Research, Alfred I duPont Hospital for Children, Wilmington, DE, USA
    Pediatr Crit Care Med 7:63-9. 2006
    ..This study tests the hypothesis that the profile of MMPs 2, 7, and 9 and the profile of TIMPs 1 and 2 will be different in TA, tracheal tissue, and lung tissue in neonatal respiratory distress...
  9. doi request reprint Airway injury resulting from repeated endotracheal intubation: Possible prevention strategies
    Adebayo Oshodi
    Nemours Research Lung Center, Alfred I duPont Hospital for Children, Wilmington, DE, USA
    Pediatr Crit Care Med 12:e34-9. 2011
    ....
  10. ncbi request reprint Recombinant human Clara cell secretory protein in acute lung injury of the rabbit: effect of route of administration
    Thomas L Miller
    Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA
    Pediatr Crit Care Med 6:698-706. 2005
    ..To test the hypothesis that intratracheal instillation of Clara cell secretory protein (CC 10) to the lung may afford greater protection than intravenous administration from ventilator-induced lung inflammation...
  11. doi request reprint Effects of oxygen concentration and exposure time on cultured human airway epithelial cells
    Yan Zhu
    Nemours Research Lung Center, Nemours, Alfred I duPont Hospital for Children, Wilmington, DE, USA
    Pediatr Crit Care Med 9:224-9. 2008
    ..To distinguish the direct effects of oxygen dose and exposure time on human airway epithelial cells. We hypothesized that progressive oxygen exposure would induce cell dysfunction and inflammation in a dose-dependent manner...
  12. ncbi request reprint Dissociation between the effects of oxygen and pressure on matrix metalloproteinase-2, -7, and -9 expression in human airway epithelial cells
    Thomas L Miller
    Nemours Research Lung Center, Alfred I duPont Hospital for Children, Wilmington, Delaware 19803, USA
    Am J Perinatol 25:481-9. 2008
    ..05). Hyperoxia and pressure differentially affected MMP activities in Calu-3 cells and may lead to the different functional and structural abnormalities observed in these in vitro studies...
  13. ncbi request reprint Growth and development in a heliox incubator environment: a long-term safety study
    Clifford J Singhaus
    Nemours Research Lung Center, Alfred I duPont Hospital for Children Nemours Research Lung Center, Wilmington, DE 19803, USA
    Neonatology 91:28-35. 2007
    ..Heliox has been shown to improve pulmonary function and may decrease energy expenditure. We hypothesized that heliox would provide a safe environment for sustained growth and development...
  14. ncbi request reprint Expression of matrix metalloproteinases 2, 7 and 9, and their tissue inhibitors 1 and 2, in developing rabbit tracheae
    Thomas L Miller
    Nemours Research Lung Center, Alfred I duPont Hospital for Children, Wilmington, Del, USA
    Biol Neonate 89:236-43. 2006
    ..The developmental changes in airway compliance oppose the changes in compliance of the developing lung; thus the expression profiles of matrix modeling proteins likely are also opposite in these developing organs...
  15. ncbi request reprint Physiologic implications of helium as a carrier gas for inhaled nitric oxide in a neonatal model of Bethanecol-induced bronchoconstriction
    Thomas L Miller
    Nemours Research Lung Center, Nemours Children s Clinic Wilmington of the Nemours Foundation, Alfred I duPont Children s Hospital, Wilmington, DE, USA
    Pediatr Crit Care Med 7:159-64. 2006
    ..We hypothesized that respiratory resistance and gas exchange would improve when iNO is delivered with heliox...
  16. doi request reprint Developmental differences in the contractile response of isolated ovine tracheal smooth muscle cells
    Rachel E Laudadio
    Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Pediatr Pulmonol 44:602-12. 2009
    ..Represented this way, the amount of shortening for all age groups was the same, but the predicted maximum velocity of the hypothetical PT tissue (125-140 days) was significantly greater than for NB...
  17. ncbi request reprint Low dose methylprednisolone prophylaxis to reduce inflammation during one-lung ventilation
    Mary C Theroux
    Alfred I duPont Hospital for Children, Wilmington, DE 19803, USA
    Paediatr Anaesth 18:857-64. 2008
    ..The specific aim of this study was to examine the efficacy of a low dose of methylprednisolone in minimizing inflammatory response in juvenile piglets when given 45-60 min prior to onset of one-lung ventilation...
  18. ncbi request reprint KL4-surfactant (Lucinactant) protects human airway epithelium from hyperoxia
    Yan Zhu
    Nemours Research Lung Center, Alfred I duPont Hospital for Children, AR 282, Wilmington, DE 19803, USA
    Pediatr Res 64:154-8. 2008
    ..001), but was never detected in Lucinactant cells. Histology indicated less injury with Lucinactant relative to Beractant and saline. These data suggest that Lucinactant was protective compared with Beractant and control...
  19. pmc High-flow nasal cannula: impact on oxygenation and ventilation in an acute lung injury model
    Meg Frizzola
    Nemours Children s Clinic of Wilmington, The Nemours Foundation, Alfred I duPont Children s Hospital, Primary Research Institution, Wilmington, Delaware 19803, USA
    Pediatr Pulmonol 46:67-74. 2011
    ..The aim of this study was to demonstrate the flow dependence of CO(2) reduction and improved oxygenation during HFNC and the dependence on leak around the nasal prongs...
  20. doi request reprint Respiratory mechanics in an infant with perinatal lethal hypophosphatasia treated with human recombinant enzyme replacement therapy
    Elena Rodriguez
    Nemours Research Lung Center, Nemours Alfred I duPont Hospital for Children, Wilmington, DE 19803, USA
    Pediatr Pulmonol 47:917-22. 2012
    ..Measurable changes in chest wall dynamics and respiratory mechanics using noninvasive technology were useful for respiratory management and therapeutic guidance of ENB-0040 treatment in this patient...
  21. pmc Skeletal dysplasias: evaluation with impulse oscillometry and thoracoabdominal motion analysis
    M E Rodriguez
    Nemours Biomedical Research, Alfred I duPont Hospital for Children, Wilmington, DE, USA
    Pediatr Pulmonol 45:679-86. 2010
    ..The objective of this study was to demonstrate distinct thoracopulmonary function patterns in children with SD...
  22. doi request reprint Multicenter comparative study of conventional mechanical gas ventilation to tidal liquid ventilation in oleic acid injured sheep
    Marla R Wolfson
    Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    ASAIO J 54:256-69. 2008
    ..As such, TLV offers a feasible ventilatory alternative as a lung protective strategy in this model of acute lung injury...
  23. pmc Use of insulin to decrease septic shock-induced myocardial depression in a porcine model
    Yosef Levenbrown
    Department of Anesthesia and Critical Care Medicine, Nemours Alfred I duPont Hospital for Children, Wilmington, DE, USA
    Inflammation 36:1494-502. 2013
    ..Although insulin attenuated septic shock-induced myocardial depression, this was not due to an anti-inflammatory effect and, therefore, likely resulted from an inotropic effect of insulin...
  24. ncbi request reprint The impact of mechanical ventilation on immature airway smooth muscle: functional, structural, histological, and molecular correlates
    Aaron B Cullen
    Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA
    Biol Neonate 90:17-27. 2006
    ..The mechanisms behind these functional differences involve ultrastructural changes in cell length, tissue matrix, and disruption of epithelial integrity. These findings help elucidate the pathogenesis of ventilator-induced airway injury...
  25. ncbi request reprint An ultrasound imaging method for in vivo tracheal bulk and Young's moduli of elasticity
    Thomas L Miller
    Nemours Research Lung Center, Alfred I duPont Hospital for Children, Wilmington, DE 19803, USA
    J Biomech 40:1615-21. 2007
    ..This methodology will provide a means to evaluate respiratory therapies with respect to airway mechanics...
  26. ncbi request reprint Association of interleukin-8 with inflammatory and innate immune components in bronchoalveolar lavage of children with chronic respiratory diseases
    Polani B Ramesh Babu
    Department of Biomedical Research, Nemours Research Lung Center, Alfred I duPont Hospital for Children, 1600 Rockland Road, Wilmington, DE 19803, USA
    Clin Chim Acta 350:195-200. 2004
    ..The host inflammatory response and innate immunity play a complex role in respiratory diseases...
  27. doi request reprint Research in high flow therapy: mechanisms of action
    Kevin Dysart
    Department of Pediatrics, Jefferson Medical College Thomas Jefferson University, Philadelphia, PA, USA
    Respir Med 103:1400-5. 2009
    ....
  28. ncbi request reprint Neonatal chest wall suspension splint: a novel and noninvasive method for support of lung volume
    Thomas L Miller
    Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Pediatr Pulmonol 39:512-20. 2005
    ..005; r = -0.56). We speculate that by improving CW stability, the use of this splint may reduce the energetic requirements of breathing and, potentially, the need for more invasive ventilatory support in the neonate...
  29. ncbi request reprint Tracheal gas insufflation-augmented continuous positive airway pressure in a spontaneously breathing model of neonatal respiratory distress
    Thomas L Miller
    Nemours Research Lung Center, Nemours Children s Clinic Wilmington, Nemours Foundation, Alfred I duPont Children s Hospital, Delaware 19803, USA
    Pediatr Pulmonol 38:386-95. 2004
    ..As such, TGI-augmented CPAP may prevent infants from requiring more invasive ventilation by reducing CO2 retention...
  30. ncbi request reprint Protein composition of apical surface fluid from the human airway cell line Calu-3: effect of ion transport mediators
    Polani B Ramesh Babu
    Nemours Research Lung Center, Alfred I duPont Hospital for Children, 1600 Rockland Road, Wilmington, DE 19803, USA
    Clin Chim Acta 347:81-8. 2004
    ..Analysis of the protein components of airway secretions is a potential means of detecting and characterizing biochemical alterations associated with airway diseases...
  31. ncbi request reprint Regulation of apical surface fluid and protein secretion in human airway epithelial cell line Calu-3
    Polani B Ramesh Babu
    Nemours Research Lung Center, Alfred I duPont Hospital for Children, Wilmington, DE, USA
    Biochem Biophys Res Commun 319:1132-7. 2004
    ..Our results demonstrate a functional link between fluid and protein secretions in Calu-3 apical surface and suggested a possible involvement of CFTR in these processes...
  32. pmc The effects of gas humidification with high-flow nasal cannula on cultured human airway epithelial cells
    Aaron Chidekel
    Nemours Biomedical Research, Nemours Research Lung Center, Nemours Alfred I duPont Hospital for Children, 1600 Rockland Road, Wilmington, DE 19803, USA Department of Pediatrics, Jefferson Medical College, Thomas Jefferson University, 1025 Walnut Street, Suite 700, Philadelphia, PA 19107, USA Department of Pediatrics, Nemours Alfred I duPont Hospital for Children, 1600 Rockland Road, Wilmington, DE 19803, USA
    Pulm Med 2012:380686. 2012
    ..001). Histological analysis showed increasing injury over time for the dry group. These data demonstrate that exposure to low humidity results in reduced epithelial cell function and increased inflammation...
  33. ncbi request reprint Pulmonary function assessment in an infant with Barnes syndrome: proactive evaluation for surgical intervention
    Thomas L Miller
    Nemours Research Lung Center, Alfred I duPont Hospital for Children, 1600 Rockland Rd, Wilmington, DE 19803, USA
    Pediatrics 118:e1264-7. 2006
    ..As a result of the evaluation, the patient was recommended for lateral thoracic expansion surgery and the ventilatory management was adjusted to focus on end-distending pressure support...
  34. pmc Lucinactant attenuates pulmonary inflammatory response, preserves lung structure, and improves physiologic outcomes in a preterm lamb model of RDS
    Marla R Wolfson
    Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Pediatr Res 72:375-83. 2012
    ..We tested the hypothesis that lucinactant may modulate lung inflammatory response to mechanical ventilation in the management of RDS and may confer greater protection than animal-derived surfactants...
  35. pmc Comparison Study of Airway Reactivity Outcomes due to a Pharmacologic Challenge Test: Impulse Oscillometry versus Least Mean Squared Analysis Techniques
    Elena Rodriguez
    Nemours Research Lung Center, Nemours Alfred I duPont Hospital for Children, Wilmington, DE 19803, USA Nemours Biomedical Research, Nemours Alfred I duPont Hospital for Children, Wilmington, DE 19803, USA Division of Clinical Pharmacology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Pulm Med 2013:618576. 2013
    ....
  36. ncbi request reprint Effects of an intratracheally delivered anti-inflammatory protein (rhCC10) on physiological and lung structural indices in a juvenile model of acute lung injury
    Thomas L Miller
    Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, and Nemours Research Lung Center, Alfred I duPont Hospital for Children, Wilmington, DE, USA
    Biol Neonate 89:159-70. 2006
    ....
  37. doi request reprint Intranasal perfluorochemical spray for preferential brain cooling in sheep
    Marla R Wolfson
    Department of Physiology and Pediatrics, Temple University School of Medicine, 3420 N Broad Street, Philadelphia, PA 19140, USA
    Neurocrit Care 8:437-47. 2008
    ..This study explores a novel NP cooling approach employing evaporative characteristics of aerosolized perfluorochemical (PFC)...
  38. pmc Pulmonary function tests in emergency department pediatric patients with acute wheezing/asthma exacerbation
    Kathryn Giordano
    Department of Emergency Medicine, Nemours Alfred I duPont Hospital for Children, Wilmington, DE 19803, USA
    Pulm Med 2012:724139. 2012
    ..Our results demonstrate that PFT measurements, in addition to asthma scores, may be useful in indicating the severity of wheezing/asthma and the need for admission...
  39. ncbi request reprint Physiologic effects of CPAP: application and monitoring
    Tami Irwin Sherman
    Nemours Research Lung Center, A I duPont Hospital for Children, Wilmington, Delaware 19803, USA
    Neonatal Netw 22:7-16. 2003
    ..This article highlights the renewed interest in CPAP therapy and current methods of monitoring...
  40. ncbi request reprint Hyperoxia-induced changes in human airway epithelial cells: the protective effect of perflubron
    Polani B Ramesh Babu
    Nemours Research Lung Center, Alfred I duPont Hospital for Children, Wilmington, DE 19803, USA
    Pediatr Crit Care Med 6:188-94. 2005
    ..To determine the protective effect of perflubron (PFB), a type of perfluorochemical liquid, in hyperoxia-induced cellular injury in the human airway epithelial cells...
  41. ncbi request reprint Heliox attenuates lung inflammation and structural alterations in acute lung injury
    Ursula S Nawab
    Division of Neonatology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA
    Pediatr Pulmonol 40:524-32. 2005
    ..These data suggest that heliox breathing may have the combined therapeutic benefits of attenuating lung inflammation by reducing mechanical and oxidative stress in the clinical management of acute lung injury...
  42. ncbi request reprint Tracheal gas insufflation as a lung-protective strategy: physiologic, histologic, and biochemical markers
    Rees E Oliver
    Department of Pediatrics, Thomas Jefferson University, Philadelphia, PA, USA
    Pediatr Crit Care Med 6:64-9. 2005
    ..Our objective was to use physiologic, histologic, and biochemical markers to test the hypothesis that tracheal gas insufflation in acute lung injury is lung protective...
  43. ncbi request reprint Airway structure, function and development in health and disease
    Thomas H Shaffer
    Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19104, USA
    Paediatr Anaesth 14:3-14. 2004
    ....
  44. ncbi request reprint Continuous tracheal gas insufflation during partial liquid ventilation in juvenile rabbits with acute lung injury
    Guangfa Zhu
    Department of Respiratory Medicine, Shanghai First People s Hospital, Shanghai, China
    J Appl Physiol 96:1415-24. 2004
    ..either treatment alone. These results indicate that combined treatment of TGI and PLV results in improved pulmonary outcome than either treatment alone in this animal model of ALI...
  45. ncbi request reprint Distinct patterns of apoptosis in the lung during liquid ventilation compared with gas ventilation
    Lin L Mantell
    CardioPulmonary Research Institute, Winthrop University Hospital, State University of New York at Stony Brook School of Medicine, Mineola, New York 11501, USA
    Am J Physiol Lung Cell Mol Physiol 283:L31-41. 2002
    ..These studies suggest that although both forms of ventilation cause regional apoptosis, LV more effectively delivers oxygen and recruits the lung more homogeneously than GV...
  46. ncbi request reprint Dose response to rhCC10-augmented surfactant therapy in a lamb model of infant respiratory distress syndrome: physiological, inflammatory, and kinetic profiles
    Beth N Shashikant
    Dept of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Appl Physiol (1985) 99:2204-11. 2005
    ....
  47. ncbi request reprint A prototype infant incubator for heliox therapy
    Clifford J Singhaus
    Department of Pediatrics, Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Biomed Instrum Technol 40:150-63. 2006
    ..Based on these positive safety/efficacy studies, study of the therapeutic impact of Hxl care on neonatal growth and development is in progress...
  48. ncbi request reprint Perfluorochemical liquids enhance delivery of superoxide dismutase to the lungs of juvenile rabbits
    Luca Brunelli
    Division of Neonatology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Pediatr Res 60:65-70. 2006
    ..These data suggest that PFCs optimize lung rhSOD delivery and might enhance the beneficial effects of rhSOD in preventing acute and chronic lung injury...
  49. ncbi request reprint If art imitates life, can laboratory models imitate clinical disease processes?
    Thomas H Shaffer
    Crit Care Med 30:2399-400. 2002
  50. ncbi request reprint Physicochemical properties of perfluorochemical liquids influence ventilatory requirements, pulmonary mechanics, and microvascular permeability during partial liquid ventilation following intestinal ischemia/reperfusion injury
    Mark P Shashikant
    Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Crit Care Med 30:2300-5. 2002
    ....
  51. ncbi request reprint Effects of perfluorochemical evaporative properties on oxygenation during partial liquid ventilation
    Mei Jy Jeng
    Department of Pediatrics, Taipei Veterans General Hospital, Taichung, Taiwan
    Pediatr Int 48:608-15. 2006
    ..The aim of this study is to compare the relationship between patho-physiological endpoints and the physical properties of three PFC liquids used in treating acute lung injury...
  52. ncbi request reprint The neonatal respiratory pump: a developmental challenge with physiologic limitations
    Jay S Greenspan
    Thomas Jefferson University Hospital, Philadelphia, USA
    Neonatal Netw 24:15-22. 2005
    ....
  53. ncbi request reprint Perfluorochemical (PFC) combinations for acute lung injury: an in vitro and in vivo study in juvenile rabbits
    Mei Jy Jeng
    Institute of Clinical Medicine, National Yang Ming University School of Medicine, and Department of Pediatrics, Children s Medical Center, Veterans General Hospital Taipei, Taipei 112, Taiwan
    Pediatr Res 53:81-8. 2003
    ..Thus, combinations of PFC liquids can be formulated to modulate the physiologic outcome in acutely injured lungs, and may prove useful for alternative PFC liquid applications...
  54. ncbi request reprint Long-term tidal liquid ventilation in premature lambs: physiologic, biochemical and histological correlates
    Cynthia Cox
    Department of Neonatology, The Bryn Mawr Hospital, Bryn Mawr, PA, USA
    Biol Neonate 84:232-42. 2003
    ..05). There was a difference in perflubron concentrations as a function of tissue (p<0.001) that correlated to lipid levels (r2=0.93, p<0.01). These data demonstrate that TLV is both safe and effective up to 72 h in premature lambs...
  55. ncbi request reprint Liquid ventilation: an adjunct for respiratory management
    Marla R Wolfson
    Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Paediatr Anaesth 14:15-23. 2004
    ..Currently, there are several theoretical and practical applications of LAV in the immature or mature lung at risk for acute respiratory distress and injury associated with mechanical ventilation...
  56. ncbi request reprint Inhaled nitric oxide therapy in the near-term or term neonate with hypoxic respiratory failure
    Leslie J Williams
    INO Therapeutics, USA
    Neonatal Netw 23:5-13. 2004
    ..Because iNO therapy will probably be used more frequently in nurseries over the next few years, more information on the safety and efficacy of its use in the broader neonatal population needs to be available...
  57. ncbi request reprint Ventilator-induced airway injury: a critical consideration during mechanical ventilation of the infant
    Jay S Greenspan
    Thomas Jefferson University Hospital, Philadelphia, USA
    Neonatal Netw 25:159-66. 2006
    ..Further, there are developmental changes that affect the susceptibility of the neonatal airway to injury. Recognizing and preventing causes of airway injury can help to ensure optimal outcomes for the critically ill neonate...
  58. ncbi request reprint Differential impact of perfluorochemical physical properties on the physiologic, histologic, and inflammatory profile in acute lung injury
    Beth N Shashikant
    Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA
    Crit Care Med 33:1096-103. 2005
    ..To evaluate the differential effects of physical properties of combinational perfluorochemical liquids (PFC) during partial liquid ventilation (PLV) on inflammatory indexes in the injured lung...
  59. doi request reprint Assessment of neonatal ventilation during high-frequency oscillatory ventilation
    Wendy J Sturtz
    Division of Neonatology, Department of Pediatrics, Thomas Jefferson University Hospital, Philadelphia, PA, USA
    Pediatr Crit Care Med 9:101-4. 2008
    ..To determine alterations in high-frequency oscillatory ventilation (HFOV) performance during clinical ventilator management...
  60. ncbi request reprint Optimizing the neonatal thermal environment
    Tami Irwin Sherman
    Discovery Laboratories, Inc, Warrington, Pennsylvania, USA
    Neonatal Netw 25:251-60. 2006
    ..This article highlights principles of thermoregulation and the technologic advances that provide thermal support to our vulnerable..
  61. ncbi request reprint Managing our first breaths: a reflection on the past several decades of neonatal pulmonary therapy
    Suzanne M Touch
    Thomas Jefferson University, Philadelphia, USA
    Neonatal Netw 21:13-20. 2002
    ..This article reviews advances in mechanical ventilation, adjuvant therapies, and respiratory drugs through the past few decades and speculates on future directions in this field...

Research Grants2

  1. Center for Pediatric Research
    Thomas Shaffer; Fiscal Year: 2007
    ..abstract_text> ..