Research Topics
Species | Carlos D RoseSummaryAffiliation: Alfred I. duPont Hospital for Children Country: USA Publications
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Detail Information
Publications
Pediatric granulomatous arthritis: an international registryCarlos D Rose
duPont Children s Hospital, Wilmington, Delaware 19899, USA
Arthritis Rheum 54:3337-44. 2006..We chose the term "pediatric granulomatous arthritis" to refer to both. An international registry was established in the spring of 2005 to define the phenotype spectrum and establish the mutation frequency and variants...
NOD2-associated pediatric granulomatous arthritis, an expanding phenotype: study of an international registry and a national cohort in SpainCarlos D Rose
Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Arthritis Rheum 60:1797-803. 2009..To study the phenotype characteristics of the largest to date cohort of patients with pediatric granulomatous arthritis (PGA) and documented mutations in the NOD2 gene...
Blau syndrome mutation of CARD15/NOD2 in sporadic early onset granulomatous arthritisCarlos D Rose
Thomas Jefferson University, duPont Children s Hospital, Wilmington, Delaware, USA
J Rheumatol 32:373-5. 2005..This would explain the profound clinical identity and the lack of disease history in the parents...
Caspase recruitment domain 15 mutations and rheumatic diseasesCarlos D Rose
Pediatric Rheumatology, duPont Children s Hospital, Philadelphia, Pennsylvania, USA
Curr Opin Rheumatol 17:579-85. 2005..The purpose of this article is to review the foundational work and current developments on a group of rheumatic disorders associated with mutations in the caspase recruitment domain 15/nucleotide oligomerization domain 2 gene...
Epidemiology of juvenile rheumatoid arthritis in the Americas: an updateCarlos D Rose
Division of Rheumatology, duPont Hospital for Children, Wilmington, DE 19899, USA
J Clin Rheumatol 12:129-30. 2006
Blau arteritis resembling Takayasu disease with a novel NOD2 mutationRaju P Khubchandani
Division of Rheumatology, duPont Children s Hospital, 1600 Rockland Road, Wilmington, DE 19899, USA
J Rheumatol 39:1888-92. 2012..To put forward a new concept--Blau arteritis, a form of large-vessel vasculitis phenotypically related to Takayasu disease but genetically and clinically part of an expanded phenotype of Blau syndrome...
Blau syndrome revisitedCarlos D Rose
Thomas Jefferson University and duPont Children s Hospital, Wilmington, Delaware, USA
Curr Opin Rheumatol 23:411-8. 2011..Not only there has been significant progress in disease characterization but also the biological pathways associated with NOD2 and related proteins of the innate immunity are better understood...
Blau syndrome and related genetic disorders causing childhood arthritisMara L Becker
Division of Pediatric Rheumatology, duPont Children's Hospital, Wilmington, DE 19899, USA
Curr Rheumatol Rep 7:427-33. 2005..This paper will review the clinical characteristics of these three disorders and their association with mutations in the CARD 15 gene...
Prolonged synovitis in pediatric Lyme arthritis cannot be predicted by clinical or laboratory parametersAnnemarie C Brescia
Division of Rheumatology, AI duPont Hospital for Children, Wilmington, DE 19803, USA
Clin Rheumatol 28:591-3. 2009..Linear and logistic regression showed no predictors of disease duration. One third of pediatric LA patients require >6 months to resolve synovitis. Duration is not associated with delay in treatment, age, or seroreactivity...
Long-term effects of immunization with recombinant lipoprotein outer surface protein a on serologic test for lyme diseasePaul T Fawcett
Immunology Laboratory, Department of Research, A I duPont Hospital for Children, Wilmington, Delaware 19803, USA
Clin Diagn Lab Immunol 11:808-10. 2004..We tested sera from 152 vaccine recipients by using in-house and commercial Western blot assays and found that vaccination caused interference in up to 25% of recipients and can persist for over 6 years...
In vitro assessment of antiborrelial activity of OspA vaccine seraPaul T Fawcett
Immunology Laboratory, Department of Research, A I duPont Hospital for Children, Wilmington, Delaware 19803, USA
Clin Diagn Lab Immunol 9:919-20. 2002..We report on an in vitro microculture assay, which can be used to provide an indicator of the need for booster doses of vaccine...
Granulomatous nephritis associated with R334Q mutation in NOD2Silvia Mónica Meiorin
J Rheumatol 34:1945-7. 2007
Infantile onset panniculitis with uveitis and systemic granulomatosis: a new clinicopathologic entityCarine H Wouters
University Hospital Gasthuisberg, Leuven, Belgium
J Pediatr 151:707-9. 2007..Neither CARD15 nor CIAS1 mutations were found. Despite immunosuppressive therapy, disease course was progressive. Response to anti-tumor necrosis factor monoclonal antibody in 3 patients is of note...
