N Mauras

Summary

Affiliation: Alfred I. duPont Hospital for Children
Country: USA

Publications

  1. ncbi An open label 12-month pilot trial on the effects of the aromatase inhibitor anastrozole in growth hormone (GH)-treated GH deficient adolescent boys
    Nelly Mauras
    Nemours Children s Clinics in Jacksonville, FL, USA
    J Pediatr Endocrinol Metab 17:1597-606. 2004
  2. ncbi Estrogen therapy in Turner syndrome: does the type, dose and mode of delivery matter?
    Nelly Mauras
    Nemours Children s Clinic, Division of Endocrinology, Diabetes at Metabolism, Jacksonville, Florida, USA
    Pediatr Endocrinol Rev 9:718-22. 2012
  3. ncbi Metformin use in children with obesity and normal glucose tolerance--effects on cardiovascular markers and intrahepatic fat
    Nelly Mauras
    Division of Endocrinology, Diabetes and Metabolism, Nemours Children s Clinic, Jacksonville, FL32207, USA
    J Pediatr Endocrinol Metab 25:33-40. 2012
  4. ncbi Pharmacokinetics and pharmacodynamics of oral and transdermal 17β estradiol in girls with Turner syndrome
    Martha Taboada
    Nemours Children s Clinic, Jacksonville, Florida 32207, USA
    J Clin Endocrinol Metab 96:3502-10. 2011
  5. ncbi Are the metabolic effects of GH and IGF-I separable?
    Nelly Mauras
    Division of Endocrinology, The Department of Pediatrics at the Nemours Children s Clinic, 807 Children s Way, Jacksonville, FL 32207, USA
    Growth Horm IGF Res 15:19-27. 2005
  6. ncbi Limited efficacy of growth hormone (GH) during transition of GH-deficient patients from adolescence to adulthood: a phase III multicenter, double-blind, randomized two-year trial
    Nelly Mauras
    Division of Endocrinology, Nemours Children s Clinic, 807 Children s Way, Jacksonville, Florida 32207, USA
    J Clin Endocrinol Metab 90:3946-55. 2005
  7. ncbi Sperm analysis in growth hormone-deficient adolescents previously treated with an aromatase inhibitor: comparison with normal controls
    Nelly Mauras
    Nemours Children s Clinic and Research Programs, Jacksonville, Florida 32207, USA
    Fertil Steril 84:239-42. 2005
  8. ncbi Growth hormone action in puberty: effects by gender
    Nelly Mauras
    Division of Pediatric Endocrinology and Metabolism, Nemours Children s Clinic, Jacksonville, FL 32207, United States
    Growth Horm IGF Res 17:463-71. 2007
  9. ncbi Metabolic effects of oral versus transdermal estrogen in growth hormone-treated girls with turner syndrome
    Nelly Mauras
    Nemours Children s Clinic, 807 Childrens Way, Jacksonville, Florida 32207, USA
    J Clin Endocrinol Metab 92:4154-60. 2007
  10. ncbi Anastrozole increases predicted adult height of short adolescent males treated with growth hormone: a randomized, placebo-controlled, multicenter trial for one to three years
    Nelly Mauras
    Nemours Children s Clinic, Division of Endocrinology, 807 Children s Way, Jacksonville, Florida 32207, USA
    J Clin Endocrinol Metab 93:823-31. 2008

Research Grants

  1. Hypoglycemia in Children and Adolescents with T1DM: Mechanisms and Prevention
    Nelly Mauras; Fiscal Year: 2007

Detail Information

Publications66

  1. ncbi An open label 12-month pilot trial on the effects of the aromatase inhibitor anastrozole in growth hormone (GH)-treated GH deficient adolescent boys
    Nelly Mauras
    Nemours Children s Clinics in Jacksonville, FL, USA
    J Pediatr Endocrinol Metab 17:1597-606. 2004
    ..To investigate whether 12 mo treatment with the aromatase inhibitor anastrozole can achieve sustained suppression of estrogen production and delay epiphyseal fusion in growth hormone deficient (GHD) adolescent males...
  2. ncbi Estrogen therapy in Turner syndrome: does the type, dose and mode of delivery matter?
    Nelly Mauras
    Nemours Children s Clinic, Division of Endocrinology, Diabetes at Metabolism, Jacksonville, Florida, USA
    Pediatr Endocrinol Rev 9:718-22. 2012
    ..Whether this translates into better body composition and metabolic outcomes in girls with hypogonadism is being actively investigated and data will soon be available...
  3. ncbi Metformin use in children with obesity and normal glucose tolerance--effects on cardiovascular markers and intrahepatic fat
    Nelly Mauras
    Division of Endocrinology, Diabetes and Metabolism, Nemours Children s Clinic, Jacksonville, FL32207, USA
    J Pediatr Endocrinol Metab 25:33-40. 2012
    ..To determine if metformin improves markers of inflammation, thrombosis, and intrahepatic fat contents in children with uncomplicated obesity...
  4. ncbi Pharmacokinetics and pharmacodynamics of oral and transdermal 17β estradiol in girls with Turner syndrome
    Martha Taboada
    Nemours Children s Clinic, Jacksonville, Florida 32207, USA
    J Clin Endocrinol Metab 96:3502-10. 2011
    ..The type, dose, and route of 17β-estradiol (E(2)) used to feminize girls with Turner syndrome (TS) is not well established...
  5. ncbi Are the metabolic effects of GH and IGF-I separable?
    Nelly Mauras
    Division of Endocrinology, The Department of Pediatrics at the Nemours Children s Clinic, 807 Children s Way, Jacksonville, FL 32207, USA
    Growth Horm IGF Res 15:19-27. 2005
    ..A comparison of these and other effects of these hormones is provided in this brief review. Subsequent studies are still needed to fully elucidate the safety and efficacy of IGF-I for use in humans...
  6. ncbi Limited efficacy of growth hormone (GH) during transition of GH-deficient patients from adolescence to adulthood: a phase III multicenter, double-blind, randomized two-year trial
    Nelly Mauras
    Division of Endocrinology, Nemours Children s Clinic, 807 Children s Way, Jacksonville, Florida 32207, USA
    J Clin Endocrinol Metab 90:3946-55. 2005
    ..Treatment of GH-deficient adolescents in transition to adulthood remains challenging...
  7. ncbi Sperm analysis in growth hormone-deficient adolescents previously treated with an aromatase inhibitor: comparison with normal controls
    Nelly Mauras
    Nemours Children s Clinic and Research Programs, Jacksonville, Florida 32207, USA
    Fertil Steril 84:239-42. 2005
    ....
  8. ncbi Growth hormone action in puberty: effects by gender
    Nelly Mauras
    Division of Pediatric Endocrinology and Metabolism, Nemours Children s Clinic, Jacksonville, FL 32207, United States
    Growth Horm IGF Res 17:463-71. 2007
    ..Adult females receiving GH may be less sensitive to the metabolic effects of GH than males, however these differences are less well studied in adolescence. We aimed to investigate if metabolic effects of GH vary by gender during puberty...
  9. ncbi Metabolic effects of oral versus transdermal estrogen in growth hormone-treated girls with turner syndrome
    Nelly Mauras
    Nemours Children s Clinic, 807 Childrens Way, Jacksonville, Florida 32207, USA
    J Clin Endocrinol Metab 92:4154-60. 2007
    ..Transdermal (TD) estrogen is often preferred over the oral route in postmenopausal and GH-deficient women taking estrogen, but this has not been studied in detail in girls...
  10. ncbi Anastrozole increases predicted adult height of short adolescent males treated with growth hormone: a randomized, placebo-controlled, multicenter trial for one to three years
    Nelly Mauras
    Nemours Children s Clinic, Division of Endocrinology, 807 Children s Way, Jacksonville, Florida 32207, USA
    J Clin Endocrinol Metab 93:823-31. 2008
    ..The process of epiphyseal fusion during puberty is regulated by estrogen, even in males...
  11. ncbi Strategies for maximizing growth in puberty in children with short stature
    Nelly Mauras
    Division of Endocrinology and Metabolism, Nemours Children s Clinic, Jacksonville, FL 32207, USA
    Pediatr Clin North Am 58:1167-79, x. 2011
    ..Safety issues regarding bone health also require further study...
  12. ncbi Pharmacokinetics and pharmacodynamics of anastrozole in pubertal boys with recent-onset gynecomastia
    Nelly Mauras
    Nemours Children s Clinic, 807 Children s Way, Jacksonville, FL 32207, USA
    J Clin Endocrinol Metab 94:2975-8. 2009
    ..Anastrozole (Arimidex) is a potent and selective reversible inhibitor of the aromatase enzyme in females...
  13. ncbi Can growth hormone counteract the catabolic effects of steroids?
    Nelly Mauras
    Division of Endocrinology, Nemours Children s Clinic, Jacksonville, FL 32207, USA
    Horm Res 72:48-54. 2009
    ..CONCLUSIONS: Both GH and IGF-I may decrease the catabolic effects of chronic steroid use in humans, particularly by enhancing lean body mass accrual and, in children, by increasing linear growth...
  14. ncbi Obesity without established comorbidities of the metabolic syndrome is associated with a proinflammatory and prothrombotic state, even before the onset of puberty in children
    Nelly Mauras
    Nemours Children s Clinic, 807 Children s Way, Jacksonville, Florida 32207, USA
    J Clin Endocrinol Metab 95:1060-8. 2010
    ..Whether biomarkers like hsCRP and fibrinogen are useful in assessing cardiovascular risk and whether these abnormalities are reversible with earlier therapeutic interventions in very young obese children requires further study...
  15. ncbi GH use in the transition of adolescence to adulthood
    Nelly Mauras
    Division Endocrinology and Metabolism, Nemours Children s Clinic, Jacksonville, FL 32207, USA
    Endocr Dev 18:109-25. 2010
    ..Those with multiple pituitary hormone deficiencies on the other hand should be replaced indefinitely with GH. The treatment of the GH-deficient adolescent in transition should be individualized...
  16. ncbi Effects of glutamine on glycemic control during and after exercise in adolescents with type 1 diabetes: a pilot study
    Nelly Mauras
    Division of Endocrinology, Diabetes and Metabolism, Nemours Children s Clinic, Jacksonville, Florida, USA
    Diabetes Care 33:1951-3. 2010
    ..To investigate if oral glutamine ameliorates exercise and postexercise nighttime hypoglycemia in type 1 diabetic adolescents...
  17. ncbi Estrogen treatment and estrogen suppression: metabolic effects in adolescence
    N Mauras
    Nemours Children s Clinic and Research Programs, Jacksonville, Florida 32211, USA
    J Pediatr Endocrinol Metab 13:1431-7. 2000
    ..In boys, selective aromatase blockade may have a role in delaying epiphyseal fusion. Large placebo-controlled trials will be required to study this effect further...
  18. ncbi Growth hormone and sex steroids. Interactions in puberty
    N Mauras
    Division of Endocrinology, Nemours Children s Clinic, Jacksonville, Florida, USA
    Endocrinol Metab Clin North Am 30:529-44. 2001
    ....
  19. ncbi Growth hormone therapy in the glucocorticosteroid-dependent child: metabolic and linear growth effects
    N Mauras
    Division of Endocrinology, Nemours Children s Clinic, 807 Children s Way, Jacksonville, FL 32207, USA
    Horm Res 56:13-8. 2001
    ..Longer term studies will be needed to better define the safety and efficacy of this approach...
  20. ncbi Strategies for maximizing growth in puberty in children with short stature
    Nelly Mauras
    Division of Endocrinology and Metabolism, Nemours Children s Clinic, Jacksonville, FL 32207, USA
    Endocrinol Metab Clin North Am 38:613-24. 2009
    ..Safety issues regarding bone health also require further study...
  21. ncbi Estrogen suppression in males: metabolic effects
    N Mauras
    Nemours Research Programs at the Nemours Children s Clinic, Jacksonville, Florida 32207, USA
    J Clin Endocrinol Metab 85:2370-7. 2000
    ....
  22. ncbi High dose recombinant human growth hormone (GH) treatment of GH-deficient patients in puberty increases near-final height: a randomized, multicenter trial. Genentech, Inc., Cooperative Study Group
    N Mauras
    Nemours Children s Clinic and Research Programs, Jacksonville, Florida 32207, USA
    J Clin Endocrinol Metab 85:3653-60. 2000
    ..In conclusion, high dose rhGH therapy may have a beneficial effect in adolescent GH-deficient patients, particularly those who are most growth retarded at the start of puberty...
  23. ncbi Recombinant human insulin-like growth factor I has significant anabolic effects in adults with growth hormone receptor deficiency: studies on protein, glucose, and lipid metabolism
    N Mauras
    Division of Endocrinology, Nemours Children s Clinic and Research Programs, Jacksonville, Florida 32207, USA
    J Clin Endocrinol Metab 85:3036-42. 2000
    ..These results suggest that, similar to GH treatment of adults with GH deficiency, rhIGF-I may be beneficial as long term replacement therapy for the adult patient with Laron's syndrome...
  24. ncbi Testosterone deficiency in young men: marked alterations in whole body protein kinetics, strength, and adiposity
    N Mauras
    Nemours Children s Clinic, Jacksonville, Florida 32207, USA
    J Clin Endocrinol Metab 83:1886-92. 1998
    ..These data suggest a direct effect of androgens on whole body lipid and protein metabolism...
  25. ncbi Insulin-like growth factor I and growth hormone (GH) treatment in GH-deficient humans: differential effects on protein, glucose, lipid, and calcium metabolism
    N Mauras
    Division of Endocrinology, Nemours Children s Clinic, Jacksonville, Florida 32207, USA
    J Clin Endocrinol Metab 85:1686-94. 2000
    ..These differences may allow for better selection of treatment modalities depending on the choice of desired effects in hypopituitarism...
  26. ncbi Growth hormone, insulin-like growth factor I and sex hormones: effects on protein and calcium metabolism
    N Mauras
    Nemours Children s Clinic and Research Programs, Jacksonville FL 32207, USA
    Acta Paediatr Suppl 88:81-3. 1999
    ..Further understanding of the physiological role of these hormones during the critical years of adolescence will give us better tools with which to treat disorders of puberty and growth...
  27. ncbi Ovarian hyperandrogenism is associated with insulin resistance to both peripheral carbohydrate and whole-body protein metabolism in postpubertal young females: a metabolic study
    N Mauras
    Nemours Children s Clinic, Jacksonville, Florida 32207, USA
    J Clin Endocrinol Metab 83:1900-5. 1998
    ..Carefully designed studies targeting interventions to improve both the hyperandrogenic and hyperinsulinemic state may prove useful even in the early juvenile stages of this disease...
  28. ncbi Recombinant human growth hormone and recombinant human insulin-like growth factor I diminish the catabolic effects of hypogonadism in man: metabolic and molecular effects
    V Y Hayes
    Divisions of Endocrinology, Nemours Children's Clinic, Baptist Medical Center, Jacksonville, Florida 32207, USA
    J Clin Endocrinol Metab 86:2211-9. 2001
    ..These hormones, particularly GH, may play a role in the treatment of hypogonadal men rendered hypogonadal pharmacologically or those unable to take full testosterone replacement. The latter requires further study...
  29. ncbi Endocrine control of body composition in infancy, childhood, and puberty
    Johannes D Veldhuis
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Medical and Graduate Schools of Medicine, General Clinical Research Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    Endocr Rev 26:114-46. 2005
    ..The present critical review examines hormonal regulation of body composition in infancy, childhood, and puberty...
  30. ncbi Synergistic effects of testosterone and growth hormone on protein metabolism and body composition in prepubertal boys
    Nelly Mauras
    Nemours Children's Clinic Division of Endocrinology and Nemours Research Program, Jacksonville, FL 32207, USA
    Metabolism 52:964-9. 2003
    ..GH and T both potentiate the development of the full body composition and metabolic changes of puberty...
  31. ncbi Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamo-somatotrope (growth hormone)-insulin-like growth factor I axis in the human: evidence from pubertal pathophysiology and sex-steroid hormone replac
    J D Veldhuis
    Division of Endocrinology, National Science Foundation Center for Biological Timing, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Clin Endocrinol Metab 82:3414-20. 1997
    ....
  32. ncbi Growth hormone has anabolic effects in glucocorticosteroid-dependent children with inflammatory bowel disease: a pilot study
    Nelly Mauras
    Nemours Children's Clinic, Jacksonville, FL, USA
    Metabolism 51:127-35. 2002
    ..We conclude that treatment with rhGH has beneficial effects in prednisone-dependent growing children. Larger studies will be needed to assess the long-term safety and efficacy of this approach...
  33. ncbi Can glutamine and growth hormone promote protein anabolism in children with cystic fibrosis?
    V Hayes
    Division of Endocrinology, Nemours Children s Clinic, Jacksonville, Fla, USA
    Horm Res 58:21-3. 2002
    ....
  34. ncbi A randomized controlled trial of insulin pump therapy in young children with type 1 diabetes
    Larry A Fox
    Nemours Children s Clinic, NE Florida Pediatric Diabetes Center, 807 Children s Way, Jacksonville, FL 32207, USA
    Diabetes Care 28:1277-81. 2005
    ..This study assesses the effects of insulin pump therapy on diabetes control and family life in children 1-6 years old with type 1 diabetes...
  35. ncbi Response of fractional synthesis rate (FSR) of fibrinogen, concentration of D-dimer and fibrinolytic balance to physical activity-based intervention in obese children
    P Balagopal
    Nemours Childrens Clinic, Jacksonville, FL 32207, USA
    J Thromb Haemost 6:1296-303. 2008
    ..Physical activity-induced reduction in obesity-related hyperfibrinogenemia in children has been reported. The underlying mechanisms remain elusive. Further, the effect of such interventions on fibrinolysis in children is scarce...
  36. ncbi Poorly controlled type 1 diabetes is associated with altered glutathione homeostasis in adolescents: apparent resistance to N-acetylcysteine supplementation
    Dominique Darmaun
    Endocrine Research, Nemours Children s Clinic, Jacksonville, FL 32207, USA
    Pediatr Diabetes 9:577-82. 2008
    ..In the presence of relative insulinopenia, either higher amino acid doses or aggressive insulin therapy may be needed to achieve this goal. This would require further study...
  37. ncbi Amino-terminal propeptide of C-type natriuretic peptide and linear growth in children: effects of puberty, testosterone, and growth hormone
    Robert C Olney
    Division of Pediatric Endocrinology, Nemours Children s Clinic Jacksonville, Jacksonville, Florida 32207, USA
    J Clin Endocrinol Metab 92:4294-8. 2007
    ..The amino-terminal propeptide of CNP (NTproCNP) is produced in equimolar amounts with CNP and is measurable in plasma, providing a potential biomarker for growth plate activity and, hence, linear growth...
  38. ncbi Influence of sex and beta2 adrenergic receptor haplotype on resting and terbutaline-stimulated whole body lipolysis
    John J Lima
    Centers for Clinical Pediatric Pharmacology and Pharmacogenetics, Nemours Children s Clinic, Jacksonville, FL 32207, USA
    Metabolism 54:492-9. 2005
    ..We conclude that compared to haplotype, sex is a more important determinant of basal lipolysis after a 12-hour fast in healthy, non-obese individuals...
  39. ncbi Randomized trial of behavioral family systems therapy for diabetes: maintenance of effects on diabetes outcomes in adolescents
    Tim Wysocki
    Nemours Childrens Clinic, Department of Biomedical Research, 807 Children s Way, Jacksonville, FL 32207, USA
    Diabetes Care 30:555-60. 2007
    ..This study evaluates a revised intervention, BFST for Diabetes (BFST-D), modified to achieve greater impact on diabetes-related family conflict, treatment adherence, and metabolic control...
  40. ncbi Increased synthesis rate of fibrinogen as a basis for its elevated plasma levels in obese female adolescents
    Prabhakaran Balagopal
    Nemours Research Program, Department of Research, Nemours Children s Clinic, Jacksonville, Florida 32207, USA
    Am J Physiol Endocrinol Metab 282:E899-904. 2002
    ..This finding may have important implications in the design of therapies for modulating plasma fibrinogen levels in obesity and/or CVD in childhood...
  41. ncbi Self-care autonomy and outcomes of intensive therapy or usual care in youth with type 1 diabetes
    Tim Wysocki
    Center for Pediatric Psychology Research, Nemours Children s Clinic, 807 Children s Way, Jacksonville, Florida 32207, USA
    J Pediatr Psychol 31:1036-45. 2006
    ..This article evaluated whether deviation from developmentally appropriate self-care autonomy moderated the effects of intensive therapy (IT) or usual care (UC) on glycosylated hemoglobin (HbA(1C)) in 142 youths with diabetes...
  42. ncbi Absence of adverse effects of severe hypoglycemia on cognitive function in school-aged children with diabetes over 18 months
    Tim Wysocki
    Division of Psychology and Psychiatry, Nemours Children s Clinic, Jacksonville, Florida 32207, USA
    Diabetes Care 26:1100-5. 2003
    ..The objective of this study was to determine whether severe hypoglycemia (SH) in children with type 1 diabetes is associated with cognitive decline over 18 months...
  43. ncbi Evidence for accelerated rates of glutathione utilization and glutathione depletion in adolescents with poorly controlled type 1 diabetes
    Dominique Darmaun
    Nemours Children s Clinic, Research Department, 5 North, 807 Children s Way, Jacksonville, FL 32207, USA
    Diabetes 54:190-6. 2005
    ..This weakened antioxidant defense may play a role in the pathogenesis of diabetes complications...
  44. ncbi Effects of glutamine and recombinant human growth hormone on protein metabolism in prepubertal children with cystic fibrosis
    Dominique Darmaun
    Division of Endocrinology, Nemours Children s Clinic, Jacksonville, Florida 32207, USA
    J Clin Endocrinol Metab 89:1146-52. 2004
    ....
  45. ncbi Pharmacokinetics and dose finding of a potent aromatase inhibitor, aromasin (exemestane), in young males
    Nelly Mauras
    Nemours Children s Clinic and Research Programs, Jacksonville, Florida 32207, USA
    J Clin Endocrinol Metab 88:5951-6. 2003
    ..The drug was well tolerated. In conclusion, exemestane is a potent aromatase inhibitor in men and an alternative to the choice of available inhibitors. Long-term efficacy and safety will need further study...
  46. ncbi Effects of behavioral family systems therapy for diabetes on adolescents' family relationships, treatment adherence, and metabolic control
    Tim Wysocki
    Center for Pediatric Psychology Research, Nemours Children s Clinic, 807 Children s Way, Jacksonville, Florida 32207, USA
    J Pediatr Psychol 31:928-38. 2006
    ..We evaluated a revised intervention, BFST for diabetes (BFST-D)...
  47. ncbi Self-management competence as a predictor of outcomes of intensive therapy or usual care in youth with type 1 diabetes
    Tim Wysocki
    Nemours Children s Clinic, Jacksonville, Florida 32207, USA
    Diabetes Care 26:2043-7. 2003
    ..This article evaluates prediction of HbA(1c) during an 18-month randomized trial of intensive therapy (IT) versus usual care (UC) for type 1 diabetes in 142 youth...
  48. ncbi Evidence for hypermetabolism in boys with constitutional delay of growth and maturation
    Joan C Han
    Division of Endocrinology, Nemours Children's Clinic--Jacksonville, 807 Children's Way, Jacksonville, Florida 32207, USA
    J Clin Endocrinol Metab 91:2081-6. 2006
    ..Additional studies are needed to determine whether augmenting nutrition to match their energy needs (with or without hormonal therapy) can improve linear and ponderal growth in patients with CDGM...
  49. ncbi Lack of accuracy of continuous glucose sensors in healthy, nondiabetic children: results of the Diabetes Research in Children Network (DirecNet) accuracy study
    Nelly Mauras
    DirecNet Coordinating Center, Tampa, Florida, USA
    J Pediatr 144:770-5. 2004
    ..CONCLUSIONS: Neither the CGMS nor the GW2B is accurate enough to establish population standards of the glycemic profile of healthy children and cannot be recommended in the workup of hypoglycemia in nondiabetic youth...
  50. ncbi Salutary effects of combining early very low-dose systemic estradiol with growth hormone therapy in girls with Turner syndrome
    Robert L Rosenfield
    The University of Chicago Pritzker School of Medicine, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 90:6424-30. 2005
    ..Optimizing pubertal estrogen replacement in girls with Turner syndrome is important...
  51. ncbi GlucoWatch G2 Biographer alarm reliability during hypoglycemia in children
    Eva Tsalikian
    DirecNet Coordinating Center, Jaeb Center for Health Research, Tampa, FL 33647, USA
    Diabetes Technol Ther 6:559-66. 2004
    ..The "down alert" alarm is triggered when extrapolation of the current glucose trend anticipates hypoglycemia to occur within the next 20 min...
  52. ncbi JDRF randomized clinical trial to assess the efficacy of real-time continuous glucose monitoring in the management of type 1 diabetes: research design and methods
    William V Tamborlane
    Diabetes Technol Ther 10:310-21. 2008
    ..RESULTS: Recruitment for the study was completed on December 15, 2007. CONCLUSION: Results of this clinical trial should help establish whether or not current RT-CGM devices are beneficial to patients with T1D...
  53. ncbi Acute depletion of plasma glutamine increases leucine oxidation in prednisone-treated humans
    Olivier Le Bacquer
    INSERM U 539, Centre de Recherche en Nutrition Humaine, Nantes, France
    Clin Nutr 26:231-8. 2007
    ....
  54. ncbi Continuous glucose monitoring and intensive treatment of type 1 diabetes
    William V Tamborlane
    N Engl J Med 359:1464-76. 2008
    ..Further work is needed to identify barriers to effectiveness of continuous monitoring in children and adolescents. (ClinicalTrials.gov number, NCT00406133.)..
  55. ncbi Use of stable isotopes to assess protein and amino acid metabolism in children and adolescents: a brief review
    Dominique Darmaun
    INSERM U539, Human Nutrition Research Center, Nantes, France
    Horm Res 64:32-7. 2005
    ..Attempts have also been made to measure amino acid/protein metabolism in selected body compartments, and to measure the kinetics of specific tissue proteins, for example, muscle, gut, or plasma proteins...
  56. ncbi Impact of exercise on overnight glycemic control in children with type 1 diabetes mellitus
    Eva Tsalikian
    DirectNet Coordinating Center, Jaeb Center for Health Research, Tampa, Florida 33647, USA
    J Pediatr 147:528-34. 2005
    ..To examine the effect of exercise on overnight hypoglycemia in children with type 1 diabetes mellitus (T1DM)...
  57. ncbi Continuous glucose monitoring in children with type 1 diabetes
    Bruce Buckingham
    J Pediatr 151:388-93, 393.e1-2. 2007
    ..The results provide a compelling rationale for conducting a randomized trial of daily use of a continuous glucose monitor in children with T1D...
  58. ncbi FreeStyle navigator continuous glucose monitoring system use in children with type 1 diabetes using glargine-based multiple daily dose regimens: results of a pilot trial Diabetes Research in Children Network (DirecNet) Study Group
    Stuart Weinzimer
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA
    Diabetes Care 31:525-7. 2008
  59. ncbi Corticosteroids increase glutamine utilization in human splanchnic bed
    Ronan Thibault
    INRA, UMR 1280, Physiologie des Adaptations Nutritionnelles, Universite de Nantes, 44093 Nantes Cedex 1, France
    Am J Physiol Gastrointest Liver Physiol 294:G548-53. 2008
    ..The role of such changes in patients receiving chronic corticoid treatment for inflammatory diseases or suffering from severe illness remains to be determined...
  60. ncbi The effects of aerobic exercise on glucose and counterregulatory hormone concentrations in children with type 1 diabetes
    Michael J Tansey
    DirecNet Coordinating Center, Jaeb Center for Health Research, Tampa, FL 33647, USA
    Diabetes Care 29:20-5. 2006
    ..To examine the acute glucose-lowering effects of aerobic exercise in children and adolescents with type 1 diabetes...
  61. ncbi A randomized multicenter trial comparing the GlucoWatch Biographer with standard glucose monitoring in children with type 1 diabetes
    H Peter Chase
    DirecNet Coordinating Center, Jaeb Center for Health Research, 15310 Amberly Drive, Suite 350, Tampa, FL 33647, USA
    Diabetes Care 28:1101-6. 2005
    ..This study assesses whether use of the GlucoWatch G2 Biographer (GW2B) in addition to standard glucose monitoring lowers HbA(1c) and reduces hypoglycemia compared with standard glucose monitoring alone...
  62. ncbi Predictors of first-year growth response to a fixed-dose growth hormone treatment in children born small for gestational age: results of an open-label, multicenter trial in the United States
    Robert Rapaport
    Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Pediatr Endocrinol Metab 21:411-22. 2008
    ..The GH dose was the major predictor of first year growth response...
  63. ncbi Use of the DirecNet Applied Treatment Algorithm (DATA) for diabetes management with a real-time continuous glucose monitor (the FreeStyle Navigator)
    Bruce Buckingham
    Pediatr Diabetes 9:142-7. 2008
    ..CONCLUSIONS: These results show the feasibility of implementing the DATA when real-time continuous glucose monitoring is initiated and support its use in future clinical trials of real-time continuous glucose monitoring...
  64. ncbi Accuracy of the modified Continuous Glucose Monitoring System (CGMS) sensor in an outpatient setting: results from a diabetes research in children network (DirecNet) study
    Michael J Tansey
    DirecNet Coordinating Center, Jaeb Center for Health Research, Tampa, FL 33647, USA
    Diabetes Technol Ther 7:109-14. 2005
    ..19%; P < 0.001]. Baseline data from a subsequent outpatient study provide an opportunity to further assess the accuracy of the modified sensor in a much larger sample of children with type 1 diabetes...
  65. ncbi The accuracy of the Guardian RT continuous glucose monitor in children with type 1 diabetes
    Michael Tansey
    Diabetes Technol Ther 10:266-72. 2008
    ..The Guardian RT has an accuracy similar to that of other available continuous glucose monitors and can give important and useful clinical information...

Research Grants2

  1. Hypoglycemia in Children and Adolescents with T1DM: Mechanisms and Prevention
    Nelly Mauras; Fiscal Year: 2007
    ..The project results will enhance clinical adoption of CGS technology. ..