John Lima

Summary

Affiliation: Alfred I. duPont Hospital for Children
Country: USA

Publications

  1. ncbi request reprint Do genetic polymorphisms alter patient response to inhaled bronchodilators?
    John J Lima
    Center for Pharmacogenomics and Translational Research, Nemours Children s Clinic, 807 Children s Way, Jacksonville, FL 32207, USA, 1 904 697 3683 1 904 687 7988
    Expert Opin Drug Metab Toxicol 10:1231-40. 2014
  2. doi request reprint Genetic influences on response to asthma pharmacotherapy
    John J Lima
    Center for Pediatric Clinical Pharmacology, Pharmacogenetics Center, Nemours Children s Clinic, 807 Children s Way, Jacksonville, FL 32207, USA
    Expert Rev Clin Pharmacol 1:649-60. 2008
  3. doi request reprint Association of CYP2C19 polymorphisms and lansoprazole-associated respiratory adverse effects in children
    John J Lima
    Center for Pharmacogenomics and Translational Research, Nemours Children s Clinic, Jacksonville, FL, USA
    J Pediatr 163:686-91. 2013
  4. pmc Influence of leukotriene pathway polymorphisms on response to montelukast in asthma
    John J Lima
    The American Lung Association Asthma Clinical Research Centers, Center for Pharmacogenetics, Nemours Children s Clinic, 807 Children s Way, Jacksonville, FL 32207, USA
    Am J Respir Crit Care Med 173:379-85. 2006
  5. ncbi request reprint The C523A beta2 adrenergic receptor polymorphism associates with markers of asthma severity in African Americans
    John J Lima
    The American Lung Association Asthma Clinical Research Centers, Jacksonville, Florida, USA
    J Asthma 43:185-91. 2006
  6. ncbi request reprint Treatment heterogeneity in asthma: genetics of response to leukotriene modifiers
    John J Lima
    Nemours Children s Clinic, Centers for Clinical Pediatric Pharmacology and Pharmacogenetics, Jacksonville, Florida 32207, USA
    Mol Diagn Ther 11:97-104. 2007
  7. pmc Association analyses of adrenergic receptor polymorphisms with obesity and metabolic alterations
    John J Lima
    Pharmacogenetics Center, Nemours Children s Clinic, Jacksonville, FL 32207, USA
    Metabolism 56:757-65. 2007
  8. ncbi request reprint A polymorphism in the NPPA gene associates with asthma
    J J Lima
    Pharmacogenetics Center, Nemours Children s Clinic, Jacksonville, FL 32207, USA
    Clin Exp Allergy 38:1117-23. 2008
  9. pmc Pharmacogenetics of asthma
    John J Lima
    Centers for Pediatric Clinical Pharmacology and Pharmacogenetics, Nemours Children s Clinic, Jacksonville, Florida 32207, USA
    Curr Opin Pulm Med 15:57-62. 2009
  10. ncbi request reprint A pharmacodynamic model of the effects of controlled-onset extended-release verapamil on 24-hour ambulatory blood pressure
    J J Lima
    Center for Clinical Pediatric Pharmacology and Pharmacogenetics, Nemours Children s Clinic, 807 Nira Street, Jacksonville, FL 32207, USA
    Int J Clin Pharmacol Ther 43:187-94. 2005

Research Grants

Detail Information

Publications30

  1. ncbi request reprint Do genetic polymorphisms alter patient response to inhaled bronchodilators?
    John J Lima
    Center for Pharmacogenomics and Translational Research, Nemours Children s Clinic, 807 Children s Way, Jacksonville, FL 32207, USA, 1 904 697 3683 1 904 687 7988
    Expert Opin Drug Metab Toxicol 10:1231-40. 2014
    ..Heritability, the proportion of phenotypic variability accounted for by genetic variation is estimated to account for 50% of pulmonary function and 28.5% for BDR...
  2. doi request reprint Genetic influences on response to asthma pharmacotherapy
    John J Lima
    Center for Pediatric Clinical Pharmacology, Pharmacogenetics Center, Nemours Children s Clinic, 807 Children s Way, Jacksonville, FL 32207, USA
    Expert Rev Clin Pharmacol 1:649-60. 2008
    ..Known sequence variants explain a small fraction of response heterogeneity to asthma drugs. More studies are required to formulate a genetic signature that will lead to the personalization of asthma treatment. ..
  3. doi request reprint Association of CYP2C19 polymorphisms and lansoprazole-associated respiratory adverse effects in children
    John J Lima
    Center for Pharmacogenomics and Translational Research, Nemours Children s Clinic, Jacksonville, FL, USA
    J Pediatr 163:686-91. 2013
    ..To determine whether cytochrome P450 (CYP)2C19 haplotype associates with lansoprazole-associated adverse event frequency...
  4. pmc Influence of leukotriene pathway polymorphisms on response to montelukast in asthma
    John J Lima
    The American Lung Association Asthma Clinical Research Centers, Center for Pharmacogenetics, Nemours Children s Clinic, 807 Children s Way, Jacksonville, FL 32207, USA
    Am J Respir Crit Care Med 173:379-85. 2006
    ..Interpatient variability in montelukast response may be related to variation in leukotriene pathway candidate genes...
  5. ncbi request reprint The C523A beta2 adrenergic receptor polymorphism associates with markers of asthma severity in African Americans
    John J Lima
    The American Lung Association Asthma Clinical Research Centers, Jacksonville, Florida, USA
    J Asthma 43:185-91. 2006
    ..018). Symptom scores, pulmonary function, and rescue inhaler use paralleled exacerbation prevalence. We conclude the 523 A allele modifies asthma severity in African Americans...
  6. ncbi request reprint Treatment heterogeneity in asthma: genetics of response to leukotriene modifiers
    John J Lima
    Nemours Children s Clinic, Centers for Clinical Pediatric Pharmacology and Pharmacogenetics, Jacksonville, Florida 32207, USA
    Mol Diagn Ther 11:97-104. 2007
    ....
  7. pmc Association analyses of adrenergic receptor polymorphisms with obesity and metabolic alterations
    John J Lima
    Pharmacogenetics Center, Nemours Children s Clinic, Jacksonville, FL 32207, USA
    Metabolism 56:757-65. 2007
    ..Because of the limited size of our populations, our results should be interpreted with caution and should be replicated in larger populations...
  8. ncbi request reprint A polymorphism in the NPPA gene associates with asthma
    J J Lima
    Pharmacogenetics Center, Nemours Children s Clinic, Jacksonville, FL 32207, USA
    Clin Exp Allergy 38:1117-23. 2008
    ..Atrial natriuretic peptide (ANP) plays an important role in the lung and in augmenting allergic inflammation in asthma. The gene encoding ANP, NPPA, is located on chromosome 1p36, a region that has been linked to asthma...
  9. pmc Pharmacogenetics of asthma
    John J Lima
    Centers for Pediatric Clinical Pharmacology and Pharmacogenetics, Nemours Children s Clinic, Jacksonville, Florida 32207, USA
    Curr Opin Pulm Med 15:57-62. 2009
    ..Herein, we review and update the pharmacogenetics and pharmaogenomics of common asthma drugs...
  10. ncbi request reprint A pharmacodynamic model of the effects of controlled-onset extended-release verapamil on 24-hour ambulatory blood pressure
    J J Lima
    Center for Clinical Pediatric Pharmacology and Pharmacogenetics, Nemours Children s Clinic, 807 Nira Street, Jacksonville, FL 32207, USA
    Int J Clin Pharmacol Ther 43:187-94. 2005
    ..To formulate and evaluate a pharmacodynamic model that characterizes the effects of S-verapamil on the circadian 24-hour ambulatory blood pressure (ABP)...
  11. ncbi request reprint Influence of sex and beta2 adrenergic receptor haplotype on resting and terbutaline-stimulated whole body lipolysis
    John J Lima
    Centers for Clinical Pediatric Pharmacology and Pharmacogenetics, Nemours Children s Clinic, Jacksonville, FL 32207, USA
    Metabolism 54:492-9. 2005
    ..We conclude that compared to haplotype, sex is a more important determinant of basal lipolysis after a 12-hour fast in healthy, non-obese individuals...
  12. ncbi request reprint Modeling the metabolic effects of terbutaline in beta2-adrenergic receptor diplotypes
    John J Lima
    Nemours Children s Clinic, Center for Clinical Pediatric Pharmacology Jacksonville, FL 32207, USA
    Clin Pharmacol Ther 76:27-37. 2004
    ..Our objective was to determine whether beta(2)-adrenergic receptor polymorphisms influence terbutaline-stimulated changes in glucose, insulin, and potassium concentrations in healthy adults...
  13. pmc Methacholine PC20 in African Americans and whites with asthma with homozygous genotypes at ADRB2 codon 16
    Kathryn Blake
    Center for Pharmacogenomics and Translational Research, Nemours Children s Clinic, 807 Children s Way, Jacksonville, FL 32207, USA
    Pulm Pharmacol Ther 26:342-7. 2013
    ....
  14. pmc Pharmacokinetics and pharmacodynamics of oral and transdermal 17β estradiol in girls with Turner syndrome
    Martha Taboada
    Nemours Children s Clinic, Jacksonville, Florida 32207, USA
    J Clin Endocrinol Metab 96:3502-10. 2011
    ..The type, dose, and route of 17β-estradiol (E(2)) used to feminize girls with Turner syndrome (TS) is not well established...
  15. ncbi request reprint Pharmacokinetics and dose finding of a potent aromatase inhibitor, aromasin (exemestane), in young males
    Nelly Mauras
    Nemours Children s Clinic and Research Programs, Jacksonville, Florida 32207, USA
    J Clin Endocrinol Metab 88:5951-6. 2003
    ..The drug was well tolerated. In conclusion, exemestane is a potent aromatase inhibitor in men and an alternative to the choice of available inhibitors. Long-term efficacy and safety will need further study...
  16. pmc Asthma in sickle cell disease: implications for treatment
    Kathryn Blake
    Biomedical Research Department, Center for Clinical Pharmacogenomics and Translational Research, Nemours Children s Clinic, 807 Children s Way, Jacksonville, FL 32207, USA
    Anemia 2011:740235. 2011
    ..Conclusion. Prospective controlled trials of drug treatment for asthma in patients who have both sickle cell disease and asthma are urgently needed...
  17. doi request reprint Population pharmacodynamic model of bronchodilator response to inhaled albuterol in children and adults with asthma
    Kathryn Blake
    Center for Clinical Pediatric Pharmacology Research, Nemours Children s Clinic, Jacksonville, FL 32207, USA
    Chest 134:981-9. 2008
    ..Because interpatient variability in bronchodilation from inhaled albuterol is large and clinically important, we characterized the albuterol dose/response relationship by pharmacodynamic modeling and quantified variability...
  18. ncbi request reprint Determination of human beta(2)-adrenoceptor haplotypes by denaturation selective amplification and subtractive genotyping
    J Wang
    Center for Clinical Pediatric Pharmacology, Nemours Children s Clinic, Jacksonville, Florida, USA
    Am J Pharmacogenomics 1:315-22. 2001
    ....
  19. doi request reprint Effect of citrus juice and SLCO2B1 genotype on the pharmacokinetics of montelukast
    E B Mougey
    Pharmacogenetics Center, Nemours Children s Clinic, 807 Children s Way, Jacksonville, FL 32207 8426, USA
    J Clin Pharmacol 51:751-60. 2011
    ..0 × 10(-5)) replicating previous observations...
  20. ncbi request reprint Low exhaled nitric oxide and a polymorphism in the NOS I gene is associated with acute chest syndrome
    K J Sullivan
    Nemours Children's Clinic, Jacksonville, Florida, USA
    Am J Respir Crit Care Med 164:2186-90. 2001
    ..FE(NO) is a sensitive marker and may be a predictor of ACS prone children...
  21. ncbi request reprint Effect of montelukast on time-course of exhaled nitric oxide in asthma: influence of LTC4 synthase A(-444)C polymorphism
    Glenn J Whelan
    Centers for Pediatric Pharmacology Research and Pharmacogenetics, Nemours Children s Clinic, Jacksonville, Florida 32207, USA
    Pediatr Pulmonol 36:413-20. 2003
    ..We further conclude that the A(-444)C polymorphism in the LTC(4) synthase gene probably contributes to interpatient variability in montelukast-evoked changes in FE(NO)* and warrants further study...
  22. pmc The arginine-16 beta2-adrenoceptor polymorphism predisposes to bronchoprotective subsensitivity in patients treated with formoterol and salmeterol
    Daniel K C Lee
    Asthma and Allergy Research Group, Department of Clinical Pharmacology, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Br J Clin Pharmacol 57:68-75. 2004
    ..The relationship between beta2-adrenoceptor polymorphisms and bronchoprotective response with long-acting beta2-adrenoceptor agonists is unknown...
  23. ncbi request reprint Effect of obesity on clinical presentation and response to treatment in asthma
    Anne E Dixon
    University of Vermont, Burlington, VT 05401, USA
    J Asthma 43:553-8. 2006
    ..Obese and non-obese asthmatics have similar lung function abnormalities, but comorbidities and altered responses to medications may significantly affect asthma control in obese people...
  24. ncbi request reprint Physician-diagnosed asthma and acute chest syndrome: associations with NOS polymorphisms
    Laurie Duckworth
    Pharmacogenetics Center, Nemours Children s Clinic, Jacksonville, Florida 32207, USA
    Pediatr Pulmonol 42:332-8. 2007
    ..No associations were found between the genotype of the NOS3 T-786C SNP and ACS. Physician-diagnosed asthma is a major risk factor for ACS. NOS1 AAT repeat polymorphism may contribute to physician-diagnosed asthma...
  25. pmc Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma
    Audrey H Poon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Pharmacogenet Genomics 18:373-82. 2008
    ..We aim to assess associations between genetic variants of CRHR2 and acute bronchodilator response in asthma...
  26. pmc Leukotriene C4 synthase polymorphisms and responsiveness to leukotriene antagonists in asthma
    Graeme P Currie
    Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    Br J Clin Pharmacol 56:422-6. 2003
    ..Our aim is to evaluate whether responsiveness to leukotriene receptor antagonists was determined by expression of the variant (C) or wild-type (A) polymorphism of this enzyme...
  27. pmc ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts
    Augusto A Litonjua
    Channing Laboratory, Pulmonary Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 178:688-94. 2008
    ..However, a substantial proportion of patients with asthma do not have a favorable response to these drugs, and identifying genetic determinants of drug response may aid in tailoring treatment for individual patients...
  28. ncbi request reprint The effect of montelukast and low-dose theophylline on cardiovascular disease risk factors in asthmatics
    Hooman Allayee
    Department of Preventive Medicine, USC Keck School of Medicine, 2250 Alcazar St, IGM 206, Los Angeles, CA 90033, USA
    Chest 132:868-74. 2007
    ..We sought to determine whether montelukast, a cysteinyl LT antagonist, and low-dose theophylline affected serum inflammatory and lipid CVD risk factors in a recently completed clinical trial in asthmatic patients...
  29. ncbi request reprint Effect of beta2-agonist treatment and spirometry on exhaled nitric oxide in healthy children and children with asthma
    Niranjan Kissoon
    Department of Pediatrics, University of Florida Health Science Center Jacksonville, Jacksonville, Florida 32207, USA
    Pediatr Pulmonol 34:203-8. 2002
    ..Alternatively, changes in FE(NO) values should be interpreted in relationship to the timing of these maneuvers...
  30. ncbi request reprint Drug receptor/effector polymorphisms and pharmacogenetics: current status and challenges
    Julie A Johnson
    University of Florida, Gainesville, Florida 32610 0486, USA
    Pharmacogenetics 13:525-34. 2003
    ..The knowledge necessary to move forward on all these fronts is not yet available, but will be increasingly accessible over the next few years...

Research Grants6

  1. LEUKOTRIENE POLYMORPHISMS & MONTELUKAST RESPONSE
    John Lima; Fiscal Year: 2002
    ..This information may lead to individualization of asthma medications based on the genetic make-up of the patient. ..
  2. POLYMORPHISMS OF B1 AND B2 RECEPTOR GENES AND OBESITY
    John Lima; Fiscal Year: 2002
    ..The information obtained from our studies are important in designing clinical trials of interventions designed to reduce body weight. ..
  3. LEUKOTRIENE POLYMORPHISMS & MONTELUKAST RESPONSE
    John Lima; Fiscal Year: 2003
    ..This information may lead to individualization of asthma medications based on the genetic make-up of the patient. ..
  4. PHARMACOGENETICS OF ASTHMA MONOTHERAPY
    John Lima; Fiscal Year: 2003
    ..The results of this pharmacogenetic study may facilitate the optimal selection of monotherapy in asthma. ..
  5. PHARMACOGENETICS OF ASTHMA MONOTHERAPY
    John Lima; Fiscal Year: 2004
    ..The results of this pharmacogenetic study may facilitate the optimal selection of monotherapy in asthma. ..
  6. PHARMACOGENETICS OF ASTHMA MONOTHERAPY
    John Lima; Fiscal Year: 2005
    ..The results of this pharmacogenetic study may facilitate the optimal selection of monotherapy in asthma. ..