Samuel S Gidding
Affiliation: Alfred I. duPont Hospital for Children
- Severe obesity associated with cardiovascular deconditioning, high prevalence of cardiovascular risk factors, diabetes mellitus/hyperinsulinemia, and respiratory compromiseSamuel S Gidding
Nemours Cardiac Center and the A I duPont Hospital for Children, Wilmington, Delaware 19899, USA
J Pediatr 144:766-9. 2004..To determine the extent and severity of obesity-related cardiorespiratory morbidity in children with body mass index (BMI) >or=40 kg/m(2)...
- Developing the 2011 Integrated Pediatric Guidelines for Cardiovascular Risk ReductionSamuel S Gidding
Nemours Cardiac Center, A I duPont Hospital for Children, Wilmington, Delaware 19803, USA
Pediatrics 129:e1311-9. 2012..Guideline development is a dynamic process that must be continuously self-critical as new evidence is acquired and sociopolitical and environmental contexts evolve...
- Cardiovascular magnetic resonance parameters of atherosclerotic plaque burden improve discrimination of prior major adverse cardiovascular eventsVenkatesh Mani
Imaging Science Laboratories Translational and Molecular Imaging Institute, Department of Radiology, Mount Sinai School of Medicine, New York, NY, USA
J Cardiovasc Magn Reson 11:10. 2009..The purpose of this study was to determine if patients with traditional risk factors and prior MACE had increased cardiovascular magnetic resonance (CMR) plaque burden measures compared to patients with risk factors but no prior events...
- Prediction of coronary artery calcium in young adults using the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) risk score: the CARDIA studySamuel S Gidding
Alfred I duPont Hospital for Children, Wilmington, DE 19899, USA
Arch Intern Med 166:2341-7. 2006....
- Dyslipidemia in the metabolic syndrome in childrenSamuel S Gidding
A I duPont Hospital for Children, 1600 Rockland Road, Wilmington, DE 19899, USA
J Cardiometab Syndr 1:282-5. 2006..Recognition of this dyslipidemia is increasingly common in pediatric practice. Treatment includes weight management, including the prevention of future excess weight gain, and exercise. Pharmacologic management is rarely required...
- Noninvasive cardiac imaging: implications for risk assessment in adolescents and young adultsSamuel S Gidding
Thomas Jefferson University, Philadelphia, PA, USA
Ann Med 40:506-13. 2008..Intervention trials using these techniques as end points may improve understanding of the natural history of acquired cardiovascular disease...
- Higher self-reported physical activity is associated with lower systolic blood pressure: the Dietary Intervention Study in Childhood (DISC)Samuel S Gidding
Nemours Cardiac Center, A I duPont Children s Hospital and Thomas Jefferson University, Wilmington, Delaware 19899, USA
Pediatrics 118:2388-93. 2006....
- Low cardiovascular risk is associated with favorable left ventricular mass, left ventricular relative wall thickness, and left atrial size: the CARDIA studySamuel S Gidding
Nemours Cardiac Center, A I duPont Hospital for Children, Wilmington, DE 19803, USA
J Am Soc Echocardiogr 23:816-22. 2010....
- Developing the evidence base for the new guidelines for reduction of cardiovascular risk for children by the National Heart, Lung, and Blood InstituteSamuel S Gidding
Nemours Cardiac Center, A I duPont Hospital for Children, 1600 Rockland Road, Wilmington, DE 19803, USA
Cardiol Young 21:165-8. 2011..This manuscript also provides some thoughts on how this process might be adapted in developing guidelines for caring for patients with congenital cardiac disease...
- Association of age and sex with cardiovascular risk factors and insulin sensitivity in overweight children and adolescentsJoanna Koenigsberg
Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA
J Cardiometab Syndr 1:253-8. 2006..Greater cardiovascular risk factor expression in overweight males 11 years and older may explain the earlier appearance of cardiovascular disease end points in overweight men...
- Right ventricle to pulmonary artery conduit improves outcome after stage I Norwood for hypoplastic left heart syndromeChristian Pizarro
Nemours Cardiac Center, Alfred I duPont Hospital for Children, Wilmington, DE, USA
Circulation 108:II155-60. 2003..We compared outcomes from the use of a RV to PA conduit (RV/PA) or a modified Blalock-Taussig shunt (BTS), physiologically distinct sources of pulmonary blood flow...
- Obesity, smoking, and multiple cardiovascular risk factors in young adult African AmericansKevin H Murtaugh
Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania, USA
Ethn Dis 12:331-5. 2002..To examine the associations between the combination of obesity and tobacco use and total cardiovascular risk score in young adult African Americans...
- Longitudinal determinants of left ventricular mass and geometry: the Coronary Artery Risk Development in Young Adults (CARDIA) StudySamuel S Gidding
Nemours Cardiac Center, A I duPont Hospital for Children, Wilmington, DE
Circ Cardiovasc Imaging 6:769-75. 2013..The purpose of this study was to identify determinants of 20-year change in left ventricular (LV) mass (LVM) and LV geometry in black and white young adults in the Coronary Artery Risk Development in Young Adults (CARDIA) Study...
- Blood pressure variability and classification of prehypertension and hypertension in adolescenceBonita Falkner
Department of Medicine, Thomas Jefferson University, 833 Chestnut St, Suite 700, Philadelphia, PA 19107, USA
Pediatrics 122:238-42. 2008..There is little information in pediatrics on the persistence of the prehypertension and hypertension classifications or on the progression of prehypertension to hypertension. This study aimed to examine those issues...
- Obesity associated inflammation in African American adolescents and adultsStephanie Deloach
Departments of Medicine SD, BF and Clinical Pharmacology and Experimental Therapeutics SWK, Thomas Jefferson University, Philadelphia, Pennsylvania and Nemours Cardiac Center SSG at A I DuPont Hospital for Children, Wilmington, Delaware
Am J Med Sci 347:357-63. 2014..C-reactive protein (CRP) is related to adiposity and metabolic risk and predicts events in adults. The objective was to determine if relationships between adiposity and CRP have similar magnitudes in adolescents as adults...
- Fontan completion in infantsChristian Pizarro
Nemours Cardiac Center, Alfred I duPont Hospital for Children, Wilmington, Delaware, USA
Ann Thorac Surg 81:2243-8; discussion 2248-9. 2006..Since the implementation of the Fontan procedure, several clinical factors have been linked to outcome. A study of the outcome after Fontan completion was undertaken with particular attention to the influence of age and cardiac diagnosis...
- The relationship of body mass index and blood pressure in primary care pediatric patientsBonita Falkner
Departments of Medicine and Pediatrics, Thomas Jefferson University, 833 Chestnut Street, Philadelphia, PA 19107, USA
J Pediatr 148:195-200. 2006..To determine whether an association of overweight, or risk of overweight, and blood pressure can be detected in children in the pediatric primary care practice setting...
- High risk blood pressure and obesity increase the risk for left ventricular hypertrophy in African-American adolescentsBonita Falkner
Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
J Pediatr 162:94-100. 2013..To examine the relative effects of high blood pressure (HBP) and obesity on left ventricular mass (LVM) among African-American adolescents; and if metabolic or inflammatory factors contribute to LVM...
- Metabolic syndrome with early aortic atherosclerosis in a childSrikant Das
Department of Pediatrics, Albert Einstein Medical Center, Philadelphia, PA, USA
J Cardiometab Syndr 1:286-7. 2006
- Glucose tolerance and cardiovascular risk in young adult African AmericansKimberly L Campbell
Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania, USA
Am J Med Sci 323:231-7. 2002..Among African Americans, there is a higher prevalence of both cardiovascular disease and type 2 diabetes. Few studies have examined longitudinally the change in glucose tolerance in younger adult African Americans...
- Changes in circulating satiety hormones in obese children: a randomized controlled physical activity-based intervention studyPrabhakaran Babu Balagopal
Nemours Children s Clinic, Jacksonville, Florida, USA
Obesity (Silver Spring) 18:1747-53. 2010..These beneficial effects appear to aid in the maintenance of body weight and reduction in cardiovascular risk...
- Stage I palliation for hypoplastic left heart syndrome in low birth weight neonates: can we justify it?Christian Pizarro
Nemours Cardiac Center Orlando, Arnold Palmer Hospital for Children and Women, 82 West Miller St, Orlando, FL 32806, USA
Eur J Cardiothorac Surg 21:716-20. 2002..To identify variables associated with poor outcome in this group, we reviewed our experience with patients with HLHS and LBW who underwent Stage I Norwood palliation...
- Lipid management in childrenFrances R Zappalla
Nemours Cardiac Center, A I duPont Hospital for Children, 1600 Rockland Road, Wilmington, DE 19803, USA
Endocrinol Metab Clin North Am 38:171-83. 2009..Genetic dyslipidemias such as familial hypercholesterolemia and the presence of multiple risk factors in the same child or adolescent may require pharmacologic therapy...
- Associations of cardiac structure with obesity, blood pressure, inflammation, and insulin resistance in African-American adolescentsSamuel S Gidding
Nemours Cardiac Center, Alfred I duPont Hospital for Children, 1600 Rockland Road, Wilmington, DE, 19803, USA
Pediatr Cardiol 35:307-14. 2014..In African-American adolescents, BMI and SBP, but not inflammatory markers or adipokines, are important correlates of LA size and LVM. ..
- Hemodynamic profile after the Norwood procedure with right ventricle to pulmonary artery conduitKevin O Maher
Nemours Cardiac Center, duPont Hospital for Children, 1600 Rockland Road, PO Box 269, Wilmington, Del 19899, USA
Circulation 108:782-4. 2003....
- Magnetic resonance imaging measures of decreased aortic strain and distensibility are proportionate to insulin resistance in adolescents with type 1 diabetes mellitusMichael A McCulloch
Nemours Cardiac Center, AI duPont Hospital for Children, Wilmington, DE, USA
Pediatr Diabetes 16:90-7. 2015..To determine whether children with type 1 diabetes mellitus (T1DM) have evidence of increased aortic stiffness or early atherosclerosis as measured by magnetic resonance imaging (MRI)...
- A double-blind randomized trial of fish oil to lower triglycerides and improve cardiometabolic risk in adolescentsSamuel S Gidding
Nemours Cardiac Center, A I duPont Hospital for Children, Wilmington, DE Division of Nephrology, Department of Internal Medicine, Thomas Jefferson University, Philadelphia, PA Electronic address
J Pediatr 165:497-503.e2. 2014..To determine the efficacy of 4 g/day fish oil to lower triglycerides and impact lipoprotein particles, inflammation, insulin resistance, coagulation, and thrombosis...
- Predicting utility of exercise tests based on history/holter in patients with premature ventricular contractionsBrad Robinson
Nemours Cardiac Center, Nemours Alfred I duPont Hospital for Children, P O Box 269, Wilmington, DE, 19899, USA
Pediatr Cardiol 36:214-8. 2015..Patients with syncope during exercise, family history of arrhythmia or SUD, or a Holter monitor showing VT warrant exercise testing to assess for CPVT. ..
- Integrated wall stress: a new methodological approach to assess ventricular workload and myocardial contractile reserveHailong Dong
Nemours Cardiac Center and Nemours Biomedical Research, Alfred I, duPont Hospital for Children, 1600 Rockland Rd, Wilmington, DE 19103, USA
J Transl Med 11:183. 2013..We measured cumulative LV wall stress throughout the cardiac cycle over unit time and tested whether this "integrated wall stress (IWS)" would provide a reliable marker of total ventricular workload...
- Usefulness of myocardial perfusion imaging with exercise testing in childrenBrad Robinson
Department of Pediatrics, Thomas Jefferson University, Jefferson Medical College, Nemours Cardiac Center, Nemours Alfred I duPont Hospital for Children, 1600 Rockland Road, Wilmington, DE 19803, USA
Pediatr Cardiol 33:1061-8. 2012..Children who had isolated chest pain with a normal ECG and echocardiogram often have false-positive studies...
- Cardiorespiratory fitness in young adulthood and the development of cardiovascular disease risk factorsMercedes R Carnethon
Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Ill, USA
JAMA 290:3092-100. 2003..Low cardiorespiratory fitness is an established risk factor for cardiovascular and total mortality; however, mechanisms responsible for these associations are uncertain...
- Successful 2 years of therapySamuel S Gidding
Pediatrics 112:448. 2003
- The aging of the cardiovascular system: when should children be treated like adults?Samuel S Gidding
J Pediatr 141:159-61. 2002
- Demographics and correlates of five-year change in echocardiographic left ventricular mass in young black and white adult men and women: the Coronary Artery Risk Development in Young Adults (CARDIA) studyJulius M Gardin
Division of Cardiology, Department of Medicine, University of California, Irvine, California, USA
J Am Coll Cardiol 40:529-35. 2002..The goal of this study was to determine the presence and correlates of change (Delta) in left ventricular (LV) mass by echocardiography in young adults...
- Influence of systolic blood pressure and body mass index on left ventricular structure in healthy African-American and white young adults: the CARDIA studyRichard Lorber
Department of Pediatrics at the Cleveland Clinic, Cleveland, Ohio, USA
J Am Coll Cardiol 41:955-60. 2003....
- PDAY risk score predicts advanced coronary artery atherosclerosis in middle-aged persons as well as youthC Alex McMahan
The University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
Atherosclerosis 190:370-7. 2007..These results support the proposal that early control of risk factors is likely to prevent or delay the onset of CHD...
- Comparison of coronary heart disease risk factors in autopsied young adults from the PDAY Study with living young adults from the CARDIA studyC Alex McMahan
Department of Pathology, The University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
Cardiovasc Pathol 16:151-8. 2007....
- Measuring children's blood pressure mattersSamuel S Gidding
Circulation 117:3163-4. 2008
- Pathobiological determinants of atherosclerosis in youth risk scores are associated with early and advanced atherosclerosisC Alex McMahan
Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
Pediatrics 118:1447-55. 2006..In this study we investigated the relation of these risk scores to the early atherosclerotic lesions...
- Dietary recommendations for children and adolescents: a guide for practitioners: consensus statement from the American Heart AssociationSamuel S Gidding
Circulation 112:2061-75. 2005..This scientific statement summarizes current available information on cardiovascular nutrition in children and makes recommendations for both primordial and primary prevention of cardiovascular disease beginning at a young age...
- Risk scores predict atherosclerotic lesions in young peopleC Alex McMahan
Department of Pathology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
Arch Intern Med 165:883-90. 2005..Atherosclerosis begins in childhood and progresses through young adulthood to form the lesions that cause coronary heart disease. These preclinical lesions are associated with coronary heart disease risk factors in young persons...
- Overweight in children and adolescents: pathophysiology, consequences, prevention, and treatmentStephen R Daniels
Circulation 111:1999-2012. 2005..In addition, treatment approaches are presented, including behavioral, pharmacological, and surgical treatment. Childhood and adolescent overweight is one of the most important current public health concerns...
- Dietary recommendations for children and adolescents: a guide for practitionersSamuel S Gidding
Pediatrics 117:544-59. 2006..This scientific statement summarizes current available information on cardiovascular nutrition in children and makes recommendations for both primordial and primary prevention of cardiovascular disease beginning at a young age...
- New cholesterol guidelines for children?Samuel S Gidding
Circulation 114:989-91. 2006
- Modifying cardiovascular risk in adolescent obesityStephen Cook
Circulation 115:2251-3. 2007
- Are we losing the game? Cardiovascular health in minority childrenSamuel S Gidding
Ethn Dis 12:171-3. 2002
- Cardiovascular complications in pediatric end-stage renal diseaseRulan S Parekh
Division of Nephrology, Departments of Pediatrics and Medicine, Johns Hopkins University, 600 North Wolfe Street, Baltimore, MD 21287 2535, USA
Pediatr Nephrol 20:125-31. 2005..Techniques for non-invasive assessment of cardiac end-organ injury are also discussed. Recommendations for monitoring of risk factors and treatment in the pediatric ESRD population are presented...
- Task Force 5: systemic hypertensionNorman M Kaplan
J Am Coll Cardiol 45:1346-8. 2005
- A longitudinal study of physical activity and heart rate recovery: CARDIA, 1987-1993Mercedes R Carnethon
Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Med Sci Sports Exerc 37:606-12. 2005..In a diverse, population-based sample, we tested whether physical activity participation was associated with higher parasympathetic function...
- The importance of randomized controlled trials in pediatric cardiologySamuel S Gidding
JAMA 298:1214-6. 2007
- Association of Pathobiologic Determinants of Atherosclerosis in Youth risk score and 15-year change in risk score with carotid artery intima-media thickness in young adults (from the Cardiovascular Risk in Young Finns Study)C Alex McMahan
Department of Pathology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
Am J Cardiol 100:1124-9. 2007..997 for a 1-point decrease). In conclusion, the change in risk score over time (decrease or increase) during adolescence and young adulthood, as well as the risk score early in life, are important predictors of atherosclerosis...
- Preventing heart disease in the 21st century: implications of the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) studyHenry C McGill
University of Texas Health Science Center at San Antonio, San Antonio, Tex, USA
Circulation 117:1216-27. 2008
- One small step for man...?Samuel S Gidding
J Pediatr 145:719-20. 2004