Dominique Darmaun

Summary

Affiliation: Alfred I. duPont Hospital for Children
Country: USA

Publications

  1. doi request reprint Acute changes in blood glucose do not alter blood glutathione synthesis in adolescents with poorly controlled type 1 diabetes mellitus
    Dominique Darmaun
    Division of Endocrinology, Diabetes, and Metabolism, Nemours Children s Clinic, Jacksonville, FL 32207, USA
    Metabolism 61:373-8. 2012
  2. doi request reprint Poorly controlled type 1 diabetes is associated with altered glutathione homeostasis in adolescents: apparent resistance to N-acetylcysteine supplementation
    Dominique Darmaun
    Endocrine Research, Nemours Children s Clinic, Jacksonville, FL 32207, USA
    Pediatr Diabetes 9:577-82. 2008
  3. ncbi request reprint Effects of glutamine and recombinant human growth hormone on protein metabolism in prepubertal children with cystic fibrosis
    Dominique Darmaun
    Division of Endocrinology, Nemours Children s Clinic, Jacksonville, Florida 32207, USA
    J Clin Endocrinol Metab 89:1146-52. 2004
  4. ncbi request reprint Evidence for accelerated rates of glutathione utilization and glutathione depletion in adolescents with poorly controlled type 1 diabetes
    Dominique Darmaun
    Nemours Children s Clinic, Research Department, 5 North, 807 Children s Way, Jacksonville, FL 32207, USA
    Diabetes 54:190-6. 2005
  5. pmc Effects of glutamine on glycemic control during and after exercise in adolescents with type 1 diabetes: a pilot study
    Nelly Mauras
    Division of Endocrinology, Diabetes and Metabolism, Nemours Children s Clinic, Jacksonville, Florida, USA
    Diabetes Care 33:1951-3. 2010
  6. ncbi request reprint Evidence for hypermetabolism in boys with constitutional delay of growth and maturation
    Joan C Han
    Division of Endocrinology, Nemours Children s Clinic Jacksonville, 807 Children s Way, Jacksonville, Florida 32207, USA
    J Clin Endocrinol Metab 91:2081-6. 2006
  7. ncbi request reprint Oxandrolone enhances skeletal muscle myosin synthesis and alters global gene expression profile in Duchenne muscular dystrophy
    Prabhakaran Balagopal
    Nemours Children s Clinic, Jacksonville, FL 32207, USA
    Am J Physiol Endocrinol Metab 290:E530-9. 2006
  8. pmc Acute depletion of plasma glutamine increases leucine oxidation in prednisone-treated humans
    Olivier Le Bacquer
    INSERM U 539, Centre de Recherche en Nutrition Humaine, Nantes, France
    Clin Nutr 26:231-8. 2007
  9. ncbi request reprint Alterations in glutamine synthetase activity in rat skeletal muscle are associated with advanced age
    Carole Pinel
    UMR INRA 1019, Unite de Nutrition Humaine, Human Nutrition Research Center, Clermont Ferrand Theix, France
    Nutrition 22:778-85. 2006
  10. ncbi request reprint Use of stable isotopes to assess protein and amino acid metabolism in children and adolescents: a brief review
    Dominique Darmaun
    INSERM U539, Human Nutrition Research Center, Nantes, France
    Horm Res 64:32-7. 2005

Collaborators

  • Nelly Mauras
  • Larry A Fox
  • Robert Olney
  • Patrick Nguyen
  • Prabhakaran Babu Balagopal
  • Dominique Meynial-Denis
  • Bernard Humbert
  • Olivier Le Bacquer
  • Henri Dumon
  • Clotilde des Robert
  • Ronan Thibault
  • Susan Welch
  • Morey Haymond
  • Carole Rouge
  • Carole Pinel
  • Joan C Han
  • Pascale Maugère
  • Lucile Martin
  • Arnaud Bourreille
  • Brenda Sager
  • Astride Altomare
  • Alexander Robins
  • Marie France de la Cochetiere
  • Geneviève Vallette
  • Christelle Volteau
  • Daniel Taillandier
  • Veronique Coxam
  • Michelle Mignon
  • Christine Cubizolles
  • Shawn Sweeten
  • Patrice Lebecque
  • Jean Paul Galmiche
  • Christian Laboisse
  • Jean Christophe Roze
  • Hugues Piloquet
  • Jack Yves Deschamps

Detail Information

Publications19

  1. doi request reprint Acute changes in blood glucose do not alter blood glutathione synthesis in adolescents with poorly controlled type 1 diabetes mellitus
    Dominique Darmaun
    Division of Endocrinology, Diabetes, and Metabolism, Nemours Children s Clinic, Jacksonville, FL 32207, USA
    Metabolism 61:373-8. 2012
    ..This finding suggests that, in adolescents with poorly controlled T1D, either (a) blood glucose per se does not regulate GSH metabolism or (b) GSH may only respond to sustained, more chronic changes in blood glucose level...
  2. doi request reprint Poorly controlled type 1 diabetes is associated with altered glutathione homeostasis in adolescents: apparent resistance to N-acetylcysteine supplementation
    Dominique Darmaun
    Endocrine Research, Nemours Children s Clinic, Jacksonville, FL 32207, USA
    Pediatr Diabetes 9:577-82. 2008
    ..In the presence of relative insulinopenia, either higher amino acid doses or aggressive insulin therapy may be needed to achieve this goal. This would require further study...
  3. ncbi request reprint Effects of glutamine and recombinant human growth hormone on protein metabolism in prepubertal children with cystic fibrosis
    Dominique Darmaun
    Division of Endocrinology, Nemours Children s Clinic, Jacksonville, Florida 32207, USA
    J Clin Endocrinol Metab 89:1146-52. 2004
    ....
  4. ncbi request reprint Evidence for accelerated rates of glutathione utilization and glutathione depletion in adolescents with poorly controlled type 1 diabetes
    Dominique Darmaun
    Nemours Children s Clinic, Research Department, 5 North, 807 Children s Way, Jacksonville, FL 32207, USA
    Diabetes 54:190-6. 2005
    ..This weakened antioxidant defense may play a role in the pathogenesis of diabetes complications...
  5. pmc Effects of glutamine on glycemic control during and after exercise in adolescents with type 1 diabetes: a pilot study
    Nelly Mauras
    Division of Endocrinology, Diabetes and Metabolism, Nemours Children s Clinic, Jacksonville, Florida, USA
    Diabetes Care 33:1951-3. 2010
    ..To investigate if oral glutamine ameliorates exercise and postexercise nighttime hypoglycemia in type 1 diabetic adolescents...
  6. ncbi request reprint Evidence for hypermetabolism in boys with constitutional delay of growth and maturation
    Joan C Han
    Division of Endocrinology, Nemours Children s Clinic Jacksonville, 807 Children s Way, Jacksonville, Florida 32207, USA
    J Clin Endocrinol Metab 91:2081-6. 2006
    ..Children with constitutional delay of growth and maturation (CDGM) tend to be thin and have a growth pattern reminiscent of nutritional insufficiency...
  7. ncbi request reprint Oxandrolone enhances skeletal muscle myosin synthesis and alters global gene expression profile in Duchenne muscular dystrophy
    Prabhakaran Balagopal
    Nemours Children s Clinic, Jacksonville, FL 32207, USA
    Am J Physiol Endocrinol Metab 290:E530-9. 2006
    ....
  8. pmc Acute depletion of plasma glutamine increases leucine oxidation in prednisone-treated humans
    Olivier Le Bacquer
    INSERM U 539, Centre de Recherche en Nutrition Humaine, Nantes, France
    Clin Nutr 26:231-8. 2007
    ....
  9. ncbi request reprint Alterations in glutamine synthetase activity in rat skeletal muscle are associated with advanced age
    Carole Pinel
    UMR INRA 1019, Unite de Nutrition Humaine, Human Nutrition Research Center, Clermont Ferrand Theix, France
    Nutrition 22:778-85. 2006
    ..Because the effects of advanced age on GS are unknown, we investigated the effect of advanced age (>24 mo) on GS activity in skeletal muscle. We hypothesized that advanced age would enhance muscle GS activity...
  10. ncbi request reprint Use of stable isotopes to assess protein and amino acid metabolism in children and adolescents: a brief review
    Dominique Darmaun
    INSERM U539, Human Nutrition Research Center, Nantes, France
    Horm Res 64:32-7. 2005
    ..Attempts have also been made to measure amino acid/protein metabolism in selected body compartments, and to measure the kinetics of specific tissue proteins, for example, muscle, gut, or plasma proteins...
  11. ncbi request reprint Does enteral glutamine modulate whole-body leucine kinetics in hypercatabolic dogs in a fed state?
    Bernard Humbert
    INSERM U 539, Centre de Recherche en Nutrition Humaine, Hotel Dieu, 3ème Etage Aile Nord, 44093 Nantes Cedex 1, France
    Metabolism 51:628-35. 2002
    ..We conclude that, in hypercatabolic adult dogs in the fed state, enteral glutamine supplementation acutely decreases leucine oxidation and improves net leucine balance, and may thus preserve body protein...
  12. ncbi request reprint Does acute glutamine depletion enhance the response of glutamine synthesis to fasting in muscle in adult and old rats?
    Dominique Meynial-Denis
    Human Nutrition Research Center at Clermont Ferrand, and Institut National de la Recherche Agronomique, Nutrition and Protein Metabolism Unit, Theix, 63122 Saint Genes Champanelle, France
    Clin Nutr 24:398-406. 2005
    ....
  13. ncbi request reprint Effect of glutamine on glutathione kinetics in vivo in dogs
    Bernard Humbert
    INSERM U 539, Centre de Recherche en Nutrition Humaine, Nantes, 44093 cedex 1, France
    J Nutr Biochem 18:10-6. 2007
    ....
  14. ncbi request reprint Glutamine metabolism in Crohn's disease: a stable isotope study
    Arnaud Bourreille
    INSERM U 539, Human Nutrition Research Center, Hotel Dieu Hospital, 2ème étage aile nord, 44093 Nantes Cedex 1, France
    Clin Nutr 23:1167-75. 2004
    ..5 hrs. None of the patients was receiving any nutritional supplement or antiinflammatory drug. All were in remission (Crohn's disease activity index < 150) and in a near-normal nutritional status...
  15. ncbi request reprint Glutamine preserves protein synthesis and paracellular permeability in Caco-2 cells submitted to "luminal fasting"
    Olivier Le Bacquer
    INSERM U 539, Centre de Recherche en Nutrition Humaine Groupe Métabolisme, Hotel Dieu, 3ème Etage Aile Nord, 44093 Nantes Cedex 1, France
    Am J Physiol Gastrointest Liver Physiol 285:G128-36. 2003
    ....
  16. ncbi request reprint Manipulation of citrulline availability in humans
    Carole Rouge
    UMR 1280, Physiologie des Adaptations Nutritionnelles, Centre de Recherche en Nutrition Humaine, Hotel Dieu Hospital, Nantes Cedex 1, France
    Am J Physiol Gastrointest Liver Physiol 293:G1061-7. 2007
    ....
  17. ncbi request reprint Corticosteroids increase glutamine utilization in human splanchnic bed
    Ronan Thibault
    INRA, UMR 1280, Physiologie des Adaptations Nutritionnelles, Universite de Nantes, 44093 Nantes Cedex 1, France
    Am J Physiol Gastrointest Liver Physiol 294:G548-53. 2008
    ..The role of such changes in patients receiving chronic corticoid treatment for inflammatory diseases or suffering from severe illness remains to be determined...
  18. ncbi request reprint Dietary protein level affects protein metabolism during the postabsorptive state in dogs
    Bernard Humbert
    Laboratory of Nutrition and Endocrinology, National Veterinary School of Nantes and INSERM U 539, Human Nutrition Research Center, Nantes, France
    J Nutr 132:1676S-8S. 2002
  19. ncbi request reprint Acute effects of intravenous glutamine supplementation on protein metabolism in very low birth weight infants: a stable isotope study
    Clotilde des Robert
    Service de Néonatologie et Réanimation Pédiatrique, Hôpital Mère et Enfant, CHU de Nantes, INSERM U 539, Centre de Recherche en Nutrition Humaine, France
    Pediatr Res 51:87-93. 2002
    ....