Research Topics
| R L BrentSummaryAffiliation: Alfred I. duPont Hospital for Children Country: USA Publications
| Collaborators
|
Detail Information
Publications
Evaluation of the reproductive and developmental risks of caffeineRobert L Brent
Thomas Jefferson University, Alfred I duPont Hospital for Children, Wilmington, Delaware 19899, USA
Birth Defects Res B Dev Reprod Toxicol 92:152-87. 2011..Pharmacokinetic studies markedly improve the ability to perform the risk analyses...
Utilization of animal studies to determine the effects and human risks of environmental toxicants (drugs, chemicals, and physical agents)Robert L Brent
Thomas Jefferson University, Alfred I duPont Hospital for Children, Laboratory of Clinical and Environmental Teratology, Wilmington, Delaware 19899, USA
Pediatrics 113:984-95. 2004..Well-performed epidemiology studies are still the best method for determining the human risk and the effects of environmental toxicants...- The current state of knowledge about the effects, risks, and science of children's environmental exposuresRobert L Brent
Thomas Jefferson University, Alfred I. duPont Hospital for Children, Laboratory of Clinical and Environmental Teratology, Wilmington, Delaware 19899, USA
Pediatrics 113:1158-66. 2004 - The pediatrician's role and responsibility in educating parents about environmental risksRobert L Brent
Thomas Jefferson University, Alfred I. duPont Hospital for Children, Laboratory of Clinical and Environmental Teratology, Wilmington, Delaware 19899, USA
Pediatrics 113:1167-72. 2004 - Utilization of juvenile animal studies to determine the human effects and risks of environmental toxicants during postnatal developmental stagesRobert L Brent
Thomas Jefferson University, Alfred I duPont Hospital for Children, Laboratory of Clinical and Environmental Teratology, Wilmington, Delaware 19899, USA
Birth Defects Res B Dev Reprod Toxicol 71:303-20. 2004..One cannot determine the magnitude of human risks from in vitro studies when they are the only source of toxicology data... - Commentary on JAMA article by Hujoel et alRobert L Brent
A I duPont Hospital for Children, PO Box 269, Wilmington, DE 19899, USA
Health Phys 88:379-81. 2005..Boice has published a recent letter concerning the Hujoel paper. The Hujoel publication has very serious deficiencies. This Forum presents analyses of these deficiencies... - Triumph and/or tragedy: the present Food and Drug Administration program of enriching grains with folic acidRobert L Brent
Department of Pediatrics, Radiology, and Pathology, Thomas Jefferson University, Alfred I. duPont Hospital for Children, Box 269, Wilmington, DE 19899, USA
Pediatrics 117:930-2. 2006 - The Food and Drug Administration must require the addition of more folic acid in "enriched" flour and other grainsRobert L Brent
Department of Pediatrics, Thomas Jefferson University, A.I. duPont Hospital for Children, Wilmington, DE 19899, USA
Pediatrics 116:753-5. 2005 - Risks and benefits of immunizing pregnant women: the risk of doing nothingRobert L Brent
Laboratory of Clinical and Environmental Teratology, Alfred I duPont Hospital for Children, Thomas Jefferson University, Wilmington, DE 19899, USA
Reprod Toxicol 21:383-9. 2006..quot;.. - Environmental causes of human congenital malformations: the pediatrician's role in dealing with these complex clinical problems caused by a multiplicity of environmental and genetic factorsRobert L Brent
Thomas Jefferson University, Alfred I duPont Hospital for Children, Laboratory of Clinical and Environmental Teratology, Wilmington, Delaware 19899, USA
Pediatrics 113:957-68. 2004.... - A pediatric perspective on the unique vulnerability and resilience of the embryo and the child to environmental toxicants: the importance of rigorous research concerning age and agentRobert L Brent
Thomas Jefferson University, Alfred I. duPont Hospital for Children, Laboratory of Clinical and Environmental Teratology, Wilmington, Delaware 19899, USA
Pediatrics 113:935-44. 2004 
The pulmonologist's role in caring for pregnant women with regard to the reproductive risks of diagnostic radiological studies or radiation therapyRobert Brent
Department of Pediatrics, Thomas Jefferson University, 1025 Walnut Street, Philadelphia, PA 19107, USA
Clin Chest Med 32:33-42, vii-viii. 2011..This article discusses radiation risks and their evaluation and pregnancy-related issues in diagnostic radiological studies...- Saving lives and changing family histories: appropriate counseling of pregnant women and men and women of reproductive age, concerning the risk of diagnostic radiation exposures during and before pregnancyRobert L Brent
Thomas Jefferson University, Alfred I duPont Hospital for Children, Wilmington, DE 19899, USA
Am J Obstet Gynecol 200:4-24. 2009..The reader is referred to the Health Physics Society website to obtain many examples of the answers to questions posed by women and men who have been exposed to radiation (www.hps.org). Then click on ATE (ask the expert)... - Lauriston S. Taylor lecture: fifty years of scientific research: the importance of scholarship and the influence of politics and controversyRobert L Brent
Thomas Jefferson University, A I duPont Hospital for Children, PO Box 269, Room 308 R1A, Wilmington, DE 19899, USA
Health Phys 93:348-79. 2007.... - How does a physician avoid prescribing drugs and medical procedures that have reproductive and developmental risks?Robert L Brent
Laboratory of Clinical and Environmental Teratology, Room 308, R A, Alfred I duPont Hospital for Children, Box 269, Wilmington, DE 19899, USA
Clin Perinatol 34:233-62, v. 2007..This article provides practical tips that obstetricians and perinatologists can use to reduce the likelihood of being a defendant in malpractice litigation... - Bendectin and birth defects: hopefully, the final chapterRobert Brent
Jefferson Medical College, Philadelphia, Pennsylvania, USA
Birth Defects Res A Clin Mol Teratol 67:79-87. 2003 - Immunization of pregnant women: reproductive, medical and societal risksRobert L Brent
Laboratory of Clinical and Environmental Teratology, Room 308 R A, Alfred I duPont Hospital for Children, Box 269, Thomas Jefferson University, Wilmington, DE 19899, USA
Vaccine 21:3413-21. 2003..This is not going to be an easy task... - The Daubert decisionRobert Brent
duPont Hospital for Children, Room 306, A/R Building, PO Box 269, Wilmington, DE 19899, USA
Pediatrics 118:2222-5. 2006 - The folate debateRobert L Brent
Department of Pediatrics, Radiology, and Pathology, Thomas Jefferson University, A.I. duPont Hospital for Children, Wilmington, Delaware, USA
Pediatrics 117:1418-9. 2006 - Nongenital malformations following exposure to progestational drugs: the last chapter of an erroneous allegationRobert L Brent
Research Department, Alfred I duPont Hospital for Children, Wilmington, Delaware 19899, USA
Birth Defects Res A Clin Mol Teratol 73:906-18. 2005..e., LRDs and CHDs)... - Bendectin: review of the medical literature of a comprehensively studied human nonteratogen and the most prevalent tortogen-litigenR L Brent
Jefferson Medical College, Alfred I duPont Institute, Wilmington, DE 19899, USA
Reprod Toxicol 9:337-49. 1995..These data were evaluated with regard to the reproductive risks of Bendectin providing a scientific framework for evaluating the views of the experts in the Bendectin litigation... - In memoriam. Robert Warwick MillerRobert L Brent
Jefferson Medical College, Philadelphia, Pennsylvania, USA
Birth Defects Res A Clin Mol Teratol 79:253-6. 2007 - Teratology in the 20th century environmental causes of congenital malformations in humans and how they were establishedRobert L Brent
Alfred I. duPont Hospital for Children, P.O. Box 269 Wilmington, DE 19899, USA
Neurotoxicol Teratol 26:1-12. 2004 - Effects of supplemental methionine on antiserum-induced dysmorphology in rat embryos cultured in vitroL B Fawcett
Department of Pediatrics, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
Teratology 61:332-41. 2000..This has provided a useful model with which to investigate the nutritional requirements of the early embryo, as well as the role of various nutrients in the etiology of congenital defects... - A history of the Teratology SocietyT H Shepard
Department of Pediatrics, University of Washington, Seattle, Washington 98195, USA
Teratology 62:301-16. 2000..The 39-year history of the Teratology Society is reviewed. An abbreviated history is outlined in table form, along with listings of the Warkany Lectures, the postgraduate courses, and officers of the Society... - Update on new developments in the study of human teratogensT H Shepard
University of Washington, Department of Pediatrics, Seattle, Washington 98195 6320, USA
Teratology 65:153-61. 2002..The purpose of this annual article is to highlight and briefly review new and significant information on agents that may be teratogenic in pregnant women. Various sources of on-line and printed information are given... - Approaches for assessing risks to sensitive populations: lessons learned from evaluating risks in the pediatric populationRonald N Hines
Medical College of Wisconsin, Department of Pediatrics, Children s Research Institute, Children s Hospital and Health Systems, Milwaukee, Wisconsin 53226 4801, USA
Toxicol Sci 113:4-26. 2010..Recommendations as to future research needs and/or alternate methodological considerations are also made... - Counseling patients exposed to ionizing radiation during pregnancyRobert L Brent
Thomas Jefferson University, Philadelphia, Pennsylvania, and Alfred I. duPont Hospital for Children, Wilmington, Delaware 19899, USA
Rev Panam Salud Publica 20:198-204. 2006..Counseling patients requires knowledge of embryology, genetics, radiation teratology, and the principles of teratology in order for the counselor to provide sympathetic, accurate, scholarly advice... - Investigations into mechanisms of amino acid supply to the rat embryo using whole-embryo cultureD A Beckman
Department of Pediatrics, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Int J Dev Biol 41:315-8. 1997..Inhibition of either endocytosis or intralysosomal proteolysis diminishes amino acid supply to the embryo, and this can result in embryonic death or maldevelopment during organogenesis... - Human milk biomonitoring data: interpretation and risk assessment issuesJudy S LaKind
Department of Pediatrics, Milton S Hershey Medical Center, Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
J Toxicol Environ Health A 68:1713-69. 2005..Discussion of these topics and the thoughts and conclusions of the panel are described in this article... - The need for vigilance: the persistence of lead poisoning in childrenTodd A Florin
American Academy of Pediatrics Center for Child Health Research, Department of Pediatrics, Center for Child Health Research, University of Rochester School of Medicine and Dentistry, Rochester, NY 14620, USA
Pediatrics 115:1767-8. 2005 - Conclusions and recommendations of the expert panel: technical workshop on human milk surveillance and biomonitoring for environmental chemicals in the United StatesCheston M Berlin
Department of Pediatrics, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
J Toxicol Environ Health A 68:1825-31. 2005 - Radiation risk to children from computed tomographyAlan S Brody
Pediatrics 120:677-82. 2007..The information in this report is provided to aid in decision-making and discussions with the health care team, patients, and families... - Further efforts to reduce the incidence of neural tube defectsRobert L Brent
Pediatrics 119:225-6. 2007 - Trichloroethylene and dichloroethylene: a critical review of teratogenicityBryan D Hardin
Veritox, Inc, Hilton Head Island, South Carolina, USA
Birth Defects Res A Clin Mol Teratol 73:931-55. 2005..We conclude that the weight of experimental and epidemiologic evidence does not support the hypothesis that TCE or DCE is a selective developmental toxicant in general or a cardiac teratogen specifically... - Diagnostic radiation in pregnancy: perception versus true risksRaanan Cohen-Kerem
Motherisk Program, Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario
J Obstet Gynaecol Can 28:43-8. 2006..However, available data suggest that current diagnostic radiation procedures are not teratogenic... - Pregnancy policyRobert L Brent
AJR Am J Roentgenol 182:819-22; author reply 822. 2004 - Evaluating emerging issues in epidemiologyJames J Collins
The Dow Chemical Co, Midland, MI 48674, USA
Regul Toxicol Pharmacol 48:296-307. 2007..We further recommend frequent and timely communication with all stakeholders, and the development of research approaches to fill gaps when the scientific data on an issue are limited...