R L Brent

Summary

Affiliation: Alfred I. duPont Hospital for Children
Country: USA

Publications

  1. pmc Evaluation of the reproductive and developmental risks of caffeine
    Robert L Brent
    Thomas Jefferson University, Alfred I duPont Hospital for Children, Wilmington, Delaware 19899, USA
    Birth Defects Res B Dev Reprod Toxicol 92:152-87. 2011
  2. ncbi request reprint Utilization of animal studies to determine the effects and human risks of environmental toxicants (drugs, chemicals, and physical agents)
    Robert L Brent
    Thomas Jefferson University, Alfred I duPont Hospital for Children, Laboratory of Clinical and Environmental Teratology, Wilmington, Delaware 19899, USA
    Pediatrics 113:984-95. 2004
  3. ncbi request reprint The current state of knowledge about the effects, risks, and science of children's environmental exposures
    Robert L Brent
    Thomas Jefferson University, Alfred I duPont Hospital for Children, Laboratory of Clinical and Environmental Teratology, Wilmington, Delaware 19899, USA
    Pediatrics 113:1158-66. 2004
  4. ncbi request reprint The pediatrician's role and responsibility in educating parents about environmental risks
    Robert L Brent
    Thomas Jefferson University, Alfred I duPont Hospital for Children, Laboratory of Clinical and Environmental Teratology, Wilmington, Delaware 19899, USA
    Pediatrics 113:1167-72. 2004
  5. ncbi request reprint Utilization of juvenile animal studies to determine the human effects and risks of environmental toxicants during postnatal developmental stages
    Robert L Brent
    Thomas Jefferson University, Alfred I duPont Hospital for Children, Laboratory of Clinical and Environmental Teratology, Wilmington, Delaware 19899, USA
    Birth Defects Res B Dev Reprod Toxicol 71:303-20. 2004
  6. ncbi request reprint Commentary on JAMA article by Hujoel et al
    Robert L Brent
    A I duPont Hospital for Children, PO Box 269, Wilmington, DE 19899, USA
    Health Phys 88:379-81. 2005
  7. ncbi request reprint Triumph and/or tragedy: the present Food and Drug Administration program of enriching grains with folic acid
    Robert L Brent
    Department of Pediatrics, Radiology, and Pathology, Thomas Jefferson University, Alfred I duPont Hospital for Children, Box 269, Wilmington, DE 19899, USA
    Pediatrics 117:930-2. 2006
  8. ncbi request reprint The Food and Drug Administration must require the addition of more folic acid in "enriched" flour and other grains
    Robert L Brent
    Department of Pediatrics, Thomas Jefferson University, A I duPont Hospital for Children, Wilmington, DE 19899, USA
    Pediatrics 116:753-5. 2005
  9. ncbi request reprint Risks and benefits of immunizing pregnant women: the risk of doing nothing
    Robert L Brent
    Laboratory of Clinical and Environmental Teratology, Alfred I duPont Hospital for Children, Thomas Jefferson University, Wilmington, DE 19899, USA
    Reprod Toxicol 21:383-9. 2006
  10. ncbi request reprint Environmental causes of human congenital malformations: the pediatrician's role in dealing with these complex clinical problems caused by a multiplicity of environmental and genetic factors
    Robert L Brent
    Thomas Jefferson University, Alfred I duPont Hospital for Children, Laboratory of Clinical and Environmental Teratology, Wilmington, Delaware 19899, USA
    Pediatrics 113:957-68. 2004

Detail Information

Publications38

  1. pmc Evaluation of the reproductive and developmental risks of caffeine
    Robert L Brent
    Thomas Jefferson University, Alfred I duPont Hospital for Children, Wilmington, Delaware 19899, USA
    Birth Defects Res B Dev Reprod Toxicol 92:152-87. 2011
    ..Pharmacokinetic studies markedly improve the ability to perform the risk analyses...
  2. ncbi request reprint Utilization of animal studies to determine the effects and human risks of environmental toxicants (drugs, chemicals, and physical agents)
    Robert L Brent
    Thomas Jefferson University, Alfred I duPont Hospital for Children, Laboratory of Clinical and Environmental Teratology, Wilmington, Delaware 19899, USA
    Pediatrics 113:984-95. 2004
    ..Well-performed epidemiology studies are still the best method for determining the human risk and the effects of environmental toxicants...
  3. ncbi request reprint The current state of knowledge about the effects, risks, and science of children's environmental exposures
    Robert L Brent
    Thomas Jefferson University, Alfred I duPont Hospital for Children, Laboratory of Clinical and Environmental Teratology, Wilmington, Delaware 19899, USA
    Pediatrics 113:1158-66. 2004
  4. ncbi request reprint The pediatrician's role and responsibility in educating parents about environmental risks
    Robert L Brent
    Thomas Jefferson University, Alfred I duPont Hospital for Children, Laboratory of Clinical and Environmental Teratology, Wilmington, Delaware 19899, USA
    Pediatrics 113:1167-72. 2004
  5. ncbi request reprint Utilization of juvenile animal studies to determine the human effects and risks of environmental toxicants during postnatal developmental stages
    Robert L Brent
    Thomas Jefferson University, Alfred I duPont Hospital for Children, Laboratory of Clinical and Environmental Teratology, Wilmington, Delaware 19899, USA
    Birth Defects Res B Dev Reprod Toxicol 71:303-20. 2004
    ..One cannot determine the magnitude of human risks from in vitro studies when they are the only source of toxicology data...
  6. ncbi request reprint Commentary on JAMA article by Hujoel et al
    Robert L Brent
    A I duPont Hospital for Children, PO Box 269, Wilmington, DE 19899, USA
    Health Phys 88:379-81. 2005
    ..Boice has published a recent letter concerning the Hujoel paper. The Hujoel publication has very serious deficiencies. This Forum presents analyses of these deficiencies...
  7. ncbi request reprint Triumph and/or tragedy: the present Food and Drug Administration program of enriching grains with folic acid
    Robert L Brent
    Department of Pediatrics, Radiology, and Pathology, Thomas Jefferson University, Alfred I duPont Hospital for Children, Box 269, Wilmington, DE 19899, USA
    Pediatrics 117:930-2. 2006
  8. ncbi request reprint The Food and Drug Administration must require the addition of more folic acid in "enriched" flour and other grains
    Robert L Brent
    Department of Pediatrics, Thomas Jefferson University, A I duPont Hospital for Children, Wilmington, DE 19899, USA
    Pediatrics 116:753-5. 2005
  9. ncbi request reprint Risks and benefits of immunizing pregnant women: the risk of doing nothing
    Robert L Brent
    Laboratory of Clinical and Environmental Teratology, Alfred I duPont Hospital for Children, Thomas Jefferson University, Wilmington, DE 19899, USA
    Reprod Toxicol 21:383-9. 2006
    ..quot;..
  10. ncbi request reprint Environmental causes of human congenital malformations: the pediatrician's role in dealing with these complex clinical problems caused by a multiplicity of environmental and genetic factors
    Robert L Brent
    Thomas Jefferson University, Alfred I duPont Hospital for Children, Laboratory of Clinical and Environmental Teratology, Wilmington, Delaware 19899, USA
    Pediatrics 113:957-68. 2004
    ....
  11. ncbi request reprint A pediatric perspective on the unique vulnerability and resilience of the embryo and the child to environmental toxicants: the importance of rigorous research concerning age and agent
    Robert L Brent
    Thomas Jefferson University, Alfred I duPont Hospital for Children, Laboratory of Clinical and Environmental Teratology, Wilmington, Delaware 19899, USA
    Pediatrics 113:935-44. 2004
  12. doi request reprint The pulmonologist's role in caring for pregnant women with regard to the reproductive risks of diagnostic radiological studies or radiation therapy
    Robert Brent
    Department of Pediatrics, Thomas Jefferson University, 1025 Walnut Street, Philadelphia, PA 19107, USA
    Clin Chest Med 32:33-42, vii-viii. 2011
    ..This article discusses radiation risks and their evaluation and pregnancy-related issues in diagnostic radiological studies...
  13. doi request reprint Saving lives and changing family histories: appropriate counseling of pregnant women and men and women of reproductive age, concerning the risk of diagnostic radiation exposures during and before pregnancy
    Robert L Brent
    Thomas Jefferson University, Alfred I duPont Hospital for Children, Wilmington, DE 19899, USA
    Am J Obstet Gynecol 200:4-24. 2009
    ..The reader is referred to the Health Physics Society website to obtain many examples of the answers to questions posed by women and men who have been exposed to radiation (www.hps.org). Then click on ATE (ask the expert)...
  14. ncbi request reprint Lauriston S. Taylor lecture: fifty years of scientific research: the importance of scholarship and the influence of politics and controversy
    Robert L Brent
    Thomas Jefferson University, A I duPont Hospital for Children, PO Box 269, Room 308 R1A, Wilmington, DE 19899, USA
    Health Phys 93:348-79. 2007
    ....
  15. ncbi request reprint How does a physician avoid prescribing drugs and medical procedures that have reproductive and developmental risks?
    Robert L Brent
    Laboratory of Clinical and Environmental Teratology, Room 308, R A, Alfred I duPont Hospital for Children, Box 269, Wilmington, DE 19899, USA
    Clin Perinatol 34:233-62, v. 2007
    ..This article provides practical tips that obstetricians and perinatologists can use to reduce the likelihood of being a defendant in malpractice litigation...
  16. ncbi request reprint Bendectin and birth defects: hopefully, the final chapter
    Robert Brent
    Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Birth Defects Res A Clin Mol Teratol 67:79-87. 2003
  17. ncbi request reprint Immunization of pregnant women: reproductive, medical and societal risks
    Robert L Brent
    Laboratory of Clinical and Environmental Teratology, Room 308 R A, Alfred I duPont Hospital for Children, Box 269, Thomas Jefferson University, Wilmington, DE 19899, USA
    Vaccine 21:3413-21. 2003
    ..This is not going to be an easy task...
  18. ncbi request reprint The Daubert decision
    Robert Brent
    duPont Hospital for Children, Room 306, A R Building, PO Box 269, Wilmington, DE 19899, USA
    Pediatrics 118:2222-5. 2006
  19. ncbi request reprint The folate debate
    Robert L Brent
    Department of Pediatrics, Radiology, and Pathology, Thomas Jefferson University, A I duPont Hospital for Children, Wilmington, Delaware, USA
    Pediatrics 117:1418-9. 2006
  20. ncbi request reprint Nongenital malformations following exposure to progestational drugs: the last chapter of an erroneous allegation
    Robert L Brent
    Research Department, Alfred I duPont Hospital for Children, Wilmington, Delaware 19899, USA
    Birth Defects Res A Clin Mol Teratol 73:906-18. 2005
    ..e., LRDs and CHDs)...
  21. ncbi request reprint Bendectin: review of the medical literature of a comprehensively studied human nonteratogen and the most prevalent tortogen-litigen
    R L Brent
    Jefferson Medical College, Alfred I duPont Institute, Wilmington, DE 19899, USA
    Reprod Toxicol 9:337-49. 1995
    ..These data were evaluated with regard to the reproductive risks of Bendectin providing a scientific framework for evaluating the views of the experts in the Bendectin litigation...
  22. ncbi request reprint In memoriam. Robert Warwick Miller
    Robert L Brent
    Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Birth Defects Res A Clin Mol Teratol 79:253-6. 2007
  23. ncbi request reprint Teratology in the 20th century environmental causes of congenital malformations in humans and how they were established
    Robert L Brent
    Alfred I duPont Hospital for Children, P O Box 269 Wilmington, DE 19899, USA
    Neurotoxicol Teratol 26:1-12. 2004
  24. ncbi request reprint Effects of supplemental methionine on antiserum-induced dysmorphology in rat embryos cultured in vitro
    L B Fawcett
    Department of Pediatrics, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Teratology 61:332-41. 2000
    ..This has provided a useful model with which to investigate the nutritional requirements of the early embryo, as well as the role of various nutrients in the etiology of congenital defects...
  25. ncbi request reprint A history of the Teratology Society
    T H Shepard
    Department of Pediatrics, University of Washington, Seattle, Washington 98195, USA
    Teratology 62:301-16. 2000
    ..The 39-year history of the Teratology Society is reviewed. An abbreviated history is outlined in table form, along with listings of the Warkany Lectures, the postgraduate courses, and officers of the Society...
  26. ncbi request reprint Update on new developments in the study of human teratogens
    T H Shepard
    University of Washington, Department of Pediatrics, Seattle, Washington 98195 6320, USA
    Teratology 65:153-61. 2002
    ..The purpose of this annual article is to highlight and briefly review new and significant information on agents that may be teratogenic in pregnant women. Various sources of on-line and printed information are given...
  27. pmc Approaches for assessing risks to sensitive populations: lessons learned from evaluating risks in the pediatric population
    Ronald N Hines
    Medical College of Wisconsin, Department of Pediatrics, Children s Research Institute, Children s Hospital and Health Systems, Milwaukee, Wisconsin 53226 4801, USA
    Toxicol Sci 113:4-26. 2010
    ..Recommendations as to future research needs and/or alternate methodological considerations are also made...
  28. ncbi request reprint Counseling patients exposed to ionizing radiation during pregnancy
    Robert L Brent
    Thomas Jefferson University, Philadelphia, Pennsylvania, and Alfred I duPont Hospital for Children, Wilmington, Delaware 19899, USA
    Rev Panam Salud Publica 20:198-204. 2006
    ..Counseling patients requires knowledge of embryology, genetics, radiation teratology, and the principles of teratology in order for the counselor to provide sympathetic, accurate, scholarly advice...
  29. ncbi request reprint Investigations into mechanisms of amino acid supply to the rat embryo using whole-embryo culture
    D A Beckman
    Department of Pediatrics, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Int J Dev Biol 41:315-8. 1997
    ..Inhibition of either endocytosis or intralysosomal proteolysis diminishes amino acid supply to the embryo, and this can result in embryonic death or maldevelopment during organogenesis...
  30. ncbi request reprint Human milk biomonitoring data: interpretation and risk assessment issues
    Judy S LaKind
    Department of Pediatrics, Milton S Hershey Medical Center, Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
    J Toxicol Environ Health A 68:1713-69. 2005
    ..Discussion of these topics and the thoughts and conclusions of the panel are described in this article...
  31. ncbi request reprint The need for vigilance: the persistence of lead poisoning in children
    Todd A Florin
    American Academy of Pediatrics Center for Child Health Research, Department of Pediatrics, Center for Child Health Research, University of Rochester School of Medicine and Dentistry, Rochester, NY 14620, USA
    Pediatrics 115:1767-8. 2005
  32. ncbi request reprint Conclusions and recommendations of the expert panel: technical workshop on human milk surveillance and biomonitoring for environmental chemicals in the United States
    Cheston M Berlin
    Department of Pediatrics, Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Toxicol Environ Health A 68:1825-31. 2005
  33. ncbi request reprint Radiation risk to children from computed tomography
    Alan S Brody
    Pediatrics 120:677-82. 2007
    ..The information in this report is provided to aid in decision-making and discussions with the health care team, patients, and families...
  34. ncbi request reprint Further efforts to reduce the incidence of neural tube defects
    Robert L Brent
    Pediatrics 119:225-6. 2007
  35. ncbi request reprint Trichloroethylene and dichloroethylene: a critical review of teratogenicity
    Bryan D Hardin
    Veritox, Inc, Hilton Head Island, South Carolina, USA
    Birth Defects Res A Clin Mol Teratol 73:931-55. 2005
    ..We conclude that the weight of experimental and epidemiologic evidence does not support the hypothesis that TCE or DCE is a selective developmental toxicant in general or a cardiac teratogen specifically...
  36. ncbi request reprint Diagnostic radiation in pregnancy: perception versus true risks
    Raanan Cohen-Kerem
    Motherisk Program, Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario
    J Obstet Gynaecol Can 28:43-8. 2006
    ..However, available data suggest that current diagnostic radiation procedures are not teratogenic...
  37. ncbi request reprint Pregnancy policy
    Robert L Brent
    AJR Am J Roentgenol 182:819-22; author reply 822. 2004
  38. ncbi request reprint Evaluating emerging issues in epidemiology
    James J Collins
    The Dow Chemical Co, Midland, MI 48674, USA
    Regul Toxicol Pharmacol 48:296-307. 2007
    ..We further recommend frequent and timely communication with all stakeholders, and the development of research approaches to fill gaps when the scientific data on an issue are limited...