R E Akins
Affiliation: Alfred I. duPont Hospital for Children
- Cardiac organogenesis in vitro: reestablishment of three-dimensional tissue architecture by dissociated neonatal rat ventricular cellsR E Akins
Department of Research, Alfred I duPont Hospital for Children, Alfred I duPont Institute of the Nemours Foundation, Wilmington, Delaware 19899, USA
Tissue Eng 5:103-18. 1999....
- Gene expression profile of bioreactor-cultured cardiac cells: activation of morphogenetic pathways for tissue engineeringRobert E Akins
Nemours Biomedical Research, A I duPont Hospital for Children, Wilmington, Delaware19803, USA
DNA Cell Biol 26:425-34. 2007..These results suggest that 3D aggregate culture of NRHCs in bioreactors is associated with the differential expression of morphogenic and angiogenic pathways similar to those seen during cardiac development...
- Three-dimensional culture alters primary cardiac cell phenotypeRobert E Akins
Nemours Biomedical Research Center, AI duPont Hospital for Children, Wilmington, Delaware 19803, USA
Tissue Eng Part A 16:629-41. 2010..These results indicate that the culture of primary cardiac cells in 3D aggregates leads to physiologically relevant alterations in component cell phenotype consistent with cardiac ventricular tissue formation and maturation...
- Exogenous metalloporphyrins alter the organization and function of cultured neonatal rat heart cells via modulation of heme oxygenase activityRobert Akins
Department of Biomedical Research, A I duPont Hospital for Children, Wilmington, Delaware, USA
J Cell Physiol 201:26-34. 2004..These results suggest that heme and its catabolites act to modulate aspects of cardiac cell function and organization...
- Dysmorphic neuromuscular junctions associated with motor ability in cerebral palsyMary C Theroux
Nemours Biomedical Research, AI duPont Hospital for Children, Wilmington, Delaware 19803, USA
Muscle Nerve 32:626-32. 2005..These results indicate that physical disability in children with CP is associated with structurally dysmorphic NMJs, which has important implications for the management of CP patients, especially during surgery and anesthesia...
- Neuromuscular junctions in cerebral palsy: presence of extrajunctional acetylcholine receptorsMary C Theroux
Department of Anesthesiology Critical Care, Alfred I duPont Hospital for Children, Wilmington, Delaware 19899, USA
Anesthesiology 96:330-5. 2002..Evidence exists that up-regulation of acetylcholine receptors (AChRs) may be present in children with CP, and the current study was undertaken to examine this possibility...
- Altered expression of muscle- and cytoskeleton-related genes in a rat strain with inherited cryptorchidismJulia S Barthold
Nemours Biomedical Research and Division of Urology, A I duPont Hospital for Children, Wilmington, Delaware 19803, USA
J Androl 29:352-66. 2008..These data suggest that the orl mutation results in a primary gubernacular defect that affects muscle development and cytoskeletal function and might alter androgen-regulated pathways...
- C Histomorphology of neuromuscular junction in Duchenne muscular dystrophyMary C Theroux
Department of Anesthesiology and Critical Care, Alfred I duPont Hospital for Children, Wilmington, DE 19899, USA
Paediatr Anaesth 18:256-9. 2008..Our objective was to better understand neuromuscular junction (NMJ) morphology in children with Duchenne muscular dystrophy (DMD)...
- Surgery and anesthesia for children who have cerebral palsyMary C Theroux
Department of Anesthesiology, Alfred I duPont Hospital for Children, Wilmington, DE 19899, USA
Anesthesiol Clin North America 23:733-43, ix. 2005..There is emerging evidence for abnormalities in their neuromuscular junction that potentially increase their anesthetic risk. In addition, there are recent data explaining possible reasons for increased bleeding in these children...
- Can tissue engineering mend broken hearts?Robert E Akins
Circ Res 90:120-2. 2002
- Growth and development in a heliox incubator environment: a long-term safety studyClifford J Singhaus
Nemours Research Lung Center, Alfred I duPont Hospital for Children Nemours Research Lung Center, Wilmington, DE 19803, USA
Neonatology 91:28-35. 2007..Heliox has been shown to improve pulmonary function and may decrease energy expenditure. We hypothesized that heliox would provide a safe environment for sustained growth and development...
- Development of neuromuscular junctions in children with cerebral palsyRobert Akins; Fiscal Year: 2007..The PIs study these interactions in order to develop therapies and treatments that will improve and sustain the physical ability and health of patients with CP. ..