R E Akins

Summary

Affiliation: Alfred I. duPont Hospital for Children
Country: USA

Publications

  1. ncbi request reprint Cardiac organogenesis in vitro: reestablishment of three-dimensional tissue architecture by dissociated neonatal rat ventricular cells
    R E Akins
    Department of Research, Alfred I duPont Hospital for Children, Alfred I duPont Institute of the Nemours Foundation, Wilmington, Delaware 19899, USA
    Tissue Eng 5:103-18. 1999
  2. ncbi request reprint Gene expression profile of bioreactor-cultured cardiac cells: activation of morphogenetic pathways for tissue engineering
    Robert E Akins
    Nemours Biomedical Research, A I duPont Hospital for Children, Wilmington, Delaware19803, USA
    DNA Cell Biol 26:425-34. 2007
  3. pmc Three-dimensional culture alters primary cardiac cell phenotype
    Robert E Akins
    Nemours Biomedical Research Center, AI duPont Hospital for Children, Wilmington, Delaware 19803, USA
    Tissue Eng Part A 16:629-41. 2010
  4. ncbi request reprint Exogenous metalloporphyrins alter the organization and function of cultured neonatal rat heart cells via modulation of heme oxygenase activity
    Robert Akins
    Department of Biomedical Research, A I duPont Hospital for Children, Wilmington, Delaware, USA
    J Cell Physiol 201:26-34. 2004
  5. ncbi request reprint Dysmorphic neuromuscular junctions associated with motor ability in cerebral palsy
    Mary C Theroux
    Nemours Biomedical Research, AI duPont Hospital for Children, Wilmington, Delaware 19803, USA
    Muscle Nerve 32:626-32. 2005
  6. ncbi request reprint Neuromuscular junctions in cerebral palsy: presence of extrajunctional acetylcholine receptors
    Mary C Theroux
    Department of Anesthesiology Critical Care, Alfred I duPont Hospital for Children, Wilmington, Delaware 19899, USA
    Anesthesiology 96:330-5. 2002
  7. doi request reprint Altered expression of muscle- and cytoskeleton-related genes in a rat strain with inherited cryptorchidism
    Julia S Barthold
    Nemours Biomedical Research and Division of Urology, A I duPont Hospital for Children, Wilmington, Delaware 19803, USA
    J Androl 29:352-66. 2008
  8. doi request reprint C Histomorphology of neuromuscular junction in Duchenne muscular dystrophy
    Mary C Theroux
    Department of Anesthesiology and Critical Care, Alfred I duPont Hospital for Children, Wilmington, DE 19899, USA
    Paediatr Anaesth 18:256-9. 2008
  9. ncbi request reprint Surgery and anesthesia for children who have cerebral palsy
    Mary C Theroux
    Department of Anesthesiology, Alfred I duPont Hospital for Children, Wilmington, DE 19899, USA
    Anesthesiol Clin North America 23:733-43, ix. 2005
  10. ncbi request reprint Can tissue engineering mend broken hearts?
    Robert E Akins
    Circ Res 90:120-2. 2002

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Cardiac organogenesis in vitro: reestablishment of three-dimensional tissue architecture by dissociated neonatal rat ventricular cells
    R E Akins
    Department of Research, Alfred I duPont Hospital for Children, Alfred I duPont Institute of the Nemours Foundation, Wilmington, Delaware 19899, USA
    Tissue Eng 5:103-18. 1999
    ....
  2. ncbi request reprint Gene expression profile of bioreactor-cultured cardiac cells: activation of morphogenetic pathways for tissue engineering
    Robert E Akins
    Nemours Biomedical Research, A I duPont Hospital for Children, Wilmington, Delaware19803, USA
    DNA Cell Biol 26:425-34. 2007
    ..These results suggest that 3D aggregate culture of NRHCs in bioreactors is associated with the differential expression of morphogenic and angiogenic pathways similar to those seen during cardiac development...
  3. pmc Three-dimensional culture alters primary cardiac cell phenotype
    Robert E Akins
    Nemours Biomedical Research Center, AI duPont Hospital for Children, Wilmington, Delaware 19803, USA
    Tissue Eng Part A 16:629-41. 2010
    ..These results indicate that the culture of primary cardiac cells in 3D aggregates leads to physiologically relevant alterations in component cell phenotype consistent with cardiac ventricular tissue formation and maturation...
  4. ncbi request reprint Exogenous metalloporphyrins alter the organization and function of cultured neonatal rat heart cells via modulation of heme oxygenase activity
    Robert Akins
    Department of Biomedical Research, A I duPont Hospital for Children, Wilmington, Delaware, USA
    J Cell Physiol 201:26-34. 2004
    ..These results suggest that heme and its catabolites act to modulate aspects of cardiac cell function and organization...
  5. ncbi request reprint Dysmorphic neuromuscular junctions associated with motor ability in cerebral palsy
    Mary C Theroux
    Nemours Biomedical Research, AI duPont Hospital for Children, Wilmington, Delaware 19803, USA
    Muscle Nerve 32:626-32. 2005
    ..These results indicate that physical disability in children with CP is associated with structurally dysmorphic NMJs, which has important implications for the management of CP patients, especially during surgery and anesthesia...
  6. ncbi request reprint Neuromuscular junctions in cerebral palsy: presence of extrajunctional acetylcholine receptors
    Mary C Theroux
    Department of Anesthesiology Critical Care, Alfred I duPont Hospital for Children, Wilmington, Delaware 19899, USA
    Anesthesiology 96:330-5. 2002
    ..Evidence exists that up-regulation of acetylcholine receptors (AChRs) may be present in children with CP, and the current study was undertaken to examine this possibility...
  7. doi request reprint Altered expression of muscle- and cytoskeleton-related genes in a rat strain with inherited cryptorchidism
    Julia S Barthold
    Nemours Biomedical Research and Division of Urology, A I duPont Hospital for Children, Wilmington, Delaware 19803, USA
    J Androl 29:352-66. 2008
    ..These data suggest that the orl mutation results in a primary gubernacular defect that affects muscle development and cytoskeletal function and might alter androgen-regulated pathways...
  8. doi request reprint C Histomorphology of neuromuscular junction in Duchenne muscular dystrophy
    Mary C Theroux
    Department of Anesthesiology and Critical Care, Alfred I duPont Hospital for Children, Wilmington, DE 19899, USA
    Paediatr Anaesth 18:256-9. 2008
    ..Our objective was to better understand neuromuscular junction (NMJ) morphology in children with Duchenne muscular dystrophy (DMD)...
  9. ncbi request reprint Surgery and anesthesia for children who have cerebral palsy
    Mary C Theroux
    Department of Anesthesiology, Alfred I duPont Hospital for Children, Wilmington, DE 19899, USA
    Anesthesiol Clin North America 23:733-43, ix. 2005
    ..There is emerging evidence for abnormalities in their neuromuscular junction that potentially increase their anesthetic risk. In addition, there are recent data explaining possible reasons for increased bleeding in these children...
  10. ncbi request reprint Can tissue engineering mend broken hearts?
    Robert E Akins
    Circ Res 90:120-2. 2002
  11. ncbi request reprint Growth and development in a heliox incubator environment: a long-term safety study
    Clifford J Singhaus
    Nemours Research Lung Center, Alfred I duPont Hospital for Children Nemours Research Lung Center, Wilmington, DE 19803, USA
    Neonatology 91:28-35. 2007
    ..Heliox has been shown to improve pulmonary function and may decrease energy expenditure. We hypothesized that heliox would provide a safe environment for sustained growth and development...

Research Grants2

  1. Development of neuromuscular junctions in children with cerebral palsy
    Robert Akins; Fiscal Year: 2007
    ..The PIs study these interactions in order to develop therapies and treatments that will improve and sustain the physical ability and health of patients with CP. ..