A V Alexandrov

Summary

Country: USA

Publications

  1. doi request reprint Timeframe for thrombolysis in acute ischaemic stroke
    Georgios Tsivgoulis
    Comprehensive Stroke Center, University of Alabama at Birmingham Hospital, Birmingham, Alabama 35294, USA
    Lancet 372:1275-6. 2008
  2. ncbi request reprint Validation of transcranial Doppler with computed tomography angiography in acute cerebral ischemia
    Georgios Tsivgoulis
    Neurosonology and Stroke Research Program, Barrow Neurological Institute, Phoenix, AZ, USA
    Stroke 38:1245-9. 2007
  3. ncbi request reprint Does clinical-CT 'mismatch' predict early response to treatment with recombinant tissue plasminogen activator?
    John Y Choi
    Stroke Program, University of Texas Houston Medical School, Houston, TX 77030, USA
    Cerebrovasc Dis 22:384-8. 2006
  4. ncbi request reprint Writing good abstracts
    Andrei V Alexandrov
    Stroke Research Program, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    Cerebrovasc Dis 23:256-9. 2007
  5. ncbi request reprint The accuracy of transcranial Doppler in the diagnosis of middle cerebral artery stenosis
    Jose C Navarro
    Department of Neurology and Psychiatry, University of Santo Tomas Hospital, Manila, Philippines
    Cerebrovasc Dis 23:325-30. 2007
  6. pmc Ultrasound enhanced thrombolysis: applications in acute cerebral ischemia
    Georgios Tsivgoulis
    Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA
    J Clin Neurol 3:1-8. 2007
  7. doi request reprint How to prepare and deliver a scientific presentation. Teaching course presentation at the 21st European Stroke Conference, Lisboa, May 2012
    Andrei V Alexandrov
    Comprehensive Stroke Center, University of Alabama Hospital, Birmingham, AL 35249, USA
    Cerebrovasc Dis 35:202-8. 2013
  8. doi request reprint CLOTBUST-hands free: initial safety testing of a novel operator-independent ultrasound device in stroke-free volunteers
    Kristian Barlinn
    Department of Neurology, Comprehensive Stroke Center, The University of Alabama at Birmingham, RWUH M226, 619 19th St South, Birmingham, AL 35249 3280, USA
    Stroke 44:1641-6. 2013
  9. doi request reprint Practice standards for transcranial Doppler (TCD) ultrasound. Part II. Clinical indications and expected outcomes
    Andrei V Alexandrov
    Comprehensive Stroke Center, University of Alabama at Birmingham, Birmingham, AL 35249 3280, USA
    J Neuroimaging 22:215-24. 2012
  10. doi request reprint Taboos and opportunities in sonothrombolysis for stroke
    Andrei V Alexandrov
    Comprehensive Stroke Center, University of Alabama Hospital, Birmingham, Alabama, USA
    Int J Hyperthermia 28:397-404. 2012

Detail Information

Publications107 found, 100 shown here

  1. doi request reprint Timeframe for thrombolysis in acute ischaemic stroke
    Georgios Tsivgoulis
    Comprehensive Stroke Center, University of Alabama at Birmingham Hospital, Birmingham, Alabama 35294, USA
    Lancet 372:1275-6. 2008
  2. ncbi request reprint Validation of transcranial Doppler with computed tomography angiography in acute cerebral ischemia
    Georgios Tsivgoulis
    Neurosonology and Stroke Research Program, Barrow Neurological Institute, Phoenix, AZ, USA
    Stroke 38:1245-9. 2007
    ..We aimed to evaluate the diagnostic accuracy of TCD against CTA in patients with acute cerebral ischemia...
  3. ncbi request reprint Does clinical-CT 'mismatch' predict early response to treatment with recombinant tissue plasminogen activator?
    John Y Choi
    Stroke Program, University of Texas Houston Medical School, Houston, TX 77030, USA
    Cerebrovasc Dis 22:384-8. 2006
    ..e., clinical-CT mismatch) may respond better to intravenous recombinant tissue plasminogen activator (i.v. rt-PA) within 3 h of symptom onset...
  4. ncbi request reprint Writing good abstracts
    Andrei V Alexandrov
    Stroke Research Program, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    Cerebrovasc Dis 23:256-9. 2007
    ..If selected appropriately, your abstract is more likely to be graded by peers with similar interests and familiarity with your work or field. Methods should describe the study design and tools of data acquisition shortly, not data...
  5. ncbi request reprint The accuracy of transcranial Doppler in the diagnosis of middle cerebral artery stenosis
    Jose C Navarro
    Department of Neurology and Psychiatry, University of Santo Tomas Hospital, Manila, Philippines
    Cerebrovasc Dis 23:325-30. 2007
    ....
  6. pmc Ultrasound enhanced thrombolysis: applications in acute cerebral ischemia
    Georgios Tsivgoulis
    Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA
    J Clin Neurol 3:1-8. 2007
    ..7-2.1 MHz pulsed wave ultrasound (EKOS catheter). Multi-national dose escalation studies of microspheres and the development of an operator independent ultrasound device are underway...
  7. doi request reprint How to prepare and deliver a scientific presentation. Teaching course presentation at the 21st European Stroke Conference, Lisboa, May 2012
    Andrei V Alexandrov
    Comprehensive Stroke Center, University of Alabama Hospital, Birmingham, AL 35249, USA
    Cerebrovasc Dis 35:202-8. 2013
    ..PRESENTATION METHODS: Commonly, presentations at major conferences include podium (oral, platform), poster or lecture, and if selected one should be prepared to..
  8. doi request reprint CLOTBUST-hands free: initial safety testing of a novel operator-independent ultrasound device in stroke-free volunteers
    Kristian Barlinn
    Department of Neurology, Comprehensive Stroke Center, The University of Alabama at Birmingham, RWUH M226, 619 19th St South, Birmingham, AL 35249 3280, USA
    Stroke 44:1641-6. 2013
    ..We aimed to evaluate safety and tolerability of a novel operator-independent ultrasound device among stroke-free volunteers...
  9. doi request reprint Practice standards for transcranial Doppler (TCD) ultrasound. Part II. Clinical indications and expected outcomes
    Andrei V Alexandrov
    Comprehensive Stroke Center, University of Alabama at Birmingham, Birmingham, AL 35249 3280, USA
    J Neuroimaging 22:215-24. 2012
    ....
  10. doi request reprint Taboos and opportunities in sonothrombolysis for stroke
    Andrei V Alexandrov
    Comprehensive Stroke Center, University of Alabama Hospital, Birmingham, Alabama, USA
    Int J Hyperthermia 28:397-404. 2012
    ..We also give a prospect for novel technologies such as operator-independent devices that aim to further spread the use of sonothrombolysis for stroke...
  11. ncbi request reprint Can the therapeutic window for tissue plasminogen activator be extended to 6 hours after stroke onset?
    Andrei V Alexandrov
    The Cerebrovascular Ultrasound Stroke Treatment Team, University of Texas Houston Medical School, TX 77030, USA
    Nat Clin Pract Cardiovasc Med 2:342-3. 2005
  12. ncbi request reprint Ultrasound and angiography in the selection of patients for carotid endarterectomy
    Andrei V Alexandrov
    The University of Texas Houston Medical School, MSB 7 044, 6431 Fannin Street, Houston, TX 77030, USA
    Curr Cardiol Rep 5:141-7. 2003
    ..Currently, more invasive angiograms are being performed, due to a variety of new experimental interventions such as angioplasty and stenting, a subject of current clinical trials...
  13. doi request reprint Current and future recanalization strategies for acute ischemic stroke
    A V Alexandrov
    Comprehensive Stroke Center, Neurovascular Ultrasound Laboratory, University of Alabama Hospital, Birmingham, AL, USA
    J Intern Med 267:209-19. 2010
    ..Arterial re-occlusion can occur with any of these approaches, and it remains a challenge since it leads to poor outcomes and no clinical trial data are available yet to determine safe strategies to prevent or reverse re-occlusion...
  14. doi request reprint Stroke and atherothrombosis: an update on the role of antiplatelet therapy
    Andrei V Alexandrov
    Comprehensive Stroke Center, University of Alabama, Birmingham, AL 35294 0017, USA
    Int J Stroke 3:175-81. 2008
    ..We examined current recommendations for the prevention of atherothrombotic events, focusing on the role of oral antiplatelet agents in patients with ischemic stroke...
  15. doi request reprint Suggestions for reviewing manuscripts
    Andrei V Alexandrov
    Comprehensive Stroke Center, University of Alabama Hospital, Birmingham, Ala, USA
    Cerebrovasc Dis 28:243-6. 2009
    ..REVIEW MEANS: Responsibly Evaluate, Verify and Improve the manuscript, Educate the authors and editors, and Weigh your expert opinion against the submitted work. Provide your review in a respectful, unbiased and timely manner...
  16. doi request reprint Ultrasound enhanced thrombolysis for stroke
    Andrei V Alexandrov
    Stroke Research and Neurosonology Program, Barrow Neurologic Institute, Phoenix, AZ, USA
    Int J Stroke 1:26-9. 2006
    ..Dose escalation studies of microbubbles, ultrasound exposure, and the development of an operator-independent ultrasound device are underway...
  17. ncbi request reprint Ischemic stunning of the brain: early recanalization without immediate clinical improvement in acute ischemic stroke
    Andrei V Alexandrov
    Center for Noninvasive Brain Perfusion Studies, Stroke Treatment Team, University of Texas Houston Medical School, 77030, USA
    Stroke 35:449-52. 2004
    ..Early arterial recanalization (ER) with intravenous tissue plasminogen activator (tPA) can lead to dramatic clinical recovery, whereas some patients do not experience immediate clinical improvement...
  18. ncbi request reprint CLOTBUST: design of a randomized trial of ultrasound-enhanced thrombolysis for acute ischemic stroke
    Andrei V Alexandrov
    Center for Noninvasive Brain Perfusion Studies, Stroke Treatment Team, University of Texas Houston Medical School, Houston, TX, USA
    J Neuroimaging 14:108-12. 2004
    ....
  19. ncbi request reprint Advances in neurosonology 2005
    Andrei V Alexandrov
    Stroke Research and Neurosonology Program, Barrow Neurological Institute, Phoenix, AZ 85013, USA
    Stroke 37:299-300. 2006
  20. doi request reprint Ultrasound enhancement of fibrinolysis
    Andrei V Alexandrov
    RWUH M226 619, 19th St S, Birmingham, AL 35249 3280, USA
    Stroke 40:S107-10. 2009
    ..Transcranial ultrasound delivery in an operator-independent and dose-controlled manner is being tested in a clinical trial...
  21. doi request reprint Use of neuroimaging in acute stroke trials
    Andrei V Alexandrov
    Comprehensive Stroke Center, University of Alabama Hospital, M226 RWUH 619 19th Street South, Birmingham, AL 35249, USA
    Expert Rev Neurother 9:885-95. 2009
    ..This article summarizes the neuroimaging techniques available currently and describes the new developments in acute stroke treatment trials...
  22. ncbi request reprint Ultrasound identification and lysis of clots
    Andrei V Alexandrov
    Department of Neurology and Radiology, Cerebrovascular Ultrasound and Center for Noninvasive Brain Perfusion Studies, Stroke Treatment Team, The University of Texas Houston Medical School, Houston, Texas, USA
    Stroke 35:2722-5. 2004
    ..Early brain perfusion augmentation, complete recanalization, and dramatic clinical recovery are feasible goals for ultrasound-enhanced thrombolysis...
  23. ncbi request reprint Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke
    Andrei V Alexandrov
    Stroke Treatment Team, University of Texas Houston Medical School, Houston 77030, USA
    N Engl J Med 351:2170-8. 2004
    ..Our objective was to determine whether ultrasonography can safely enhance the thrombolytic activity of t-PA...
  24. doi request reprint Prevalence and risk factors associated with reversed Robin Hood syndrome in acute ischemic stroke
    Andrei V Alexandrov
    Comprehensive Stroke Center Neurology, The University of Alabama at Birmingham, RWUH M226, 619 19th Street South, Birmingham, AL 35249 3280, USA
    Stroke 40:2738-42. 2009
    ..We describe a hemodynamic steal and associated neurological deterioration, the reversed Robin Hood syndrome (RRHS). We aimed to investigate the frequency and factors associated with RRHS...
  25. doi request reprint Slow recruitment in clinical trials: failure is not an option!
    Andrei V Alexandrov
    Stroke Research and Neurosonology Program, Barrow Neurological Institute, Suite 300 Neurology, 500 West Thomas Rd, Phoenix, AZ 85013, USA
    Int J Stroke 1:160. 2006
  26. ncbi request reprint Ultrasound-enhanced thrombolysis for stroke: clinical significance
    Andrei V Alexandrov
    Department of Neurology and Radiology, Houston Medical School, The University of Texas, MSB 7044 6431 Fannin Street, Houston, TX 77030, USA
    Eur J Ultrasound 16:131-40. 2002
    ..Dramatic clinical recovery from stroke and complete recanalization shortly after TPA bolus are feasible goals for thrombolysis assisted with TCD monitoring...
  27. doi request reprint Priorities in stroke research: a US perspective
    Andrei V Alexandrov
    Comprehensive Stroke Center, University of Alabama at Birmingham, Birmingham, AL, USA
    Int J Stroke 3:14-5. 2008
  28. doi request reprint Velocity criteria for intracranial stenosis revisited: an international multicenter study of transcranial Doppler and digital subtraction angiography
    LiMin Zhao
    Comprehensive Stroke Center, University of Alabama Hospital, 619 19th Street South, Birmingham, AL 35249, USA
    Stroke 42:3429-34. 2011
    ..Intracranial atherosclerotic disease is associated with a high risk of stroke recurrence. We aimed to determine accuracy of transcranial Doppler screening at laboratories that share the same standardized scanning protocol...
  29. ncbi request reprint Insonation method and diagnostic flow signatures for transcranial power motion (M-mode) Doppler
    Andrei V Alexandrov
    Center for Noninvasive Brain Perfusion Studies, Stroke Treatment Team, University of Texas Houston Medical School, Houston, TX, USA
    J Neuroimaging 12:236-44. 2002
    ..Insonation protocol for PMD and spectral transcranial Doppler (TCD) with typical PMD flow signatures is described in serial patients with acute stroke symptoms examined via conventional windows with a PMD/TCD unit...
  30. ncbi request reprint Practice standards for transcranial Doppler ultrasound: part I--test performance
    Andrei V Alexandrov
    Barrow Neurological Institute, Phoenix, AZ 85013, USA
    J Neuroimaging 17:11-8. 2007
    ....
  31. ncbi request reprint Ultrasound-enhanced thrombolysis for acute ischemic stroke: phase I. Findings of the CLOTBUST trial
    Andrei V Alexandrov
    Center for Noninvasive Brain Perfusion Studies, Stroke Treatment Team, University of Texas Houston Medical School, Houston, TX, USA
    J Neuroimaging 14:113-7. 2004
    ..The authors present Phase I data of the CLOTBUST (Combined Lysis of Thrombus in Brain ischemia using transcranial Ultrasound and Systemic TPA)...
  32. pmc A pilot randomized clinical safety study of sonothrombolysis augmentation with ultrasound-activated perflutren-lipid microspheres for acute ischemic stroke
    Andrei V Alexandrov
    Comprehensive Stroke Center Neurology, The University of Alabama at Birmingham, RWUH M226, 619 19th St South, Birmingham, AL 35249 3280, USA
    Stroke 39:1464-9. 2008
    ..Ultrasound transiently expands perflutren-lipid microspheres (muS), transmitting energy momentum to surrounding fluids. We report a pilot safety/feasibility study of ultrasound-activated muS with systemic tissue plasminogen activator (tPA)...
  33. ncbi request reprint The Spencer's Curve: clinical implications of a classic hemodynamic model
    Andrei V Alexandrov
    Stroke Research and Neurosonology Program, Barrow Neurological Institute, Phoenix, AZ 85013, USA
    J Neuroimaging 17:6-10. 2007
    ....
  34. ncbi request reprint Yield of transcranial Doppler in acute cerebral ischemia
    A V Alexandrov
    Center for Noninvasive Brain Perfusion Studies and the Stroke Treatment Team, University of Texas Houston Medical School, USA
    Stroke 30:1604-9. 1999
    ..The objective of this study was to evaluate the yield of emergent transcranial Doppler (TCD) for the evaluation of acute cerebral ischemia...
  35. ncbi request reprint High rate of complete recanalization and dramatic clinical recovery during tPA infusion when continuously monitored with 2-MHz transcranial doppler monitoring
    A V Alexandrov
    Center for Noninvasive Brain Perfusion Studies, Stroke Treatment Team, University of Texas Houston Medical School, USA
    Stroke 31:610-4. 2000
    ..Transcranial Doppler (TCD) with low MHz frequency can determine arterial occlusion and monitor recanalization and may potentiate thrombolysis...
  36. ncbi request reprint Speed of intracranial clot lysis with intravenous tissue plasminogen activator therapy: sonographic classification and short-term improvement
    A V Alexandrov
    Center for Noninvasive Brain Perfusion Studies, Stroke Treatment Team, University of Texas Houston Medical School, Houston, Texas, USA
    Circulation 103:2897-902. 2001
    ..Arterial recanalization precedes clinical improvement or may lead to hemorrhage or reperfusion injury. Speed of clot lysis was not previously measured in human stroke...
  37. ncbi request reprint Arterial status after intravenous TPA therapy for ischaemic stroke. A need for further interventions
    I Christou
    Center for Noninvasive Brain Perfusion Studies, Stroke Treatment Team, University of Texas Houston Medical School, Houston, Texas, USA
    Int Angiol 20:208-13. 2001
    ..Intravenous tissue plasminogen activator (TPA) is an approved therapy for acute ischaemic stroke in the United States. We aimed to noninvasively monitor the therapy to determine arterial recanalisation and persisting vascular abnormalities...
  38. ncbi request reprint Intravenous tissue-type plasminogen activator therapy for ischemic stroke: Houston experience 1996 to 2000
    J C Grotta
    Stroke Treatment Team, University of Texas Houston Medical School, Box 7 044, 6431 Fannin St, Houston, TX 77030, USA
    Arch Neurol 58:2009-13. 2001
    ..Our center is experienced in treating large numbers of stroke patients with intravenous tPA...
  39. ncbi request reprint Is the benefit of early recanalization sustained at 3 months? A prospective cohort study
    Lise A Labiche
    Center for Noninvasive Brain Perfusion Studies, Stroke Program, University of Texas, Houston Medical School, Houston, USA
    Stroke 34:695-8. 2003
    ..Early arterial recanalization can lead to dramatic recovery (DR) during intravenous tissue plasminogen activator (tPA) therapy. However, it remains unclear whether this clinical recovery is sustained 3 months after stroke...
  40. ncbi request reprint tPA-associated reperfusion after acute stroke demonstrated by SPECT
    J C Grotta
    Department of Neurology, University of Texas Health Science Center, Houston 77030, USA
    Stroke 29:429-32. 1998
    ....
  41. ncbi request reprint Effect of body positioning during transcranial Doppler detection of right-to-left shunts
    A Y Lao
    Neurosonology and Stroke Research Program, Barrow Neurological Institute, Phoenix, AZ, USA
    Eur J Neurol 14:1035-9. 2007
    ..However, if microB are detected in the supine position, additional testing for RLS in alternative positions may be found to be worthwhile...
  42. doi request reprint Ultrasound enhanced thrombolysis in acute arterial ischemia
    Georgios Tsivgoulis
    Comprehensive Stroke Center, Department of Neurology, University of Alabama at Birmingham, Suite 226, RWUHM, 1719 6th Avenue South, Birmingham, AL 35294, USA
    Ultrasonics 48:303-11. 2008
    ..Multi-national dose escalation studies of microspheres and the development of an operator independent ultrasound device are underway...
  43. ncbi request reprint Early dramatic recovery during intravenous tissue plasminogen activator infusion: clinical pattern and outcome in acute middle cerebral artery stroke
    Robert A Felberg
    Stroke Program, Department of Neurology, University of Texas Houston Medical School, USA
    Stroke 33:1301-7. 2002
    ..The prevalence, clinical characteristics, and outcome of patients experiencing dramatic recovery is not well described...
  44. ncbi request reprint Thrombotic occlusion of the common carotid artery (CCA) in acute ischemic stroke treated with intravenous tissue plasminogen activator (TPA)
    V K Sharma
    Department of Neurology, Barrow Neurological Institute, Phoenix, AZ 85013, USA
    Eur J Neurol 14:237-40. 2007
    ..Recanalization occurred in intracranial vessels only. Marked early neurological improvement occurred in two of three patients. CCA occlusions should not be considered contra-indication to systemic thrombolysis...
  45. ncbi request reprint Brain single-photon emission CT with HMPAO and safety of thrombolytic therapy in acute ischemic stroke. Proceedings of the meeting of the SPECT Safe Thrombolysis Study Collaborators and the members of the Brain Imaging Council of the Society of Nuclear Me
    A V Alexandrov
    University of Texas, Houston 77030, USA
    Stroke 28:1830-4. 1997
    ....
  46. ncbi request reprint Acute stroke: therapeutic transcranial Doppler sonography
    R Mikulik
    Department of Neurology, University of Texas Health Science Center at Houston, 77030, USA
    Front Neurol Neurosci 21:150-61. 2006
    ..Also, the potential enhancement of sonothrombolysis with microbubbles is discussed...
  47. ncbi request reprint Heads down: flat positioning improves blood flow velocity in acute ischemic stroke
    Anne W Wojner-Alexander
    Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Neurology 64:1354-7. 2005
    ..Acute stroke patients are routinely positioned with the head of the bed (HOB) elevated at 30 degrees despite lack of evidence for increased intracranial pressure...
  48. doi request reprint Safety and efficacy of ultrasound-enhanced thrombolysis: a comprehensive review and meta-analysis of randomized and nonrandomized studies
    Georgios Tsivgoulis
    Comprehensive Stroke Center, Department of Neurology, University of Alabama at Birmingham Hospital, Birmingham, Ala 35294 3280, USA
    Stroke 41:280-7. 2010
    ..We performed a meta-analysis to evaluate the safety and efficacy of ultrasound-enhanced thrombolysis compared to the current standard of care (intravenous tPA)...
  49. doi request reprint Quantification of microspheres appearance in brain vessels: implications for residual flow velocity measurements, dose calculations, and potential drug delivery
    Vijay K Sharma
    Comprehensive Stroke Center, University of Alabama at Birmingham, AL 35249 3280, USA
    Stroke 39:1476-81. 2008
    ..Characteristics of ultrasound-activated gaseous microspheres (muS) reflective of their size and quantities are needed for future dose-escalation and drug delivery trials...
  50. ncbi request reprint Intravenous tissue plasminogen activator and flow improvement in acute ischemic stroke patients with internal carotid artery occlusion
    Ioannis Christou
    Department of Neurology, University of Texas Houston Medical School, 6431 Fannin, MSB 7 044, Houston, TX 77030, USA
    J Neuroimaging 12:119-23. 2002
    ..Vascular imaging, safety, and outcome of TPA therapy for ICA occlusion is not well described. Our goal was to determine the site of occlusion, early recanalization after TPA infusion, and its relationship to outcome...
  51. ncbi request reprint Safety and feasibility of a lower dose intravenous TPA therapy for ischemic stroke beyond the first three hours
    Ken Uchino
    Stroke Program, Department of Neurology, University of Texas Houston Medical School, USA
    Cerebrovasc Dis 19:260-6. 2005
    ..The risk/benefit ratio is more unfavorable beyond this time, but some patients might still benefit. We designed a pilot study with the hypothesis that lower dose TPA might be safe in selected patients treated beyond 3 h...
  52. doi request reprint Safety and dose-escalation study design of Transcranial Ultrasound in Clinical SONolysis for acute ischemic stroke: the TUCSON Trial
    Andrew D Barreto
    Department of Neurology, University of Texas Houston Stroke Team, Houston, TX, USA
    Int J Stroke 4:42-8. 2009
    ..The signal-of-efficacy is determined by rates of recanalization, dramatic or early clinical recovery within 2 h, clinical recovery at 24-36 h and independent outcome (mRS 0-2) at 90 days...
  53. ncbi request reprint Thrombolysis, stroke units and other strategies for reducing acute stroke costs
    T H Wein
    Department of Neurology, University of Texas Houston Medical School, USA
    Pharmacoeconomics 14:603-11. 1998
    ..Because only a minority of patients who have a stroke are currently eligible for thrombolysis, implementation of specialised and standardised stroke care may further enhance cost benefits and improve patient outcomes...
  54. ncbi request reprint Thrombolytic therapy in an adolescent ischemic stroke
    E A Noser
    Department of Neurology, University of Texas Houston Medical School, 77030 1501, USA
    J Child Neurol 16:286-8. 2001
    ..This case illustrates the importance of early recognition of stroke and the utility of thrombolytics in treating ischemic infarcts in the adolescent population...
  55. ncbi request reprint Aggressive mechanical clot disruption: a safe adjunct to thrombolytic therapy in acute stroke?
    Elizabeth A Noser
    Department of Neurology, University of Texas Houston Medical School, USA
    Stroke 36:292-6. 2005
    ..This study evaluated the safety and efficacy of aggressive mechanical clot disruption (AMCD) in acute stroke patients with persisting middle cerebral artery (MCA) or internal carotid artery (ICA) occlusion after thrombolytic therapy...
  56. ncbi request reprint Grading carotid stenosis with ultrasound. An interlaboratory comparison
    A V Alexandrov
    Center for Noninvasive Brain Perfusion Studies, University of Texas Houston Medical School 77030, USA
    Stroke 28:1208-10. 1997
    ..We compared the performance of two independent laboratories using similar equipment (ATL-HDI Ultramark 9) but different interpretation criteria...
  57. ncbi request reprint A broad diagnostic battery for bedside transcranial Doppler to detect flow changes with internal carotid artery stenosis or occlusion
    I Christou
    Center for Noninvasive Brain Perfusion Studies, Stroke Program, University of Texas-Houston, USA
    J Neuroimaging 11:236-42. 2001
    ....
  58. ncbi request reprint Predictors of tube feeding in acute stroke patients with dysphagia
    A W Wojner
    School of Nursing, Department of Neurology, University of Texas at Houston, Houston, Texas, USA
    AACN Clin Issues 11:531-40. 2000
    ..Findings from this study may assist healthcare providers in the early identification of stroke patients at risk for clinically significant neurogenic oropharyngeal dysphagia, facilitating reduction of untoward outcomes...
  59. ncbi request reprint Outcome in hyperglycemic stroke with ultrasound-augmented thrombolytic therapy
    S R Martini
    Department of Neurology, Baylor College of Medicine and the Michael E DeBakey Veterans Affairs Medical Center Stroke Program, Houston, TX 77030, USA
    Neurology 67:700-2. 2006
    ..We found that ultrasound's benefit on 90-day outcome was primarily apparent at higher glucose levels, suggesting that ultrasound therapy may improve outcome following hyperglycemic stroke...
  60. ncbi request reprint Correlation of peak systolic velocity and angiographic measurement of carotid stenosis revisited
    A V Alexandrov
    Neurovascular Doppler Laboratory, Sunnybrook Health Science Center, University of Toronto, Canada
    Stroke 28:339-42. 1997
    ..We compared PSV and angiographic measurements at our center together with known physiological relationships to investigate the accuracy of ultrasound...
  61. doi request reprint Sonothrombolysis in the management of acute ischemic stroke
    Marta Rubiera
    Comprehensive Stroke Center, University of Alabama Hospital, Birmingham, Alabama, USA
    Am J Cardiovasc Drugs 10:5-10. 2010
    ..Operator-independent devices, different MB-related techniques, and other ultrasound parameters for improving and spreading sonothrombolysis are being tested...
  62. doi request reprint Association of pretreatment ASPECTS scores with tPA-induced arterial recanalization in acute middle cerebral artery occlusion
    Georgios Tsivgoulis
    Neurosonology and Stroke Research Program, Barrow Neurological Institute, Phoenix, Arizona, USA
    J Neuroimaging 18:56-61. 2008
    ..We evaluated the potential relationship between pretreatment ASPECTS and tPA-induced recanalization in patients with MCA occlusions...
  63. ncbi request reprint Arterial reocclusion in stroke patients treated with intravenous tissue plasminogen activator
    Andrei V Alexandrov
    Stroke Treatment Team, University of Texas Houston Medical School, Houston, TX 77030, USA
    Neurology 59:862-7. 2002
    ....
  64. ncbi request reprint Detection of reversed basilar flow with power-motion Doppler after acute occlusion predicts favorable outcome
    Marc Ribo
    Stroke Treatment Team, Medical School, The University of Texas Houston, USA
    Stroke 35:79-82. 2004
    ..We aimed to determine clinical significance of PMD-TCD demonstration of reversed basilar flow in patients with basilar artery (BA) occlusion...
  65. ncbi request reprint Residual flow signals predict complete recanalization in stroke patients treated with TPA
    Lise A Labiche
    Stroke Program, University of Texas Medical School at Houston, TX, USA
    J Neuroimaging 13:28-33. 2003
    ..The authors aimed to correlate the presence of residual flow signals in the middle cerebral artery (MCA) with completeness of recanalization after intravenous tissue plasminogen activator (TPA)...
  66. ncbi request reprint Intravenous TPA for very old stroke patients
    Chin I Chen
    Stroke Treatment Team, The University of Texas, Houston, USA
    Eur Neurol 54:140-4. 2005
    ..We studied safety and recanalization/recovery in patients older than 80 years treated with TPA and compared them with younger stroke patients...
  67. ncbi request reprint Houston paramedic and emergency stroke treatment and outcomes study (HoPSTO)
    Anne W Wojner-Alexandrov
    Department of Neurology, University of Texas Houston, Houston, TX 77030, USA
    Stroke 36:1512-8. 2005
    ..We wanted to measure and improve paramedic and hospital performance through implementation of the Brain Attack Coalition and American Stroke Association guidelines...
  68. ncbi request reprint Aortic dissection presenting as an acute ischemic stroke for thrombolysis
    Ken Uchino
    Department of Neurology, University of Texas Houston Medical School, Houston, TX, USA
    J Neuroimaging 15:281-3. 2005
    ..An experienced sonographer with skills to perform rapid intra- and extracranial examinations may help to change the treatment plan for acute stroke patients...
  69. ncbi request reprint How to write a research paper
    Andrei V Alexandrov
    Stroke Treatment Team, Houston Medical School, University of Texas, Houston, TX 77030, USA
    Cerebrovasc Dis 18:135-8. 2004
    ..They sometimes develop a mental condition equivalent to that known by neurologists as writer's cramp. It may result in permanent damage to academic career. This paper provides advice how to prevent or treat this condition...
  70. ncbi request reprint Effect of head positioning on intracranial blood flow velocities in acute ischemic stroke: a pilot study
    Anne W Wojner
    Department of Neurology, University of Texas Houston Medical School, USA
    Crit Care Nurs Q 24:57-66. 2002
    ....
  71. ncbi request reprint Association of pretreatment blood pressure with tissue plasminogen activator-induced arterial recanalization in acute ischemic stroke
    Georgios Tsivgoulis
    Neurosonology and Stroke Research Program, Barrow Neurological Institute, Phoenix, Arizona, USA
    Stroke 38:961-6. 2007
    ..We aimed to evaluate the potential relationship between pretreatment SBP and tPA-induced recanalization...
  72. ncbi request reprint Telemedicine-guided carotid and transcranial ultrasound: a pilot feasibility study
    Robert Mikulik
    Department of Neurology, University of Texas Health Science Center, Houston, TX 77030, USA
    Stroke 37:229-30. 2006
    ..We explored the feasibility of telemedicine (TM)-guided TCD/CD administered by a health care provider inexperienced with ultrasound...
  73. doi request reprint End-diastolic velocity increase predicts recanalization and neurological improvement in patients with ischemic stroke with proximal arterial occlusions receiving reperfusion therapies
    Andrei V Alexandrov
    Comprehensive Stroke Center, University of Alabama at Birmingham Hospital, Birmingham, Alabama, USA
    Stroke 41:948-52. 2010
    ..We sought to investigate which flow velocity parameter was associated with complete recanalization/reperfusion and neurological improvement in patients receiving reperfusion therapies...
  74. doi request reprint Applications and advantages of power motion-mode Doppler in acute posterior circulation cerebral ischemia
    Georgios Tsivgoulis
    Comprehensive Stroke Center, University of Alabama at Birmingham Hospital RWUH M226, 619 19th St S, Birmingham, AL 35294, USA
    Stroke 39:1197-204. 2008
    ..We aimed to evaluate the diagnostic accuracy of PMD-TCD against angiography in detection of acute posterior circulation stenoocclusive disease...
  75. ncbi request reprint Argatroban tPA stroke study: study design and results in the first treated cohort
    Rebecca M Sugg
    Department of Neurology, University of Texas Houston Medical School, 6431 Fannin, Houston, TX 77030, USA
    Arch Neurol 63:1057-62. 2006
    ..Argatroban is a direct thrombin inhibitor that safely augments the benefit of rtPA in animal stroke models. There are no human data on this combination...
  76. ncbi request reprint Yield and accuracy of urgent combined carotid/transcranial ultrasound testing in acute cerebral ischemia
    Oleg Y Chernyshev
    Stroke Treatment Team, University of Texas Houston, Texas 77005, USA
    Stroke 36:32-7. 2005
    ..We aimed to determine the yield and accuracy of NVUE to identify lesions amenable for interventional treatment (LAITs)...
  77. ncbi request reprint Ultrasound-enhanced thrombolysis in acute ischemic stroke: potential, failures, and safety
    Georgios Tsivgoulis
    Comprehensive Stroke Center, Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Neurotherapeutics 4:420-7. 2007
    ..7-2.1 MHz pulsed-wave ultrasound (EKOS catheter). Multinational dose escalation studies of microspheres and the development of an operator-independent ultrasound device are underway...
  78. ncbi request reprint Revascularization grading in endovascular acute ischemic stroke therapy
    O O Zaidat
    Department of Neurology, Medical College of Wisconsin Froedtert Hospital, Milwaukee, WI, USA
    Neurology 79:S110-6. 2012
    ..It is anticipated that clinical efficacy will be well correlated with revascularization of viable tissue in a timely manner...
  79. doi request reprint Association of reversed Robin Hood syndrome with risk of stroke recurrence
    P Palazzo
    Comprehensive Stroke Center Neurology, The University of Alabama at Birmingham, RWUH M226, 619 19 St, South Birmingham, AL 35249 3280, USA
    Neurology 75:2003-8. 2010
    ..We sought to investigate the association of RRHS with risk of stroke recurrence in a single-center cohort study...
  80. doi request reprint A spectrum of knock-type Doppler signals in the intracranial vessels
    Georgios Tsivgoulis
    Department of Neurology, Comprehensive Stroke Center, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Stroke 40:644-7. 2009
    ..However, the nature of KTDS has not been prospectively defined. We aimed at describing the spectral and power motion Doppler characteristics of KTDS and ultrasound exposure conditions that lead to their appearance...
  81. ncbi request reprint Painless aortic dissection with unusual extension into intracranial internal carotid arteries
    Iyadurai Stanley
    Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA
    Cerebrovasc Dis 24:314-5. 2007
  82. doi request reprint Perfusion augmentation in acute stroke using mechanical counter-pulsation-phase IIa: effect of external counterpulsation on middle cerebral artery mean flow velocity in five healthy subjects
    Anne W Alexandrov
    Comprehensive Stroke Center, University of Alabama, Birmingham, AL 35249 3280, USA
    Stroke 39:2760-4. 2008
    ..We sought to determine ECPs effect on middle cerebral artery (MCA) blood flow augmentation in normal controls as a first step to support future clinical trials in acute stroke...
  83. doi request reprint Diagnostic criteria and yield of real-time transcranial Doppler monitoring of intra-arterial reperfusion procedures
    Marta Rubiera
    Comprehensive Stroke Center, University of Alabama Hospital, Birmingham, AL, USA
    Stroke 41:695-9. 2010
    ..We implemented continuous transcranial Doppler (TCD) monitoring during these procedures to detect any potentially harmful flow changes. Here, we report diagnostic criteria and yield of TCD monitoring...
  84. pmc Association of higher diastolic blood pressure levels with cognitive impairment
    G Tsivgoulis
    Comprehensive Stroke Center, University of Alabama at Birmingham, RWUH M226, 1530 3rd Avenue S, Birmingham, AL 35294 3280, USA
    Neurology 73:589-95. 2009
    ..We evaluated the cross-sectional relationship of blood pressure (BP) components with cognitive impairment after adjusting for potential confounders...
  85. ncbi request reprint Citicoline. Ferrer Internacional
    A V Alexandrov
    Department of Neurology, University of Texas, Houston 77030, USA
    Curr Opin Investig Drugs 2:1757-62. 2001
    ..In December 1999, US rights to the commercialization of citicoline were licensed to Takeda...
  86. ncbi request reprint Noninvasive detection of diffuse intracranial disease
    Vijay K Sharma
    Neurosonology and Stroke Research Program, Barrow Neurological Institute, Phoenix, Arizona, USA
    Stroke 38:3175-81. 2007
    ..We assessed the frequency and accuracy for detection of focal and diffuse intracranial stenoses using novel diagnostic criteria that take into account increased resistance to flow with widespread lesions...
  87. doi request reprint Detection of right-to-left shunts: comparison between the International Consensus and Spencer Logarithmic Scale criteria
    Annabelle Y Lao
    Neurosonology and Stroke Research Program, Barrow Neurological Institute, Phoenix, AZ 85013, USA
    J Neuroimaging 18:402-6. 2008
    ..Spencer Logarithmic Scale (SLS) offers more grades of RLS with detection of >30 microB corresponding to a large shunt. We compared the yield of ICC and SLS in detection and quantification of a large RLS...
  88. doi request reprint Intravenous thrombolysis followed by intra-arterial thrombolysis and mechanical thrombectomy for the treatment of pediatric ischemic stroke
    Georgios Tsivgoulis
    Comprehensive Stroke Center, Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Neurol Sci 275:151-3. 2008
    ..Combined systemic and intra-arterial thrombolysis followed by mechanical thrombectomy can be feasible and may be considered as means of achieving reperfusion in pediatric ischemic stroke patients with persisting arterial occlusion...
  89. doi request reprint Safety and tolerability of early noninvasive ventilatory correction using bilevel positive airway pressure in acute ischemic stroke
    Georgios Tsivgoulis
    Comprehensive Stroke Center, University of Alabama at Birmingham Hospital, Birmingham, AL, USA
    Stroke 42:1030-4. 2011
    ..We sought to determine safety and tolerability of NIVC initiated on hospital admission without polysomnography study...
  90. ncbi request reprint Intracranial balloon angioplasty of acute terminal internal carotid artery occlusions
    Joon K Song
    Division of Interventional Neuroradiology, University of Texas Medical School, Houston 77030, USA
    AJNR Am J Neuroradiol 23:1308-12. 2002
    ..At 1-month follow-up, both patients were alive with neurologic deficits. For acute carotid T occlusion, balloon angioplasty should be considered a first-line endovascular therapy...
  91. ncbi request reprint Analysis of emboli during carotid stenting with distal protection device
    Chin I Chen
    Stroke Treatment Team, University of Texas, Houston, USA
    Cerebrovasc Dis 21:223-8. 2006
    ..Our goal was to apply this technology to initially characterize emboli detected during carotid stenting with distal protection...
  92. ncbi request reprint The accuracy of transcranial Doppler in the diagnosis of stenosis or occlusion of the terminal internal carotid artery
    Jose C Navarro
    University of Santo Tomas, Espana, Manila, Philippines
    J Neuroimaging 14:314-8. 2004
    ..The accuracy parameters for lesions located in the terminal internal carotid artery (TICA) are less known, unlike other basal cerebral vessels...
  93. ncbi request reprint Highlights of the guidelines for screening of extracranial carotid artery disease: a statement for healthcare professionals from the Multidisciplinary Practice Guidelines Committee of the American Society of Neuroimaging; cosponsored by the Society of Vas
    Adnan I Qureshi
    Zeenat Qureshi Stroke Research Center, University of Minnesota, Minneapolis 55415
    J Endovasc Ther 14:469-74. 2007
  94. ncbi request reprint Reversed Robin Hood syndrome in acute ischemic stroke patients
    Andrei V Alexandrov
    Stroke 38:3045-8. 2007
    ..Recurrent hemodynamic and neurological changes with persisting arterial occlusions may be attributable to cerebral blood flow steal from ischemic to nonaffected brain...
  95. ncbi request reprint Therapeutic applications of transcranial ultrasound devices
    Andrei V Alexandrov
    Expert Rev Med Devices 4:1-3. 2007
  96. ncbi request reprint Accuracy of serial National Institutes of Health Stroke Scale scores to identify artery status in acute ischemic stroke
    Robert Mikulik
    Department of Neurology, University of Texas Health Science Center at Houston, USA
    Circulation 115:2660-5. 2007
    ..We sought to determine the accuracy of serial National Institutes of Health Stroke Scale (NIHSS) scores to detect complete early recanalization of the middle cerebral artery...
  97. ncbi request reprint Screening for intracranial stenosis with transcranial Doppler: the accuracy of mean flow velocity thresholds
    Robert A Felberg
    Stroke Program, Department of Neurology, Ochsner Foundation Clinic and Hospital, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    J Neuroimaging 12:9-14. 2002
    ..Transcranial Doppler (TCD) is a convenient noninvasive screen for intracranial stenosis. The accuracy of different mean flow velocity (MFV) thresholds for determining the degree of stenosis remains uncertain...
  98. ncbi request reprint Derivation of power M-mode transcranial Doppler criteria for angiographic proven MCA occlusion
    Maher Saqqur
    Department of Medicine, University of Alberta, Alberta, Canada
    J Neuroimaging 16:323-8. 2006
    ..Stringent transcranial Doppler (TCD) criteria for diagnosing occlusion are needed for more reliable TCD performance at bedside in the acute stroke setting...
  99. doi request reprint Acute stroke imaging research roadmap
    Max Wintermark
    University of California, San Francisco, Department of Radiology, Neuroradiology Section, 505 Parnassus Avenue, Box 0628, San Francisco, CA 94143 0628, USA
    Stroke 39:1621-8. 2008
    ..The present article summarizes these recommendations and examines practical steps to achieve them...
  100. ncbi request reprint Nonpulsatile cerebral perfusion in patient with acute neurological deficits
    Yo Sik Kim
    Department of Neurology, Wonkwang University School of Medicine, Jeonbuk, Korea
    Stroke 37:1562-4. 2006
    ..We report a patient who had complete recovery from initial neurological deficits in spite of nonpulsatile perfusion in the middle cerebral artery...