Allan R Shepard

Summary

Affiliation: Alcon Research
Country: USA

Publications

  1. pmc Characterization of rabbit myocilin: Implications for human myocilin glycosylation and signal peptide usage
    Allan R Shepard
    Alcon Research, Ltd, 6201 South Freeway, Fort Worth, TX 76134, USA
    BMC Genet 4:5. 2003
  2. ncbi Importance of quantitative PCR primer location for short interfering RNA efficacy determination
    Allan R Shepard
    Glaucoma Research, Alcon Research Ltd, Fort Worth, TX 76134, USA
    Anal Biochem 344:287-8. 2005
  3. ncbi Glaucoma-causing myocilin mutants require the Peroxisomal targeting signal-1 receptor (PTS1R) to elevate intraocular pressure
    Allan R Shepard
    Glaucoma Research, Alcon Research, Ltd, Fort Worth, TX 76134, USA
    Hum Mol Genet 16:609-17. 2007
  4. doi Adenoviral gene transfer of active human transforming growth factor-{beta}2 elevates intraocular pressure and reduces outflow facility in rodent eyes
    Allan R Shepard
    Alcon Research, Ltd, Fort Worth, Texas, USA
    Invest Ophthalmol Vis Sci 51:2067-76. 2010
  5. ncbi TGFbeta2-induced changes in human trabecular meshwork: implications for intraocular pressure
    Debra L Fleenor
    Glaucoma Research, Alcon Research, Ltd, Fort Worth, Texas 76134, USA
    Invest Ophthalmol Vis Sci 47:226-34. 2006
  6. ncbi Evaluation of inducible nitric oxide synthase in glaucomatous optic neuropathy and pressure-induced optic nerve damage
    Iok Hou Pang
    Alcon Research, Ltd, Fort Worth, Texas, USA
    Invest Ophthalmol Vis Sci 46:1313-21. 2005
  7. ncbi Corneal wound healing in New Zealand White Rabbits following anterior keratectomy and treatment with moxifloxacin ophthalmic solution 0.5% or gatifloxacin ophthalmic solution 0.3%
    K Keven Williams
    Alcon Research, Ltd, Forth Worth, TX 76134, USA
    J Ocul Pharmacol Ther 23:517-25. 2007
  8. doi Identification of PDE6D as a molecular target of anecortave acetate via a methotrexate-anchored yeast three-hybrid screen
    Allan R Shepard
    Alcon, A Novartis Company, Fort Worth, TX 76134, USA
    ACS Chem Biol 8:549-58. 2013

Detail Information

Publications8

  1. pmc Characterization of rabbit myocilin: Implications for human myocilin glycosylation and signal peptide usage
    Allan R Shepard
    Alcon Research, Ltd, 6201 South Freeway, Fort Worth, TX 76134, USA
    BMC Genet 4:5. 2003
    ..To better understand the role myocilin plays in steroid-induced glaucoma and open-angle glaucoma, we examined rabbit myocilin for use in the rabbit animal model of steroid-induced glaucoma...
  2. ncbi Importance of quantitative PCR primer location for short interfering RNA efficacy determination
    Allan R Shepard
    Glaucoma Research, Alcon Research Ltd, Fort Worth, TX 76134, USA
    Anal Biochem 344:287-8. 2005
  3. ncbi Glaucoma-causing myocilin mutants require the Peroxisomal targeting signal-1 receptor (PTS1R) to elevate intraocular pressure
    Allan R Shepard
    Glaucoma Research, Alcon Research, Ltd, Fort Worth, TX 76134, USA
    Hum Mol Genet 16:609-17. 2007
    ..This is the first demonstration of a disease resulting from mutation-induced exposure of a cryptic signaling site that causes mislocalization of mutant protein to peroxisomes and the first disease-gene-based animal model of human POAG...
  4. doi Adenoviral gene transfer of active human transforming growth factor-{beta}2 elevates intraocular pressure and reduces outflow facility in rodent eyes
    Allan R Shepard
    Alcon Research, Ltd, Fort Worth, Texas, USA
    Invest Ophthalmol Vis Sci 51:2067-76. 2010
    ..0001). Conclusions. The adenoviral TGFbeta2 rodent model displays the glaucoma risk factors of elevated IOP and decreased aqueous outflow facility and may potentially serve as a model for studying glaucoma...
  5. ncbi TGFbeta2-induced changes in human trabecular meshwork: implications for intraocular pressure
    Debra L Fleenor
    Glaucoma Research, Alcon Research, Ltd, Fort Worth, Texas 76134, USA
    Invest Ophthalmol Vis Sci 47:226-34. 2006
    ..This study was undertaken to investigate effects of TGFbeta2 on secretion of fibronectin and the protease inhibitor plasminogen activator inhibitor (PAI)-1 from human TM cell cultures and perfused human ocular anterior segments...
  6. ncbi Evaluation of inducible nitric oxide synthase in glaucomatous optic neuropathy and pressure-induced optic nerve damage
    Iok Hou Pang
    Alcon Research, Ltd, Fort Worth, Texas, USA
    Invest Ophthalmol Vis Sci 46:1313-21. 2005
    ..To determine whether inducible nitric oxide synthase (NOS-2) is involved in glaucomatous optic neuropathy...
  7. ncbi Corneal wound healing in New Zealand White Rabbits following anterior keratectomy and treatment with moxifloxacin ophthalmic solution 0.5% or gatifloxacin ophthalmic solution 0.3%
    K Keven Williams
    Alcon Research, Ltd, Forth Worth, TX 76134, USA
    J Ocul Pharmacol Ther 23:517-25. 2007
    ..5% as base or gatifloxacin 0.3% ophthalmic solution following anterior keratectomy...
  8. doi Identification of PDE6D as a molecular target of anecortave acetate via a methotrexate-anchored yeast three-hybrid screen
    Allan R Shepard
    Alcon, A Novartis Company, Fort Worth, TX 76134, USA
    ACS Chem Biol 8:549-58. 2013
    ..The identification of PDE6D as the molecular binding partner of AA provides insight into the role of this drug candidate in treating glaucoma...