Alcon Research

Summary

Organization: Alcon Research
Country: USA

Top Publications

  1. doi A new coordinate system convention in schematic eye modeling
    Michael J Simpson
    Alcon Laboratories Inc, Ft Worth, Texas 76134, USA
    J Refract Surg 26:780-5. 2010
  2. ncbi Self-reported visual impairment and mortality: a French nationwide perspective
    G Berdeaux
    Conservatoire National des Arts et Metiers, Paris, France
    Ophthalmic Epidemiol 14:80-7. 2007
  3. ncbi AL-34662: a potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist
    Najam A Sharif
    Ophthalmology Discovery Research, Alcon Research, Ltd, Fort Worth, TX 76134, USA
    J Ocul Pharmacol Ther 23:1-13. 2007
  4. ncbi Glaucoma-causing myocilin mutants require the Peroxisomal targeting signal-1 receptor (PTS1R) to elevate intraocular pressure
    Allan R Shepard
    Glaucoma Research, Alcon Research, Ltd, Fort Worth, TX 76134, USA
    Hum Mol Genet 16:609-17. 2007
  5. ncbi Serotonin-2 (5-HT2) receptor-mediated signal transduction in human ciliary muscle cells: role in ocular hypotension
    Najam A Sharif
    Ophthalmology Discovery Research, Alcon Research, Ltd, Fort Worth, TX 76134 2099, USA
    J Ocul Pharmacol Ther 22:389-401. 2006
  6. ncbi Preclinical pharmacology of AL-12182, a new ocular hypotensive 11-oxa prostaglandin analog
    Najam A Sharif
    Ophthalmology Discovery Research, Alcon Research, Ltd, Fort Worth, TX 76137, USA
    J Ocul Pharmacol Ther 22:291-309. 2006
  7. ncbi Adjunctive glaucoma therapy use associated with travoprost, bimatoprost, and latanoprost
    David Covert
    Alcon Research Ltd, Fort Worth, TX, USA
    Curr Med Res Opin 22:971-6. 2006
  8. ncbi Protein expression in a transformed trabecular meshwork cell line: proteome analysis
    H Thomas Steely
    Alcon Research, Ltd, Fort Worth, TX 76134, USA
    Mol Vis 12:372-83. 2006
  9. ncbi The decline of the photopic negative response (PhNR) in the rat after optic nerve transection
    B Li
    Alcon Research Ltd, Fort Worth, TX 76134, USA
    Doc Ophthalmol 111:23-31. 2005
  10. ncbi 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity
    Jesse A May
    Ophthalmology Discovery Research, Alcon Research, Ltd, 6201 South Freeway, Fort Worth, Texas 76134, USA
    J Med Chem 49:318-28. 2006

Detail Information

Publications62

  1. doi A new coordinate system convention in schematic eye modeling
    Michael J Simpson
    Alcon Laboratories Inc, Ft Worth, Texas 76134, USA
    J Refract Surg 26:780-5. 2010
    ..To discuss standardizing methods for presenting results from schematic eye calculations where light is entering the eye and forming an image on the retina...
  2. ncbi Self-reported visual impairment and mortality: a French nationwide perspective
    G Berdeaux
    Conservatoire National des Arts et Metiers, Paris, France
    Ophthalmic Epidemiol 14:80-7. 2007
    ..To estimate the association between self-reported visual impairment and mortality...
  3. ncbi AL-34662: a potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist
    Najam A Sharif
    Ophthalmology Discovery Research, Alcon Research, Ltd, Fort Worth, TX 76134, USA
    J Ocul Pharmacol Ther 23:1-13. 2007
    ..A variety of well-documented in vitro and in vivo procedures were utilized to study the pharmacological attributes of AL-34662...
  4. ncbi Glaucoma-causing myocilin mutants require the Peroxisomal targeting signal-1 receptor (PTS1R) to elevate intraocular pressure
    Allan R Shepard
    Glaucoma Research, Alcon Research, Ltd, Fort Worth, TX 76134, USA
    Hum Mol Genet 16:609-17. 2007
    ..This is the first demonstration of a disease resulting from mutation-induced exposure of a cryptic signaling site that causes mislocalization of mutant protein to peroxisomes and the first disease-gene-based animal model of human POAG...
  5. ncbi Serotonin-2 (5-HT2) receptor-mediated signal transduction in human ciliary muscle cells: role in ocular hypotension
    Najam A Sharif
    Ophthalmology Discovery Research, Alcon Research, Ltd, Fort Worth, TX 76134 2099, USA
    J Ocul Pharmacol Ther 22:389-401. 2006
    ....
  6. ncbi Preclinical pharmacology of AL-12182, a new ocular hypotensive 11-oxa prostaglandin analog
    Najam A Sharif
    Ophthalmology Discovery Research, Alcon Research, Ltd, Fort Worth, TX 76137, USA
    J Ocul Pharmacol Ther 22:291-309. 2006
    ....
  7. ncbi Adjunctive glaucoma therapy use associated with travoprost, bimatoprost, and latanoprost
    David Covert
    Alcon Research Ltd, Fort Worth, TX, USA
    Curr Med Res Opin 22:971-6. 2006
    ..This study contrasts the utilization of adjunctive medication associated with travoprost, bimatoprost, or latanoprost, as primary glaucoma therapies...
  8. ncbi Protein expression in a transformed trabecular meshwork cell line: proteome analysis
    H Thomas Steely
    Alcon Research, Ltd, Fort Worth, TX 76134, USA
    Mol Vis 12:372-83. 2006
    ..The aim of this study was to initiate a proteomic survey of GTM3 cells as the initial step toward characterization of the complete human TM proteome...
  9. ncbi The decline of the photopic negative response (PhNR) in the rat after optic nerve transection
    B Li
    Alcon Research Ltd, Fort Worth, TX 76134, USA
    Doc Ophthalmol 111:23-31. 2005
    ..To investigate the contribution to the photopic negative response (PhNR) of the electroretinogram (ERG) by retinal ganglion cells (RGCs). The PhNR was assessed longitudinally following optic nerve transection (ONTx)...
  10. ncbi 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity
    Jesse A May
    Ophthalmology Discovery Research, Alcon Research, Ltd, 6201 South Freeway, Fort Worth, Texas 76134, USA
    J Med Chem 49:318-28. 2006
    ..Compound 9 appears to be an excellent 5-HT(2) receptor agonist for conducting further studies directed toward a clinical proof-of-concept study for this class of ocular hypotensive agents...
  11. ncbi TGFbeta2-induced changes in human trabecular meshwork: implications for intraocular pressure
    Debra L Fleenor
    Glaucoma Research, Alcon Research, Ltd, Fort Worth, Texas 76134, USA
    Invest Ophthalmol Vis Sci 47:226-34. 2006
    ..This study was undertaken to investigate effects of TGFbeta2 on secretion of fibronectin and the protease inhibitor plasminogen activator inhibitor (PAI)-1 from human TM cell cultures and perfused human ocular anterior segments...
  12. ncbi Corneal staining and subjective symptoms with multipurpose solutions as a function of time
    Renee J Garofalo
    Alcon Research, Ltd, Fort Worth, TX 76134 2099, USA
    Eye Contact Lens 31:166-74. 2005
    ..Short-term changes in corneal staining and ocular symptoms were assessed at defined intervals to evaluate combinations of three soft lenses and four multipurpose solutions...
  13. ncbi Enantiomeric purity assay of moxifloxacin hydrochloride by capillary electrophoresis
    Lou Ann Cruz
    Department of Analytical Chemistry, Alcon Research Limited, 6201 South Freeway, Ft Worth, TX 76134, USA
    J Pharm Biomed Anal 38:8-13. 2005
    ..05-5%). The method was used to investigate whether racemization was a potential degradation pathway for the drug substance, both in the solid state and in solution...
  14. ncbi Ocular hypotensive DP-class prostaglandin receptor affinities determined by quantitative autoradiography on human eye sections
    Najam A Sharif
    Molecular Pharmacology Unit, Alcon Research, Ltd, Fort Worth, TX 76134 2099, USA
    J Ocul Pharmacol Ther 21:121-32. 2005
    ..The pharmacological attributes of [3H]BWA868C-labeled receptor sites studied using in situ quantitative autoradiography matched those previously documented for several other DP-receptor-containing cells and tissues...
  15. ncbi [Pharmacological profile and clinical efficacy of olopatadine hydrochloride ophthalmic solution (Patanol 0.1% ophthalmic solution)]
    Masakazu Watanabe
    Nihon Yakurigaku Zasshi 130:221-31. 2007
  16. doi Comprehensive report of the efficacy, safety, quality of life, and work impact of Olopatadine 0.6% and Olopatadine 0.4% treatment in patients with seasonal allergic rhinitis
    Carol J Fairchild
    Alcon Laboratories, Inc, 6201 South Freeway, Fort Worth, Texas 76134, USA
    Allergy Asthma Proc 28:716-23. 2007
    ..This analysis indicates that Olo is a safe and effective intranasal treatment and is associated with significant improvement in QoL and ability to perform work and conduct usual activities of SAR patients...
  17. doi Development of a liquid enzyme-based ceruminolytic product
    Nuria Jimenez
    Department of Pharmaceutical Development, Alcon R and D Laboratories, El Masnou, Spain
    J Pharm Sci 97:4970-82. 2008
    ..Long-term stability studies confirmed that the formulation maintained >75% enzyme stability for 24 months at 5 and 25 degrees C and after reconstitution at room temperature for up to 1 day...
  18. pmc Disseminated zygomycosis in a cynomolgus monkey (Macaca fascicularis)
    Cristóbal J Torres-Urbano
    Animal Resources Unit, Alcon Laboratories, Fort Worth, Texas, USA
    J Am Assoc Lab Anim Sci 49:75-8. 2010
    ..This is the first reported case of zygomycosis in a cynomolgus monkey...
  19. ncbi Review of inactive ingredients in antibiotic ear drops
    G Michael Wall
    Alcon Research, Ltd, 6201 South Freeway, Fort Worth, TX 76134, USA
    Ear Nose Throat J 88:E21-9. 2009
    ....
  20. doi Opportunities and challenges in the development of combination therapy for the treatment of retinal diseases
    Thomas C Hohman
    Retina Products, Alcon Research Ltd, Fort Worth, Texas 76134, USA
    Retina 29:S51-3. 2009
    ..Because of these limitations, the identification of effective adjunctive therapies is considered an urgent goal...
  21. pmc Human conjunctival epithelial cell responses to platelet-activating factor (PAF): signal transduction and release of proinflammatory cytokines
    Najam A Sharif
    Pharmaceutical Products Research, Core Pharmacology and Imaging, Alcon Research Ltd, Fort Worth, TX 76134, USA
    Mol Vis 15:1153-61. 2009
    ....
  22. doi Ocular pharmacokinetics and hypotensive activity of PF-04475270, an EP4 prostaglandin agonist in preclinical models
    Ganesh Prasanna
    Department of Ocular Biology, Pfizer Inc, San Diego, CA 92121, USA
    Exp Eye Res 89:608-17. 2009
    ..EP4 agonists could be considered as potential targets for lowering IOP for the treatment of glaucoma and ocular hypertension...
  23. pmc A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension
    Ying Yu
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0725, USA
    Circulation 119:2313-22. 2009
    ..This study sought to identify single-nucleotide polymorphisms (SNPs) in the TRPC6 gene promoter that are associated with IPAH and have functional significance in regulating TRPC6 activity in PASMCs...
  24. doi Dynamic photorefraction system: an offline application for the dynamic analysis of ocular focus and pupil size from photorefraction images
    Rajaraman Suryakumar
    School of Optometry, University of Waterloo, Waterloo, Ontario, Canada N2L3G1
    Comput Biol Med 39:195-205. 2009
    ..In addition, the system can interface with any custom built photorefractor allowing a widespread application in vision science experiments involving simultaneous measures of ocular focus and pupil size...
  25. doi Discovery of 13-oxa prostaglandin analogs as antiglaucoma agents: synthesis and biological activity
    Zixia Feng
    Medicinal Chemistry, Ophthalmic Products Research, Alcon Research Ltd, 6201 South Freeway, Mail code R2 39, Fort Worth, TX 76134, USA
    Bioorg Med Chem 17:576-84. 2009
    ..8 microg). AL-16049 also produced no signs of ocular irritation or discomfort in the cat at the doses evaluated...
  26. ncbi Optimizing distance image quality of an aspheric multifocal intraocular lens using a comprehensive statistical design approach
    Xin Hong
    Alcon Laboratories, Inc 6201 South Freeway, Fort Worth, Texas 76134, USA
    Opt Express 16:20920-34. 2008
    ..g. positioning error, biometric variation). Monte Carlo optimized results indicated that a lens spherical aberration of -0.10 microm provided optimal distance image quality...
  27. doi Corneal staining reductions observed after treatment with Systane Lubricant Eye Drops
    Mike T Christensen
    Alcon Laboratories, Ltd, Fort Worth, Texas 76134 2099, USA
    Adv Ther 25:1191-9. 2008
    ....
  28. pmc Pharmacological properties and discriminative stimulus effects of a novel and selective 5-HT2 receptor agonist AL-38022A [(S)-2-(8,9-dihydro-7H-pyrano[2,3-g]indazol-1-yl)-1-methylethylamine]
    Jesse A May
    Ophthalmology Discovery Research, Alcon Research, Ltd, 6201 South Freeway, Fort Worth, Texas 76134, United States
    Pharmacol Biochem Behav 91:307-14. 2009
    ..The pharmacological profile of AL-38022A suggests that it could be a useful tool in defining 5-HT2 receptor signaling and receptor characterization where 5-HT may function as a neurotransmitter...
  29. ncbi Controlled flow-through dissolution methodology: a high-performance system
    Larry E Stevens
    Alcon Research, Ltd, Fort Worth, TX, USA
    Pharm Dev Technol 13:135-53. 2008
    ..The convective diffusion/dissolution process was also simulated by using finite element modeling with predictions agreeing with measurements to within a few percent...
  30. doi Cat iris sphincter smooth-muscle contraction: comparison of FP-class prostaglandin analog agonist activities
    Najam A Sharif
    Ophthalmology Discovery Research, Alcon Research Ltd, Fort Worth, TX 76134, USA
    J Ocul Pharmacol Ther 24:152-63. 2008
    ..84). These data confirm the presence of functional FP-receptors in the cat iris sphincter, which are exquisitely well coupled and which respond to a variety of FP-class PG analogs with differing potencies...
  31. ncbi Amoebicidal activity of multipurpose contact lens solutions
    Sally L Buck
    Alcon Research, Ltd, Fort Worth, TX 76134, USA
    Eye Contact Lens 31:62-6. 2005
    ..To compare the amoebicidal activity of two commercially available multipurpose contact lens care systems, by using cyst and trophozoite growth of two strains each of Acanthamoeba castellanii and Acanthamoeba polyphaga...
  32. ncbi Evaluation of inducible nitric oxide synthase in glaucomatous optic neuropathy and pressure-induced optic nerve damage
    Iok Hou Pang
    Alcon Research, Ltd, Fort Worth, Texas, USA
    Invest Ophthalmol Vis Sci 46:1313-21. 2005
    ..To determine whether inducible nitric oxide synthase (NOS-2) is involved in glaucomatous optic neuropathy...
  33. ncbi Real-time intracellular Ca2+ mobilization by travoprost acid, bimatoprost, unoprostone, and other analogs via endogenous mouse, rat, and cloned human FP prostaglandin receptors
    Curtis R Kelly
    Molecular Pharmacology Unit, Pharmaceutical Products Research, Alcon Research, Ltd, Fort Worth, Texas 76134, USA
    J Pharmacol Exp Ther 304:238-45. 2003
    ....
  34. ncbi The effect of storage temperatures on the in vitro properties of a polyanhydride implant containing gentamicin
    Y Tian
    Alcon Laboratories, R2 45, 6201 South Freeway, Fort Worth, Texas 76134 2099, USA
    Drug Dev Ind Pharm 28:897-903. 2002
    ....
  35. ncbi Agonist activity of bimatoprost, travoprost, latanoprost, unoprostone isopropyl ester and other prostaglandin analogs at the cloned human ciliary body FP prostaglandin receptor
    N A Sharif
    Molecular Pharmacology Unit, Alcon Research, Ltd, Fort Worth, Texas 76134 2099, USA
    J Ocul Pharmacol Ther 18:313-24. 2002
    ..0 - 2.1 microM; n = 3). These studies have demonstrated, for the first time, agonist activities of the currently known and marketed ocular hypotensive prostaglandin analogs at the cloned human ciliary body FP prostaglandin receptor...
  36. ncbi Identification and characterization of the ocular hypotensive efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist, and AL-6598, a DP prostaglandin receptor agonist
    Mark R Hellberg
    Department of Medicinal Chemistry, Alcon Research Ltd, 6201 South Freeway, Fort Worth, TX 76134, USA
    Surv Ophthalmol 47:S13-33. 2002
    ..The acute and, apparently, conjunctival hyperemia associated with topical ocular AL-6598 can be attenuated while maintaining intraocular pressure-lowering efficacy by formulating with brimonidine...
  37. ncbi The Devonport incident, the Clothier Report, and related matters--30 years on
    Brian R Matthews
    Alcon Laboratories Ltd, Pentagon Park, Boundary Way, Hemel, Hempstead, HP2 7UD, UK
    PDA J Pharm Sci Technol 56:137-49. 2002
  38. ncbi Pharmacological and molecular biological (RT-PCR) characterization of functional TP prostanoid receptors in immortalized human non-pigmented ciliary epithelial cells
    N A Sharif
    Molecular Pharmacology Unit, Alcon Research Ltd, Fort Worth, Texas 76134 2099, USA
    J Ocul Pharmacol Ther 18:141-62. 2002
    ..The TPalpha receptors on NPE cells may be responsible for inhibiting aqueous humor production and may help explain the intraocular pressure-lowering effects of certain TP agonists...
  39. ncbi Cloned human EP1 prostanoid receptor pharmacology characterized using radioligand binding techniques
    Najam A Sharif
    Molecular Pharmacology Unit, Alcon Research, Ltd, Fort Worth, Texas 76134, USA
    J Pharm Pharmacol 54:539-47. 2002
    ..g. ZK118182 (K = 73.4 +/- 8.6 nM) and ZK110841 (K = 166 +/- 20 nM)). All FP (e.g. travoprost acid, fluprostenol), IP (iloprost) and TP (SQ29548) receptor-specific ligands exhibited low affinity (Ki > or = 1 microM)...
  40. ncbi Pharmacology of functional endogenous IP prostanoid receptors in NCB-20 cells: comparison with binding data from human platelets
    J Y Crider
    Molecular Pharmacology Unit, Alcon Research, Ltd, Forth Worth, TX 76134 2099, USA
    Prostaglandins Leukot Essent Fatty Acids 65:253-8. 2001
    ..These studies provide functional and binding information for a broad range of both natural and synthetic prostanoid receptor ligands at the endogenous IP receptor in two different cell types...
  41. ncbi Ocular bioavailability of ciprofloxacin in sustained release formulations
    T L Ke
    Alcon Research, Ltd, Fort Worth, Texas 76134, USA
    J Ocul Pharmacol Ther 17:555-63. 2001
    ..These topical ocular formulations have prophylactic utility for prevention of post-surgical infection, offering greater efficacy and safety than currently available treatments...
  42. ncbi The use of proteomics in ophthalmic research
    H T Steely
    Alcon Research Ltd, Fort Worth, TX 76134, USA
    Pharmacogenomics 1:267-80. 2000
    ..Herein, we review published proteomic literature in the broad context of ophthalmic diseases involving various tissues of the eye...
  43. ncbi Activities of the USP Microbiology Subcommittee of Revision during the 1995-2000 revision cycle
    S V Sutton
    Alcon Research Ltd, 6201 South Freeway, Fort Worth, TX, USA, 76134
    PDA J Pharm Sci Technol 55:33-48. 2001
    ..Where appropriate, changes in the USP that did not fall under the direct purview of the MCB Subcommittee but of interest to the microbiology community are also discussed...
  44. pmc Pharmacology and autoradiography of human DP prostanoid receptors using [(3)H]-BWA868C, a DP receptor-selective antagonist radioligand
    N A Sharif
    Molecular Pharmacology Unit, Alcon Research Ltd, 6201 South Freeway, Fort Worth, Texas, TX 76134, USA
    Br J Pharmacol 131:1025-38. 2000
    ..3)H]-BWA868C may prove useful for future homogenate-based and autoradiographic studies on the DP receptor...
  45. ncbi Affinities, selectivities, potencies, and intrinsic activities of natural and synthetic prostanoids using endogenous receptors: focus on DP class prostanoids
    N A Sharif
    Molecular Pharmacology Unit, Alcon Research, Ltd, Fort Worth, Texas 76134 2099, USA
    J Pharmacol Exp Ther 293:321-8. 2000
    ..9-8.2, n = 5-9). The pharmacological properties of some natural and numerous DP class synthetic prostanoids have been determined using endogenous receptors...
  46. ncbi Finite and infinitesimal representations of the vasculature: ocular drug clearance by vascular and hydraulic effects
    Paul J Missel
    Drug Delivery, Alcon Research Ltd, Mail Stop R2 45, 6201 South Freeway, Fort Worth, TX 76134, USA
    Ann Biomed Eng 30:1128-39. 2002
    ..Transport becomes diffusion limited at high vascular clearance. Hydraulic flow restricts the range in concentration predicted in the vitreous compared to zero flow. Hydraulic influences for small, rapidly cleared drugs can be neglected...
  47. ncbi Bimatoprost (Lumigan((R))) is an agonist at the cloned human ocular FP prostaglandin receptor: real-time FLIPR-based intracellular Ca(2+) mobilization studies
    N A Sharif
    Molecular Pharmacology Unit R2 19, Alcon Research Limited, 6201 South Freeway, 76134, Fort Worth, TX, USA
    Prostaglandins Leukot Essent Fatty Acids 68:27-33. 2003
    ..Therefore, the prodrug bimatoprost and its hydrolytic product, bimatoprost free acid, bind to and activate the human ocular FP prostaglandin receptor to mobilize [Ca(2+)](i), thus behaving as FP receptor agonists...
  48. ncbi Evaluation of the ocular hypotensive response of serotonin 5-HT1A and 5-HT2 receptor ligands in conscious ocular hypertensive cynomolgus monkeys
    Jesse A May
    Ophthalmic Products Research, Alcon Research, Ltd, 6201 South Freeway, Ft Worth, TX 76134, USA
    J Pharmacol Exp Ther 306:301-9. 2003
    ....
  49. ncbi Vision-related quality of life in patients suffering from age-related macular degeneration
    Gilles H Berdeaux
    Alcon Research Ltd, 92563 Rueil Malmaison, France
    Am J Ophthalmol 139:271-9. 2005
    ..To evaluate the relative impact of best and worst eye on vision-related quality of life in patients suffering from age-related macular degeneration (AMD)...
  50. ncbi Reexamination of convective diffusion/drug dissolution in a laminar flow channel: accurate prediction of dissolution rate
    Paul J Missel
    Drug Delivery, Alcon Research Ltd, Fort Worth, Texas 76134, USA
    Pharm Res 21:2300-6. 2004
    ....
  51. ncbi [The strategies for optic never protection in glaucoma patients]
    Iok Hou Pang
    Zhonghua Yan Ke Za Zhi 40:783-7. 2004
  52. ncbi The role of calcium in signal transduction processes in Sertoli cells
    Eleonora Gorczyńska-Fjälling
    Department of Obstetrics and Gynaecology, University of Sydney, Sydney 2006, New South Wales, Australia
    Reprod Biol 4:219-41. 2004
    ..This argues for the possible existence of a short term non-genomic signaling pathway in hormonal regulation of Sertoli cell function in addition to the classical longer term, slower genomic response...
  53. ncbi Dissolution of anecortave acetate in a cylindrical flow cell: re-evaluation of convective diffusion/drug dissolution for sparingly soluble drugs
    Paul J Missel
    Drug Delivery, Alcon Research, Ltd, Fort Worth, TX 76134, USA
    Pharm Dev Technol 9:453-9. 2004
    ..The current approach may be utilized to provide estimates of dissolution rates for any geometry and set of hydrodynamic conditions that can be numerically calculated...
  54. ncbi Cloned human 5-HT1A receptor pharmacology determined using agonist binding and measurement of cAMP accumulation
    Najam A Sharif
    Molecular Pharmacology Unit, Pharmaceutical Products Research, Alcon Research, Ltd, Fort Worth, TX 76134 2099, USA
    J Pharm Pharmacol 56:1267-74. 2004
    ..58, P <0.05). The present study provides a detailed pharmacological characterization of the ch-5-HT1A receptor using binding and functional assays...
  55. ncbi The disposition and bioavailability of 35S-GSH from 35S-GSSG in BSS PLUS in rabbit ocular tissues
    James C Veltman
    Department of Research Toxicology, Alcon Research, Ltd, Ft Worth, TX, USA
    J Ocul Pharmacol Ther 20:256-68. 2004
    ..The data from this study demonstrate that 35S-GSSG in BSS PLUS is metabolized and taken up by ocular cells and that 35S-GSH becomes incorporated into the intracellular GSH pool of ocular tissues...
  56. ncbi Alcon CustomCornea platform with LADARWave and LADARVision
    Kevin K Liedel
    Alcon Orlando Technology Center, 2501 Discovery Drive, Orlando, FL 32826, USA
    Ophthalmol Clin North Am 17:161-72, vi. 2004
    ..The technology behind these two systems and the clinical outcomes achieved using CustomCornea will be discussed...
  57. ncbi Inflammation-mediated retinal edema in the rabbit is inhibited by topical nepafenac
    M A Kapin
    Ophthalmic Products Research, Alcon Research Ltd, Fort Worth, Texas 76134 2099, USA
    Inflammation 27:281-91. 2003
    ....
  58. ncbi Real-time direct measurement of nitric oxide in bovine perfused eye trabecular meshwork using a clark-type electrode
    J C Millar
    Department of Biology and Health Science, Faculty of Science, Technology and Design, University of Luton, Park Square Campus, Luton, England
    J Ocul Pharmacol Ther 19:299-313. 2003
    ..8 +/- 1.6 microM to 1.1 +/- 0.9 microM, mean +/- SDM), whereas timolol alone (1 microM-1 mM) had no effect. NO is generated tonically in bovine TM and increases in response to epinephrine...
  59. ncbi Aqueous outflow-enhancing effect of tert-butylhydroquinone: involvement of AP-1 activation and MMP-3 expression
    Iok Hou Pang
    Alcon Research, Ltd, Fort Worth, Texas 76134, USA
    Invest Ophthalmol Vis Sci 44:3502-10. 2003
    ..To test the effect of stimulators of activator protein (AP)-1, on expression of stromelysin (MMP-3) in human TM cells and on aqueous outflow in perfused human anterior segments...
  60. ncbi Involvement of AP-1 in interleukin-1alpha-stimulated MMP-3 expression in human trabecular meshwork cells
    Debra L Fleenor
    Alcon Research, Ltd, Fort Worth, Texas 76134, USA
    Invest Ophthalmol Vis Sci 44:3494-501. 2003
    ..In the present study, pharmacological tools were used to delineate the signaling mechanism involved in the effect of IL-1alpha on MMP-3 production in human TM cells compared with other ocular cells...
  61. ncbi The hydrolysis of the prostaglandin analog prodrug bimatoprost to 17-phenyl-trinor PGF2alpha by human and rabbit ocular tissue
    Mark R Hellberg
    Alcon Research Ltd, Fort Worth, Texas 76134, USA
    J Ocul Pharmacol Ther 19:97-103. 2003
    ..Taken together, the data strongly suggests that the ocular hypotensive effect of bimatoprost can be attributed to its activity as a prostaglandin receptor agonist either directly or through its role as a prostaglandin agonist prodrug...
  62. ncbi Clinical efficacy and safety of brinzolamide (Azopt), a new topical carbonic anhydrase inhibitor for primary open-angle glaucoma and ocular hypertension. Brinzolamide Primary Therapy Study Group
    L H Silver
    Alcon Laboratories Inc, Fort Worth, Texas 76134, USA
    Am J Ophthalmol 126:400-8. 1998
    ..To determine the intraocular pressure-lowering efficacy and safety of brinzolamide 1.0%, compared with dorzolamide 2.0% and timolol 0.5%...