Research Topics
| D S Woodruff-PakSummaryAffiliation: Albert Einstein Medical Center Country: USA Publications
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Detail Information
Publications
Galantamine: effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learningD S Woodruff-Pak
Research and Technology Development, Albert Einstein Healthcare Network, Philadelphia, PA 19141, USA
Proc Natl Acad Sci U S A 98:2089-94. 2001..0 mg/kg Gal, and all Gal-treated rabbits had lower levels of brain AChE. The efficacy of Gal in a learning paradigm severely impaired in AD is consistent with outcomes in clinical studies...
Nicotinic modulation in an animal model of a form of associative learning impaired in Alzheimer's diseaseD S Woodruff-Pak
Department of Psychology, Temple University, Philadelphia, PA 19122, USA
Behav Brain Res 113:11-9. 2000..The efficacy of galantamine in a learning paradigm that shows severe impairment in AD indicates that the drug may be effective as a cognition-enhancer in AD...- Mecamylamine interactions with galantamine and donepezil: effects on learning, acetylcholinesterase, and nicotinic acetylcholine receptorsD S Woodruff-Pak
Research and Technology Development, Albert Einstein Healthcare Network, Philadelphia, PA 19141, USA
Neuroscience 117:439-47. 2003.... - Nefiracetam ameliorates learning deficits in older rabbits and may act via the hippocampusD S Woodruff-Pak
Laboratory of Cognitive Neuroscience, Philadelphia Geriatric Center, PA 19141, USA
Behav Brain Res 83:179-84. 1997..Nefiracetam ameliorated EBCC in older rabbits only when the hippocampus was intact... - Predictors of eyeblink classical conditioning over the adult age spanD S Woodruff-Pak
Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122, USA
Psychol Aging 13:193-205. 1998..Reaction time and explicit memory measures did not account for a significant amount of the variance in eyeblink conditioning. Age-related effects in the cerebellum apparently affect timing and learning in normal adults... - A nicotinic cholinergic agonist (GTS-21) and eyeblink classical conditioning: acquisition, retention, and relearning in older rabbitsD S Woodruff-Pak
Department of Psychology, Temple University, Philadelphia, PA 19122, USA
Exp Aging Res 26:323-36. 2000..Differences in relearning were in the predicted direction but did not attain statistical significance. Results indicate that treatment with GTS-21 ameliorates learning beyond the period when the drug is actually administered... - Nimodipine ameliorates impaired eyeblink classical conditioning in older rabbits in the long-delay paradigmD S Woodruff-Pak
Department of Psychology, Temple University, Philadelphia, PA 19122, USA
Neurobiol Aging 18:641-9. 1997..Acquisition with the 5 mg/kg dose was significantly faster. Existing evidence suggested that nimodipine acted in the hippocampus, but we could not rule out the possibility that the drug also affected conditioning via the cerebellum... - MRI-assessed volume of cerebellum correlates with associative learningD S Woodruff-Pak
Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122, USA
Neurobiol Learn Mem 76:342-57. 2001..Individual differences in classical eyeblink conditioning are associated with differences in cerebellar volume, supporting Thompson's model of a cerebellar cortical role in facilitating this form of associative learning... - Eyeblink classical conditioning differentiates normal aging from Alzheimer's diseaseD S Woodruff-Pak
Department of Psychology, Temple University, Temple University School of Medicine, Philadelphia, PA 19122, USA
Integr Physiol Behav Sci 36:87-108. 2001.... - No apparent age differences in hippocampal theta frequency in rabbits aged 3-50 monthsD S Woodruff Pak
Dept of Psychology, Temple University, Philadelphia, PA 19122
Compr Gerontol A 2:24-8. 1988..Results suggest that rabbits as young as 2.5 years old show behavioral deficits in conditioning, but hippocampal EEG frequency was not correlated with the age differences in behavior...