D S Woodruff-Pak

Summary

Affiliation: Albert Einstein Medical Center
Country: USA

Publications

  1. pmc Galantamine: effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning
    D S Woodruff-Pak
    Research and Technology Development, Albert Einstein Healthcare Network, Philadelphia, PA 19141, USA
    Proc Natl Acad Sci U S A 98:2089-94. 2001
  2. ncbi request reprint Nicotinic modulation in an animal model of a form of associative learning impaired in Alzheimer's disease
    D S Woodruff-Pak
    Department of Psychology, Temple University, Philadelphia, PA 19122, USA
    Behav Brain Res 113:11-9. 2000
  3. ncbi request reprint Mecamylamine interactions with galantamine and donepezil: effects on learning, acetylcholinesterase, and nicotinic acetylcholine receptors
    D S Woodruff-Pak
    Research and Technology Development, Albert Einstein Healthcare Network, Philadelphia, PA 19141, USA
    Neuroscience 117:439-47. 2003
  4. ncbi request reprint Nefiracetam ameliorates learning deficits in older rabbits and may act via the hippocampus
    D S Woodruff-Pak
    Laboratory of Cognitive Neuroscience, Philadelphia Geriatric Center, PA 19141, USA
    Behav Brain Res 83:179-84. 1997
  5. ncbi request reprint Predictors of eyeblink classical conditioning over the adult age span
    D S Woodruff-Pak
    Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Psychol Aging 13:193-205. 1998
  6. ncbi request reprint A nicotinic cholinergic agonist (GTS-21) and eyeblink classical conditioning: acquisition, retention, and relearning in older rabbits
    D S Woodruff-Pak
    Department of Psychology, Temple University, Philadelphia, PA 19122, USA
    Exp Aging Res 26:323-36. 2000
  7. ncbi request reprint Nimodipine ameliorates impaired eyeblink classical conditioning in older rabbits in the long-delay paradigm
    D S Woodruff-Pak
    Department of Psychology, Temple University, Philadelphia, PA 19122, USA
    Neurobiol Aging 18:641-9. 1997
  8. ncbi request reprint MRI-assessed volume of cerebellum correlates with associative learning
    D S Woodruff-Pak
    Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Neurobiol Learn Mem 76:342-57. 2001
  9. ncbi request reprint Eyeblink classical conditioning differentiates normal aging from Alzheimer's disease
    D S Woodruff-Pak
    Department of Psychology, Temple University, Temple University School of Medicine, Philadelphia, PA 19122, USA
    Integr Physiol Behav Sci 36:87-108. 2001
  10. ncbi request reprint No apparent age differences in hippocampal theta frequency in rabbits aged 3-50 months
    D S Woodruff Pak
    Dept of Psychology, Temple University, Philadelphia, PA 19122
    Compr Gerontol A 2:24-8. 1988

Collaborators

Detail Information

Publications10

  1. pmc Galantamine: effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning
    D S Woodruff-Pak
    Research and Technology Development, Albert Einstein Healthcare Network, Philadelphia, PA 19141, USA
    Proc Natl Acad Sci U S A 98:2089-94. 2001
    ..0 mg/kg Gal, and all Gal-treated rabbits had lower levels of brain AChE. The efficacy of Gal in a learning paradigm severely impaired in AD is consistent with outcomes in clinical studies...
  2. ncbi request reprint Nicotinic modulation in an animal model of a form of associative learning impaired in Alzheimer's disease
    D S Woodruff-Pak
    Department of Psychology, Temple University, Philadelphia, PA 19122, USA
    Behav Brain Res 113:11-9. 2000
    ..The efficacy of galantamine in a learning paradigm that shows severe impairment in AD indicates that the drug may be effective as a cognition-enhancer in AD...
  3. ncbi request reprint Mecamylamine interactions with galantamine and donepezil: effects on learning, acetylcholinesterase, and nicotinic acetylcholine receptors
    D S Woodruff-Pak
    Research and Technology Development, Albert Einstein Healthcare Network, Philadelphia, PA 19141, USA
    Neuroscience 117:439-47. 2003
    ....
  4. ncbi request reprint Nefiracetam ameliorates learning deficits in older rabbits and may act via the hippocampus
    D S Woodruff-Pak
    Laboratory of Cognitive Neuroscience, Philadelphia Geriatric Center, PA 19141, USA
    Behav Brain Res 83:179-84. 1997
    ..Nefiracetam ameliorated EBCC in older rabbits only when the hippocampus was intact...
  5. ncbi request reprint Predictors of eyeblink classical conditioning over the adult age span
    D S Woodruff-Pak
    Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Psychol Aging 13:193-205. 1998
    ..Reaction time and explicit memory measures did not account for a significant amount of the variance in eyeblink conditioning. Age-related effects in the cerebellum apparently affect timing and learning in normal adults...
  6. ncbi request reprint A nicotinic cholinergic agonist (GTS-21) and eyeblink classical conditioning: acquisition, retention, and relearning in older rabbits
    D S Woodruff-Pak
    Department of Psychology, Temple University, Philadelphia, PA 19122, USA
    Exp Aging Res 26:323-36. 2000
    ..Differences in relearning were in the predicted direction but did not attain statistical significance. Results indicate that treatment with GTS-21 ameliorates learning beyond the period when the drug is actually administered...
  7. ncbi request reprint Nimodipine ameliorates impaired eyeblink classical conditioning in older rabbits in the long-delay paradigm
    D S Woodruff-Pak
    Department of Psychology, Temple University, Philadelphia, PA 19122, USA
    Neurobiol Aging 18:641-9. 1997
    ..Acquisition with the 5 mg/kg dose was significantly faster. Existing evidence suggested that nimodipine acted in the hippocampus, but we could not rule out the possibility that the drug also affected conditioning via the cerebellum...
  8. ncbi request reprint MRI-assessed volume of cerebellum correlates with associative learning
    D S Woodruff-Pak
    Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Neurobiol Learn Mem 76:342-57. 2001
    ..Individual differences in classical eyeblink conditioning are associated with differences in cerebellar volume, supporting Thompson's model of a cerebellar cortical role in facilitating this form of associative learning...
  9. ncbi request reprint Eyeblink classical conditioning differentiates normal aging from Alzheimer's disease
    D S Woodruff-Pak
    Department of Psychology, Temple University, Temple University School of Medicine, Philadelphia, PA 19122, USA
    Integr Physiol Behav Sci 36:87-108. 2001
    ....
  10. ncbi request reprint No apparent age differences in hippocampal theta frequency in rabbits aged 3-50 months
    D S Woodruff Pak
    Dept of Psychology, Temple University, Philadelphia, PA 19122
    Compr Gerontol A 2:24-8. 1988
    ..Results suggest that rabbits as young as 2.5 years old show behavioral deficits in conditioning, but hippocampal EEG frequency was not correlated with the age differences in behavior...