Louis M Weiss

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc The Toxoplasma gondii Cyst Wall Protein CST1 Is Critical for Cyst Wall Integrity and Promotes Bradyzoite Persistence
    Tadakimi Tomita
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, New York, United States of America
    PLoS Pathog 9:e1003823. 2013
  2. pmc The 12th International Workshops on Opportunistic Protists (IWOP-12)
    Louis M Weiss
    Departments of Medicine and Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Eukaryot Microbiol 60:298-308. 2013
  3. pmc Trypanosoma cruzi infection of cultured adipocytes results in an inflammatory phenotype
    Fnu Nagajyothi
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    Obesity (Silver Spring) 16:1992-7. 2008
  4. pmc Microarray analysis of the mammalian thromboxane receptor-Trypanosoma cruzi interaction
    Herbert B Tanowitz
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY USA
    Cell Cycle 10:1132-43. 2011
  5. pmc Comprehensive proteomic analysis of membrane proteins in Toxoplasma gondii
    Fa Yun Che
    Department of Pathology, Biodefense Proteomics Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Cell Proteomics 10:M110.000745. 2011
  6. pmc Computational analysis and experimental validation of gene predictions in Toxoplasma gondii
    Joseph M Dybas
    Biodefense Proteomics Research Center, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 3:e3899. 2008
  7. pmc Protein kinase A catalytic subunit interacts and phosphorylates members of trans-sialidase super-family in Trypanosoma cruzi
    Yi Bao
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Microbes Infect 12:716-26. 2010
  8. pmc Chagas disease, adipose tissue and the metabolic syndrome
    Fnu Nagajyothi
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mem Inst Oswaldo Cruz 104:219-25. 2009
  9. pmc Response of adipose tissue to early infection with Trypanosoma cruzi (Brazil strain)
    Fnu Nagajyothi
    Department of Pathology, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY, USA
    J Infect Dis 205:830-40. 2012
  10. pmc Alterations in myocardial gene expression associated with experimental Trypanosoma cruzi infection
    Shankar Mukherjee
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Genomics 91:423-32. 2008

Collaborators

Detail Information

Publications93

  1. pmc The Toxoplasma gondii Cyst Wall Protein CST1 Is Critical for Cyst Wall Integrity and Promotes Bradyzoite Persistence
    Tadakimi Tomita
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, New York, United States of America
    PLoS Pathog 9:e1003823. 2013
    ..These results indicate that CST1 functions as a key structural component that confers essential sturdiness to the T. gondii tissue cyst critical for persistence of bradyzoite forms. ..
  2. pmc The 12th International Workshops on Opportunistic Protists (IWOP-12)
    Louis M Weiss
    Departments of Medicine and Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Eukaryot Microbiol 60:298-308. 2013
    ....
  3. pmc Trypanosoma cruzi infection of cultured adipocytes results in an inflammatory phenotype
    Fnu Nagajyothi
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    Obesity (Silver Spring) 16:1992-7. 2008
    ..cruzi-infected adipocytes. Overall, these data implicate the adipocyte as an important target of T. cruzi, and one which contributes significantly to the inflammatory response observed in Chagas disease...
  4. pmc Microarray analysis of the mammalian thromboxane receptor-Trypanosoma cruzi interaction
    Herbert B Tanowitz
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY USA
    Cell Cycle 10:1132-43. 2011
    ..These data underscore the importance of the interaction of the parasite with mammalian TP and may explain the increased mortality and cardiovascular pathology observed in infected TP null mice...
  5. pmc Comprehensive proteomic analysis of membrane proteins in Toxoplasma gondii
    Fa Yun Che
    Department of Pathology, Biodefense Proteomics Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Cell Proteomics 10:M110.000745. 2011
    ..gondii or to the Apicomplexa, providing a set of gene predictions ripe for experimental investigation, and potentially suitable targets for the development of therapeutic strategies...
  6. pmc Computational analysis and experimental validation of gene predictions in Toxoplasma gondii
    Joseph M Dybas
    Biodefense Proteomics Research Center, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 3:e3899. 2008
    ..An essential step towards understanding molecular mechanisms controlling transitions between the various life stages and identifying candidate drug targets is to accurately characterize the T. gondii proteome...
  7. pmc Protein kinase A catalytic subunit interacts and phosphorylates members of trans-sialidase super-family in Trypanosoma cruzi
    Yi Bao
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Microbes Infect 12:716-26. 2010
    ..The identified trans-sialidases have PKA consensus phosphorylation sites located near the endoplasmic reticulum retention motif in the N-terminal. These data support that PKA phosphorylates trans-sialidase super family members in vivo...
  8. pmc Chagas disease, adipose tissue and the metabolic syndrome
    Fnu Nagajyothi
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mem Inst Oswaldo Cruz 104:219-25. 2009
    ..Adipose tissue is an important target tissue of T. cruzi and the infection of this tissue is associated with a profound impact on systemic metabolism, increasing the risk of metabolic syndrome...
  9. pmc Response of adipose tissue to early infection with Trypanosoma cruzi (Brazil strain)
    Fnu Nagajyothi
    Department of Pathology, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY, USA
    J Infect Dis 205:830-40. 2012
    ..The mRNA levels of cytokines, chemokines, and their receptors were increased. Nuclear Factor Kappa B levels were increased in BAT, whereas Iκκ-γ levels increased in WAT. Adipose tissue is an early target of T. cruzi infection...
  10. pmc Alterations in myocardial gene expression associated with experimental Trypanosoma cruzi infection
    Shankar Mukherjee
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Genomics 91:423-32. 2008
    ..These data may provide insight into the pathogenesis of chagasic cardiomyopathy and provide new targets for intervention...
  11. pmc Crucial role of the central leptin receptor in murine Trypanosoma cruzi (Brazil strain) infection
    Fnu Nagajyothi
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    J Infect Dis 202:1104-13. 2010
    ..These findings suggest that leptin resistance in individuals with obesity and diabetes mellitus may have adverse consequences in T. cruzi infection...
  12. pmc Curcumin treatment provides protection against Trypanosoma cruzi infection
    Fnu Nagajyothi
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, NY, USA
    Parasitol Res 110:2491-9. 2012
    ..These data suggest that curcumin and its derivatives could be a suitable drug for the amelioration of chagasic heart disease...
  13. pmc Interactions of Encephalitozoon cuniculi polar tube proteins
    Boumediene Bouzahzah
    Department of Pathology, Division of Tropical Medicine and Parasitology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Infect Immun 78:2745-53. 2010
    ..Further studies of polar tube proteins and their structural interactions may help elucidate the formation of the polar tube during the invasion process...
  14. pmc Alterations in glucose homeostasis in a murine model of Chagas disease
    Fnu Nagajyothi
    Division of Parasitology and Tropical Medicine, Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Pathol 182:886-94. 2013
    ..cruzi-induced hypoglycemia, despite reduced insulin, but elevated glucagon levels. The data establishes a complex, multi-tissue relationship between T. cruzi infection, Chagas disease, and host glucose homeostasis...
  15. pmc Analysis of the glycoproteome of Toxoplasma gondii using lectin affinity chromatography and tandem mass spectrometry
    Qilie Luo
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Microbes Infect 13:1199-210. 2011
    ..Studies of the function of glycosylation of these proteins may help elucidate mechanism(s) involved in invasion improving drug therapy as well as identify glycoproteins that may prove to be useful as vaccine candidates...
  16. ncbi request reprint Cell cycle regulatory proteins in the liver in murine Trypanosoma cruzi infection
    Boumediene Bouzahzah
    Department of Pathology at Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cell Cycle 5:2396-400. 2006
    ..Thus infection caused a reversion to a fetal/neonatal phenotype. These data provide a molecular basis for cell proliferation in the liver following T. cruzi infection...
  17. pmc Identification of a functional prostanoid-like receptor in the protozoan parasite, Trypanosoma cruzi
    Shankar Mukherjee
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, USA
    Parasitol Res 112:1417-25. 2013
    ..It may, however, also control parasite differentiation and proliferation in the infected host allowing the infection to progress to a chronic state...
  18. pmc Molecular cloning and characterization of mitogen-activated protein kinase 2 in Trypanosoma cruzi
    Yi Bao
    Departments of Pathology and Medicine, Bronx, NY, USA
    Cell Cycle 9:2888-96. 2010
    ..Overexpression of TcMAPK2 in epimastigotes inhibited growth and development leading to death. TcMAPK2 has an important role in the stress response of the parasite and may be important in regulating proliferation and differentiation...
  19. pmc Molecular cloning and characterization of mitogen-activated protein kinase 2 in Toxoplasma gondii
    Huan Huang
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
    Cell Cycle 10:3519-26. 2011
    ..gondii. Since TgMAPK2 is significantly different from its mammalian counterpart, it may be useful as a drug target. This work establishes a foundation for further study for this unique kinase...
  20. ncbi request reprint Heterologous expression of an Encephalitozoon cuniculi aquaporin in Xenopus oocytes
    Kaya Ghosh
    Department of Pathology, Division of Tropical Medicine and Parasitology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Eukaryot Microbiol 53:S72-3. 2006
  21. pmc Post-translational modifications to Toxoplasma gondii alpha- and beta-tubulins include novel C-terminal methylation
    Hui Xiao
    Departments of Pathology, Laboratory for Macromolecular Analysis and Proteomics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Proteome Res 9:359-72. 2010
    ..Methylation, a PTM not previously described on tubulin, was also detected. Methylated tubulins were not detected in the host cells, human foreskin fibroblasts, suggesting that this may be a modification specific to the Apicomplexa...
  22. pmc Mechanisms of Trypanosoma cruzi persistence in Chagas disease
    Fnu Nagajyothi
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
    Cell Microbiol 14:634-43. 2012
    ..Ongoing and future research will continue to help refining the models of T. cruzi invasion and persistence in diverse tissues and organs in the host...
  23. pmc Perspectives on Trypanosoma cruzi-induced heart disease (Chagas disease)
    Herbert B Tanowitz
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Prog Cardiovasc Dis 51:524-39. 2009
    ..The treatment of this infection has shortcomings that need to be addressed. Cardiac transplantation and bone marrow stem cell therapy for persons with Chagas disease have received increasing research attention in recent years...
  24. pmc Identification of a new spore wall protein from Encephalitozoon cuniculi
    Yanji Xu
    Albert Einstein College of Medicine, 1300 Morris Park Avenue, Room 504 Forchheimer Building, Bronx, NY 10461, USA
    Infect Immun 74:239-47. 2006
    ..SWP3 has several potential O-glycosylation sites, and it is possible that it is a mannosylated protein like the major polar tube protein (PTP1)...
  25. pmc Thromboxane A2 is a key regulator of pathogenesis during Trypanosoma cruzi infection
    Anthony W Ashton
    Department of Medicine, Divisions of Cardiology and Infectious Disease, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Exp Med 204:929-40. 2007
    ..cruzi infection is possibly an important determinant of mortality and parasitism. A deeper understanding of the role of TXA(2) may result in novel therapeutic targets for a disease with limited treatment options...
  26. pmc Cognitive dysfunction in mice infected with Plasmodium berghei strain ANKA
    Mahalia S Desruisseaux
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Infect Dis 197:1621-7. 2008
    ..This murine model should facilitate the study of adjunctive methods to ameliorate adverse neurological outcomes in cerebral malaria...
  27. pmc EPIC-DB: a proteomics database for studying Apicomplexan organisms
    Carlos J Madrid-Aliste
    Biodefense Proteomics Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    BMC Genomics 10:38. 2009
    ..High throughput methods necessitate publicly accessible and easily queried databases for efficiently and logically storing, displaying, and analyzing the large volume of data...
  28. pmc Externally triggered egress is the major fate of Toxoplasma gondii during acute infection
    Tadakimi Tomita
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 183:6667-80. 2009
    ..ETE represents a novel example of interaction between a parasite infectious cycle and host microenvironment...
  29. ncbi request reprint Endothelin in a murine model of cerebral malaria
    Fabiana S Machado
    Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York 10016, USA
    Exp Biol Med (Maywood) 231:1176-81. 2006
    ....
  30. pmc Trypanosoma cruzi utilizes the host low density lipoprotein receptor in invasion
    Fnu Nagajyothi
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    PLoS Negl Trop Dis 5:e953. 2011
    ....
  31. pmc Aspirin treatment of mice infected with Trypanosoma cruzi and implications for the pathogenesis of Chagas disease
    Shankar Mukherjee
    Division of Parasitology, Department of Pathology, Albert Einstein College of Medicine, New York City, New York, United States of America
    PLoS ONE 6:e16959. 2011
    ..A deeper understanding of the mechanism of ASA action may provide clues to the differences between host response in the acute and chronic T. cruzi infection...
  32. pmc The histone code of Toxoplasma gondii comprises conserved and unique posttranslational modifications
    Sheila C Nardelli
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
    MBio 4:e00922-13. 2013
    ....
  33. ncbi request reprint Molecular cloning and characterization of the protein kinase A regulatory subunit of Trypanosoma cruzi
    Huan Huang
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Mol Biochem Parasitol 149:242-5. 2006
  34. pmc A new vesicular compartment in Encephalitozoon cuniculi
    Kaya Ghosh
    Department of Pathology, Division of Tropical Medicine and Parasitology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Microbes Infect 14:324-8. 2012
    ..cuniculi mitosomes...
  35. pmc Acquired infection with Toxoplasma gondii in adult mice results in sensorimotor deficits but normal cognitive behavior despite widespread brain pathology
    Maria Gulinello
    Behavioral Core Facility, Department of Neuroscience, 1410 Pelham Pkwy S K925, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Microbes Infect 12:528-37. 2010
    ..Such changes point out the subtle interaction of this parasite with its intermediate hosts and are consistent with ideas about increased predation being an outcome of infection...
  36. pmc Branching network of proteinaceous filaments within the parasitophorous vacuole of Encephalitozoon cuniculi and Encephalitozoon hellem
    Kaya Ghosh
    Department of Pathology, Division of Tropical Medicine and Parasitology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Room 504 Forchheimer, Bronx, NY 10461, USA
    Infect Immun 79:1374-85. 2011
    ....
  37. pmc Metabolism of an alkyl polyamine analog by a polyamine oxidase from the microsporidian Encephalitozoon cuniculi
    Cyrus J Bacchi
    Haskins Laboratories, Pace University, 41 Park Row, New York, NY 10038, USA
    Antimicrob Agents Chemother 53:2599-604. 2009
    ..cuniculi. The results in this study demonstrate competitive inhibition of oxidase activity by BW-1 and support further studies of this oxidase activity by the parasite and host...
  38. pmc Trypanosoma cruzi infection induces proliferation of vascular smooth muscle cells
    Ghada S Hassan
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Infect Immun 74:152-9. 2006
    ..Taken together, these data suggest that T. cruzi infection stimulates smooth muscle cell proliferation and is likely a result of the upregulation of the ERK-cyclin D1-endothelin-1 pathway...
  39. pmc Photo-assisted peptide enrichment in protein complex cross-linking analysis of a model homodimeric protein using mass spectrometry
    Funing Yan
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proteomics 11:4109-15. 2011
    ..These technical improvements allow this method to be used for investigating protein-protein interactions in complex biological samples...
  40. doi request reprint Glycosylation of the major polar tube protein of Encephalitozoon cuniculi
    Boumediene Bouzahzah
    Department of Pathology, Division of Parasitology and Tropical Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Parasitol Res 107:761-4. 2010
    ..The observed post-translational mannosylation of PTP1 may be involved in the functional properties of the polar tube, including its adherence to host cells during penetration...
  41. ncbi request reprint Cyclin and caveolin expression in an acute model of murine Chagasic myocarditis
    Fnu Nagajyothi
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cell Cycle 5:107-12. 2006
    ....
  42. ncbi request reprint Protein kinase A regulatory subunit interacts with P-Type ATPases in Trypanosoma cruzi
    Yi Bao
    Department of Pathology and Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
    Am J Trop Med Hyg 80:941-3. 2009
    ..We found that the PKA regulatory subunit interacts with several P-type ATPases. These P-type ATPases may play a role in anchoring PKA to the plasma membrane in T. cruzi...
  43. pmc Role of protein kinase A in Trypanosoma cruzi
    Yi Bao
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 76:4757-63. 2008
    ..Taken together, these findings demonstrate the importance of cAMP-PKA signaling in this organism...
  44. pmc Toxoplasma: the next 100years
    Kami Kim
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Microbes Infect 10:978-84. 2008
    ..This review addresses recent advances in our understanding of the developmental biology and host-pathogen relationships of T. gondii...
  45. pmc Structure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470
    John Jeff Alvarado
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Biochem Parasitol 168:158-67. 2009
    ..bieneusi MetAP2. Comparison of microsporidian MetAP2 structures with human MetAP2 provides insights into the design of inhibitors that might exhibit specificity for microsporidian MetAP2...
  46. ncbi request reprint Microarray technology in the investigation of diseases of myocardium with special reference to infection
    Shankar Mukherjee
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Front Biosci 11:1802-13. 2006
    ..This paper provides an overview of microarray technology and its recent developments followed by its usage in studies of cardiovascular disease and how it pertains to viral and parasitic infections of the heart...
  47. pmc Functional characterization of a putative aquaporin from Encephalitozoon cuniculi, a microsporidia pathogenic to humans
    Kaya Ghosh
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Int J Parasitol 36:57-62. 2006
    ..EcAQP exhibits sequence identity to AQP A of Dictyostelium discoideum (26%) and human AQP 2 (24%). Further study of AQPs in microsporidia and their potential inhibitors may yield novel therapeutic agents for microsporidian infections...
  48. ncbi request reprint Chagas disease, adipose tissue and the metabolic syndrome
    Fnu Nagajyothi
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA
    Mem Inst Oswaldo Cruz 104:219-25. 2009
    ..Adipose tissue is an important target tissue of T. cruzi and the infection of this tissue is associated with a profound impact on systemic metabolism, increasing the risk of metabolic syndrome...
  49. pmc 3-Methyladenine blocks Toxoplasma gondii division prior to centrosome replication
    Yubao Wang
    Department of Pathology, Albert Einstein College of Medicine, Golding 704, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Mol Biochem Parasitol 173:142-53. 2010
    ..Elucidation of the mechanism of 3-MA inhibition may provide insight into the control of parasite growth...
  50. pmc Coordinate control of host centrosome position, organelle distribution, and migratory response by Toxoplasma gondii via host mTORC2
    Yubao Wang
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 285:15611-8. 2010
    ....
  51. pmc A method for rapid regulation of protein expression in Trypanosoma cruzi
    Yan Fen Ma
    Department of Pathology, Albert Einstein College of Medicine, Jack and Pearl Resnick Campus, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Int J Parasitol 42:33-7. 2012
    ..This vector allows rapid and reversible protein expression and efficient functional analysis of proteins in different T. cruzi life cycle stages...
  52. pmc Proliferation of Toxoplasma gondii in inflammatory macrophages in vivo is associated with diminished oxygen radical production in the host cell
    Sunder P Shrestha
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, G704, Bronx, NY 10461, USA
    Int J Parasitol 36:433-41. 2006
    ..ROS function and parasite evasion of this function may contribute significantly to the balance between host defense and disease progression during acute infection...
  53. pmc Host cell autophagy is induced by Toxoplasma gondii and contributes to parasite growth
    Yubao Wang
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 284:1694-701. 2009
    ..These findings indicate a new role for autophagy as a pathway by which parasites may effectively compete with the host cell for limiting anabolic resources...
  54. ncbi request reprint Microarray analysis of changes in gene expression in a murine model of chronic chagasic cardiomyopathy
    Shankar Mukherjee
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Parasitol Res 91:187-96. 2003
    ..The regulated genes are interpreted in the pathogenesis of chagasic heart disease...
  55. pmc Imaging of small-animal models of infectious diseases
    Linda A Jelicks
    Department of Physiology and Biophysics and the Gruss Magnetic Resonance Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Pathol 182:296-304. 2013
    ..Imaging studies permit enhanced information through longitudinal studies of the same animal during the infection. Herein, we briefly review recent studies of animal models of infectious disease that have used imaging modalities...
  56. pmc Toxoplasmosis: A history of clinical observations
    Louis M Weiss
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Int J Parasitol 39:895-901. 2009
    ..gondii as a cause of human disease. This review examines the clinical manifestations of infection with T. gondii and the history of the discovery of these manifestations...
  57. pmc Cerebral malaria: we have come a long way
    Henry J Shikani
    Division of Parasitology and Tropical Medicine, Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    Am J Pathol 181:1484-92. 2012
    ..The present review highlights information gleaned from these studies, especially in terms of their contributions to the understanding of cerebral malaria...
  58. pmc Improved techniques for endogenous epitope tagging and gene deletion in Toxoplasma gondii
    Rajendra Upadhya
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Microbiol Methods 85:103-13. 2011
    ..gondii UPRT gene locus as a test case. The methods described in this paper represent an improved strategy for efficient epitope tagging and gene disruptions in T. gondii...
  59. pmc Cyclic nucleotide kinases and tachyzoite-bradyzoite transition in Toxoplasma gondii
    Michael S Eaton
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Int J Parasitol 36:107-14. 2006
    ..The beta-GAL/CAT reporter parasite provides a method to quantify and compare agents that cause differentiation in T. gondii...
  60. ncbi request reprint Phosphoramidon treatment improves the consequences of chagasic heart disease in mice
    Linda A Jelicks
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, U S A
    Clin Sci (Lond) 103:267S-271S. 2002
    ..These data are consistent with the hypothesis that ET-1 contributes to the pathogenesis of murine chagasic cardiomyopathy and suggests that interventions targeting ET-1 would improve the outcome in chagasic heart disease...
  61. ncbi request reprint Risedronate in the treatment of Murine Chagas' disease
    Boumediene Bouzahzah
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Parasitol Res 96:184-7. 2005
    ..In addition, it underscores the need to use different strains of T. cruzi...
  62. pmc The novel ETA receptor antagonist HJP-272 prevents cerebral microvascular hemorrhage in cerebral malaria and synergistically improves survival in combination with an artemisinin derivative
    Minxian Dai
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, United States
    Life Sci 91:687-92. 2012
    ....
  63. doi request reprint Blastocystis: to treat or not to treat
    Christina M Coyle
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Clin Infect Dis 54:105-10. 2012
    ..Metronidazole is the drug of choice. Additional studies are required to determine pathogenicity and appropriate therapy...
  64. pmc Intracellular parasitism with Toxoplasma gondii stimulates mammalian-target-of-rapamycin-dependent host cell growth despite impaired signalling to S6K1 and 4E-BP1
    Yubao Wang
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cell Microbiol 11:983-1000. 2009
    ..The Toxoplasma-infected cell provides a unique example of non-canonical mTOR activation supporting growth that is independent of signalling through either S6K1 or 4E-BP1...
  65. pmc System for expression of microsporidian methionine amino peptidase type 2 (MetAP2) in the yeast Saccharomyces cerevisiae
    Rajendra Upadhya
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Antimicrob Agents Chemother 50:3389-95. 2006
    ..These yeast strains should permit high-throughput screening for the identification of new inhibitors with high specificity and activity toward microsporidian MetAP2...
  66. pmc Cerebral malaria: a vasculopathy
    Mahalia S Desruisseaux
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461
    Am J Pathol 176:1075-8. 2010
    ..This Commentary highlights recent advances in research on cerebral malaria...
  67. pmc Role of endothelin 1 in the pathogenesis of chronic chagasic heart disease
    Herbert B Tanowitz
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Infect Immun 73:2496-503. 2005
    ..These data provide further evidence of a role for ET-1, particularly cardiac myocyte-derived ET-1, in the pathogenesis of chronic Chagasic cardiomyopathy...
  68. ncbi request reprint Role of cardiac myocyte-derived endothelin-1 in chagasic cardiomyopathy: molecular genetic evidence
    Huan Huang
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park, Bronx, New York, NY 10461, U S A
    Clin Sci (Lond) 103:263S-266S. 2002
    ..These data provide further support for a role for ET-1 in the pathogenesis of chronic chagasic heart disease, and indicate that cardiac myocytes are an important source of ET-1 in this disease...
  69. ncbi request reprint Babesiosis in humans: a treatment review
    Louis M Weiss
    Division of Infectious Diseases, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Room 504 Forchheimer Building, Bronx, New York, 10461, USA
    Expert Opin Pharmacother 3:1109-15. 2002
    ..This paper reviews the literature on the treatment of human babesiosis and the animal models of these human pathogens...
  70. ncbi request reprint Characterization of recombinant microsporidian methionine aminopeptidase type 2
    Louis M Weiss
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Eukaryot Microbiol 50:597-9. 2003
  71. ncbi request reprint Molecular cloning and expression of the catalytic subunit of protein kinase A from Trypanosoma cruzi
    Huan Huang
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Int J Parasitol 32:1107-15. 2002
    ..cruzi and are the first demonstration of PKI-inhibitory phosphotransferase activity in an expressed protozoan protein kinase A catalytic subunit...
  72. ncbi request reprint Deficiency in the anti-apoptotic protein A1-a results in a diminished acute inflammatory response
    Amos Orlofsky
    Department of Pathology, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 168:1840-6. 2002
    ..Increased apoptosis in inflammatory neutrophils was observed sporadically in A1-a-deficient mice. Regulation of apoptosis by A1-a may be an important proinflammatory event in acute host responses...
  73. pmc Toxoplasma gondii proteomics
    Louis M Weiss
    Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Forchheimer 504, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Expert Rev Proteomics 6:303-13. 2009
    ..Web-based resources, such as EPIC-DB and ToxoDB, provide proteomic data and support for studies on T. gondii. This review will summarize the current status of proteomic research on T. gondii...
  74. ncbi request reprint Microsporidia 2003: IWOP-8
    Louis M Weiss
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Eukaryot Microbiol 50:566-8. 2003
  75. ncbi request reprint The International Congress on Toxoplasmosis
    Louis M Weiss
    Department of Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    Int J Parasitol 34:249-52. 2004
    ..The presented research covered the epidemiology, immunology, cellular biology and molecular biology of this pathogen...
  76. pmc Fatal myositis due to the microsporidian Brachiola algerae, a mosquito pathogen
    Christina M Coyle
    Department of Medicine, Jacobi Medical Center, Bronx, NY 10461, USA
    N Engl J Med 351:42-7. 2004
  77. pmc Nonprotein based enrichment method to analyze peptide cross-linking in protein complexes
    Funing Yan
    Department of Biochemistry, and Biodefense Proteomics Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Anal Chem 81:7149-59. 2009
    ..These features may make the method suitable to investigate protein-protein interactions in biological samples...
  78. pmc Toxoplasma gondii: the model apicomplexan
    Kami Kim
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Int J Parasitol 34:423-32. 2004
    ..While results in T. gondii will not always be applicable to other Apicomplexa, T. gondii remains an important model system for understanding the biology of apicomplexan parasites...
  79. ncbi request reprint Cardioprotective effects of phosphoramidon on myocardial structure and function in murine Chagas' disease
    Linda A Jelicks
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Int J Parasitol 32:1497-506. 2002
    ....
  80. ncbi request reprint Effects of early and late verapamil administration on the development of cardiomyopathy in experimental chronic Trypanosoma cruzi (Brazil strain) infection
    Andrea P De Souza
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Parasitol Res 92:496-501. 2004
    ..Our data underscore the hypothesis that early events determine the progression to cardiomyopathy and that early treatment with verapamil can prevent such progression...
  81. ncbi request reprint Significance of inducible nitric oxide synthase in acute myocarditis caused by Trypanosoma cruzi (Tulahuen strain)
    Madhulika Chandra
    Department of Medicine, Cardiovascular and Infectious Diseases Divisions, The Jack D Weiler Hospital of the Albert Einstein College of Medicine, 1825 Eastchester Road, Room W1 70, Bronx, NY 10461, USA
    Int J Parasitol 32:897-905. 2002
    ....
  82. pmc Investigations into microsporidian methionine aminopeptidase type 2: a therapeutic target for microsporidiosis
    Hong Zhang
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Folia Parasitol (Praha) 52:182-92. 2005
    ..These reagents provide new tools for the development of in vitro assay systems to screen candidate compounds for use as new therapeutic agents for the treatment of microsporidiosis...
  83. ncbi request reprint Cardioprotective effects of verapamil on myocardial structure and function in a murine model of chronic Trypanosoma cruzi infection (Brazil Strain): an echocardiographic study
    Madhulika Chandra
    Division of Cardiology, Department of Medicine, Albert Einstein College of Medicine and the Montefiore Medical Center, 1300 Morris Park Avenue, Bronx, New York, NY 10461, USA
    Int J Parasitol 32:207-15. 2002
    ..These data provide cardiac structural and functional correlates for the previously observed cardioprotective effects of verapamil in chronic chagasic cardiomyopathy...
  84. ncbi request reprint Caveolin-1 null (-/-) mice show dramatic reductions in life span
    David S Park
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Biochemistry 42:15124-31. 2003
    ..In addition, aged Cav-1 null mice may provide a new animal model to study the pathogenesis and treatment of progressive hypertrophic cardiomyopathy and sudden cardiac death syndrome...
  85. pmc Caveolin-1/3 double-knockout mice are viable, but lack both muscle and non-muscle caveolae, and develop a severe cardiomyopathic phenotype
    David S Park
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Pathol 160:2207-17. 2002
    ..Thus, dual ablation of both Cav-1 and Cav-3 genes in mice leads to a pleiotropic defect in caveolae formation and severe cardiomyopathy...
  86. pmc Identification and characterisation of a regulatory region in the Toxoplasma gondii hsp70 genomic locus
    Yan Fen Ma
    Division of Parasitology and Tropical Medicine, Department of Pathology, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Room 504 Forchheimer Building, Bronx, New York 10461 USA
    Int J Parasitol 34:333-46. 2004
    ..These data support the identification of a pH responsive cis-regulatory element in the T. gondii hsp70 gene locus. A model of the interaction of hsp70 and small heat shock proteins (e.g. BAG1) in development is presented...
  87. pmc Glycosylation of the major polar tube protein of Encephalitozoon hellem, a microsporidian parasite that infects humans
    Yanji Xu
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Infect Immun 72:6341-50. 2004
    ..hellem infection compared to wild-type CHO cells. These data suggest that the O-mannosylation of PTP1 may have functional significance for the ability of microsporidia to invade their host cells...
  88. ncbi request reprint Lectin binding of the major polar tube protein (PTP1) and its role in invasion
    Yanji Xu
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Eukaryot Microbiol 50:600-1. 2003
  89. ncbi request reprint The adipocyte as an important target cell for Trypanosoma cruzi infection
    Terry P Combs
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 280:24085-94. 2005
    ....
  90. ncbi request reprint Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts
    Alex W Cohen
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol Cell Physiol 284:C457-74. 2003
    ..In addition, endothelial and inducible nitric oxide synthase levels are dramatically upregulated. Thus loss of caveolin-1 expression drives p42/44 MAP kinase activation and cardiac hypertrophy...
  91. ncbi request reprint Microsporidia 2006: IWOP-9
    Kaya Ghosh
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue Room F504, Bronx, New York 10461, USA
    J Eukaryot Microbiol 53:S52-4. 2006
  92. pmc Trypanosoma cruzi infection activates extracellular signal-regulated kinase in cultured endothelial and smooth muscle cells
    Shankar Mukherjee
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Infect Immun 72:5274-82. 2004
    ..These data suggest a possible molecular paradigm for the pathogenesis of the vasculopathy and the cardiovascular remodeling associated with T. cruzi infection...
  93. pmc Activation of transcription factors AP-1 and NF-kappa B in murine Chagasic myocarditis
    Huan Huang
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 71:2859-67. 2003
    ..Cyclin D1 expression was also increased. These observations provide a molecular basis for the activation of pathways involved in cardiac remodeling in chagasic cardiomyopathy...