Weigang Wang

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi request reprint Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors
    Weigang Wang
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 64:8585-94. 2004
  2. pmc Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors
    Evanthia T Roussos
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Breast Cancer Res 12:R101. 2010
  3. pmc WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells
    Corina Sarmiento
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
    J Cell Biol 180:1245-60. 2008
  4. ncbi request reprint Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors
    Weigang Wang
    Department of Anatomy and Structural Biology and Gruss Lipper Center for Biophotonics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cancer Res 67:3505-11. 2007
  5. pmc Cofilin determines the migration behavior and turning frequency of metastatic cancer cells
    Mazen Sidani
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    J Cell Biol 179:777-91. 2007
  6. ncbi request reprint Tumor cells caught in the act of invading: their strategy for enhanced cell motility
    Weigang Wang
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Trends Cell Biol 15:138-45. 2005
  7. pmc The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors
    Weigang Wang
    Department of Anatomy and Structural Biology and 2Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Biol 173:395-404. 2006
  8. ncbi request reprint A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors
    Jeffrey Wyckoff
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 64:7022-9. 2004
  9. ncbi request reprint Spatial and temporal control of cofilin activity is required for directional sensing during chemotaxis
    Ghassan Mouneimne
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Curr Biol 16:2193-205. 2006
  10. pmc Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo
    Sumanta Goswami
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Clin Exp Metastasis 26:153-9. 2009

Detail Information

Publications18

  1. ncbi request reprint Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors
    Weigang Wang
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 64:8585-94. 2004
    ..ZBP1 reexpression also inhibited metastasis from tumors. These experiments support the involvement in metastasis of the pathways identified in invasive cells, which are regulated by ZBP1...
  2. pmc Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors
    Evanthia T Roussos
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Breast Cancer Res 12:R101. 2010
    ..Whether Mena is required for tumor progression is still unknown. Here we report the effects of Mena deficiency on tumor progression, metastasis and on normal mammary gland development...
  3. pmc WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells
    Corina Sarmiento
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
    J Cell Biol 180:1245-60. 2008
    ..These data show that coordinate regulation between the WASP family and mDia proteins controls the balance between lamellar and lamellipodial protrusion activity...
  4. ncbi request reprint Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors
    Weigang Wang
    Department of Anatomy and Structural Biology and Gruss Lipper Center for Biophotonics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cancer Res 67:3505-11. 2007
    ....
  5. pmc Cofilin determines the migration behavior and turning frequency of metastatic cancer cells
    Mazen Sidani
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    J Cell Biol 179:777-91. 2007
    ..The changes in cell shape, directional migration, and turning frequency were related to the re-localization of Arp2/3 complex to one pole of the cell upon suppression of cofilin expression...
  6. ncbi request reprint Tumor cells caught in the act of invading: their strategy for enhanced cell motility
    Weigang Wang
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Trends Cell Biol 15:138-45. 2005
    ..These results support a "tumor microenvironment invasion model" and provide new target opportunities for cancer therapy...
  7. pmc The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors
    Weigang Wang
    Department of Anatomy and Structural Biology and 2Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Biol 173:395-404. 2006
    ..LIMK1-mediated decreases or increases in the activity of the cofilin pathway are shown to cause proportional decreases or increases in motility, intravasation, and metastasis of tumor cells...
  8. ncbi request reprint A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors
    Jeffrey Wyckoff
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 64:7022-9. 2004
    ..This work provides the first direct evidence for a synergistic interaction between macrophages and tumor cells during cell migration in vivo and indicates a mechanism for how macrophages may contribute to metastasis...
  9. ncbi request reprint Spatial and temporal control of cofilin activity is required for directional sensing during chemotaxis
    Ghassan Mouneimne
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Curr Biol 16:2193-205. 2006
    ..We have tested this hypothesis by investigating whether activation of endogenous cofilin is spatially and temporally linked to sensing an EGF point source in carcinoma cells...
  10. pmc Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo
    Sumanta Goswami
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Clin Exp Metastasis 26:153-9. 2009
    ..The Mena isoform switching pattern described here may provide a new biomarker for the presence of metastatic cancer cells and for prognosis...
  11. ncbi request reprint Breast cancer cells isolated by chemotaxis from primary tumors show increased survival and resistance to chemotherapy
    Sumanta Goswami
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 64:7664-7. 2004
    ..In addition, these results indicate that tumor cells that are chemotactic and migratory in response to epidermal growth factor in the primary tumor have a survival advantage over stationary tumor cells...
  12. pmc Gene expression analysis on small numbers of invasive cells collected by chemotaxis from primary mammary tumors of the mouse
    Weigang Wang
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    BMC Biotechnol 3:13. 2003
    ..We have combined chemotaxis-based cell collection of the invasive subpopulation of cells within the primary tumor with array-based gene expression analysis to identify the genes necessary for the process of carcinoma cell invasion...
  13. pmc Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophages
    Elaine Y Lin
    Department of Developmental and Molecular Biology, Center of Reproductive Biology and Women s Health, Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Oncol 1:288-302. 2007
    ..This study suggests that macrophage-produced VEGF regulates malignant progression through stimulating tumor angiogenesis, leukocytic infiltration and tumor cell invasion...
  14. ncbi request reprint Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling
    Weigang Wang
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 62:6278-88. 2002
    ..We conclude that aligning cell behavior in vivo with patterns of gene expression can lead to new insights into the microenvironment of carcinoma cells in the primary tumor and the molecular mechanisms behind cell behavior...
  15. ncbi request reprint GFP expression in the mammary gland for imaging of mammary tumor cells in transgenic mice
    Fayyaz Ahmed
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 62:7166-9. 2002
    ..These animals provide a range of expression of GFP that is suitable for analysis of transgenic mammary tumors and metastases in vivo at the single cell level of resolution...
  16. ncbi request reprint The cofilin pathway in breast cancer invasion and metastasis
    Weigang Wang
    Experimental Therapeutics, ImClone Systems Incorporated, New York, New York, USA
    Nat Rev Cancer 7:429-40. 2007
    ..These results predict that inhibitors directed at the output of the cofilin pathway will have therapeutic benefit in combating metastasis...
  17. ncbi request reprint Involvement of ghrelin-growth hormone secretagogue receptor system in pathoclinical profiles of digestive system cancer
    Zhigang Wang
    Department of General Surgery, Shanghai Jiaotong University Affiliated No 6 Hospital, Shanghai 200233, China
    Acta Biochim Biophys Sin (Shanghai) 39:992-8. 2007
    ..For the first time, we identified the distribution of ghrelin receptor in digestive system cancers. Our results implied that the ghrelin-GHS-R system might be involved in the pathoclinical profiles of digestive cancers...
  18. doi request reprint PD-L1/PD-1 signal deficiency promotes allogeneic immune responses and accelerates heart allograft rejection
    Weigang Wang
    Division of Transplantation, Department of Surgery, University of Washington Medical Center, Seattle, WA 98195, USA
    Transplantation 86:836-44. 2008
    ..PD-L1, a ligand for programmed death 1 (PD-1), delivers a negative costimulatory signal to T cells and plays a critical role in the regulation of peripheral tolerance...