Research Topics
Genomes and Genes | Weigang WangSummaryAffiliation: Albert Einstein College of Medicine Country: USA Publications
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Detail Information
Publications
Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumorsWeigang Wang
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cancer Res 64:8585-94. 2004..ZBP1 reexpression also inhibited metastasis from tumors. These experiments support the involvement in metastasis of the pathways identified in invasive cells, which are regulated by ZBP1...
Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumorsEvanthia T Roussos
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Breast Cancer Res 12:R101. 2010..Whether Mena is required for tumor progression is still unknown. Here we report the effects of Mena deficiency on tumor progression, metastasis and on normal mammary gland development...- WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cellsCorina Sarmiento
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
J Cell Biol 180:1245-60. 2008..These data show that coordinate regulation between the WASP family and mDia proteins controls the balance between lamellar and lamellipodial protrusion activity... - Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumorsWeigang Wang
Department of Anatomy and Structural Biology and Gruss Lipper Center for Biophotonics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Cancer Res 67:3505-11. 2007.... 
Cofilin determines the migration behavior and turning frequency of metastatic cancer cellsMazen Sidani
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
J Cell Biol 179:777-91. 2007..The changes in cell shape, directional migration, and turning frequency were related to the re-localization of Arp2/3 complex to one pole of the cell upon suppression of cofilin expression...- Tumor cells caught in the act of invading: their strategy for enhanced cell motilityWeigang Wang
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Trends Cell Biol 15:138-45. 2005..These results support a "tumor microenvironment invasion model" and provide new target opportunities for cancer therapy... - The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumorsWeigang Wang
Department of Anatomy and Structural Biology and 2Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Cell Biol 173:395-404. 2006..LIMK1-mediated decreases or increases in the activity of the cofilin pathway are shown to cause proportional decreases or increases in motility, intravasation, and metastasis of tumor cells... - A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumorsJeffrey Wyckoff
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cancer Res 64:7022-9. 2004..This work provides the first direct evidence for a synergistic interaction between macrophages and tumor cells during cell migration in vivo and indicates a mechanism for how macrophages may contribute to metastasis... - Spatial and temporal control of cofilin activity is required for directional sensing during chemotaxisGhassan Mouneimne
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
Curr Biol 16:2193-205. 2006..We have tested this hypothesis by investigating whether activation of endogenous cofilin is spatially and temporally linked to sensing an EGF point source in carcinoma cells... - Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivoSumanta Goswami
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Clin Exp Metastasis 26:153-9. 2009..The Mena isoform switching pattern described here may provide a new biomarker for the presence of metastatic cancer cells and for prognosis... - Breast cancer cells isolated by chemotaxis from primary tumors show increased survival and resistance to chemotherapySumanta Goswami
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cancer Res 64:7664-7. 2004..In addition, these results indicate that tumor cells that are chemotactic and migratory in response to epidermal growth factor in the primary tumor have a survival advantage over stationary tumor cells... - Gene expression analysis on small numbers of invasive cells collected by chemotaxis from primary mammary tumors of the mouseWeigang Wang
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
BMC Biotechnol 3:13. 2003..We have combined chemotaxis-based cell collection of the invasive subpopulation of cells within the primary tumor with array-based gene expression analysis to identify the genes necessary for the process of carcinoma cell invasion... - Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profilingWeigang Wang
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cancer Res 62:6278-88. 2002..We conclude that aligning cell behavior in vivo with patterns of gene expression can lead to new insights into the microenvironment of carcinoma cells in the primary tumor and the molecular mechanisms behind cell behavior... - Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophagesElaine Y Lin
Department of Developmental and Molecular Biology, Center of Reproductive Biology and Women s Health, Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Mol Oncol 1:288-302. 2007..This study suggests that macrophage-produced VEGF regulates malignant progression through stimulating tumor angiogenesis, leukocytic infiltration and tumor cell invasion... - GFP expression in the mammary gland for imaging of mammary tumor cells in transgenic miceFayyaz Ahmed
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cancer Res 62:7166-9. 2002..These animals provide a range of expression of GFP that is suitable for analysis of transgenic mammary tumors and metastases in vivo at the single cell level of resolution... - The cofilin pathway in breast cancer invasion and metastasisWeigang Wang
Experimental Therapeutics, ImClone Systems Incorporated, New York, New York, USA
Nat Rev Cancer 7:429-40. 2007..These results predict that inhibitors directed at the output of the cofilin pathway will have therapeutic benefit in combating metastasis... - Involvement of ghrelin-growth hormone secretagogue receptor system in pathoclinical profiles of digestive system cancerZhigang Wang
Department of General Surgery, Shanghai Jiaotong University Affiliated No 6 Hospital, Shanghai 200233, China
Acta Biochim Biophys Sin (Shanghai) 39:992-8. 2007..For the first time, we identified the distribution of ghrelin receptor in digestive system cancers. Our results implied that the ghrelin-GHS-R system might be involved in the pathoclinical profiles of digestive cancers... 
PD-L1/PD-1 signal deficiency promotes allogeneic immune responses and accelerates heart allograft rejectionWeigang Wang
Division of Transplantation, Department of Surgery, University of Washington Medical Center, Seattle, WA 98195, USA
Transplantation 86:836-44. 2008..PD-L1, a ligand for programmed death 1 (PD-1), delivers a negative costimulatory signal to T cells and plays a critical role in the regulation of peripheral tolerance...