Genomes and Genes
Patricia M Vuguin
Affiliation: Albert Einstein College of Medicine
- Animal models for small for gestational age and fetal programming of adult diseasePatricia M Vuguin
Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA
Horm Res 68:113-23. 2007..This review describes animal models for intrauterine growth retardation and assesses their potentials and limitations at aiming to improve strategies for the prevention of adult disease...
- Hepatic insulin resistance precedes the development of diabetes in a model of intrauterine growth retardationPatricia Vuguin
Children s Hospital at Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA
Diabetes 53:2617-22. 2004....
- Prediction models for insulin resistance in girls with premature adrenarche. The premature adrenarche insulin resistance score: PAIR scorePatricia Vuguin
Division of Pediatric Endocrinology, Children s Hospital at Montefiore Medical Center, Bronx, NY 10467, USA
Horm Res 65:185-91. 2006..The purpose of this study was to develop an accurate regression model to predict insulin resistance in girls with premature adrenarche...
- Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturationPatricia M Vuguin
Division of Pediatric Endocrinology, Children s Hospital at Montefiore Medical Center, 111 East 210th Street, Bronx, New York 10476, USA
Endocrinology 147:3995-4006. 2006..These findings suggest that GLU participates in a feedback loop that regulates the proportion of the different endocrine cell types in islets, the number of islets per pancreas, and development of the mature alpha-cell phenotype...
- Shared effects of genetic and intrauterine and perinatal environment on the development of metabolic syndromePatricia M Vuguin
Division of Pediatric Endocrinology, Children s Hospital at Montefiore, Bronx, New York, United States of America
PLoS ONE 8:e63021. 2013..These results suggest that the interaction between in utero-perinatal environment and genotype plays a critical role in the developmental origin of health and disease...
- Neonatal exendin-4 treatment reduces oxidative stress and prevents hepatic insulin resistance in intrauterine growth-retarded ratsElisabeth L Raab
Department of Pediatrics, Children s Hospital Los Angeles, Los Angeles, California, USA
Am J Physiol Regul Integr Comp Physiol 297:R1785-94. 2009..These results indicate that exposure to exendin-4 in the newborn period reverses the adverse consequences of fetal programming and prevents the development of hepatic insulin resistance...
- Critical periods of increased fetal vulnerability to a maternal high fat dietMaria del Mar Plata
Department of Pediatrics, Albert Einstein College of Medicine, 10461 Bronx, NY, USA
Reprod Biol Endocrinol 12:80. 2014..Studies were performed to determine whether maternal exposure to HF diet at different stages during pregnancy had different effects on the fetus, including hepatic gene expression...
- Effects of genetics and in utero diet on murine pancreatic developmentChia Lei Lin
Departments of PediatricsNeonatologyBiochemistryObstetrics and Gynecology and Women s HealthMedicineAlbert Einstein College of Medicine, 1300 Morris Park Avenue, F312, Bronx, New York 10461, USADepartment of PediatricsHofstra School of Medicine, Cohen Children s Medical Center, 1991 Marcus Avenue, Lake Success, New York 11402, USA
J Endocrinol 222:217-27. 2014..Thus, interactions between IU diet and fetal genetics may play a critical role in the developmental origins of health and disease. ..
- Maternal substrate utilization programs the development of the metabolic syndrome in male mice exposed to high fat in uteroKirsten Hartil
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Pediatr Res 66:368-73. 2009..In contrast, male offspring of G4+/- HFD mothers did not exhibit any characteristics of metabolic syndrome. These data suggest that differences in maternal substrate utilization influence offspring metabolic phenotype...
- Pancreatic beta-cell overexpression of the glucagon receptor gene results in enhanced beta-cell function and massRichard W Gelling
Department of Biochemistry, Pediatric Endocrinology, Children s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York, Bronx, NY 10461, USA
Am J Physiol Endocrinol Metab 297:E695-707. 2009..These data indicate that increased pancreatic beta-cell expression of the Gcgr increased insulin secretion, pancreatic insulin content, beta-cell mass, and, when mice were fed a HFD, partially protected against hyperglycemia and IGT...
- Presentation and 5-year follow-up of type 2 diabetes mellitus in African-American and Caribbean-Hispanic adolescentsGabriela Grinstein
Department of Pediatrics, Division of Pediatric Endocrinology, Albert Einstein College of Medicine, Bronx, NY, USA
Horm Res 60:121-6. 2003..We report the presentation and 5-year follow-up of 89 African-American (AA) and Caribbean-Hispanic (CH) youths with type 2 diabetes mellitus (T2DM) followed at the Montefiore Medical Center, Bronx, N.Y., USA, from 1990 to 2000...
- Animal models of in utero exposure to a high fat diet: a reviewLyda Williams
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Biochim Biophys Acta 1842:507-19. 2014..Identifying and understanding the causal factors responsible for this metabolic dysregulation is vital to curtailing these epidemics. This article is part of a Special Issue entitled: Modulation of Adipose Tissue in Health and Disease. ..
- Assessing insulin resistance: application of a fasting glucose to insulin ratio in growth hormone-treated childrenTania S Burgert
Division of Pediatric Endocrinology, Children s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY 10467, USA
Horm Res 57:37-42. 2002..A fasting serum glucose (mg/dl) to plasma insulin (microU/ml) ratio (FGIR) of < 7 was recently suggested as a screening tool for IR in certain pediatric patients...
- Central and opposing effects of IGF-I and IGF-binding protein-3 on systemic insulin actionRadhika H Muzumdar
Division of Pediatric Endocrinology, Children s Hospital at Montefiore, New York, USA
Diabetes 55:2788-96. 2006..Marked, opposing, and independent physiological effects of IGF-I and IGFBP-3 through central mechanisms may have implications on potential strategies in specific modulation of peripheral insulin action...
- Decrease in glucose-stimulated insulin secretion with aging is independent of insulin actionRadhika Muzumdar
Division of Pediatric Endocrinology, Children s Hospital at Montefiore, Institute for Aging Research and Diabetes Research and Training Center, and the Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
Diabetes 53:441-6. 2004....
- Minireview: Epigenetic programming of diabetes and obesity: animal modelsYoshinori Seki
Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
Endocrinology 153:1031-8. 2012..This review article is focused solely on studies in animal models that demonstrate epigenetic changes that are correlated with manifestation of metabolic disease, including diabetes and/or obesity...
- Nestin expression in pancreatic endocrine and exocrine cells of mice lacking glucagon signalingMamdouh H Kedees
Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
Dev Dyn 236:1126-33. 2007..We conclude that nestin+ cells located in the pancreatic primordium generate the cells of the endocrine and exocrine lineages. Furthermore, our results suggest that nestin expression is regulated by glucagon signaling...
- Nutrition, Early Development and Glucose MetabolismPatricia Vuguin; Fiscal Year: 2007..abstract_text> ..