Patricia M Vuguin

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi Animal models for small for gestational age and fetal programming of adult disease
    Patricia M Vuguin
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA
    Horm Res 68:113-23. 2007
  2. ncbi Hepatic insulin resistance precedes the development of diabetes in a model of intrauterine growth retardation
    Patricia Vuguin
    Children s Hospital at Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Diabetes 53:2617-22. 2004
  3. ncbi Prediction models for insulin resistance in girls with premature adrenarche. The premature adrenarche insulin resistance score: PAIR score
    Patricia Vuguin
    Division of Pediatric Endocrinology, Children s Hospital at Montefiore Medical Center, Bronx, NY 10467, USA
    Horm Res 65:185-91. 2006
  4. ncbi Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation
    Patricia M Vuguin
    Division of Pediatric Endocrinology, Children s Hospital at Montefiore Medical Center, 111 East 210th Street, Bronx, New York 10476, USA
    Endocrinology 147:3995-4006. 2006
  5. pmc Shared effects of genetic and intrauterine and perinatal environment on the development of metabolic syndrome
    Patricia M Vuguin
    Division of Pediatric Endocrinology, Children s Hospital at Montefiore, Bronx, New York, United States of America
    PLoS ONE 8:e63021. 2013
  6. pmc Neonatal exendin-4 treatment reduces oxidative stress and prevents hepatic insulin resistance in intrauterine growth-retarded rats
    Elisabeth L Raab
    Department of Pediatrics, Children s Hospital Los Angeles, Los Angeles, California, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1785-94. 2009
  7. pmc Maternal substrate utilization programs the development of the metabolic syndrome in male mice exposed to high fat in utero
    Kirsten Hartil
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Pediatr Res 66:368-73. 2009
  8. pmc Pancreatic beta-cell overexpression of the glucagon receptor gene results in enhanced beta-cell function and mass
    Richard W Gelling
    Department of Biochemistry, Pediatric Endocrinology, Children s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York, Bronx, NY 10461, USA
    Am J Physiol Endocrinol Metab 297:E695-707. 2009
  9. ncbi Presentation and 5-year follow-up of type 2 diabetes mellitus in African-American and Caribbean-Hispanic adolescents
    Gabriela Grinstein
    Department of Pediatrics, Division of Pediatric Endocrinology, Albert Einstein College of Medicine, Bronx, NY, USA
    Horm Res 60:121-6. 2003
  10. pmc Animal models of in utero exposure to a high fat diet: a review
    Lyda Williams
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Biochim Biophys Acta 1842:507-19. 2014

Research Grants

  1. Nutrition, Early Development and Glucose Metabolism
    Patricia Vuguin; Fiscal Year: 2007

Collaborators

Detail Information

Publications15

  1. ncbi Animal models for small for gestational age and fetal programming of adult disease
    Patricia M Vuguin
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA
    Horm Res 68:113-23. 2007
    ..This review describes animal models for intrauterine growth retardation and assesses their potentials and limitations at aiming to improve strategies for the prevention of adult disease...
  2. ncbi Hepatic insulin resistance precedes the development of diabetes in a model of intrauterine growth retardation
    Patricia Vuguin
    Children s Hospital at Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Diabetes 53:2617-22. 2004
    ....
  3. ncbi Prediction models for insulin resistance in girls with premature adrenarche. The premature adrenarche insulin resistance score: PAIR score
    Patricia Vuguin
    Division of Pediatric Endocrinology, Children s Hospital at Montefiore Medical Center, Bronx, NY 10467, USA
    Horm Res 65:185-91. 2006
    ..The purpose of this study was to develop an accurate regression model to predict insulin resistance in girls with premature adrenarche...
  4. ncbi Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation
    Patricia M Vuguin
    Division of Pediatric Endocrinology, Children s Hospital at Montefiore Medical Center, 111 East 210th Street, Bronx, New York 10476, USA
    Endocrinology 147:3995-4006. 2006
    ..These findings suggest that GLU participates in a feedback loop that regulates the proportion of the different endocrine cell types in islets, the number of islets per pancreas, and development of the mature alpha-cell phenotype...
  5. pmc Shared effects of genetic and intrauterine and perinatal environment on the development of metabolic syndrome
    Patricia M Vuguin
    Division of Pediatric Endocrinology, Children s Hospital at Montefiore, Bronx, New York, United States of America
    PLoS ONE 8:e63021. 2013
    ..These results suggest that the interaction between in utero-perinatal environment and genotype plays a critical role in the developmental origin of health and disease...
  6. pmc Neonatal exendin-4 treatment reduces oxidative stress and prevents hepatic insulin resistance in intrauterine growth-retarded rats
    Elisabeth L Raab
    Department of Pediatrics, Children s Hospital Los Angeles, Los Angeles, California, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1785-94. 2009
    ..These results indicate that exposure to exendin-4 in the newborn period reverses the adverse consequences of fetal programming and prevents the development of hepatic insulin resistance...
  7. pmc Maternal substrate utilization programs the development of the metabolic syndrome in male mice exposed to high fat in utero
    Kirsten Hartil
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Pediatr Res 66:368-73. 2009
    ..In contrast, male offspring of G4+/- HFD mothers did not exhibit any characteristics of metabolic syndrome. These data suggest that differences in maternal substrate utilization influence offspring metabolic phenotype...
  8. pmc Pancreatic beta-cell overexpression of the glucagon receptor gene results in enhanced beta-cell function and mass
    Richard W Gelling
    Department of Biochemistry, Pediatric Endocrinology, Children s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York, Bronx, NY 10461, USA
    Am J Physiol Endocrinol Metab 297:E695-707. 2009
    ..These data indicate that increased pancreatic beta-cell expression of the Gcgr increased insulin secretion, pancreatic insulin content, beta-cell mass, and, when mice were fed a HFD, partially protected against hyperglycemia and IGT...
  9. ncbi Presentation and 5-year follow-up of type 2 diabetes mellitus in African-American and Caribbean-Hispanic adolescents
    Gabriela Grinstein
    Department of Pediatrics, Division of Pediatric Endocrinology, Albert Einstein College of Medicine, Bronx, NY, USA
    Horm Res 60:121-6. 2003
    ..We report the presentation and 5-year follow-up of 89 African-American (AA) and Caribbean-Hispanic (CH) youths with type 2 diabetes mellitus (T2DM) followed at the Montefiore Medical Center, Bronx, N.Y., USA, from 1990 to 2000...
  10. pmc Animal models of in utero exposure to a high fat diet: a review
    Lyda Williams
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Biochim Biophys Acta 1842:507-19. 2014
    ..Identifying and understanding the causal factors responsible for this metabolic dysregulation is vital to curtailing these epidemics. This article is part of a Special Issue entitled: Modulation of Adipose Tissue in Health and Disease. ..
  11. ncbi Assessing insulin resistance: application of a fasting glucose to insulin ratio in growth hormone-treated children
    Tania S Burgert
    Division of Pediatric Endocrinology, Children s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY 10467, USA
    Horm Res 57:37-42. 2002
    ..A fasting serum glucose (mg/dl) to plasma insulin (microU/ml) ratio (FGIR) of < 7 was recently suggested as a screening tool for IR in certain pediatric patients...
  12. ncbi Central and opposing effects of IGF-I and IGF-binding protein-3 on systemic insulin action
    Radhika H Muzumdar
    Division of Pediatric Endocrinology, Children s Hospital at Montefiore, New York, USA
    Diabetes 55:2788-96. 2006
    ..Marked, opposing, and independent physiological effects of IGF-I and IGFBP-3 through central mechanisms may have implications on potential strategies in specific modulation of peripheral insulin action...
  13. ncbi Decrease in glucose-stimulated insulin secretion with aging is independent of insulin action
    Radhika Muzumdar
    Division of Pediatric Endocrinology, Children s Hospital at Montefiore, Institute for Aging Research and Diabetes Research and Training Center, and the Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
    Diabetes 53:441-6. 2004
    ....
  14. pmc Minireview: Epigenetic programming of diabetes and obesity: animal models
    Yoshinori Seki
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Endocrinology 153:1031-8. 2012
    ..This review article is focused solely on studies in animal models that demonstrate epigenetic changes that are correlated with manifestation of metabolic disease, including diabetes and/or obesity...
  15. ncbi Nestin expression in pancreatic endocrine and exocrine cells of mice lacking glucagon signaling
    Mamdouh H Kedees
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
    Dev Dyn 236:1126-33. 2007
    ..We conclude that nestin+ cells located in the pancreatic primordium generate the cells of the endocrine and exocrine lineages. Furthermore, our results suggest that nestin expression is regulated by glucagon signaling...

Research Grants1

  1. Nutrition, Early Development and Glucose Metabolism
    Patricia Vuguin; Fiscal Year: 2007
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