Jan Vijg

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing
    Saurabh Gombar
    Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    BMC Genomics 13:353. 2012
  2. doi request reprint Genome instability and aging
    Jan Vijg
    Department of Genetics, Albert Einstein College of Medicine, New York, NY 10461, USA
    Annu Rev Physiol 75:645-68. 2013
  3. pmc Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila
    Ana Maria Garcia
    Department of Biology, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA
    Genome Biol 12:R121. 2011
  4. pmc Measuring genome instability in aging - a mini-review
    Wenge Li
    Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Gerontology 58:129-38. 2012
  5. pmc High preservation of CpG Cytosine methylation patterns at imprinted gene Loci in liver and brain of aged mice
    Silvia Gravina
    Department of Genetics, Albert Einstein College of Medicine, New York, New York, United States of America
    PLoS ONE 8:e73496. 2013
  6. doi request reprint Aging: a sirtuin shake-up?
    Jan Vijg
    Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cell 135:797-8. 2008
  7. pmc DNA damage in normally and prematurely aged mice
    Alexander Y Maslov
    Department of Genetics, Albert Einstein College of Medicine, New York, NY, 10461, USA
    Aging Cell 12:467-77. 2013
  8. pmc Direct, genome-wide assessment of DNA mutations in single cells
    Michael Gundry
    Department of Genetics, Albert Einstein College of Medicine, New York, NY 10461, USA
    Nucleic Acids Res 40:2032-40. 2012
  9. pmc Chromosome-specific accumulation of aneuploidy in the aging mouse brain
    Francesca Faggioli
    Department of Genetics, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
    Hum Mol Genet 21:5246-53. 2012
  10. doi request reprint Fast mitochondrial DNA isolation from mammalian cells for next-generation sequencing
    Wilber Quispe-Tintaya
    Albert Einstein College of Medicine, Department of Genetics, New York, NY
    Biotechniques 55:133-6. 2013

Collaborators

Detail Information

Publications16

  1. pmc Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing
    Saurabh Gombar
    Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    BMC Genomics 13:353. 2012
    ..Despite their demonstrated roles in age-associated pathologies, little is known about the role of miRNAs in human aging and longevity...
  2. doi request reprint Genome instability and aging
    Jan Vijg
    Department of Genetics, Albert Einstein College of Medicine, New York, NY 10461, USA
    Annu Rev Physiol 75:645-68. 2013
    ....
  3. pmc Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila
    Ana Maria Garcia
    Department of Biology, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA
    Genome Biol 12:R121. 2011
    ..To address this, we used a lacZ reporter system in wild-type and several mutant strains of Drosophila melanogaster to analyze mechanisms of mutagenesis throughout their lifespan...
  4. pmc Measuring genome instability in aging - a mini-review
    Wenge Li
    Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Gerontology 58:129-38. 2012
    ..A review of the current methods of mutation detection is timely in view of the lack of insight as to the magnitude of somatic mutation accumulation, the types of mutations that accumulate, and their functional consequences...
  5. pmc High preservation of CpG Cytosine methylation patterns at imprinted gene Loci in liver and brain of aged mice
    Silvia Gravina
    Department of Genetics, Albert Einstein College of Medicine, New York, New York, United States of America
    PLoS ONE 8:e73496. 2013
    ....
  6. doi request reprint Aging: a sirtuin shake-up?
    Jan Vijg
    Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cell 135:797-8. 2008
    ..In this issue, Oberdoerffer et al. (2008) report that SIRT1, the mammalian ortholog of Sir2, is involved in DNA damage-induced chromatin reorganization, which promotes genome stability in mammalian cells...
  7. pmc DNA damage in normally and prematurely aged mice
    Alexander Y Maslov
    Department of Genetics, Albert Einstein College of Medicine, New York, NY, 10461, USA
    Aging Cell 12:467-77. 2013
    ..This suggests that factors other than DNA damage per se, for example, cellular responses to DNA damage, are responsible for the aging phenotype in mice...
  8. pmc Direct, genome-wide assessment of DNA mutations in single cells
    Michael Gundry
    Department of Genetics, Albert Einstein College of Medicine, New York, NY 10461, USA
    Nucleic Acids Res 40:2032-40. 2012
    ..This method can be applied as a direct measure of exposure to mutagenic agents and for assessing genotypic heterogeneity within tissues or cell populations...
  9. pmc Chromosome-specific accumulation of aneuploidy in the aging mouse brain
    Francesca Faggioli
    Department of Genetics, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
    Hum Mol Genet 21:5246-53. 2012
    ..Such high levels of genome instability could well be a factor in age-related neurodegeneration...
  10. doi request reprint Fast mitochondrial DNA isolation from mammalian cells for next-generation sequencing
    Wilber Quispe-Tintaya
    Albert Einstein College of Medicine, Department of Genetics, New York, NY
    Biotechniques 55:133-6. 2013
    ..The percentage of sequencing reads aligned to mtDNA was about 22% for non-amplified samples and greater than 99% for samples subjected to 10 cycles of long-range-PCR with mtDNA specific primers. ..
  11. doi request reprint Genome instability, cancer and aging
    Alexander Y Maslov
    Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Biochim Biophys Acta 1790:963-9. 2009
    ..Here, we review age-related changes in the mammalian genome and their possible functional consequences, with special emphasis on genome instability in stem/progenitor cells...
  12. doi request reprint Epigenetic factors in aging and longevity
    Silvia Gravina
    Department of Genetics, Albert Einstein College of Medicine, 1301 Morris Park Ave, Bronx, New York, NY 10461, USA
    Pflugers Arch 459:247-58. 2010
    ..Increased understanding of those aging-related processes that are driven by epigenetic mechanisms will allow for the development of novel epigenetic-based diagnostic, preventive, and therapeutic strategies for age-related diseases...
  13. doi request reprint A dual-activation, adenoviral-based system for the controlled induction of DNA double-strand breaks by the restriction endonuclease SacI
    Alexander Y Maslov
    Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Biotechniques 47:847-54. 2009
    ..This system should be useful for studying the processing of randomly induced DSBs and their effects on cell fate, without the side effects normally associated with radiation or chemical treatment...
  14. pmc Chromosomal aneuploidy in the aging brain
    Francesca Faggioli
    Department of Genetics, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    Mech Ageing Dev 132:429-36. 2011
    ..Here, we will review chromosomal aneuploidy in the aging brain, its possible causes, its consequences for cellular homeostasis and its possible link to functional decline and neuropathies...
  15. pmc Myc-dependent genome instability and lifespan in Drosophila
    Christina Greer
    Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 8:e74641. 2013
    ..Our data provide the first evidence that Myc may act as a pro-aging factor, possibly through its ability to greatly increase genome instability. ..
  16. pmc Direct mutation analysis by high-throughput sequencing: from germline to low-abundant, somatic variants
    Michael Gundry
    Albert Einstein College of Medicine, Department of Genetics, New York, NY 10461, United States
    Mutat Res 729:1-15. 2012
    ..Some possible approaches to gain access to low-abundance mutations are discussed, with a brief overview of new sequencing platforms that are currently waiting in the wings to advance this exploding field even further...