VYTAUTAS VERSELIS

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi request reprint Connexin hemichannels and cell-cell channels: comparison of properties
    V K Verselis
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Braz J Med Biol Res 33:379-89. 2000
  2. ncbi request reprint Connexin-GFPs shed light on regulation of cell-cell communication by gap junctions
    Vytas K Verselis
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Curr Drug Targets 3:483-99. 2002
  3. pmc Divalent cations regulate connexin hemichannels by modulating intrinsic voltage-dependent gating
    Vytas K Verselis
    Albert Einstein College of Medicine, Bronx, NY 10561, USA
    J Gen Physiol 132:315-27. 2008
  4. pmc Loop gating of connexin hemichannels involves movement of pore-lining residues in the first extracellular loop domain
    Vytas K Verselis
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 284:4484-93. 2009

Research Grants

  1. MECHANISMS OF GATING AND PERMEATION IN GAP JUNCTIONS
    VYTAUTAS VERSELIS; Fiscal Year: 2007
  2. Biophysics of CNS Connexins
    VYTAUTAS VERSELIS; Fiscal Year: 2006
  3. MECHANISMS OF GATING AND PERMEATION IN GAP JUNCTIONS
    VYTAUTAS VERSELIS; Fiscal Year: 2004
  4. MECHANISMS OF GATING AND PERMEATION IN GAP JUNCTIONS
    VYTAUTAS VERSELIS; Fiscal Year: 2000
  5. MECHANISMS OF GATING AND PERMEATION IN GAP JUNCTIONS
    VYTAUTAS K VERSELIS; Fiscal Year: 2010

Detail Information

Publications4

  1. ncbi request reprint Connexin hemichannels and cell-cell channels: comparison of properties
    V K Verselis
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Braz J Med Biol Res 33:379-89. 2000
    ..The ability of Cx46, and perhaps other connexins, to form functional unapposed hemichannels that are opened by moderate depolarization may represent an unexplored role of connexins as mediators of transport across the plasma membrane...
  2. ncbi request reprint Connexin-GFPs shed light on regulation of cell-cell communication by gap junctions
    Vytas K Verselis
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Curr Drug Targets 3:483-99. 2002
    ....
  3. pmc Divalent cations regulate connexin hemichannels by modulating intrinsic voltage-dependent gating
    Vytas K Verselis
    Albert Einstein College of Medicine, Bronx, NY 10561, USA
    J Gen Physiol 132:315-27. 2008
    ..Thus, we demonstrate that both forms of voltage dependence are intrinsic gating mechanisms in Cx46 hemichannels and that the action of external divalent cations is to selectively modulate loop gating...
  4. pmc Loop gating of connexin hemichannels involves movement of pore-lining residues in the first extracellular loop domain
    Vytas K Verselis
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 284:4484-93. 2009
    ..These results indicate that metal ions access the cysteine side chains through the open pore and that closure of the loop gate involves movement of the TM1/E1 region that results in local narrowing of the large aqueous connexin pore...

Research Grants18

  1. MECHANISMS OF GATING AND PERMEATION IN GAP JUNCTIONS
    VYTAUTAS VERSELIS; Fiscal Year: 2007
    ..A number of mutations have been recently reported that map to areas important in gating and permeability and we will undertake functional analyses to examine possible mechanisms of disease associated with Cx46 dysfunction. ..
  2. Biophysics of CNS Connexins
    VYTAUTAS VERSELIS; Fiscal Year: 2006
    ..abstract_text> ..
  3. MECHANISMS OF GATING AND PERMEATION IN GAP JUNCTIONS
    VYTAUTAS VERSELIS; Fiscal Year: 2004
    ..We will characterize the functional properties of humCx46, which have not been reported, and examine the basis of altered or loss of function of Cx46 caused by the N63 substitution. ..
  4. MECHANISMS OF GATING AND PERMEATION IN GAP JUNCTIONS
    VYTAUTAS VERSELIS; Fiscal Year: 2000
    ....
  5. MECHANISMS OF GATING AND PERMEATION IN GAP JUNCTIONS
    VYTAUTAS K VERSELIS; Fiscal Year: 2010
    ..A number of mutations have been recently reported that map to areas important in gating and permeability and we will undertake functional analyses to examine possible mechanisms of disease associated with Cx46 dysfunction. ..