Verselis V, Trelles M, Rubinos C, Bargiello T, Srinivas M. Loop gating of connexin hemichannels involves movement of pore-lining residues in the first extracellular loop domain. J Biol Chem. 2009;284:4484-93 pubmed publisher
..These results indicate that metal ions access the cysteine side chains through the open pore and that closure of the loop gate involves movement of the TM1/E1 region that results in local narrowing of the large aqueous connexin pore. ..