J Verghese

..to determine the association of high sensitivity C-reactive protein (HsCRP) levels with a risk of mobility disability and decline in older adults with and without vascular disease...

..Identifying quantitative gait markers of falls in older adults may improve diagnostic assessments and suggest novel intervention targets...

..Prospective studies and clinical trials are needed to define the causal role of cognitive leisure activities in influencing vascular risk for cognitive decline...

..Identifying quantitative gait markers of preclinical dementia may lead to new insights into early disease stages, improve diagnostic assessments and identify new preventive strategies...

..To study the influence of leisure activity participation on risk of development of amnestic mild cognitive impairment (aMCI)...

..To conduct a systematic clinical and quantitative assessment of gait in older adults with mild cognitive impairment (MCI) syndromes...

..To examine clinical and functional correlates of self-reported difficulty in climbing up or climbing down stairs in older adults...

..5, 95% CI 5.5-28.4) or either (HR 5.9, 95% CI 3.6-9.7) had higher risk of VD over five years. Diagnosing HRNG is a clinically relevant approach to identifying older adults at high risk of VD over short intervals...

..To examine the effect of 2 instructions on the same walking while talking (WWT) task on task prioritization by nondisabled subjects...

..The role of blood pressure (BP) as a risk factor for dementia is complex and may be age dependent. In very old individuals, low BP might increase risk for dementia, perhaps by reducing cerebral perfusion pressure...

..POLD is a rare cause of adult-onset leukodystrophy presenting with dementia. Ovarian dysgenesis is extremely rare in the absence of demonstrable chromosomal abnormalities and extends the clinical spectrum of POLD...

..Neurological gaits and subtypes are independent predictors of falls in older adults. Neurological gait assessments will help clinicians identify and institute preventive measures in older adults at high risk for falls...

..It is unclear whether increased participation in leisure activities lowers the risk of dementia or participation in leisure activities declines during the preclinical phase of dementia...

..Limited attentional resources may increase the risk for falls in older individuals. We examined the reliability and validity of divided attention tasks, walking while talking (WWT), in predicting falls...

..Neurologic abnormalities affecting gait occur early in several types of non-Alzheimer's dementias, but their value in predicting the development of dementia is uncertain...

..Early life education and participation in cognitively stimulating leisure activities later in life are 2 factors thought to reflect cognitive reserve, which may delay the onset of the memory decline in the preclinical stages of dementia...

..To test the cognitive reserve hypothesis by examining the effect of education on memory decline during the preclinical course of dementia...

..Dementia incidence increases dramatically from age 65 to age 85, with many studies reporting a doubling every 5 years. The incidence beyond age 85 is not established...

..These results suggest that ERT initiated soon after surgical menopause can have long-term neuroprotective effects in cognitively intact women...

..To determine whether offspring of parents with exceptional longevity (OPEL) have a lower rate of dementia than offspring of parents with usual survival (OPUS)...

..These findings suggest a differential effect in relating the Val(158)Met polymorphism to gait and to cognitive function while supporting the previously described sexual dimorphism in the phenotypic expressions of COMT...

..The objective of this study was to test the hypothesis that a measure of hippocampal neuronal metabolism was associated with verbal memory in nondemented older adults after controlling for hippocampal volume...

..8, 95% CI 1-3.3, P = 0.04) but not age, duration of disease, or clinical severity in a binary logistic regression model. Autonomic disturbances are common (55%) in CTS, occurring with increasing severity of electrophysiologic findings...

..Vascular risk factors and depression were strongly associated with PG, and should be explored further...

..However, few studies have investigated the association of walking speed with risk of incident ischemic stroke...

..Memory was not associated with either single or recurrent falls. These findings are relevant to risk assessment and prevention of falls and point to possible shared neural substrates of cognitive and motor function...

..However, cognitive remediation as a strategy to improve mobility has not been investigated...

..Neuropsychological tests are used to predict and diagnose dementia. However, to our knowledge, no studies to date have examined whether within-person across-neuropsychological test variability predicts dementia...

..Distinct neurobiological hippocampal substrates may support decreased stride length and increased stride length variability in older adults...

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..To develop and assess telephone-based screening tests for dementia, especially Alzheimer's disease (AD)...

..Our objective was to develop tests of navigation and study their cognitive correlates in nondemented older adults...

..To study the epidemiology of gait disorders in community-residing older adults and their association with death and institutionalization...

..The modest sensitivity of either the HVLT or the MMSE alone suggests that further neuropsychological evaluation is required to confirm dementia diagnosis...

..These findings suggest that gait velocity and cognitive function may have both shared and independent brain substrates. Future studies should explore gait velocity and cognitive function as predictors of dementia and falls...

..Our findings suggest that optimized RWR scoring of word list free recall can improve detection of mild AD compared to conventional scoring...

..Our findings support consistency of gait measurements during the earliest stages of disability...

..Cognitive fatigue is conceptualized as an executive failure to maintain and optimize performance over acute but sustained cognitive effort resulting in performance that is lower and more variable than the individual's optimal ability...

..The findings suggest that greater attention needs to be paid to objective evidence of CTS severity rather than subjective complaints when evaluating elderly adults presenting for clinical evaluation of CTS...

..6, 95% CI 1.2-2.3), AD (OR 1.5, 95% CI 1.0-2.1) and VaD (OR 2.0, 95% CI 1.4-3.0). Leukoencephalopathy, large infarcts, and higher vascular burden is associated with the clinical expression of dementia and subtypes...

..To develop and compare norms for widely used gait parameters in adults aged 70 and older using cross-sectional (conventional) and longitudinal (robust) approaches accounting for important confounders such as disease effects on gait...

..To determine the influence of homocysteine on mobility decline in older adults...

..The distribution of causes of neuropathies in young-old and old-old patients, in a hospital-based sample, is age-related. Future studies need to include the old-old to better understand the nature of neuropathy in the elderly...

..Therefore, the LRRK2 mutation has a relatively high frequency in the AJ population, is not fully penetrant for parkinsonism in the elderly, and does not appear to be commonly associated with late-onset dementia...

..The quantitative gait measures in this sample of nondisabled nonagenarians provide a yardstick to compare younger-age groups...

..The results add further evidence that PA is distinct from AD and indicate that decreased Abeta degradation by NEP is unlikely to contribute significantly to amyloid deposition in PA or, in many cases, of AD...

..In a retrospective chart review of 18 autopsy-confirmed cases of dementia with Lewy bodies, delusions were reported in 5 subjects (27.8%), of whom 1 had misidentification delusions much like Capgras' syndrome...

..The career development activities in this application will enable the candidate to be an independent investigator in aging, a clinical expert in cognitive and physical disability, and a mentor for the next generation of investigators. ..