J Verghese

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc Social networks and their role in preventing dementia
    Jagan A Pillai
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA
    Indian J Psychiatry 51:S22-8. 2009
  2. pmc High-sensitivity C-reactive protein and mobility disability in older adults
    Joe Verghese
    Neurology, Albert Einstein College of Medicine, 1165 Morris Park Avenue, Einstein Aging Study, Bronx, NY 10461, USA
    Age Ageing 41:541-5. 2012
  3. pmc Quantitative gait markers and incident fall risk in older adults
    Joe Verghese
    MBBS, Einstein Aging Study, Albert Einstein College of Medicine, Yeshiva University, 1165 Morris Park Avenue, Room 338, Bronx, NY 10461, USA
    J Gerontol A Biol Sci Med Sci 64:896-901. 2009
  4. ncbi request reprint High risk neurological gait syndrome and vascular dementia
    J Verghese
    Einstein Aging Study, Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, U S A
    J Neural Transm 114:1249-52. 2007
  5. pmc Leisure activities and the risk of amnestic mild cognitive impairment in the elderly
    J Verghese
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Neurology 66:821-7. 2006
  6. pmc Self-reported difficulty in climbing up or down stairs in nondisabled elderly
    Joe Verghese
    Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
    Arch Phys Med Rehabil 89:100-4. 2008
  7. pmc Gait dysfunction in mild cognitive impairment syndromes
    Joe Verghese
    Department of Neurology, Einstein Aging Study, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Am Geriatr Soc 56:1244-51. 2008
  8. pmc Walking while talking: effect of task prioritization in the elderly
    Joe Verghese
    Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA
    Arch Phys Med Rehabil 88:50-3. 2007
  9. pmc Quantitative gait dysfunction and risk of cognitive decline and dementia
    Joe Verghese
    Department of Neurology, Albert Einstein College of Medicine, 1165 Morris Park Avenue, Room 338, Bronx, New York 10461, USA
    J Neurol Neurosurg Psychiatry 78:929-35. 2007
  10. ncbi request reprint Low blood pressure and the risk of dementia in very old individuals
    J Verghese
    Einstein Aging Study, Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neurology 61:1667-72. 2003

Research Grants

  1. Latent Mobility Abnormalities and Disability
    Joe Verghese; Fiscal Year: 2006

Detail Information

Publications53

  1. pmc Social networks and their role in preventing dementia
    Jagan A Pillai
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA
    Indian J Psychiatry 51:S22-8. 2009
    ..A deeper analysis of the nature of social networks and dementia pertinent to Indian society is awaited...
  2. pmc High-sensitivity C-reactive protein and mobility disability in older adults
    Joe Verghese
    Neurology, Albert Einstein College of Medicine, 1165 Morris Park Avenue, Einstein Aging Study, Bronx, NY 10461, USA
    Age Ageing 41:541-5. 2012
    ..to determine the association of high sensitivity C-reactive protein (HsCRP) levels with a risk of mobility disability and decline in older adults with and without vascular disease...
  3. pmc Quantitative gait markers and incident fall risk in older adults
    Joe Verghese
    MBBS, Einstein Aging Study, Albert Einstein College of Medicine, Yeshiva University, 1165 Morris Park Avenue, Room 338, Bronx, NY 10461, USA
    J Gerontol A Biol Sci Med Sci 64:896-901. 2009
    ..Identifying quantitative gait markers of falls in older adults may improve diagnostic assessments and suggest novel intervention targets...
  4. ncbi request reprint High risk neurological gait syndrome and vascular dementia
    J Verghese
    Einstein Aging Study, Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, U S A
    J Neural Transm 114:1249-52. 2007
    ..5, 95% CI 5.5-28.4) or either (HR 5.9, 95% CI 3.6-9.7) had higher risk of VD over five years. Diagnosing HRNG is a clinically relevant approach to identifying older adults at high risk of VD over short intervals...
  5. pmc Leisure activities and the risk of amnestic mild cognitive impairment in the elderly
    J Verghese
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Neurology 66:821-7. 2006
    ..To study the influence of leisure activity participation on risk of development of amnestic mild cognitive impairment (aMCI)...
  6. pmc Self-reported difficulty in climbing up or down stairs in nondisabled elderly
    Joe Verghese
    Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
    Arch Phys Med Rehabil 89:100-4. 2008
    ..To examine clinical and functional correlates of self-reported difficulty in climbing up or climbing down stairs in older adults...
  7. pmc Gait dysfunction in mild cognitive impairment syndromes
    Joe Verghese
    Department of Neurology, Einstein Aging Study, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Am Geriatr Soc 56:1244-51. 2008
    ..To conduct a systematic clinical and quantitative assessment of gait in older adults with mild cognitive impairment (MCI) syndromes...
  8. pmc Walking while talking: effect of task prioritization in the elderly
    Joe Verghese
    Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA
    Arch Phys Med Rehabil 88:50-3. 2007
    ..To examine the effect of 2 instructions on the same walking while talking (WWT) task on task prioritization by nondisabled subjects...
  9. pmc Quantitative gait dysfunction and risk of cognitive decline and dementia
    Joe Verghese
    Department of Neurology, Albert Einstein College of Medicine, 1165 Morris Park Avenue, Room 338, Bronx, New York 10461, USA
    J Neurol Neurosurg Psychiatry 78:929-35. 2007
    ..Identifying quantitative gait markers of preclinical dementia may lead to new insights into early disease stages, improve diagnostic assessments and identify new preventive strategies...
  10. ncbi request reprint Low blood pressure and the risk of dementia in very old individuals
    J Verghese
    Einstein Aging Study, Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neurology 61:1667-72. 2003
    ..The role of blood pressure (BP) as a risk factor for dementia is complex and may be age dependent. In very old individuals, low BP might increase risk for dementia, perhaps by reducing cerebral perfusion pressure...
  11. pmc Neurological gait abnormalities and risk of falls in older adults
    Joe Verghese
    Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, 1165 Morris Park Avenue, Room 301, Bronx, NY 10461, USA
    J Neurol 257:392-8. 2010
    ..Neurological gaits and subtypes are independent predictors of falls in older adults. Neurological gait assessments will help clinicians identify and institute preventive measures in older adults at high risk for falls...
  12. ncbi request reprint Adult onset pigmentary orthochromatic leukodystrophy with ovarian dysgenesis
    J Verghese
    Department of Neurology, Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Eur J Neurol 9:663-70. 2002
    ..POLD is a rare cause of adult-onset leukodystrophy presenting with dementia. Ovarian dysgenesis is extremely rare in the absence of demonstrable chromosomal abnormalities and extends the clinical spectrum of POLD...
  13. ncbi request reprint Abnormality of gait as a predictor of non-Alzheimer's dementia
    Joe Verghese
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    N Engl J Med 347:1761-8. 2002
    ..Neurologic abnormalities affecting gait occur early in several types of non-Alzheimer's dementias, but their value in predicting the development of dementia is uncertain...
  14. ncbi request reprint Validity of divided attention tasks in predicting falls in older individuals: a preliminary study
    Joe Verghese
    Departments of Neurology and Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Am Geriatr Soc 50:1572-6. 2002
    ..Limited attentional resources may increase the risk for falls in older individuals. We examined the reliability and validity of divided attention tasks, walking while talking (WWT), in predicting falls...
  15. pmc Leisure activities and risk of vascular cognitive impairment in older adults
    Joe Verghese
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Geriatr Psychiatry Neurol 22:110-8. 2009
    ..Prospective studies and clinical trials are needed to define the causal role of cognitive leisure activities in influencing vascular risk for cognitive decline...
  16. ncbi request reprint Leisure activities and the risk of dementia in the elderly
    Joe Verghese
    Einstein Aging Study, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    N Engl J Med 348:2508-16. 2003
    ..It is unclear whether increased participation in leisure activities lowers the risk of dementia or participation in leisure activities declines during the preclinical phase of dementia...
  17. pmc Cognitive activities delay onset of memory decline in persons who develop dementia
    C B Hall
    Department of Epidemiology and Population Health, and Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Neurology 73:356-61. 2009
    ..Early life education and participation in cognitively stimulating leisure activities later in life are 2 factors thought to reflect cognitive reserve, which may delay the onset of the memory decline in the preclinical stages of dementia...
  18. ncbi request reprint Education delays accelerated decline on a memory test in persons who develop dementia
    C B Hall
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10462, USA
    Neurology 69:1657-64. 2007
    ..To test the cognitive reserve hypothesis by examining the effect of education on memory decline during the preclinical course of dementia...
  19. ncbi request reprint Dementia incidence may increase more slowly after age 90: results from the Bronx Aging Study
    C B Hall
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA
    Neurology 65:882-6. 2005
    ..Dementia incidence increases dramatically from age 65 to age 85, with many studies reporting a doubling every 5 years. The incidence beyond age 85 is not established...
  20. ncbi request reprint Cognitive performance in surgically menopausal women on estrogen
    J Verghese
    Einstein Aging Study, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neurology 55:872-4. 2000
    ..These results suggest that ERT initiated soon after surgical menopause can have long-term neuroprotective effects in cognitively intact women...
  21. pmc Exceptional parental longevity associated with lower risk of Alzheimer's disease and memory decline
    Richard B Lipton
    Einstein Aging Study, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Am Geriatr Soc 58:1043-9. 2010
    ..To determine whether offspring of parents with exceptional longevity (OPEL) have a lower rate of dementia than offspring of parents with usual survival (OPUS)...
  22. pmc Hippocampal neurochemistry, neuromorphometry, and verbal memory in nondemented older adults
    M E Zimmerman
    Albert Einstein College of Medicine, Saul R Korey Department of Neurology, 1165 Morris Park Ave, Room 343, Bronx, NY 10461, USA
    Neurology 70:1594-600. 2008
    ..The objective of this study was to test the hypothesis that a measure of hippocampal neuronal metabolism was associated with verbal memory in nondemented older adults after controlling for hippocampal volume...
  23. pmc Differential effects of COMT on gait and executive control in aging
    R Holtzer
    Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, United States
    Neurobiol Aging 31:523-31. 2010
    ..These findings suggest a differential effect in relating the Val(158)Met polymorphism to gait and to cognitive function while supporting the previously described sexual dimorphism in the phenotypic expressions of COMT...
  24. ncbi request reprint Autonomic dysfunction in idiopathic carpal tunnel syndrome
    J Verghese
    Saul R Korey Department of Neurology Einstein Aging Study, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Muscle Nerve 23:1209-13. 2000
    ..8, 95% CI 1-3.3, P = 0.04) but not age, duration of disease, or clinical severity in a binary logistic regression model. Autonomic disturbances are common (55%) in CTS, occurring with increasing severity of electrophysiologic findings...
  25. ncbi request reprint A comparison of community-residing older adults with frontal and parkinsonian gaits
    Anne Ambrose
    Department of Physical Medicine and Rehabilitation, Mt Sinai Medical Center, New York, NY, USA
    J Neurol Sci 248:215-8. 2006
    ..Vascular risk factors and depression were strongly associated with PG, and should be explored further...
  26. doi request reprint Walking speed and risk of incident ischemic stroke among postmenopausal women
    Aileen P McGinn
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue Belfer 1006A, Bronx, NY 10461, USA
    Stroke 39:1233-9. 2008
    ..However, few studies have investigated the association of walking speed with risk of incident ischemic stroke...
  27. pmc Within-person across-neuropsychological test variability and incident dementia
    Roee Holtzer
    Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
    JAMA 300:823-30. 2008
    ..Neuropsychological tests are used to predict and diagnose dementia. However, to our knowledge, no studies to date have examined whether within-person across-neuropsychological test variability predicts dementia...
  28. pmc Egocentric and exocentric navigation skills in older adults
    Amy E Sanders
    Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Gerontol A Biol Sci Med Sci 63:1356-63. 2008
    ..Our objective was to develop tests of navigation and study their cognitive correlates in nondemented older adults...
  29. pmc MRI- and MRS-derived hippocampal correlates of quantitative locomotor function in older adults
    Molly E Zimmerman
    Saul R Korey Department of Neurology, Albert Einstein College of Medicine, 1165 Morris Park Avenue, Room 343, Bronx, NY 10461, USA
    Brain Res 1291:73-81. 2009
    ..Distinct neurobiological hippocampal substrates may support decreased stride length and increased stride length variability in older adults...
  30. doi request reprint Effect of cognitive remediation on gait in sedentary seniors
    Joe Verghese
    Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, 1165 Morris Park Avenue, Bronx, NY 10461, USA
    J Gerontol A Biol Sci Med Sci 65:1338-43. 2010
    ..However, cognitive remediation as a strategy to improve mobility has not been investigated...
  31. pmc The relationship between specific cognitive functions and falls in aging
    Roee Holtzer
    Ferkauf Graduate School of Psychology, Albert Einstein College of Medicine, Yeshiva University, NY 10461, USA
    Neuropsychology 21:540-8. 2007
    ..Memory was not associated with either single or recurrent falls. These findings are relevant to risk assessment and prevention of falls and point to possible shared neural substrates of cognitive and motor function...
  32. pmc Cognitive and mobility profile of older social dancers
    Joe Verghese
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Am Geriatr Soc 54:1241-4. 2006
    ....
  33. ncbi request reprint Screening for dementia by telephone using the memory impairment screen
    Richard B Lipton
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Am Geriatr Soc 51:1382-90. 2003
    ..To develop and assess telephone-based screening tests for dementia, especially Alzheimer's disease (AD)...
  34. pmc Epidemiology of gait disorders in community-residing older adults
    Joe Verghese
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Am Geriatr Soc 54:255-61. 2006
    ..To study the epidemiology of gait disorders in community-residing older adults and their association with death and institutionalization...
  35. ncbi request reprint Detecting dementia with the Hopkins Verbal Learning Test and the Mini-Mental State Examination
    Gail Kuslansky
    Einstein Aging Study, Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York City, NY 10461, USA
    Arch Clin Neuropsychol 19:89-104. 2004
    ..The modest sensitivity of either the HVLT or the MMSE alone suggests that further neuropsychological evaluation is required to confirm dementia diagnosis...
  36. ncbi request reprint Cognitive processes related to gait velocity: results from the Einstein Aging Study
    Roee Holtzer
    Yeshiva University, Bronx, NY 10461, USA
    Neuropsychology 20:215-23. 2006
    ..These findings suggest that gait velocity and cognitive function may have both shared and independent brain substrates. Future studies should explore gait velocity and cognitive function as predictors of dementia and falls...
  37. ncbi request reprint Retention weighted recall improves discrimination of Alzheimer's disease
    Herman Buschke
    Department of Neurology, Kennedy 912, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Int Neuropsychol Soc 12:436-40. 2006
    ..Our findings suggest that optimized RWR scoring of word list free recall can improve detection of mild AD compared to conventional scoring...
  38. pmc Predisability and gait patterns in older adults
    Joe Verghese
    Division of Cognitive and Motor Aging, Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, 1165 Morris Park Avenue, Bronx, NY 10461, USA
    Gait Posture 33:98-101. 2011
    ..Our findings support consistency of gait measurements during the earliest stages of disability...
  39. pmc Cognitive fatigue defined in the context of attention networks
    Roee Holtzer
    Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 18:108-28. 2011
    ..Cognitive fatigue is conceptualized as an executive failure to maintain and optimize performance over acute but sustained cognitive effort resulting in performance that is lower and more variable than the individual's optimal ability...
  40. pmc Carpal tunnel syndrome in older adults
    Scott Blumenthal
    Department of Neurology, Montefiore Medical Center, Albert Einstein College of Medicine, 1165 Morris Park Avenue, Bronx, New York 10461, USA
    Muscle Nerve 34:78-83. 2006
    ..The findings suggest that greater attention needs to be paid to objective evidence of CTS severity rather than subjective complaints when evaluating elderly adults presenting for clinical evaluation of CTS...
  41. pmc Contribution of vascular pathology to the clinical expression of dementia
    Dorothea Strozyk
    Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Neurobiol Aging 31:1710-20. 2010
    ..6, 95% CI 1.2-2.3), AD (OR 1.5, 95% CI 1.0-2.1) and VaD (OR 2.0, 95% CI 1.4-3.0). Leukoencephalopathy, large infarcts, and higher vascular burden is associated with the clinical expression of dementia and subtypes...
  42. pmc Homocysteine and mobility in older adults
    Lydia Rolita
    Department of General Internal Medicine, New York University School of Medicine, New York, New York 10461, USA
    J Am Geriatr Soc 58:545-50. 2010
    ..To determine the influence of homocysteine on mobility decline in older adults...
  43. pmc Conventional and robust quantitative gait norms in community-dwelling older adults
    Mooyeon Oh-Park
    Department of Physical Medicine and Rehabilitation, Albert Einstein College of Medicine, Bronx, New York, USA
    J Am Geriatr Soc 58:1512-8. 2010
    ..To develop and compare norms for widely used gait parameters in adults aged 70 and older using cross-sectional (conventional) and longitudinal (robust) approaches accounting for important confounders such as disease effects on gait...
  44. ncbi request reprint Peripheral neuropathy in young-old and old-old patients
    J Verghese
    Montefiore Medical Center, Department of Neurology, Albert Einstein College of Medicine, 1165 Morris Park Avenue, Bronx, New York 10467, USA
    Muscle Nerve 24:1476-81. 2001
    ..The distribution of causes of neuropathies in young-old and old-old patients, in a hospital-based sample, is age-related. Future studies need to include the old-old to better understand the nature of neuropathy in the elderly...
  45. ncbi request reprint Increased frequency of the LRRK2 G2019S mutation in an elderly Ashkenazi Jewish population is not associated with dementia
    Rachel Saunders-Pullman
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, United States
    Neurosci Lett 402:92-6. 2006
    ..Therefore, the LRRK2 mutation has a relatively high frequency in the AJ population, is not fully penetrant for parkinsonism in the elderly, and does not appear to be commonly associated with late-onset dementia...
  46. ncbi request reprint Reliability and validity of a telephone-based mobility assessment questionnaire
    Joe Verghese
    Age Ageing 33:628-32. 2004
  47. ncbi request reprint Antemortem memory impairment screen performance is correlated with postmortem Alzheimer pathology
    Joe Verghese
    J Am Geriatr Soc 51:1043-5. 2003
  48. pmc Gait characteristics in nondisabled community-residing nonagenarians
    Mahesh Krishnamurthy
    Division of Geriatrics, New York University Medical Center, New York, USA
    Arch Phys Med Rehabil 87:541-5. 2006
    ..To determine gait performance in community-residing nonagenarians...
  49. ncbi request reprint Decreased neprilysin immunoreactivity in Alzheimer disease, but not in pathological aging
    Deng Shun Wang
    Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    J Neuropathol Exp Neurol 64:378-85. 2005
    ..The results add further evidence that PA is distinct from AD and indicate that decreased Abeta degradation by NEP is unlikely to contribute significantly to amyloid deposition in PA or, in many cases, of AD...
  50. ncbi request reprint To view or not to view: television and mental health
    Joe Verghese
    South Med J 99:202. 2006
  51. pmc Capgras' syndrome in dementia with Lewy bodies
    Andrew G Marantz
    Greenwich High School, Greenwich, Connecticut, USA
    J Geriatr Psychiatry Neurol 15:239-41. 2002
    ..In a retrospective chart review of 18 autopsy-confirmed cases of dementia with Lewy bodies, delusions were reported in 5 subjects (27.8%), of whom 1 had misidentification delusions much like Capgras' syndrome...
  52. ncbi request reprint Walking while talking: a dopamine-responsive task in early Parkinson's disease
    Paul S Kwon
    J Am Geriatr Soc 53:735-7. 2005
  53. ncbi request reprint A clinicopathological study of rest tremors in the elderly
    Joe Verghese
    J Am Geriatr Soc 52:1781-3. 2004

Research Grants2

  1. Latent Mobility Abnormalities and Disability
    Joe Verghese; Fiscal Year: 2006
    ..The career development activities in this application will enable the candidate to be an independent investigator in aging, a clinical expert in cognitive and physical disability, and a mentor for the next generation of investigators. ..