Matthew A Tremblay
Affiliation: Albert Einstein College of Medicine
- Tau phosphorylated at tyrosine 394 is found in Alzheimer's disease tangles and can be a product of the Abl-related kinase, ArgMatthew A Tremblay
Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Alzheimers Dis 19:721-33. 2010..Given the reported role of Arg in oxidative stress response and neural development, the ability to phosphorylate tau at Y394 implicates Arg as a potential player in the pathogenesis of Alzheimer's disease and other tauopathies...
- Neuronal c-Abl overexpression leads to neuronal loss and neuroinflammation in the mouse forebrainSarah D Schlatterer
Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
J Alzheimers Dis 25:119-33. 2011..Given the evidence of c-Abl activation in the human AD brain combined with the pathological phenotype of AblPP/tTA mice, it is likely that aberrant c-Abl activity may play a role in neurodegenerative disease...