Research Topics
Species | M SrinivasSummaryAffiliation: Albert Einstein College of Medicine Country: USA Publications
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Publications
Quinine blocks specific gap junction channel subtypesM Srinivas
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Proc Natl Acad Sci U S A 98:10942-7. 2001..Moreover, quinine derivatives that are excluded from other types of membrane channels may provide molecules with connexin-specific as well as connexin-selective blocking activity...
Closure of gap junction channels by arylaminobenzoatesMiduturu Srinivas
Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Mol Pharmacol 63:1389-97. 2003..We propose that FFA inhibits gap junctions by inducing a conformational change in the protein upon binding to a site that is presumably located within the membrane...- TPA induced expression and function of human connexin 26 by post-translational mechanisms in stably transfected neuroblastoma cellsT Kojima
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, USA
Cell Struct Funct 24:435-41. 1999..These results suggest that induction of exogenous Cx26 in neuroblastoma cells by TPA treatment is controlled by post-translational mechanisms... - Temporal expression of neuronal connexins during hippocampal ontogenyR Rozental
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Brain Res Brain Res Rev 32:57-71. 2000..In addition, we describe the functional properties and expression pattern of the newly discovered neuronal-specific gap junctional protein, Cx36, in the developing mouse fetal hippocampus and in the rat retina and brain... - Properties of gap junction channels formed by Cx46 alone and in combination with Cx50M G Hopperstad
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Biophys J 79:1954-66. 2000..We conclude that different combinations of Cx46 and Cx50 within gap junction channels lead to unique biophysical properties... - Growth-suppressive function of human connexin32 in a conditional immortalized mouse hepatocyte cell lineT Kojima
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
In Vitro Cell Dev Biol Anim 37:589-98. 2001..Cx32 transfectants using a conditional immortalized mouse hepatocyte may be useful for examining the mechanisms of growth and differentiation in hepatocytes by gap junction expression... - Block of specific gap junction channel subtypes by 2-aminoethoxydiphenyl borate (2-APB)Donglin Bai
Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
J Pharmacol Exp Ther 319:1452-8. 2006..The differential efficacy of block by 2-APB of gap junction channels formed by different connexins may provide a useful tool that could be exploited in gap junction research to selectively block certain gap junction channel subtypes... - Functional characterization of a naturally occurring Cx50 truncationAdam M DeRosa
Graduate Program in Genetics, State University of New York, Stony Brook, NY 11794 8661, USA
Invest Ophthalmol Vis Sci 47:4474-81. 2006..This study evaluates the functional consequences of this endogenous truncation by characterizing the properties of a C-terminal truncated Cx50 protein... - Mefloquine effects on the lens suggest cooperative gating of gap junction channelsFrancisco J Martinez-Wittinghan
Department of Physiology and Biophysics, State University of New York, Stony Brook, NY 11794-8661, USA
J Membr Biol 211:163-71. 2006..These results suggest the two types of channels interact and gate cooperatively... - Transfection of mammalian cells with connexins and measurement of voltage sensitivity of their gap junctionsCristiane Del Corsso
The Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, New York 10461, USA
Nat Protoc 1:1799-809. 2006..Electrophysiological protocols are presented for analysis of voltage dependence and single-channel conductance of gap junction channels as well as for studies of chemical gating of these channels... - Optimal lens epithelial cell proliferation is dependent on the connexin isoform providing gap junctional couplingThomas W White
Department of Physiology and Biophysics, Stony Brook University, Stony Brook, New York, USA
Invest Ophthalmol Vis Sci 48:5630-7. 2007..To determine which connexins functionally contribute to epithelial cell coupling and proliferation, junctional coupling from epithelial cells of wild-type and knockin mice was examined... - Regulation of connexin hemichannels by monovalent cationsMiduturu Srinivas
State University of New York College of Optometry, New York, NY 10036, USA
J Gen Physiol 127:67-75. 2006..Our results demonstrate a new, robust means of regulating hemichannels through a combination of extracellular monovalent and divalent cations, principally Na+, K+, and Ca2+... - New possible roles for aquaporin-4 in astrocytes: cell cytoskeleton and functional relationship with connexin43Grazia P Nicchia
Department of General and Environmental Physiology and Centre of Excellence in Comparative Genomics CEGBA, University of Bari, Bari, Italy
FASEB J 19:1674-6. 2005..Finally, the strong down-regulation of Cx43 and cell coupling in AQP4 KD mouse astrocytes indicate that a functional relationship likely exists between water channels and gap junctions in brain astrocytes... - Correlative studies of gating in Cx46 and Cx50 hemichannels and gap junction channelsMiduturu Srinivas
Department of Biological Sciences, State University of New York College of Optometry, New York, New York, USA
Biophys J 88:1725-39. 2005.... - Divalent cations regulate connexin hemichannels by modulating intrinsic voltage-dependent gatingVytas K Verselis
Albert Einstein College of Medicine, Bronx, NY 10561, USA
J Gen Physiol 132:315-27. 2008..Thus, we demonstrate that both forms of voltage dependence are intrinsic gating mechanisms in Cx46 hemichannels and that the action of external divalent cations is to selectively modulate loop gating... - Prospects for rational development of pharmacological gap junction channel blockersDavid C Spray
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Curr Drug Targets 3:455-64. 2002.... - Virtual cloning, functional expression, and gating analysis of human connexin31.9Thomas W White
Department of Physiology and Biophysics, State University of New York, Stony Brook 11794 8661, USA
Am J Physiol Cell Physiol 283:C960-70. 2002..Thus Cx31.9 is a novel human connexin that forms channels with unique functional properties... - Molecular cloning and functional expression of zfCx52.6: a novel connexin with hemichannel-forming properties expressed in horizontal cells of the zebrafish retinaGeorg Zoidl
Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, University Street 150, D 44801 Bochum, Germany
J Biol Chem 279:2913-21. 2004.... - Potent block of Cx36 and Cx50 gap junction channels by mefloquineScott J Cruikshank
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Proc Natl Acad Sci U S A 101:12364-9. 2004..Thus, mefloquine is expected to be a useful tool to study the functional roles of Cx36 and Cx50...