M Srinivas

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc Quinine blocks specific gap junction channel subtypes
    M Srinivas
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 98:10942-7. 2001
  2. ncbi request reprint Closure of gap junction channels by arylaminobenzoates
    Miduturu Srinivas
    Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Mol Pharmacol 63:1389-97. 2003
  3. ncbi request reprint TPA induced expression and function of human connexin 26 by post-translational mechanisms in stably transfected neuroblastoma cells
    T Kojima
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, USA
    Cell Struct Funct 24:435-41. 1999
  4. ncbi request reprint Temporal expression of neuronal connexins during hippocampal ontogeny
    R Rozental
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Brain Res Brain Res Rev 32:57-71. 2000
  5. pmc Properties of gap junction channels formed by Cx46 alone and in combination with Cx50
    M G Hopperstad
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Biophys J 79:1954-66. 2000
  6. ncbi request reprint Growth-suppressive function of human connexin32 in a conditional immortalized mouse hepatocyte cell line
    T Kojima
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    In Vitro Cell Dev Biol Anim 37:589-98. 2001
  7. ncbi request reprint Block of specific gap junction channel subtypes by 2-aminoethoxydiphenyl borate (2-APB)
    Donglin Bai
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    J Pharmacol Exp Ther 319:1452-8. 2006
  8. pmc Functional characterization of a naturally occurring Cx50 truncation
    Adam M DeRosa
    Graduate Program in Genetics, State University of New York, Stony Brook, NY 11794 8661, USA
    Invest Ophthalmol Vis Sci 47:4474-81. 2006
  9. ncbi request reprint Mefloquine effects on the lens suggest cooperative gating of gap junction channels
    Francisco J Martinez-Wittinghan
    Department of Physiology and Biophysics, State University of New York, Stony Brook, NY 11794 8661, USA
    J Membr Biol 211:163-71. 2006
  10. ncbi request reprint Transfection of mammalian cells with connexins and measurement of voltage sensitivity of their gap junctions
    Cristiane Del Corsso
    The Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, New York 10461, USA
    Nat Protoc 1:1799-809. 2006

Collaborators

Detail Information

Publications19

  1. pmc Quinine blocks specific gap junction channel subtypes
    M Srinivas
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 98:10942-7. 2001
    ..Moreover, quinine derivatives that are excluded from other types of membrane channels may provide molecules with connexin-specific as well as connexin-selective blocking activity...
  2. ncbi request reprint Closure of gap junction channels by arylaminobenzoates
    Miduturu Srinivas
    Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Mol Pharmacol 63:1389-97. 2003
    ..We propose that FFA inhibits gap junctions by inducing a conformational change in the protein upon binding to a site that is presumably located within the membrane...
  3. ncbi request reprint TPA induced expression and function of human connexin 26 by post-translational mechanisms in stably transfected neuroblastoma cells
    T Kojima
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, USA
    Cell Struct Funct 24:435-41. 1999
    ..These results suggest that induction of exogenous Cx26 in neuroblastoma cells by TPA treatment is controlled by post-translational mechanisms...
  4. ncbi request reprint Temporal expression of neuronal connexins during hippocampal ontogeny
    R Rozental
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Brain Res Brain Res Rev 32:57-71. 2000
    ..In addition, we describe the functional properties and expression pattern of the newly discovered neuronal-specific gap junctional protein, Cx36, in the developing mouse fetal hippocampus and in the rat retina and brain...
  5. pmc Properties of gap junction channels formed by Cx46 alone and in combination with Cx50
    M G Hopperstad
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Biophys J 79:1954-66. 2000
    ..We conclude that different combinations of Cx46 and Cx50 within gap junction channels lead to unique biophysical properties...
  6. ncbi request reprint Growth-suppressive function of human connexin32 in a conditional immortalized mouse hepatocyte cell line
    T Kojima
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    In Vitro Cell Dev Biol Anim 37:589-98. 2001
    ..Cx32 transfectants using a conditional immortalized mouse hepatocyte may be useful for examining the mechanisms of growth and differentiation in hepatocytes by gap junction expression...
  7. ncbi request reprint Block of specific gap junction channel subtypes by 2-aminoethoxydiphenyl borate (2-APB)
    Donglin Bai
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    J Pharmacol Exp Ther 319:1452-8. 2006
    ..The differential efficacy of block by 2-APB of gap junction channels formed by different connexins may provide a useful tool that could be exploited in gap junction research to selectively block certain gap junction channel subtypes...
  8. pmc Functional characterization of a naturally occurring Cx50 truncation
    Adam M DeRosa
    Graduate Program in Genetics, State University of New York, Stony Brook, NY 11794 8661, USA
    Invest Ophthalmol Vis Sci 47:4474-81. 2006
    ..This study evaluates the functional consequences of this endogenous truncation by characterizing the properties of a C-terminal truncated Cx50 protein...
  9. ncbi request reprint Mefloquine effects on the lens suggest cooperative gating of gap junction channels
    Francisco J Martinez-Wittinghan
    Department of Physiology and Biophysics, State University of New York, Stony Brook, NY 11794 8661, USA
    J Membr Biol 211:163-71. 2006
    ..These results suggest the two types of channels interact and gate cooperatively...
  10. ncbi request reprint Transfection of mammalian cells with connexins and measurement of voltage sensitivity of their gap junctions
    Cristiane Del Corsso
    The Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, New York 10461, USA
    Nat Protoc 1:1799-809. 2006
    ..Electrophysiological protocols are presented for analysis of voltage dependence and single-channel conductance of gap junction channels as well as for studies of chemical gating of these channels...
  11. ncbi request reprint Optimal lens epithelial cell proliferation is dependent on the connexin isoform providing gap junctional coupling
    Thomas W White
    Department of Physiology and Biophysics, Stony Brook University, Stony Brook, New York, USA
    Invest Ophthalmol Vis Sci 48:5630-7. 2007
    ..To determine which connexins functionally contribute to epithelial cell coupling and proliferation, junctional coupling from epithelial cells of wild-type and knockin mice was examined...
  12. pmc Regulation of connexin hemichannels by monovalent cations
    Miduturu Srinivas
    State University of New York College of Optometry, New York, NY 10036, USA
    J Gen Physiol 127:67-75. 2006
    ..Our results demonstrate a new, robust means of regulating hemichannels through a combination of extracellular monovalent and divalent cations, principally Na+, K+, and Ca2+...
  13. ncbi request reprint New possible roles for aquaporin-4 in astrocytes: cell cytoskeleton and functional relationship with connexin43
    Grazia P Nicchia
    Department of General and Environmental Physiology and Centre of Excellence in Comparative Genomics CEGBA, University of Bari, Bari, Italy
    FASEB J 19:1674-6. 2005
    ..Finally, the strong down-regulation of Cx43 and cell coupling in AQP4 KD mouse astrocytes indicate that a functional relationship likely exists between water channels and gap junctions in brain astrocytes...
  14. pmc Correlative studies of gating in Cx46 and Cx50 hemichannels and gap junction channels
    Miduturu Srinivas
    Department of Biological Sciences, State University of New York College of Optometry, New York, New York, USA
    Biophys J 88:1725-39. 2005
    ....
  15. pmc Divalent cations regulate connexin hemichannels by modulating intrinsic voltage-dependent gating
    Vytas K Verselis
    Albert Einstein College of Medicine, Bronx, NY 10561, USA
    J Gen Physiol 132:315-27. 2008
    ..Thus, we demonstrate that both forms of voltage dependence are intrinsic gating mechanisms in Cx46 hemichannels and that the action of external divalent cations is to selectively modulate loop gating...
  16. ncbi request reprint Prospects for rational development of pharmacological gap junction channel blockers
    David C Spray
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Curr Drug Targets 3:455-64. 2002
    ....
  17. ncbi request reprint Virtual cloning, functional expression, and gating analysis of human connexin31.9
    Thomas W White
    Department of Physiology and Biophysics, State University of New York, Stony Brook 11794 8661, USA
    Am J Physiol Cell Physiol 283:C960-70. 2002
    ..Thus Cx31.9 is a novel human connexin that forms channels with unique functional properties...
  18. ncbi request reprint Molecular cloning and functional expression of zfCx52.6: a novel connexin with hemichannel-forming properties expressed in horizontal cells of the zebrafish retina
    Georg Zoidl
    Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, University Street 150, D 44801 Bochum, Germany
    J Biol Chem 279:2913-21. 2004
    ....
  19. pmc Potent block of Cx36 and Cx50 gap junction channels by mefloquine
    Scott J Cruikshank
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 101:12364-9. 2004
    ..Thus, mefloquine is expected to be a useful tool to study the functional roles of Cx36 and Cx50...