Research Topics
| Lawrence J SolinSummaryAffiliation: Albert Einstein Medical Center Country: USA Publications
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Publications
Prognostic value of biologic subtype and the 21-gene recurrence score relative to local recurrence after breast conservation treatment with radiation for early stage breast carcinoma: results from the Eastern Cooperative Oncology Group E2197 studyLawrence J Solin
Department of Radiation Oncology, Albert Einstein Medical Center, 5501 Old York Road, Philadelphia, PA 19141, USA
Breast Cancer Res Treat 134:683-92. 2012..03). The 10-year rates of local recurrence and local-regional recurrence were reasonably low in all subsets of patients. Neither biologic subtype nor 21-gene recurrence score should preclude breast conservation treatment with radiation...
Successful treatment of a T4 lung tumor with vertebral body invasion using fiducial markers in the thoracic spine for image-guided radiation therapy: A case reportAnudh K Jain
Department of Radiation Oncology, Albert Einstein Medical Center, 5501 Old York Road, Philadelphia, PA 19141, USA
J Med Case Reports 5:470. 2011..abstract:..
The impact of adding radiation treatment after breast conservation surgery for ductal carcinoma in situ of the breastLawrence J Solin
Department of Radiation Oncology, Albert Einstein Medical Center, 5501 Old York Rd, Philadelphia, PA 19141, USA
J Natl Cancer Inst Monogr 2010:187-92. 2010..Careful follow-up, including yearly surveillance mammography, after initial breast conservation treatment with radiation is warranted for the early detection of potentially salvageable local and local-regional recurrences...
Outcome after breast conservation treatment with radiation for women with triple-negative early-stage invasive breast carcinomaLawrence J Solin
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19141, USA
Clin Breast Cancer 9:96-100. 2009..The current study was performed to determine the relationship of triple-negative tumor status to outcome after breast conservation treatment with radiation...
Counterview: Pre-operative breast MRI (magnetic resonance imaging) is not recommended for all patients with newly diagnosed breast cancerLawrence J Solin
Department of Radiation Oncology, Albert Einstein Medical Center, 5501 Old York Road, Philadelphia, PA 19141, USA
Breast 19:7-9. 2010..In summary, the routine use of pre-operative breast MRI is not warranted for the typical patient with a newly diagnosed early stage breast cancer...
Risk factors for lymphedema after breast cancer treatmentSandra A Norman
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
Cancer Epidemiol Biomarkers Prev 19:2734-46. 2010..As cancer treatments evolve, it is important to reevaluate their effect on lymphedema risk in breast cancer survivors...
Coronary artery findings after left-sided compared with right-sided radiation treatment for early-stage breast cancerCandace R Correa
Department of Radiation Oncology, Radiology Cardiovascular Imaging Section, Medicine Division of Cardiovascular Medicine, and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA
J Clin Oncol 25:3031-7. 2007....
Time-course of arm lymphedema and potential risk factors for progression of lymphedema after breast conservation treatment for early stage breast cancerVoichita Bar Ad
Department of Radiation Oncology, University of Pennsylvania, 111 S 11th Street, Philadelphia, PA 19107, USA
Breast J 18:219-25. 2012..001). Progression of ALE is a common occurrence. The current study provides support for the utility of routine arm measurements after breast cancer treatment to facilitate timely diagnosis and treatment of ALE...
Salvage treatment for local or local-regional recurrence after initial breast conservation treatment with radiation for ductal carcinoma in situLawrence J Solin
Department of Radiation Oncology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
Eur J Cancer 41:1715-23. 2005..Close follow-up after initial breast conservation treatment with radiation is warranted for the early detection of potentially salvageable local and local-regional recurrences...
Long-term outcome after breast-conservation treatment with radiation for mammographically detected ductal carcinoma in situ of the breastLawrence J Solin
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Cancer 103:1137-46. 2005..The objective of the current study was to determine the long-term outcome after breast-conservation surgery followed by definitive breast irradiation for women with mammographically detected DCIS of the breast...
Long-term outcome for mammographically detected ductal carcinoma in situ managed with breast conservation treatment: prognostic significance of reexcisionNeha Vapiwala
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Cancer J 12:25-32. 2006....
Relationship of breast magnetic resonance imaging to outcome after breast-conservation treatment with radiation for women with early-stage invasive breast carcinoma or ductal carcinoma in situLawrence J Solin
Department of Radiation Oncology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
J Clin Oncol 26:386-91. 2008..To determine the relationship of breast magnetic resonance imaging (MRI) to outcome after breast-conservation treatment (BCT) with radiation for women with early-stage invasive breast carcinoma or ductal carcinoma in situ...
Regional nodal recurrence after breast conservation treatment with radiotherapy for women with early-stage breast carcinomaJ Nicholas Lukens
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
Int J Radiat Oncol Biol Phys 73:1475-81. 2009..To report the long-term outcomes for women presenting with regional lymph node recurrence after breast conservation treatment with radiotherapy for Stage I and II invasive breast carcinoma...
Similar long-term results of breast-conservation treatment for Stage I and II invasive lobular carcinoma compared with invasive ductal carcinoma of the breast: The University of Pennsylvania experienceRoberto J Santiago
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cancer 103:2447-54. 2005..40). CONCLUSIONS: Breast-conservation treatment yielded similar long-term results for women with early-stage, invasive lobular carcinoma and women with the more prevalent invasive ductal carcinoma...
Late cardiac mortality and morbidity in early-stage breast cancer patients after breast-conservation treatmentEleanor E R Harris
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Clin Oncol 24:4100-6. 2006..This study was undertaken as a comprehensive examination of the long-term cardiac mortality and morbidity after breast irradiation using contemporary irradiation techniques...
Proceedings of the international consensus conference on breast cancer risk, genetics, & risk management, April, 2007Gordon F Schwartz
Department of Surgery, Jefferson Medical College, Philadelphia, Pennsylvania, USA
Cancer 113:2627-37. 2008..These risk reduction strategies were evaluated fully, and recommendations were made for the care of patients in each risk category. These guidelines for patient care were approved by the entire group of experts...
Biopsy findings after breast conservation therapy for early-stage invasive breast cancerNeha Vapiwala
Department of Radiation Oncology, Hospital of University of Pennsylvania, Philadelphia, PA 19104, USA
Int J Radiat Oncol Biol Phys 69:490-7. 2007..To determine the patterns and factors predictive of positive ipsilateral breast biopsy after conservation therapy for early-stage breast cancer...
Ten-year multi-institutional results of breast-conserving surgery and radiotherapy in BRCA1/2-associated stage I/II breast cancerLori J Pierce
Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, MI 48109 0010, USA
J Clin Oncol 24:2437-43. 2006..We compared the outcome of breast-conserving surgery and radiotherapy in BRCA1/2 mutation carriers with breast cancer versus that of matched sporadic controls...
Prognosis after regional lymph node recurrence in patients with stage I-II breast carcinoma treated with breast conservation therapyEleanor E R Harris
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Cancer 98:2144-51. 2003..The authors evaluated the risk factors for regional lymph node recurrence and the prognosis of patients with regional nodal recurrence after breast conservation therapy for Stage I-II breast carcinoma...
Association between tangential beam treatment parameters and cardiac abnormalities after definitive radiation treatment for left-sided breast cancerCandace R Correa
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
Int J Radiat Oncol Biol Phys 72:508-16. 2008....
Ten-year outcome after combined modality therapy for inflammatory breast cancerEleanor E R Harris
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
Int J Radiat Oncol Biol Phys 55:1200-8. 2003..To evaluate the long-term outcome of combined modality therapy for inflammatory breast cancer...
Cardiac morbidity and mortality after breast conservation treatment in patients with early-stage breast cancer and preexisting cardiac diseaseRuchika Gutt
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, USA
Clin Breast Cancer 8:443-8. 2008..This study was undertaken to determine the risk of late cardiac morbidity and mortality in patients with preexisting cardiac disease treated with contemporary radiation techniques for early-stage breast cancer...
Impact of concurrent versus sequential tamoxifen with radiation therapy in early-stage breast cancer patients undergoing breast conservation treatmentEleanor E R Harris
Department of Radiaton Oncology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
J Clin Oncol 23:11-6. 2005..To assess the impact of sequencing of tamoxifen and radiation therapy (RT) on outcomes in early-stage breast cancer...
Fifteen-year results of breast-conserving surgery and definitive irradiation for Stage I and II breast carcinoma: the University of Pennsylvania experienceRoberto J Santiago
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Int J Radiat Oncol Biol Phys 58:233-40. 2004..CONCLUSION: These high rates of survival and local control confirm that breast conservation therapy yields favorable results in women with early breast cancer into the second decade after treatment...
Time course of mild arm lymphedema after breast conservation treatment for early-stage breast cancerVoichita Bar Ad
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
Int J Radiat Oncol Biol Phys 76:85-90. 2010..Arm lymphedema is a potential consequence of the treatment for breast carcinoma. The objective of this retrospective study was to characterize the progression of mild arm lymphedema after breast conservation treatment for breast cancer...
Extensive retraction artifact correlates with lymphatic invasion and nodal metastasis and predicts poor outcome in early stage breast carcinomaGeza Acs
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Am J Surg Pathol 31:129-40. 2007..Rather, it likely signifies important biologic changes that alter tumor-stromal interactions and contribute to lymphatic spread and tumor progression...
The impact of comorbidities on outcomes for elderly women treated with breast-conservation treatment for early-stage breast cancerEleanor E R Harris
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Int J Radiat Oncol Biol Phys 70:1453-9. 2008..Breast cancer incidence increases with age and is a major cause of morbidity and mortality in elderly women, but is not well studied in this population. Comorbidities often impact on the management of breast cancer in elderly women...
Outcome after treatment of patients with mammographically occult, magnetic resonance imaging-detected breast cancer presenting with axillary lymphadenopathyChanghu Chen
Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia 19104, USA
Clin Breast Cancer 5:72-7. 2004....
Adjuvant therapy in stage I carcinoma of the breast: the influence of multigene analyses and molecular phenotypingGordon F Schwartz
Breast Care Center, Professor of Surgery and Medical Oncology, Jefferson Medical College, Philadelphia, PA 19107, USA
Breast J 18:303-11. 2012..These molecular data are not currently sufficiently mature to make them part of decision making algorithms of recommendations for the treatment of individual patients...
Outcomes after breast conservation treatment with radiation in women with prior nonbreast malignancy and subsequent invasive breast carcinomaDeepika Nemani
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
Int J Radiat Oncol Biol Phys 73:1055-60. 2009..This report analyzes the outcomes in patients with Stage I and II breast cancer after breast conservation treatment (BCT) with a prior nonbreast malignancy...
Skin-sparing mastectomy and immediate reconstruction is an acceptable treatment option for patients with high-risk breast carcinomaKevin J Downes
Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cancer 103:906-13. 2005....
Paget's disease of the nipple as local recurrence after breast-conservation treatment for early-stage breast cancerJohn P Plastaras
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
Clin Breast Cancer 6:349-53. 2005..9, 10.6, 3.1, and 3.8 years. Paget's disease as local recurrence after BCT is uncommon and can be treated with salvage therapy if detected early...
MRI before reexcision surgery in patients with breast cancerJanie M Lee
Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
AJR Am J Roentgenol 182:473-80. 2004..All patients underwent contrast-enhanced MRI before further surgery and subsequently underwent either reexcision lumpectomy or mastectomy with histopathologic correlation...
The impact of HER-2 status on local recurrence in women with stage I-II breast cancer treated with breast-conserving therapyEleanor E R Harris
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA
Breast J 12:431-6. 2006..15). There was no difference in local recurrence after BCT between HER-2-positive and negative breast cancers at 5 years. Therefore HER-2 overexpression does not appear to be a contraindication to BCT...
Conservative management of Paget disease of the breast with radiotherapy: 10- and 15-year resultsJennifer K Marshall
Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
Cancer 97:2142-9. 2003....
The impact of re-excision and residual disease on local recurrence after breast conservation treatment for patients with early stage breast cancerAhmed N Ali
Department of Radiation Oncology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Clin Breast Cancer 11:400-5. 2011..However, with reasonably low local recurrence rates in all subgroups, neither re-excision nor residual disease on re-excision are contraindications for breast conservation treatment...
Twenty-year incidence and patterns of contralateral breast cancer after breast conservation treatment with radiationChristine E Hill-Kayser
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Int J Radiat Oncol Biol Phys 66:1313-9. 2006..This study was undertaken to determine the incidence of contralateral breast cancer (CLB) after treatment for early-stage breast cancer with breast-conserving treatment (BCT), and to observe patterns of CLB presentation...
Method of primary tumor detection as a risk factor for local and distant recurrence after breast-conservation treatment for early-stage breast cancerJulia Tchou
Department of Surgery, Division of Endocrine and Oncologic Surgery, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
Clin Breast Cancer 8:143-8. 2008....
Breast conservation treatment for patients presenting with axillary lymphadenopathy from presumed primary breast cancer: the role of breast magnetic resonance imaging for stagingChanghu Chen
Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
Clin Breast Cancer 3:219-22. 2002..These 3 cases illustrate the potential for breast conservation treatment for patients presenting with axillary adenopathy from a presumed primary breast cancer but without either mammographic or breast MRI findings...
Long-term clinical and cosmetic outcomes after breast conservation treatment for women with early-stage breast carcinoma according to the type of breast boostChristine E Hill-Kayser
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
Int J Radiat Oncol Biol Phys 79:1048-54. 2011..The present study was performed to compare outcomes after breast conservation treatment with iridium-192 implant boost vs. electron boost...
Adjuvant therapy in stage I carcinoma of the breast: the influence of multigene analyses and molecular phenotypingGordon F Schwartz
Breast Care Center, Department of Surgery and Medical Oncology, Jefferson Medical College, Philadelphia, Pennsylvania, USA
Cancer 118:2031-8. 2012..Breast Health International and the Kimmel Cancer Center of Thomas Jefferson University cosponsored a consensus conference that included an international group of experts...
Proceedings of the international consensus conference on breast cancer risk, genetics, & risk management, April, 2007Gordon F Schwartz
Jefferson Medical College, 1015 Chestnut Street, Suite 510, Philadelphia, PA 19107 4305, USA
Breast J 15:4-16. 2009..These risk reduction strategies were evaluated fully, and recommendations were made for the care of patients in each of the risk categories. These guidelines for patient care were approved by the entire group of experts...
Proceedings of the Consensus Conference on Breast Conservation, April 28 to May 1, 2005, Milan, ItalyGordon F Schwartz
Department of Surgery, Jefferson Medical College, Philadelphia, Pennsylvania 19107-4305, USA
Cancer 107:242-50. 2006
American College of Radiology appropriateness criteria on conservative surgery and radiation: stages I and II breast carcinomaJulia R White
Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 4801, USA
J Am Coll Radiol 5:701-13. 2008..Successful breast conservation relies on understanding key elements for patient selection, evaluation, treatment contraindications, radiation therapy methods, and integration with systemic therapy...
Relation between the method of detection of initial breast carcinoma and the method of detection of subsequent ipsilateral local recurrence and contralateral breast carcinomaChanghu Chen
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cancer 98:1596-602. 2003....
Efficacy of radiotherapy for ovarian ablation: results of a breast intergroup studyLorie L Hughes
Department of Radiation Oncology, WellStar Kennestone Hospital, Marietta, GA 30060, USA
Cancer 101:969-72. 2004..In the current study, we report the efficacy of pelvic RT with this dose-fractionation scheme in the induction of ovarian ablation...
Breast-conserving surgery and radiotherapy in early-stage breast cancer: the importance of local controlAbram Recht
Department of Radiation Oncology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Semin Radiat Oncol 21:3-9. 2011....
Factors associated with residual disease on re-excision in patients with ductal carcinoma in situ of the breastEleanor E R Harris
Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cancer J 9:42-8. 2003..This study examines the factors associated with the presence of residual disease at re-excision in patients with ductal carcinoma in situ of the breast...
Mammographic appearance of recurrent breast cancer after breast conservation therapySusan P Weinstein
Department of Radiology, University of Pennsylvania Health System, 3400 Spruce Street, Philadelphia, PA 19104, USA
Acad Radiol 15:240-4. 2008..To compare the mammographic appearance of recurrent breast cancer to the primary tumor in patients treated with breast conservation therapy...
Use of lymphoscintigraphy in radiation treatment of primary breast cancer in the context of lymphedema risk reductionIndra J Das
Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN, USA
Radiother Oncol 100:293-8. 2011..The goal of this study was to determine the feasibility of SPECT/CT scintigraphic method for mapping lymphatic drainage for radiation therapy of breast cancer...
Modulation of the anti-cancer efficacy of microtubule-targeting agents by cellular growth conditionsJay F Dorsey
Department of Radiation Oncology and Radiation Biology and Imaging Program, Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Cancer Biol Ther 9:809-18. 2010..Collectively these findings suggest mechanisms by which growth conditions may contribute to resistance to rapid killing by microtubule-disrupting drugs...
Outcomes after breast conservation treatment with radiation in women with ductal carcinoma in situ and prior nonbreast malignancyDeepika N Shah
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Breast J 15:649-52. 2009..In this cohort of 14 patients treated for DCIS of the breast after a prior nonbreast malignancy, treatment for DCIS resulted in a high rate of local control and should be considered for curative intent...
MR imaging screening of the contralateral breast in patients with newly diagnosed breast cancer: preliminary resultsSteven G Lee
Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
Radiology 226:773-8. 2003..To investigate the role of screening magnetic resonance (MR) imaging in the detection of synchronous contralateral breast cancer in patients with newly diagnosed breast cancer...
Analysis of interfraction and intrafraction variation during tangential breast irradiation with an electronic portal imaging deviceRyan P Smith
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
Int J Radiat Oncol Biol Phys 62:373-8. 2005....
Incidence and patterns of distant metastases for patients with early-stage breast cancer after breast conservation treatmentAbigail T Berman
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
Clin Breast Cancer 13:88-94. 2013..Patterns of metastatic failure by specific anatomic site are not well described in the literature...
Accelerated partial breast irradiation : a legitimate treatment option?Lawrence J Solin
Department of Radiation Oncology, University of Pennsylvania, PA, USA
Clin Breast Cancer 4:379. 2004
Primary mucosa-associated lymphoid tissue lymphoma of the breastRamji R Rajendran
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA
Clin Breast Cancer 8:187-8. 2008..Herein, a case is presented of a patient with primary MALT lymphoma of the breast. Issues in diagnosis and breast-conservation treatment, as it pertains to primary MALT lymphoma of the breast, will be discussed...
Choice of beam energy and dosimetric implications for radiation treatment in a subpopulation of women with large breasts in the United States and JapanIndra J Das
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
Med Dosim 31:216-23. 2006..Simple guidelines are provided for dose uniformity in breast with respect to chest wall separation, body weight, bra size, and breast volume with tangential field irradiations...
Effect of breast magnetic resonance imaging on the clinical management of women with early-stage breast carcinomaGayle F Tillman
Department of Radiation Oncology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
J Clin Oncol 20:3413-23. 2002..0089). CONCLUSIONS: Breast MRI alters the clinical management for a sizable fraction of women with early-stage breast cancer and appears to offer clinically useful information for determining optimal local treatment...
Lymphedema in breast cancer survivors: incidence, degree, time course, treatment, and symptomsSandra A Norman
Department of Medicine, Division of Hematology Oncology, Center for Clinical Epidemiologyand Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
J Clin Oncol 27:390-7. 2009..To examine the incidence, degree, time course, treatment, and symptoms of lymphedema in breast cancer survivors...
Decision-analytic model and cost-effectiveness evaluation of postmastectomy radiation therapy in high-risk premenopausal breast cancer patientsJason H Lee
Department of Radiation Oncology, Division of General Internal Medicine, University of Pennsylvania Medical Center, Philadelphia, PA, USA
J Clin Oncol 20:2713-25. 2002..To present a decision model that describes the clinical and economic outcomes of node-positive breast cancer with and without postmastectomy radiation therapy (PMRT)...
Lack of compliance with national vaccination guidelines in oncology patients receiving radiation therapyStephanie S Yee
Department of Radiation Oncology, Hospital of the University of Pennsylvania School of Medicine, Philadelphia 19104, USA
J Support Oncol 8:28-34. 2010..Recommended vaccinations may now include that for the Influenza A virus (H1N1)...
