Rajat Singh

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. doi request reprint Autophagy and regulation of lipid metabolism
    Rajat Singh
    Department of Medicine Endocrinology and Molecular Pharmacology, Albert Einstein College of Medicine, Forchheimer 505, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Results Probl Cell Differ 52:35-46. 2010
  2. pmc Hypothalamic lipophagy and energetic balance
    Rajat Singh
    Department of Medicine Endocrinology and Molecular Pharmacology, Member of the Diabetes Research Center Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Aging (Albany NY) 3:934-42. 2011
  3. pmc Autophagy in the cellular energetic balance
    Rajat Singh
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cell Metab 13:495-504. 2011
  4. pmc Loss of autophagy in hypothalamic POMC neurons impairs lipolysis
    Susmita Kaushik
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    EMBO Rep 13:258-65. 2012
  5. pmc Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance
    Susmita Kaushik
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cell Metab 14:173-83. 2011
  6. pmc Autophagy regulates adipose mass and differentiation in mice
    Rajat Singh
    Department of Medicine, Albert Einstein College of Medicine, New York, New York10461, USA
    J Clin Invest 119:3329-39. 2009
  7. pmc Macroautophagy and chaperone-mediated autophagy are required for hepatocyte resistance to oxidant stress
    Yongjun Wang
    Department of Medicine and Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hepatology 52:266-77. 2010
  8. pmc Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance
    Rajat Singh
    Department of Medicine, Albert Einstein College of Medicine Bronx, NY 10461, USA
    Hepatology 49:87-96. 2009
  9. pmc Nuclear factor κB up-regulation of CCAAT/enhancer-binding protein β mediates hepatocyte resistance to tumor necrosis factor α toxicity
    Yongjun Wang
    Department of Medicine and Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hepatology 52:2118-26. 2010
  10. pmc Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development
    Nuria Martínez-López
    1 Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA 2 Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    EMBO Rep 14:795-803. 2013

Collaborators

Detail Information

Publications16

  1. doi request reprint Autophagy and regulation of lipid metabolism
    Rajat Singh
    Department of Medicine Endocrinology and Molecular Pharmacology, Albert Einstein College of Medicine, Forchheimer 505, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Results Probl Cell Differ 52:35-46. 2010
    ....
  2. pmc Hypothalamic lipophagy and energetic balance
    Rajat Singh
    Department of Medicine Endocrinology and Molecular Pharmacology, Member of the Diabetes Research Center Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Aging (Albany NY) 3:934-42. 2011
    ..The present article discusses this recent finding, as well as considers possible future directions that may help better understand how neuronal autophagy, and its possible reduction during aging, may affect whole body energy balance...
  3. pmc Autophagy in the cellular energetic balance
    Rajat Singh
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cell Metab 13:495-504. 2011
    ..This recently discovered interplay between autophagy and lipid and carbohydrate metabolism reveals the existence of a dynamic feedback between autophagy and cellular energy balance...
  4. pmc Loss of autophagy in hypothalamic POMC neurons impairs lipolysis
    Susmita Kaushik
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    EMBO Rep 13:258-65. 2012
    ..Modulating hypothalamic autophagy might have implications for preventing obesity and metabolic syndrome of ageing...
  5. pmc Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance
    Susmita Kaushik
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cell Metab 14:173-83. 2011
    ..Regulation of hypothalamic autophagy could become an effective intervention in conditions such as obesity and the metabolic syndrome...
  6. pmc Autophagy regulates adipose mass and differentiation in mice
    Rajat Singh
    Department of Medicine, Albert Einstein College of Medicine, New York, New York10461, USA
    J Clin Invest 119:3329-39. 2009
    ..Autophagy therefore functions to regulate body lipid accumulation by controlling adipocyte differentiation and determining the balance between white and brown fat...
  7. pmc Macroautophagy and chaperone-mediated autophagy are required for hepatocyte resistance to oxidant stress
    Yongjun Wang
    Department of Medicine and Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hepatology 52:266-77. 2010
    ..CMA inhibition sensitized cells to death from menadione through a mechanism different from that of a loss of macroautophagy, because death occurred in the absence of JNK/c-Jun overactivation or ATP depletion...
  8. pmc Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance
    Rajat Singh
    Department of Medicine, Albert Einstein College of Medicine Bronx, NY 10461, USA
    Hepatology 49:87-96. 2009
    ....
  9. pmc Nuclear factor κB up-regulation of CCAAT/enhancer-binding protein β mediates hepatocyte resistance to tumor necrosis factor α toxicity
    Yongjun Wang
    Department of Medicine and Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hepatology 52:2118-26. 2010
    ..In the absence of NF-κB signaling, proteasomal degradation of C/EBPβ is increased by a JNK-independent mechanism and promotes death from TNFα...
  10. pmc Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development
    Nuria Martínez-López
    1 Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA 2 Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    EMBO Rep 14:795-803. 2013
    ..Decreased MA in myogenic progenitors with age and/or overnutrition might contribute to the metabolic defects and sarcopenia observed in these conditions. ..
  11. pmc Macroautophagy regulates energy metabolism during effector T cell activation
    Vanessa M Hubbard
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 185:7349-57. 2010
    ..These results suggest that macroautophagy is an actively regulated process in T cells that can be induced in response to TCR engagement to accommodate the bioenergetic requirements of activated T cells...
  12. pmc Chronic oxidative stress sensitizes hepatocytes to death from 4-hydroxynonenal by JNK/c-Jun overactivation
    Rajat Singh
    Department of Medicine and Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol Gastrointest Liver Physiol 297:G907-17. 2009
    ....
  13. pmc Autophagy proteins regulate ERK phosphorylation
    Nuria Martínez-López
    1 Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA 2 Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nat Commun 4:2799. 2013
    ..Decreased ERK phosphorylation in Atg5⁻/⁻ cells does not occur from overactive phosphatases. Our findings thus reveal an unconventional function of ATG proteins as cellular scaffolds in the regulation of ERK phosphorylation...
  14. pmc Alterations in glucose homeostasis in a murine model of Chagas disease
    Fnu Nagajyothi
    Division of Parasitology and Tropical Medicine, Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Pathol 182:886-94. 2013
    ..cruzi-induced hypoglycemia, despite reduced insulin, but elevated glucagon levels. The data establishes a complex, multi-tissue relationship between T. cruzi infection, Chagas disease, and host glucose homeostasis...
  15. pmc Lipophagy: connecting autophagy and lipid metabolism
    Rajat Singh
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Int J Cell Biol 2012:282041. 2012
    ..Defective lipophagy has been already linked to important metabolic disorders such as fatty liver, obesity and atherosclerosis, and the age-dependent decrease in autophagy could underline the basis for the metabolic syndrome of aging...
  16. pmc Autophagy regulates lipid metabolism
    Rajat Singh
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nature 458:1131-5. 2009
    ..This study identifies a critical function for autophagy in lipid metabolism that could have important implications for human diseases with lipid over-accumulation such as those that comprise the metabolic syndrome...