Mazen Sidani

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc Cofilin determines the migration behavior and turning frequency of metastatic cancer cells
    Mazen Sidani
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    J Cell Biol 179:777-91. 2007
  2. ncbi request reprint Probing the microenvironment of mammary tumors using multiphoton microscopy
    Mazen Sidani
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Mammary Gland Biol Neoplasia 11:151-63. 2006
  3. pmc The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors
    Weigang Wang
    Department of Anatomy and Structural Biology and 2Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Biol 173:395-404. 2006
  4. ncbi request reprint Spatial and temporal control of cofilin activity is required for directional sensing during chemotaxis
    Ghassan Mouneimne
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Curr Biol 16:2193-205. 2006
  5. pmc WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells
    Corina Sarmiento
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
    J Cell Biol 180:1245-60. 2008
  6. pmc Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation
    Ghassan Mouneimne
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    J Cell Biol 166:697-708. 2004
  7. ncbi request reprint Epidermal growth factor receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasis
    Chengsen Xue
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 66:192-7. 2006
  8. ncbi request reprint A neural Wiskott-Aldrich Syndrome protein-mediated pathway for localized activation of actin polymerization that is regulated by cortactin
    Stephan J Kempiak
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Biol Chem 280:5836-42. 2005
  9. ncbi request reprint Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors
    Weigang Wang
    Department of Anatomy and Structural Biology and Gruss Lipper Center for Biophotonics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cancer Res 67:3505-11. 2007
  10. ncbi request reprint Cofilin promotes actin polymerization and defines the direction of cell motility
    Mousumi Ghosh
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Science 304:743-6. 2004

Detail Information

Publications11

  1. pmc Cofilin determines the migration behavior and turning frequency of metastatic cancer cells
    Mazen Sidani
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    J Cell Biol 179:777-91. 2007
    ..The changes in cell shape, directional migration, and turning frequency were related to the re-localization of Arp2/3 complex to one pole of the cell upon suppression of cofilin expression...
  2. ncbi request reprint Probing the microenvironment of mammary tumors using multiphoton microscopy
    Mazen Sidani
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Mammary Gland Biol Neoplasia 11:151-63. 2006
    ..Results show that the tumor microenvironment is a dynamic place where interactions between tumor cells, macrophages, blood vessels, and extracellular matrix fibers define the metastatic phenotype...
  3. pmc The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors
    Weigang Wang
    Department of Anatomy and Structural Biology and 2Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Biol 173:395-404. 2006
    ..LIMK1-mediated decreases or increases in the activity of the cofilin pathway are shown to cause proportional decreases or increases in motility, intravasation, and metastasis of tumor cells...
  4. ncbi request reprint Spatial and temporal control of cofilin activity is required for directional sensing during chemotaxis
    Ghassan Mouneimne
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Curr Biol 16:2193-205. 2006
    ..We have tested this hypothesis by investigating whether activation of endogenous cofilin is spatially and temporally linked to sensing an EGF point source in carcinoma cells...
  5. pmc WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells
    Corina Sarmiento
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
    J Cell Biol 180:1245-60. 2008
    ..These data show that coordinate regulation between the WASP family and mDia proteins controls the balance between lamellar and lamellipodial protrusion activity...
  6. pmc Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation
    Ghassan Mouneimne
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    J Cell Biol 166:697-708. 2004
    ..Therefore, our results demonstrate that the early PLC and cofilin-dependent barbed end transient is required for the initiation of protrusions and is involved in setting the direction of cell movement in response to EGF...
  7. ncbi request reprint Epidermal growth factor receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasis
    Chengsen Xue
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 66:192-7. 2006
    ....
  8. ncbi request reprint A neural Wiskott-Aldrich Syndrome protein-mediated pathway for localized activation of actin polymerization that is regulated by cortactin
    Stephan J Kempiak
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Biol Chem 280:5836-42. 2005
    ....
  9. ncbi request reprint Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors
    Weigang Wang
    Department of Anatomy and Structural Biology and Gruss Lipper Center for Biophotonics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cancer Res 67:3505-11. 2007
    ....
  10. ncbi request reprint Cofilin promotes actin polymerization and defines the direction of cell motility
    Mousumi Ghosh
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Science 304:743-6. 2004
    ..We propose a role for cofilin that is distinct from its role as an actin-depolymerizing factor...
  11. ncbi request reprint Quinoxaline 1,4-dioxides are novel angiogenesis inhibitors that potentiate antitumor effects of ionizing radiation
    Hala Gali-Muhtasib
    Department of Biology, American University of Beirut, Beirut, Lebanon
    Int J Oncol 24:1121-31. 2004
    ..These findings should stimulate further research in other tumor models as these compounds could have potential clinical applications in cancer therapy...