Dynamic sorting of nuclear components into distinct nucleolar caps during transcriptional inhibitionYaron Shav-Tal
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, 76100 Israel
Mol Biol Cell 16:2395-413. 2005
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PSF and p54(nrb)/NonO--multi-functional nuclear proteinsYaron Shav-Tal
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
FEBS Lett 531:109-14. 2002
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From silencing to gene expression: real-time analysis in single cellsSusan M Janicki
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Cell 116:683-98. 2004
..Using this system, we are able to correlate changes in chromatin structure with the progression of transcriptional activation allowing us to obtain a real-time integrative view of gene expression...
Dynamics of single mRNPs in nuclei of living cellsYaron Shav-Tal
Departments of Anatomy and Structural Biology and Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Science 304:1797-800. 2004
..This observation resolves a controversy, showing that the energetic requirements of nuclear mRNP trafficking are consistent with a diffusional model...
Stepwise RNP assembly at the site of H/ACA RNA transcription in human cellsXavier Darzacq
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine Bronx, NY 10461, USA
J Cell Biol 173:207-18. 2006
..Our analyses indicate that NAF1 binds NAP57 and escorts it to the nascent H/ACA RNA and that GAR1 then replaces NAF1 to yield mature H/ACA RNPs in Cajal bodies and nucleoli...
The mesenchyme expresses T cell receptor mRNAs: relevance to cell growth controlMira Barda-Saad
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
Oncogene 21:2029-36. 2002
..This cell cycle dependent expression, considered together with the correlation between growth properties and the level of TCR expression by cell clones, implies association of mesenchymal TCR with cell growth control...
Dynamics of transcription and mRNA exportXavier Darzacq
Department of Anatomy, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Curr Opin Cell Biol 17:332-9. 2005
..By contrast, an understanding of the dynamics of an individual gene's expression in real time is just beginning to emerge following recent technological developments...
Assembling an intermediate filament network by dynamic cotranslationLynne Chang
Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
J Cell Biol 172:747-58. 2006
..The results show that the motility and targeting of peripherin mRNPs, their translational control, and the assembly of an IF cytoskeletal system are linked together in a process we have termed dynamic cotranslation...
In vivo dynamics of RNA polymerase II transcriptionXavier Darzacq
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Nat Struct Mol Biol 14:796-806. 2007
..Our systems approach, quantifying both polymerase and mRNA kinetics on a defined DNA template in vivo with high temporal resolution, opens new avenues for studying regulation of transcriptional processes in vivo...