David A Shafritz

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc Stem cells, cell transplantation and liver repopulation
    Michael Oertel
    Marion Bessin Liver Research Center, Division of Hepatology, Department of Medicine, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Biochim Biophys Acta 1782:61-74. 2008
  2. ncbi request reprint Liver stem cells and model systems for liver repopulation
    David A Shafritz
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Hepatol 36:552-64. 2002
  3. ncbi request reprint Liver stem cells and prospects for liver reconstitution by transplanted cells
    David A Shafritz
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Hepatology 43:S89-98. 2006
  4. doi request reprint Purification of fetal liver stem/progenitor cells containing all the repopulation potential for normal adult rat liver
    Michael Oertel
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, USA
    Gastroenterology 134:823-32. 2008
  5. ncbi request reprint Properties of cryopreserved fetal liver stem/progenitor cells that exhibit long-term repopulation of the normal rat liver
    Michael Oertel
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Stem Cells 24:2244-51. 2006
  6. ncbi request reprint Cell competition leads to a high level of normal liver reconstitution by transplanted fetal liver stem/progenitor cells
    Michael Oertel
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
    Gastroenterology 130:507-20; quiz 590. 2006
  7. pmc Activin A, p15INK4b signaling, and cell competition promote stem/progenitor cell repopulation of livers in aging rats
    Anuradha Menthena
    Marion Bessin Liver Research Center, Division of Gastroenterology and Liver Diseases, Department of Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
    Gastroenterology 140:1009-20. 2011
  8. ncbi request reprint Comparison of hepatic properties and transplantation of Thy-1(+) and Thy-1(-) cells isolated from embryonic day 14 rat fetal liver
    Michael Oertel
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    Hepatology 46:1236-45. 2007
  9. ncbi request reprint Bone marrow progenitors are not the source of expanding oval cells in injured liver
    Anuradha Menthena
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Stem Cells 22:1049-61. 2004
  10. ncbi request reprint Purification and characterization of mouse fetal liver epithelial cells with high in vivo repopulation capacity
    Dirk Nierhoff
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hepatology 42:130-9. 2005

Collaborators

  • Gordon M Keller
  • Michael Oertel
  • Mariana Dabeva
  • Atsushi Ogawa
  • Chandan Guha
  • L Zhu
  • Kosho Yamanouchi
  • Hoby P Hetherington
  • Jiri Zavadil
  • Sigrid Schulte
  • Erwin P Bottinger
  • Martin E Adelson
  • CHARLES ROGLER
  • T Lapidot
  • Dirk Nierhoff
  • Anuradha Menthena
  • Christoph I Koehler
  • Daqian Sun
  • Wenjun Ju
  • Valerie Gouon-Evans
  • Charles S Landis
  • Ran Oren
  • Yuan Qing Chen
  • Petko M Petkov
  • Ray Hwang Yuan
  • Orit Kollet
  • Ethel Hurston
  • Mladen I Yovchev
  • Jaswinderpal S Sandhu
  • Rani S Sellers
  • Hao Ren
  • Tobias Goeser
  • Lauretta Levoci
  • Leslie E Rogler
  • Alan Koretsky
  • Joerg Heyer
  • Liping Yu
  • Atsushi Kubo
  • Dirk Nierhof
  • Hongchao Zhou
  • Namita Roy-Chowdhury
  • Raju Kucherlapati
  • Lise Boussemart
  • Jayanta Roy-Chowdhury
  • Paul Gadue
  • Sankar Mohan
  • Isabel Zvibel
  • Eyal Gur
  • Yigal Breitman
  • Alexandra Traister
  • Eli Brazovsky
  • Zamir Halpern
  • David Goetz
  • Tearina Chu
  • Jaswinder Sandhu
  • Petar N Grozdanov
  • Robert Carver
  • Shalin Shah
  • Niloyjyoti Deb
  • Arnon Nagler
  • David Neufeld
  • Joy Kahn
  • Michel Revel
  • Jenny Suriawinata
  • Izhar Hardan
  • Emi Ogawa
  • Ayelet Dar
  • Shoham Shivtiel
  • Asaf Spiegel
  • Swan N Thung
  • Polina Goichberg
  • Fernando Arenzana-Seisdedos
  • Sarit Samira
  • Alexander Kalinkovich

Detail Information

Publications23

  1. pmc Stem cells, cell transplantation and liver repopulation
    Michael Oertel
    Marion Bessin Liver Research Center, Division of Hepatology, Department of Medicine, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Biochim Biophys Acta 1782:61-74. 2008
    ..This review will characterize these various cell types and compare the properties of these cells and the conditions under which they do or do not repopulate the liver following their transplantation...
  2. ncbi request reprint Liver stem cells and model systems for liver repopulation
    David A Shafritz
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Hepatol 36:552-64. 2002
  3. ncbi request reprint Liver stem cells and prospects for liver reconstitution by transplanted cells
    David A Shafritz
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Hepatology 43:S89-98. 2006
    ....
  4. doi request reprint Purification of fetal liver stem/progenitor cells containing all the repopulation potential for normal adult rat liver
    Michael Oertel
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, USA
    Gastroenterology 134:823-32. 2008
    ..However, for clinical applications, it will be essential to transplant highly enriched cells, while maintaining high repopulation potential...
  5. ncbi request reprint Properties of cryopreserved fetal liver stem/progenitor cells that exhibit long-term repopulation of the normal rat liver
    Michael Oertel
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Stem Cells 24:2244-51. 2006
    ..This study is the first to show a high level of long-term liver replacement with cryopreserved fetal liver cells, an essential requirement for future clinical applications...
  6. ncbi request reprint Cell competition leads to a high level of normal liver reconstitution by transplanted fetal liver stem/progenitor cells
    Michael Oertel
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
    Gastroenterology 130:507-20; quiz 590. 2006
    ....
  7. pmc Activin A, p15INK4b signaling, and cell competition promote stem/progenitor cell repopulation of livers in aging rats
    Anuradha Menthena
    Marion Bessin Liver Research Center, Division of Gastroenterology and Liver Diseases, Department of Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
    Gastroenterology 140:1009-20. 2011
    ..Highly proliferative fetal liver stem/progenitor cells (FLSPCs) repopulate livers of normal recipients by cell competition. We investigated the mechanisms by which FLSPCs repopulate livers of older compared with younger rats...
  8. ncbi request reprint Comparison of hepatic properties and transplantation of Thy-1(+) and Thy-1(-) cells isolated from embryonic day 14 rat fetal liver
    Michael Oertel
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    Hepatology 46:1236-45. 2007
    ..However, SDF-1alpha expression was augmented in bile ducts and oval cells in retrorsine/partial hepatectomy-treated liver, and this correlated with liver repopulation by Thy-1(+) cells...
  9. ncbi request reprint Bone marrow progenitors are not the source of expanding oval cells in injured liver
    Anuradha Menthena
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Stem Cells 22:1049-61. 2004
    ..These data demonstrate that the sources of oval cells and small hepatocytes in the injured liver are endogenous liver progenitors and that they do not arise through transdifferentiation from BM cells...
  10. ncbi request reprint Purification and characterization of mouse fetal liver epithelial cells with high in vivo repopulation capacity
    Dirk Nierhoff
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hepatology 42:130-9. 2005
    ..Supplementary material for this article can be found on the HEPATOLOGY website (http://www.interscience.wiley.com/jpages/0270-9139/suppmat/index.html)...
  11. ncbi request reprint Inactivation of p27Kip1 promotes chemical mouse liver tumorigenesis in the resistant strain C57BL/6J
    Daqian Sun
    Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center and Albert Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Mol Carcinog 47:47-55. 2008
    ..These results reveal a liver tumor suppressor role of p27 in this resistant mouse strain, and the need to further study the role of Cdk2 kinase in liver tumor promotion by p27 inactivation...
  12. pmc Model systems and experimental conditions that lead to effective repopulation of the liver by transplanted cells
    David A Shafritz
    Marion Bessin Liver Research Center, Department of Medicine and Division of Hepatology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Int J Biochem Cell Biol 43:198-213. 2011
    ....
  13. ncbi request reprint Hepatic stem cells and liver repopulation
    Mariana D Dabeva
    Department of Medicine, Albert Einstein College of Medicine, Marion Bessin Liver Research Center, Bronx, New York 10461, USA
    Semin Liver Dis 23:349-62. 2003
    ..Multilineage adult progenitor cells of mesenchymal origin from bone marrow, muscle, and brain may turn out to be the long-sought primitive potential stem cells remaining in adult tissues...
  14. ncbi request reprint Noninvasive evaluation of liver repopulation by transplanted hepatocytes using 31P MRS imaging in mice
    Charles S Landis
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
    Hepatology 44:1250-8. 2006
    ..Our results provide groundwork for future development of clinical protocols for HT...
  15. ncbi request reprint New cell surface markers for murine fetal hepatic stem cells identified through high density complementary DNA microarrays
    Dirk Nierhoff
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
    Hepatology 46:535-47. 2007
    ..Our analysis identified 24 new/potential cell surface markers for murine fetal hepatic stem cells, of which Nope may be particularly useful in future studies to identify, characterize and isolate hepatic stem cells from the AL...
  16. ncbi request reprint Repopulation of rat liver by fetal hepatoblasts and adult hepatocytes transduced ex vivo with lentiviral vectors
    Michael Oertel
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hepatology 37:994-1005. 2003
    ....
  17. ncbi request reprint Gene expression pattern in hepatic stem/progenitor cells during rat fetal development using complementary DNA microarrays
    Petko M Petkov
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Hepatology 39:617-27. 2004
    ..Supplementary material for this article can be found on the HEPATOLOGY website (http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html)...
  18. ncbi request reprint p27Kip1 inactivation provides a proliferative advantage to transplanted hepatocytes in DPPIV/Rag2 double knockout mice after repeated host liver injury
    Ray Hwang Yuan
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Cell Transplant 12:907-19. 2003
    ..These properties of p27-deficient hepatocytes could prove useful as a target for liver repopulation in patients with intermittent or a low level of chronic liver injury...
  19. pmc Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation
    Wenjun Ju
    Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Pl, Box 1118, New York, New York 10029, USA
    Mol Cell Biol 26:654-67. 2006
    ..Collectively, these results demonstrate that Smad2 suppresses hepatocyte growth and dedifferentiation independent of TGF-beta signaling. Smad2 is not required for TGF-beta-stimulated apoptosis, EMT, and growth inhibition in hepatocytes...
  20. ncbi request reprint BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm
    Valerie Gouon-Evans
    Department of Gene and Cell Medicine, Black Family Stem Cell Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA
    Nat Biotechnol 24:1402-11. 2006
    ..Together, these findings establish a developmental pathway in embryonic stem cell differentiation cultures that leads to efficient generation of cells with an immature hepatocytic phenotype...
  21. pmc HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver
    Orit Kollet
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Clin Invest 112:160-9. 2003
    ..Our results suggest the potential of hematopoietic CD34+/CXCR4+cells to respond to stress signals from nonhematopoietic injured organs as an important mechanism for tissue targeting and repair...
  22. ncbi request reprint A human hepatocyte factory
    David A Shafritz
    Nat Biotechnol 25:871-2. 2007
  23. ncbi request reprint Whole fetal liver transplantation--a new approach to cell therapy
    Ran Oren
    Liver Unit, Department of Gastroenterology, Tel Aviv Sourasky Medical Center TASMC, Tel Aviv, Israel
    Liver Transpl 11:929-33. 2005
    ..In conclusion, the results of this study raise the possibility that fetal liver transplantation could serve as a model for genetic metabolic liver diseases...