Bridget Shafit-Zagardo

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during experimental autoimmune encephalomyelitis
    Jason G Weinger
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    J Neuroinflammation 8:49. 2011
  2. pmc GAS6 enhances repair following cuprizone-induced demyelination
    Vladislav Tsiperson
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 5:e15748. 2010
  3. ncbi request reprint Fyn phosphorylates human MAP-2c on tyrosine 67
    S Pilar Zamora-Leon
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 280:1962-70. 2005
  4. pmc In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation
    Jason G Weinger
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurochem 106:134-46. 2008
  5. pmc Up-regulation of soluble Axl and Mer receptor tyrosine kinases negatively correlates with Gas6 in established multiple sclerosis lesions
    Jason G Weinger
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Pathol 175:283-93. 2009
  6. ncbi request reprint The growth arrest-specific gene product Gas6 promotes the survival of human oligodendrocytes via a phosphatidylinositol 3-kinase-dependent pathway
    Sai Latha Shankar
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 23:4208-18. 2003
  7. ncbi request reprint Multiple sclerosis: re-expression of a developmental pathway that restricts oligodendrocyte maturation
    Gareth R John
    Department of Pathology Neuropathology, Albert Einstein College of Medicine, Bronx, New York, USA
    Nat Med 8:1115-21. 2002
  8. pmc Interferon regulatory factor 3 inhibits astrocyte inflammatory gene expression through suppression of the proinflammatory miR-155 and miR-155*
    Leonid Tarassishin
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
    Glia 59:1911-22. 2011
  9. ncbi request reprint Disruption of the actin network enhances MAP-2c and Fyn-induced process outgrowth
    S Pilar Zamora-Leon
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cell Motil Cytoskeleton 62:110-23. 2005
  10. doi request reprint Axl-/- mice have delayed recovery and prolonged axonal damage following cuprizone toxicity
    Hannah J Hoehn
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Brain Res 1240:1-11. 2008

Collaborators

  • Olivier Loudig
  • Jonathan M Backer
  • Gary J Schwartz
  • Hyeon Sook Suh
  • Heather A Arnett
  • Kakuri M Omari
  • Gareth R John
  • Fernando Macian
  • Jason G Weinger
  • Sai Latha Shankar
  • Vladislav Tsiperson
  • S Pilar Zamora-Leon
  • Celia F Brosnan
  • Brian Varnum
  • Kathleen O'Guin
  • Bhupesh Parashar
  • Leonid Tarassishin
  • Cedric S Raine
  • Hannah J Hoehn
  • Sunhee C Lee
  • Melissa A Cosenza
  • Michael F Goldberg
  • Anne L Prieto
  • Avital Bauman
  • Xiaosong Li
  • Kurt Marsden
  • Ying Yan
  • Albert Sohn
  • Pouyan Gohari
  • Sarah Bourdon
  • Yvonne Kress
  • Mimi Kim
  • Greg Lemke
  • Bhadrasain Vikram
  • Anne Bresnick
  • James Butler
  • Kathy O'Guin
  • Chidi Okwuaka
  • Sridhar Mani
  • Melissa Krupski
  • Trevor N Stitt
  • Michael Cammer
  • F Arthur McMorris
  • Ross S Basch
  • Meng Liang Zhao
  • Sai L Shankar

Detail Information

Publications14

  1. pmc Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during experimental autoimmune encephalomyelitis
    Jason G Weinger
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    J Neuroinflammation 8:49. 2011
    ..To test for this, we studied the susceptibility of Axl-/- mice to experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis...
  2. pmc GAS6 enhances repair following cuprizone-induced demyelination
    Vladislav Tsiperson
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 5:e15748. 2010
    ..Relative to PBS-treated mice, rhGas6-treated mice had fewer activated microglia in the corpus callosum by Iba1 immunostaining. The data show that rhGas6 treatment resulted in more efficient repair following cuprizone-induced injury...
  3. ncbi request reprint Fyn phosphorylates human MAP-2c on tyrosine 67
    S Pilar Zamora-Leon
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 280:1962-70. 2005
    ..Thus, MAP-2c can directly recruit multiple signaling proteins important for central nervous system development...
  4. pmc In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation
    Jason G Weinger
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurochem 106:134-46. 2008
    ....
  5. pmc Up-regulation of soluble Axl and Mer receptor tyrosine kinases negatively correlates with Gas6 in established multiple sclerosis lesions
    Jason G Weinger
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Pathol 175:283-93. 2009
    ..These data suggest that in multiple sclerosis lesions, dysregulation of protective Gas6 receptor signaling may prolong lesion activity...
  6. ncbi request reprint The growth arrest-specific gene product Gas6 promotes the survival of human oligodendrocytes via a phosphatidylinositol 3-kinase-dependent pathway
    Sai Latha Shankar
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 23:4208-18. 2003
    ..Thus Gas6 sustains human fetal oligodendrocyte viability by receptor activation and downstream signaling via the PI3-kinase/Akt pathway...
  7. ncbi request reprint Multiple sclerosis: re-expression of a developmental pathway that restricts oligodendrocyte maturation
    Gareth R John
    Department of Pathology Neuropathology, Albert Einstein College of Medicine, Bronx, New York, USA
    Nat Med 8:1115-21. 2002
    ..These data are the first to implicate the Notch pathway in the limited remyelination in MS. Thus, Notch may represent a potential target for therapeutic intervention in this disease...
  8. pmc Interferon regulatory factor 3 inhibits astrocyte inflammatory gene expression through suppression of the proinflammatory miR-155 and miR-155*
    Leonid Tarassishin
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
    Glia 59:1911-22. 2011
    ..Our results demonstrate a novel proinflammatory role for miR-155/miR-155* in human astrocytes and suggest that IRF3 can suppress neuroinflammation through regulating immunomodulatory miRNA expression. © 2011 Wiley-Liss, Inc...
  9. ncbi request reprint Disruption of the actin network enhances MAP-2c and Fyn-induced process outgrowth
    S Pilar Zamora-Leon
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cell Motil Cytoskeleton 62:110-23. 2005
    ..These studies suggest that independent of one another MAP-2c and Fyn are able to induce process outgrowth and in concert can initiate and enhance process outgrowth in an additive manner...
  10. doi request reprint Axl-/- mice have delayed recovery and prolonged axonal damage following cuprizone toxicity
    Hannah J Hoehn
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Brain Res 1240:1-11. 2008
    ....
  11. ncbi request reprint UCN-01 alters phosphorylation of Akt and GSK3beta and induces apoptosis in six independent human neuroblastoma cell lines
    Sai Latha Shankar
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurochem 90:702-11. 2004
    ..Thus, UCN-01 was effective at inducing apoptosis in neuroblastoma cell lines...
  12. ncbi request reprint Up-regulation of MAP2e-expressing oligodendrocytes in the white matter of patients with HIV-1 encephalitis
    Melissa A Cosenza
    Department of Pathology, Albert Einstein College of Medicine, Bronx NY 10461, USA
    Neuropathol Appl Neurobiol 28:480-8. 2002
    ..Our results demonstrate that MAP2e can serve as a marker of white matter damage in HIVE and support the notion that oligodendrocyte damage/repair occurs during HIV-1 infection...
  13. ncbi request reprint Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis
    Sai Latha Shankar
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 26:5638-48. 2006
    ..We conclude that gas6 signaling through the Axl receptor and the PI3 kinase/Akt1 survival pathway protects oligodendrocytes from growth factor withdrawal and TNFalpha-mediated cell death...
  14. ncbi request reprint Inhibition of human neuroblastoma cell growth by CAY10404, a highly selective Cox-2 inhibitor
    Bhupesh Parashar
    Department of Radiation Oncology, Montefiore Medical Center, Bronx, NY 10461, USA
    J Neurooncol 71:141-8. 2005
    ....