Bridget Shafit-Zagardo

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc GAS6 enhances repair following cuprizone-induced demyelination
    Vladislav Tsiperson
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 5:e15748. 2010
  2. doi request reprint Axl-/- mice have delayed recovery and prolonged axonal damage following cuprizone toxicity
    Hannah J Hoehn
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Brain Res 1240:1-11. 2008
  3. ncbi request reprint Fyn phosphorylates human MAP-2c on tyrosine 67
    S Pilar Zamora-Leon
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 280:1962-70. 2005
  4. ncbi request reprint Multiple sclerosis: re-expression of a developmental pathway that restricts oligodendrocyte maturation
    Gareth R John
    Department of Pathology Neuropathology, Albert Einstein College of Medicine, Bronx, New York, USA
    Nat Med 8:1115-21. 2002
  5. pmc Mice devoid of Tau have increased susceptibility to neuronal damage in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis
    Jason G Weinger
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neuropathol Exp Neurol 71:422-33. 2012
  6. pmc Suppression of inflammatory responses during myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis is regulated by AKT3 signaling
    Vladislav Tsiperson
    Department of Pathology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
    J Immunol 190:1528-39. 2013
  7. pmc In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation
    Jason G Weinger
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurochem 106:134-46. 2008
  8. pmc Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during experimental autoimmune encephalomyelitis
    Jason G Weinger
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    J Neuroinflammation 8:49. 2011
  9. ncbi request reprint The growth arrest-specific gene product Gas6 promotes the survival of human oligodendrocytes via a phosphatidylinositol 3-kinase-dependent pathway
    Sai Latha Shankar
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 23:4208-18. 2003
  10. pmc Interferon regulatory factor 3 inhibits astrocyte inflammatory gene expression through suppression of the proinflammatory miR-155 and miR-155*
    Leonid Tarassishin
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
    Glia 59:1911-22. 2011

Collaborators

Detail Information

Publications17

  1. pmc GAS6 enhances repair following cuprizone-induced demyelination
    Vladislav Tsiperson
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 5:e15748. 2010
    ..Relative to PBS-treated mice, rhGas6-treated mice had fewer activated microglia in the corpus callosum by Iba1 immunostaining. The data show that rhGas6 treatment resulted in more efficient repair following cuprizone-induced injury...
  2. doi request reprint Axl-/- mice have delayed recovery and prolonged axonal damage following cuprizone toxicity
    Hannah J Hoehn
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Brain Res 1240:1-11. 2008
    ....
  3. ncbi request reprint Fyn phosphorylates human MAP-2c on tyrosine 67
    S Pilar Zamora-Leon
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 280:1962-70. 2005
    ..Thus, MAP-2c can directly recruit multiple signaling proteins important for central nervous system development...
  4. ncbi request reprint Multiple sclerosis: re-expression of a developmental pathway that restricts oligodendrocyte maturation
    Gareth R John
    Department of Pathology Neuropathology, Albert Einstein College of Medicine, Bronx, New York, USA
    Nat Med 8:1115-21. 2002
    ..These data are the first to implicate the Notch pathway in the limited remyelination in MS. Thus, Notch may represent a potential target for therapeutic intervention in this disease...
  5. pmc Mice devoid of Tau have increased susceptibility to neuronal damage in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis
    Jason G Weinger
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neuropathol Exp Neurol 71:422-33. 2012
    ....
  6. pmc Suppression of inflammatory responses during myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis is regulated by AKT3 signaling
    Vladislav Tsiperson
    Department of Pathology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
    J Immunol 190:1528-39. 2013
    ..These results indicate that AKT3 signaling contributes to the protection of mice against EAE...
  7. pmc In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation
    Jason G Weinger
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurochem 106:134-46. 2008
    ....
  8. pmc Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during experimental autoimmune encephalomyelitis
    Jason G Weinger
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    J Neuroinflammation 8:49. 2011
    ..To test for this, we studied the susceptibility of Axl-/- mice to experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis...
  9. ncbi request reprint The growth arrest-specific gene product Gas6 promotes the survival of human oligodendrocytes via a phosphatidylinositol 3-kinase-dependent pathway
    Sai Latha Shankar
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 23:4208-18. 2003
    ..Thus Gas6 sustains human fetal oligodendrocyte viability by receptor activation and downstream signaling via the PI3-kinase/Akt pathway...
  10. pmc Interferon regulatory factor 3 inhibits astrocyte inflammatory gene expression through suppression of the proinflammatory miR-155 and miR-155*
    Leonid Tarassishin
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
    Glia 59:1911-22. 2011
    ..Our results demonstrate a novel proinflammatory role for miR-155/miR-155* in human astrocytes and suggest that IRF3 can suppress neuroinflammation through regulating immunomodulatory miRNA expression. © 2011 Wiley-Liss, Inc...
  11. ncbi request reprint Gas6 enhances axonal ensheathment by MBP+ membranous processes in human DRG/OL promyelinating co-cultures
    Kathleen N O'Guin
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue Bronx, NY 10461, U S A
    ASN Neuro 6:e00135. 2014
    ....
  12. pmc Up-regulation of soluble Axl and Mer receptor tyrosine kinases negatively correlates with Gas6 in established multiple sclerosis lesions
    Jason G Weinger
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Pathol 175:283-93. 2009
    ..These data suggest that in multiple sclerosis lesions, dysregulation of protective Gas6 receptor signaling may prolong lesion activity...
  13. ncbi request reprint Disruption of the actin network enhances MAP-2c and Fyn-induced process outgrowth
    S Pilar Zamora-Leon
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cell Motil Cytoskeleton 62:110-23. 2005
    ..These studies suggest that independent of one another MAP-2c and Fyn are able to induce process outgrowth and in concert can initiate and enhance process outgrowth in an additive manner...
  14. ncbi request reprint UCN-01 alters phosphorylation of Akt and GSK3beta and induces apoptosis in six independent human neuroblastoma cell lines
    Sai Latha Shankar
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurochem 90:702-11. 2004
    ..Thus, UCN-01 was effective at inducing apoptosis in neuroblastoma cell lines...
  15. ncbi request reprint Up-regulation of MAP2e-expressing oligodendrocytes in the white matter of patients with HIV-1 encephalitis
    Melissa A Cosenza
    Department of Pathology, Albert Einstein College of Medicine, Bronx NY 10461, USA
    Neuropathol Appl Neurobiol 28:480-8. 2002
    ..Our results demonstrate that MAP2e can serve as a marker of white matter damage in HIVE and support the notion that oligodendrocyte damage/repair occurs during HIV-1 infection...
  16. ncbi request reprint Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis
    Sai Latha Shankar
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 26:5638-48. 2006
    ..We conclude that gas6 signaling through the Axl receptor and the PI3 kinase/Akt1 survival pathway protects oligodendrocytes from growth factor withdrawal and TNFalpha-mediated cell death...
  17. ncbi request reprint Inhibition of human neuroblastoma cell growth by CAY10404, a highly selective Cox-2 inhibitor
    Bhupesh Parashar
    Department of Radiation Oncology, Montefiore Medical Center, Bronx, NY 10461, USA
    J Neurooncol 71:141-8. 2005
    ....