Nicolas F Schlecht

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc Cervical, anal and oral HPV in an adolescent inner-city health clinic providing free vaccinations
    Nicolas F Schlecht
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 7:e37419. 2012
  2. pmc A comparison of clinically utilized human papillomavirus detection methods in head and neck cancer
    Nicolas F Schlecht
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA
    Mod Pathol 24:1295-305. 2011
  3. pmc Unique DNA methylation loci distinguish anatomic site and HPV status in head and neck squamous cell carcinoma
    Roberto A Lleras
    Authors Affiliations Departments of Pathology Epidemiology and Population Health Pediatrics, Microbiology and Immunology Obstetrics, Gynecology and Women s Health, Albert Einstein College of Medicine and Department of Otorhinolaryngology Head and Neck Surgery, Montefiore Medical Center, Medical Arts Pavilion, Bronx, New York
    Clin Cancer Res 19:5444-55. 2013
  4. pmc Cytoplasmic ezrin and moesin correlate with poor survival in head and neck squamous cell carcinoma
    Nicolas F Schlecht
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine and Montefiore Medical Center, 1300 Morris Park Avenue, Bronx, NY, 10461, USA
    Head Neck Pathol 6:232-43. 2012
  5. pmc Site-specific molecular signatures predict aggressive disease in HNSCC
    Thomas J Belbin
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Head Neck Pathol 2:243-56. 2008
  6. pmc Low-level expression of microRNAs let-7d and miR-205 are prognostic markers of head and neck squamous cell carcinoma
    Geoffrey Childs
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Am J Pathol 174:736-45. 2009
  7. ncbi request reprint Variants of human papillomaviruses 16 and 18 and their natural history in human immunodeficiency virus-positive women
    Nicolas F Schlecht
    Albert Einstein College of Medicine, Department of Epidemiology and Population Health, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Gen Virol 86:2709-20. 2005
  8. doi request reprint The histone deacetylase inhibitor LBH589 inhibits expression of mitotic genes causing G2/M arrest and cell death in head and neck squamous cell carcinoma cell lines
    Michael B Prystowsky
    Department of Pathology, Albert Einstein College of Medicine and Montefiore Medical Center, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Pathol 218:467-77. 2009
  9. ncbi request reprint Pilot study of mucosal genetic differences in early smokers and nonsmokers
    Richard V Smith
    Department of Otorhinolaryngology Head and Neck Surgery, Albert Einstein College of Medicine, 3400 Bainbridge Avenue, Bronx, NY 10467, USA
    Laryngoscope 116:1375-9. 2006
  10. pmc Comorbidity, human papillomavirus infection and head and neck cancer survival in an ethnically diverse population
    Ashish A Ankola
    Department of Otorhinolaryngology Head and Neck Surgery, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Oral Oncol 49:911-7. 2013

Collaborators

Detail Information

Publications23

  1. pmc Cervical, anal and oral HPV in an adolescent inner-city health clinic providing free vaccinations
    Nicolas F Schlecht
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 7:e37419. 2012
    ..Published human papillomavirus (HPV) vaccine trials indicate efficacy is strongest for those naive to the vaccine-types. However, few high-risk young women have been followed and cervical HPV has been the predominant outcome measure...
  2. pmc A comparison of clinically utilized human papillomavirus detection methods in head and neck cancer
    Nicolas F Schlecht
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA
    Mod Pathol 24:1295-305. 2011
    ..Further testing is warranted before these assays should be recommended for clinical HPV detection...
  3. pmc Unique DNA methylation loci distinguish anatomic site and HPV status in head and neck squamous cell carcinoma
    Roberto A Lleras
    Authors Affiliations Departments of Pathology Epidemiology and Population Health Pediatrics, Microbiology and Immunology Obstetrics, Gynecology and Women s Health, Albert Einstein College of Medicine and Department of Otorhinolaryngology Head and Neck Surgery, Montefiore Medical Center, Medical Arts Pavilion, Bronx, New York
    Clin Cancer Res 19:5444-55. 2013
    ....
  4. pmc Cytoplasmic ezrin and moesin correlate with poor survival in head and neck squamous cell carcinoma
    Nicolas F Schlecht
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine and Montefiore Medical Center, 1300 Morris Park Avenue, Bronx, NY, 10461, USA
    Head Neck Pathol 6:232-43. 2012
    ....
  5. pmc Site-specific molecular signatures predict aggressive disease in HNSCC
    Thomas J Belbin
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Head Neck Pathol 2:243-56. 2008
    ..Predictions of outcome based on gene expression profiling are therefore heavily influenced by the anatomic site of the primary tumor...
  6. pmc Low-level expression of microRNAs let-7d and miR-205 are prognostic markers of head and neck squamous cell carcinoma
    Geoffrey Childs
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Am J Pathol 174:736-45. 2009
    ....
  7. ncbi request reprint Variants of human papillomaviruses 16 and 18 and their natural history in human immunodeficiency virus-positive women
    Nicolas F Schlecht
    Albert Einstein College of Medicine, Department of Epidemiology and Population Health, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Gen Virol 86:2709-20. 2005
    ..If non-European variants are more oncogenic, the effect may involve a late stage in cervical tumorigenesis...
  8. doi request reprint The histone deacetylase inhibitor LBH589 inhibits expression of mitotic genes causing G2/M arrest and cell death in head and neck squamous cell carcinoma cell lines
    Michael B Prystowsky
    Department of Pathology, Albert Einstein College of Medicine and Montefiore Medical Center, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Pathol 218:467-77. 2009
    ....
  9. ncbi request reprint Pilot study of mucosal genetic differences in early smokers and nonsmokers
    Richard V Smith
    Department of Otorhinolaryngology Head and Neck Surgery, Albert Einstein College of Medicine, 3400 Bainbridge Avenue, Bronx, NY 10467, USA
    Laryngoscope 116:1375-9. 2006
    ..This technique has been successfully applied to head and neck squamous cell carcinoma (HNSCC) and thyroid carcinomas; however, little has been done to evaluate premalignant states...
  10. pmc Comorbidity, human papillomavirus infection and head and neck cancer survival in an ethnically diverse population
    Ashish A Ankola
    Department of Otorhinolaryngology Head and Neck Surgery, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Oral Oncol 49:911-7. 2013
    ..To demonstrate the importance of comorbid conditions in head and neck squamous cell carcinoma (HNSCC), we assessed the association between comorbidity and survival in an inner-city population of HNSCC patients...
  11. ncbi request reprint Natural history and possible reactivation of human papillomavirus in human immunodeficiency virus-positive women
    Howard D Strickler
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Belfer 1308, Bronx, NY 10461, USA
    J Natl Cancer Inst 97:577-86. 2005
    ....
  12. doi request reprint Validation of the histologic risk model in a new cohort of patients with head and neck squamous cell carcinoma
    Margaret Brandwein-Gensler
    Einstein Montefiore Head and Neck Research Group, Department of Pathology, Bronx, NY, USA
    Am J Surg Pathol 34:676-88. 2010
    ..We have developed a novel risk model that can become a basis for developing new treatment paradigms. Here we report on the performance of our model in a new multicenter cohort...
  13. ncbi request reprint Prognostic value of human papillomavirus in the survival of head and neck cancer patients: an overview of the evidence
    Nicolas F Schlecht
    Departments of Epidemiology and Population Health, Division of Epidemiology and Medicine, Division of Oncology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Oncol Rep 14:1239-47. 2005
    ..The introduction of prophylactic and therapeutic HPV vaccines could have important implications for the prevention and control of a substantial fraction of HNSCC...
  14. pmc Human papillomavirus-associated head and neck squamous cell carcinoma survival: a comparison by tumor site and initial treatment
    Christian R Salazar
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10641, USA
    Head Neck Pathol 8:77-87. 2014
    ..No selective treatment advantage is observed for HPV-positive tumors, although clinical trials are needed to evaluate which treatment modalities provide the most benefit for HPV-positive HNSCC...
  15. ncbi request reprint Differential tissue and subcellular expressionof ERM proteins in normal and malignant tissues: cytoplasmic ezrin expression has prognostic signficance for head and neck squamous cell carcinoma
    Rashna Madan
    Department of Pathology, Albert Einstein College of Medicine, Montefiore Medical Center, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Head Neck 28:1018-27. 2006
    ..TMA sections were evaluated for ERM protein expression immunohistochemically. The results were compared across clinical and histopathologic variables..
  16. pmc Hypermethylation of a cluster of Kr├╝ppel-type zinc finger protein genes on chromosome 19q13 in oropharyngeal squamous cell carcinoma
    Roberto A Lleras
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    Am J Pathol 178:1965-74. 2011
    ..The aberrant methylation of these genes represents a new avenue of exploration for pathways affected in this disease...
  17. pmc The role of the human papillomavirus in the pathogenesis of Schneiderian inverted papillomas: an analytic overview of the evidence
    William Lawson
    Department of Otolaryngology, Mount Sinai School of Medicine, New York, NY 10021, USA
    Head Neck Pathol 2:49-59. 2008
    ..in IP vary so greatly? What is the relationship between low-risk (LR) and high-risk (HR) HPV types and HPV detection rates in IP? Is there a relationship between the presence and type of HPV in IP and recurrence and malignant progression?..
  18. ncbi request reprint Lack of agreement between cervicography and cytology and the effect of human papillomavirus infection and viral load
    Nicolas F Schlecht
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA
    J Low Genit Tract Dis 10:229-37. 2006
    ..Cohort studies of the natural history of human papillomavirus (HPV) infection and cervical squamous intraepithelial lesions with repeated screening allow the comparison of different macroscopic and microscopic diagnostic methods...
  19. pmc Lymphocytic host response to oral squamous cell carcinoma: an adaptive T-cell response at the tumor interface
    Sara Maleki
    Departments of Pathology, Einstein Montefiore Head and Neck Research Group, Bronx, NY, USA
    Head Neck Pathol 5:117-22. 2011
    ..Immune response at the tumor interface correlates with an adaptive T cell response; the degree of cytotoxic CD8+ cells infiltrate can distinguish between strong and intermediate LHR at the interface of oral carcinomas...
  20. pmc Low-level expression of miR-375 correlates with poor outcome and metastasis while altering the invasive properties of head and neck squamous cell carcinomas
    Thomas Harris
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Pathol 180:917-28. 2012
    ..We conclude that miR-375 represents a potential prognostic marker of poor outcome and metastasis in HNSCC and that it may function by suppressing the tumor's invasive properties...
  21. ncbi request reprint KLF6 allelic loss is associated with tumor recurrence and markedly decreased survival in head and neck squamous cell carcinoma
    Miriam S Teixeira
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Cancer 121:1976-83. 2007
    ..Taken together, these findings suggest that KLF6 LOH represents a clinically-relevant biomarker predicting patient survival and tumor recurrence and that dysregulation of KLF6 function plays an important role in HNSCC progression...
  22. ncbi request reprint Thyroid fine needle aspiration cytology: follicular lesions and the gray zone
    Jonathan Somma
    Department of Pathology, Montefiore Medical Center, New York, New York, USA
    Acta Cytol 54:123-31. 2010
    ..To identifiy categories of potentially neoplastic, nonpapillary follicular lesions of the thyroid that would reduce the number of lobectomies for nonneoplastic disease...
  23. doi request reprint Genetic variants in TAP are associated with high-grade cervical neoplasia
    Mark H Einstein
    Albert Einstein College of Medicine, Bronx, New York, USA
    Clin Cancer Res 15:1019-23. 2009
    ..Consistent with heterogeneity in MHC expression is the individual variability in clearing detectable HPV infections. Genetic polymorphisms in TAP genes may affect protein structure, function, and the ability to clear HPV infection...