Philipp E Scherer

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi request reprint Adipose tissue: from lipid storage compartment to endocrine organ
    Philipp E Scherer
    Department of Cell Biology, Diabetes Research and Training Center, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Diabetes 55:1537-45. 2006
  2. ncbi request reprint Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion
    Terence M Williams
    Department of Molecular Pharmacology and Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 279:51630-46. 2004
  3. pmc Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases
    Hee Yun Suk
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 288:3477-88. 2013
  4. pmc Role of resistin in diet-induced hepatic insulin resistance
    Evan D Muse
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 114:232-9. 2004
  5. pmc Trypanosoma cruzi infection of cultured adipocytes results in an inflammatory phenotype
    Fnu Nagajyothi
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    Obesity (Silver Spring) 16:1992-7. 2008
  6. ncbi request reprint Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity
    Utpal B Pajvani
    Department of Cell Biology, Division of Endocrinology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Biol Chem 279:12152-62. 2004
  7. ncbi request reprint Caveolin-3 knockout mice show increased adiposity and whole body insulin resistance, with ligand-induced insulin receptor instability in skeletal muscle
    Franco Capozza
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Am J Physiol Cell Physiol 288:C1317-31. 2005
  8. ncbi request reprint The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species
    Ying Lin
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 280:4617-26. 2005
  9. pmc Alterations in glucose homeostasis in a murine model of Chagas disease
    Fnu Nagajyothi
    Division of Parasitology and Tropical Medicine, Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Pathol 182:886-94. 2013
  10. pmc Proangiogenic contribution of adiponectin toward mammary tumor growth in vivo
    Shira Landskroner-Eiger
    Department of Cell Biology, Center of Reproductive Biology and Womens Health, Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Clin Cancer Res 15:3265-76. 2009

Collaborators

Detail Information

Publications99

  1. ncbi request reprint Adipose tissue: from lipid storage compartment to endocrine organ
    Philipp E Scherer
    Department of Cell Biology, Diabetes Research and Training Center, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Diabetes 55:1537-45. 2006
    ..The intensity and complexity of these signals are highly regulated, differ in each fat pad, and are dramatically affected by various disease states...
  2. ncbi request reprint Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion
    Terence M Williams
    Department of Molecular Pharmacology and Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 279:51630-46. 2004
    ..These results demonstrate, for the first time, that caveolin-1 is a potent suppressor of mammary tumor growth and metastasis using novel in vivo animal model approaches...
  3. pmc Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases
    Hee Yun Suk
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 288:3477-88. 2013
    ..These data also indicate that potentiated cAMP signaling pathway may provide an alternative molecular pathogenesis for the metabolic complications elicited by CsA in transplant patients...
  4. pmc Role of resistin in diet-induced hepatic insulin resistance
    Evan D Muse
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 114:232-9. 2004
    ..These results provide strong support for a physiological role of resistin in the development of hepatic insulin resistance in this model...
  5. pmc Trypanosoma cruzi infection of cultured adipocytes results in an inflammatory phenotype
    Fnu Nagajyothi
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    Obesity (Silver Spring) 16:1992-7. 2008
    ..cruzi-infected adipocytes. Overall, these data implicate the adipocyte as an important target of T. cruzi, and one which contributes significantly to the inflammatory response observed in Chagas disease...
  6. ncbi request reprint Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity
    Utpal B Pajvani
    Department of Cell Biology, Division of Endocrinology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Biol Chem 279:12152-62. 2004
    ..These observations suggest that the HMW adiponectin complex is the active form of this protein, which we directly demonstrate in vivo by its ability to depress serum glucose levels in a dose-dependent manner...
  7. ncbi request reprint Caveolin-3 knockout mice show increased adiposity and whole body insulin resistance, with ligand-induced insulin receptor instability in skeletal muscle
    Franco Capozza
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Am J Physiol Cell Physiol 288:C1317-31. 2005
    ..These findings may have clinical implications for the early diagnosis and treatment of caveolinopathies...
  8. ncbi request reprint The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species
    Ying Lin
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 280:4617-26. 2005
    ..Combined, these results highlight the importance ROS production in adipocytes and the associated insulin resistance and inflammatory response...
  9. pmc Alterations in glucose homeostasis in a murine model of Chagas disease
    Fnu Nagajyothi
    Division of Parasitology and Tropical Medicine, Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Pathol 182:886-94. 2013
    ..cruzi-induced hypoglycemia, despite reduced insulin, but elevated glucagon levels. The data establishes a complex, multi-tissue relationship between T. cruzi infection, Chagas disease, and host glucose homeostasis...
  10. pmc Proangiogenic contribution of adiponectin toward mammary tumor growth in vivo
    Shira Landskroner-Eiger
    Department of Cell Biology, Center of Reproductive Biology and Womens Health, Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Clin Cancer Res 15:3265-76. 2009
    ..To explore the association of APN with breast cancer and tumor angiogenesis, we took an in vivo approach aiming to study its role in the mouse mammary tumor virus (MMTV)-polyoma middle T antigen (PyMT) mammary tumor model...
  11. pmc Phosphofructokinase muscle-specific isoform requires caveolin-3 expression for plasma membrane recruitment and caveolar targeting: implications for the pathogenesis of caveolin-related muscle diseases
    Federica Sotgia
    Departments of Molecular Pharmacology and Cell Biology, and The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Pathol 163:2619-34. 2003
    ....
  12. ncbi request reprint A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity
    Terry P Combs
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Endocrinology 145:367-83. 2004
    ....
  13. pmc Obesity-associated improvements in metabolic profile through expansion of adipose tissue
    Ja Young Kim
    Department of Cell Biology, Albert Einstein College of Medicine, New York, New York, USA
    J Clin Invest 117:2621-37. 2007
    ..These mice therefore represent what we believe is a novel model of morbid obesity associated with an improved metabolic profile...
  14. ncbi request reprint Regulation of resistin expression and circulating levels in obesity, diabetes, and fasting
    Michael W Rajala
    Department of Cell Biology and Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Diabetes 53:1671-9. 2004
    ..Taken together, these findings suggest that the nutritional regulation of resistin and changes in resistin gene expression and circulating levels in obesity are mediated, at least in part, through insulin and glucose...
  15. pmc Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI
    Tayeba Khan
    Department of Cell Biology, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Cell Biol 29:1575-91. 2009
    ....
  16. ncbi request reprint Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy
    Utpal B Pajvani
    Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nat Med 11:797-803. 2005
    ....
  17. pmc Chagas disease, adipose tissue and the metabolic syndrome
    Fnu Nagajyothi
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mem Inst Oswaldo Cruz 104:219-25. 2009
    ..Adipose tissue is an important target tissue of T. cruzi and the infection of this tissue is associated with a profound impact on systemic metabolism, increasing the risk of metabolic syndrome...
  18. ncbi request reprint Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis: role of INK4a/CAV-1 in mammary epithelial cell hyperplasia
    Terence M Williams
    Department of Molecular Pharmacology, Albert Einsten Cancer Center, Albert Einsten College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 279:24745-56. 2004
    ..Our results provide important new evidence for the transformation suppressor properties of Cav-1 and the first molecular genetic evidence that Cav-1 cooperates with a tumor suppressor, namely the INK4a genetic locus...
  19. pmc Role of transcription factor NFAT in glucose and insulin homeostasis
    Teddy T C Yang
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Mol Cell Biol 26:7372-87. 2006
    ..Together, these results establish a role for NFAT in glucose/insulin homeostasis and expand the repertoire of NFAT function to metabolic pathogenesis and adipokine gene transcription...
  20. pmc PANIC-ATTAC: a mouse model for inducible and reversible beta-cell ablation
    Zhao V Wang
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA
    Diabetes 57:2137-48. 2008
    ..Here, we present a mouse model for inducible and reversible ablation of pancreatic beta-cells named the PANIC-ATTAC (pancreatic islet beta-cell apoptosis through targeted activation of caspase 8) mouse...
  21. ncbi request reprint Role of caveolin-1 in the modulation of lipolysis and lipid droplet formation
    Alex W Cohen
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Diabetes 53:1261-70. 2004
    ..Taken together, our data provide the first molecular genetic evidence that caveolin-1 plays a critical functional and structural role in the modulation of both lipid droplet biogenesis and metabolism in vivo...
  22. ncbi request reprint Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity
    Utpal B Pajvani
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 278:9073-85. 2003
    ..Combined, these results shed new light on the regulation of this complex protein and suggest a new model for in vivo activation of the protein, implicating a serum reductase activity...
  23. ncbi request reprint Insulin-sensitizing effects of thiazolidinediones are not linked to adiponectin receptor expression in human fat or muscle
    Weijie Li
    Departments of Medicine, Surgery, and Cell Biology, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol Endocrinol Metab 292:E1301-7. 2007
    ..Although TZDs probably exert many of their effects via adiponectin, changes in these receptors do not appear to be necessary for their insulin-sensitizing effects...
  24. pmc Impact of simvastatin on adipose tissue: pleiotropic effects in vivo
    Tayeba Khan
    Departments of Cell Biology, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Endocrinology 150:5262-72. 2009
    ..Our data demonstrate that statins have major effects on the cellular physiology of the adipocyte on multiple levels...
  25. pmc Response of adipose tissue to early infection with Trypanosoma cruzi (Brazil strain)
    Fnu Nagajyothi
    Department of Pathology, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY, USA
    J Infect Dis 205:830-40. 2012
    ..The mRNA levels of cytokines, chemokines, and their receptors were increased. Nuclear Factor Kappa B levels were increased in BAT, whereas Iκκ-γ levels increased in WAT. Adipose tissue is an early target of T. cruzi infection...
  26. doi request reprint Adipocyte-derived factors potentiate nutrient-induced production of plasminogen activator inhibitor-1 by macrophages
    Preeti Kishore
    Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Sci Transl Med 2:20ra15. 2010
    ..Together, our data suggest that adipocyte-derived factors prime adipose macrophages so that they respond to nutritional signals (FFAs) by releasing a key inflammatory adipokine, PAI-1...
  27. ncbi request reprint Caveolin-1-deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissue
    Alex W Cohen
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Physiol Cell Physiol 285:C222-35. 2003
    ..These data provide evidence that the lean body phenotype observed in the Cav-1 knockout mice is due, at least in part, to a defect in insulin-regulated lipogenesis...
  28. doi request reprint Associations of testosterone and sex hormone binding globulin with adipose tissue hormones in midlife women
    Rachel P Wildman
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA
    Obesity (Silver Spring) 21:629-36. 2013
    ..Therefore, we assessed the associations between testosterone (T) and sex hormone binding globulin (SHBG) with leptin, high molecular weight (HMW) adiponectin, and the soluble form of the leptin receptor (sOB-R) in healthy midlife women...
  29. pmc Adipokines linking obesity with colorectal cancer risk in postmenopausal women
    Gloria Y F Ho
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 72:3029-37. 2012
    ..Hyperinsulinemia and hyperleptinemia may therefore partially explain the adiposity association with colorectal cancer in postmenopausal women...
  30. ncbi request reprint Mechanisms of early insulin-sensitizing effects of thiazolidinediones in type 2 diabetes
    Julia Tonelli
    Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Diabetes 53:1621-9. 2004
    ..Thus, only 21 days of pioglitazone therapy improved insulin action in humans with type 2 diabetes. Increased abundance of the HMW adiponectin multimer may contribute to the hepatic insulin-sensitizing effects of these agents...
  31. ncbi request reprint Caveolin-1 expression is essential for proper nonshivering thermogenesis in brown adipose tissue
    Alex W Cohen
    Department of Molecular Pharmacology, The Albert Einstein Cancer Center, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Diabetes 54:679-86. 2005
    ..Taken together, our data provide the first molecular genetic evidence that caveolin-1 plays a critical functional and structural role in the modulation of thermogenesis via an effect on lipid mobilization...
  32. pmc Resistin, but not adiponectin and leptin, is associated with the risk of ischemic stroke among postmenopausal women: results from the Women's Health Initiative
    Swapnil N Rajpathak
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Stroke 42:1813-20. 2011
    ..We aimed to examine the associations of 3 adipokines (adiponectin, leptin, and resistin) with the risk of ischemic stroke...
  33. pmc Crucial role of the central leptin receptor in murine Trypanosoma cruzi (Brazil strain) infection
    Fnu Nagajyothi
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    J Infect Dis 202:1104-13. 2010
    ..These findings suggest that leptin resistance in individuals with obesity and diabetes mellitus may have adverse consequences in T. cruzi infection...
  34. pmc Adipose tissue, diabetes and Chagas disease
    Herbert B Tanowitz
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    Adv Parasitol 76:235-50. 2011
    ..The adipocyte is both a target of infection and a reservoir for the parasite during the chronic phase from which recrudescence of the infection may occur during periods of immunosuppression...
  35. ncbi request reprint Role of caveolin and caveolae in insulin signaling and diabetes
    Alex W Cohen
    Department of Molecular Pharmacology, Albert Einstein Diabetes Research and Training Center, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Am J Physiol Endocrinol Metab 285:E1151-60. 2003
    ..We present a critical discussion of these recent findings...
  36. ncbi request reprint Apoptosis through targeted activation of caspase 8 ("ATTAC-mice"): novel mouse models of inducible and reversible tissue ablation
    Maria E Trujillo
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cell Cycle 4:1141-5. 2005
    ..Here we describe several ongoing areas of research employing the FAT-ATTAC mouse; in addition we describe potential uses of the targeted transgenic apoptotic approach to study other cell types of interest...
  37. pmc Hypothalamic resistin induces hepatic insulin resistance
    Evan D Muse
    Department of Molecular Pharmacology, Albert Einstein College of Medicine of Yeshiva University, New York, NY 10461, USA
    J Clin Invest 117:1670-8. 2007
    ..These results unveil what we believe to be a novel site of action of resistin on GP and inflammation and suggest that hypothalamic resistin action can contribute to hyperglycemia in type 2 diabetes mellitus...
  38. pmc Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention
    Zhao V Wang
    Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Mol Cell Biol 27:3716-31. 2007
    ..One mechanism for increasing circulating levels of specific adiponectin complexes by peroxisome proliferator-activated receptor gamma agonists may be selective upregulation of rate-limiting chaperones...
  39. doi request reprint Gender differences in adiponectin modulation of cardiac remodeling in mice deficient in endothelial nitric oxide synthase
    Jorge L Durand
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Biochem 113:3276-87. 2012
    ..Our results demonstrate a sexual dimorphism in response of the heart to alterations in eNOS and adiponectin during high fat feeding and suggest that adiponectin might require eNOS for some of its metabolic effects...
  40. pmc Mechanisms of Trypanosoma cruzi persistence in Chagas disease
    Fnu Nagajyothi
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
    Cell Microbiol 14:634-43. 2012
    ..Ongoing and future research will continue to help refining the models of T. cruzi invasion and persistence in diverse tissues and organs in the host...
  41. ncbi request reprint Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists
    Andrea R Nawrocki
    Department of Cell Biology, Division of Endocrinology, and Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 281:2654-60. 2006
    ..In summary, adiponectin is an important contributor to PPARgamma-mediated improvements in glucose tolerance through mechanisms that involve the activation of the AMPK pathway...
  42. pmc Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment
    Puneeth Iyengar
    Department of Cell Biology, Albert Einstein Cancer Center, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 115:1163-76. 2005
    ..Therefore, adipocytes play a vital role in defining the ECM environment for normal and tumor-derived ductal epithelial cells and contribute significantly to tumor growth at early stages through secretion and processing of collagen VI...
  43. ncbi request reprint ATR/TEM8 is highly expressed in epithelial cells lining Bacillus anthracis' three sites of entry: implications for the pathogenesis of anthrax infection
    Gloria Bonuccelli
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Am J Physiol Cell Physiol 288:C1402-10. 2005
    ..These results suggest that the ATR/TEM8 expression pattern that we describe here is highly relevant for understanding the pathogenesis of anthrax infection...
  44. ncbi request reprint The delicate balance between fat and muscle: adipokines in metabolic disease and musculoskeletal inflammation
    Andrea R Nawrocki
    Department of Cell Biology and Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Curr Opin Pharmacol 4:281-9. 2004
    ..In addition, adipocytes accumulate within the skeletal muscle and exert direct paracrine effects on muscle insulin sensitivity...
  45. ncbi request reprint Cyclin and caveolin expression in an acute model of murine Chagasic myocarditis
    Fnu Nagajyothi
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cell Cycle 5:107-12. 2006
    ....
  46. pmc Thromboxane A2 is a key regulator of pathogenesis during Trypanosoma cruzi infection
    Anthony W Ashton
    Department of Medicine, Divisions of Cardiology and Infectious Disease, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Exp Med 204:929-40. 2007
    ..cruzi infection is possibly an important determinant of mortality and parasitism. A deeper understanding of the role of TXA(2) may result in novel therapeutic targets for a disease with limited treatment options...
  47. ncbi request reprint Adiponectin: systemic contributor to insulin sensitivity
    Utpal B Pajvani
    Department of Cell Biology and Diabetes Research and Training Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Curr Diab Rep 3:207-13. 2003
    ..The phenotypes of adiponectin-deficient and transgenic adiponectin-overproducing animal models underscore the role of adiponectin in the maintenance of glucose and lipid homeostasis...
  48. ncbi request reprint Adipocyte differentiation induces dynamic changes in NF-kappaB expression and activity
    Anders H Berg
    Dept of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, New York, NY 10461, USA
    Am J Physiol Endocrinol Metab 287:E1178-88. 2004
    ..These effects are mediated by a secretory product of adipocytes that is unlikely to be IL-6 or TNF-alpha...
  49. pmc Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production
    Michael W Rajala
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA
    J Clin Invest 111:225-30. 2003
    ..These results support the notion that a novel family of fat- and gut-derived circulating proteins modulates hepatic insulin action...
  50. ncbi request reprint Keynote review: the adipocyte as a drug discovery target
    Andrea R Nawrocki
    Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Drug Discov Today 10:1219-30. 2005
    ..Here, we want to highlight various areas of adipocyte physiology that have not yet been explored pharmacologically and emphasize some of the limitations associated with these pharmacotherapies...
  51. pmc A prospective study of inflammation markers and endometrial cancer risk in postmenopausal hormone nonusers
    Tao Wang
    Division of Biostatistics, Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cancer Epidemiol Biomarkers Prev 20:971-7. 2011
    ..We examined the associations of three inflammation markers, C-reactive protein (CRP), interleukin (IL)-6 and tumor necrosis factor (TNF)-α, with risk of endometrial cancer...
  52. ncbi request reprint Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin
    Terry P Combs
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Diabetes 52:268-76. 2003
    ..In summary, Acrp30 levels in serum are under complex hormonal control and may play a key role in determining systemic insulin sensitivity under the respective conditions...
  53. ncbi request reprint Adiponectin/Acrp30, an adipocyte-specific secretory factor: physiological relevance during development
    Puneeth Iyengar
    Department of Cell Biology, Diabetes Research and Training Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Pediatr Diabetes 4:32-7. 2003
    ....
  54. pmc Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D
    Hong Zhu
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Mol Cell Biol 30:4379-90. 2010
    ..This novel signaling system also provides unique functional insights into the complications elicited by CsA in transplant patients...
  55. ncbi request reprint Cell type-specific expression and coregulation of murine resistin and resistin-like molecule-alpha in adipose tissue
    Michael W Rajala
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Endocrinol 16:1920-30. 2002
    ..Additionally, we show that resistin and RELMalpha levels are not subject to regulation by proinflammatory stimuli. Finally, acute hyperglycemia leads to up-regulation of resistin and RELMalpha transcription in various adipose depots...
  56. ncbi request reprint Chagas disease, adipose tissue and the metabolic syndrome
    Fnu Nagajyothi
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA
    Mem Inst Oswaldo Cruz 104:219-25. 2009
    ..Adipose tissue is an important target tissue of T. cruzi and the infection of this tissue is associated with a profound impact on systemic metabolism, increasing the risk of metabolic syndrome...
  57. ncbi request reprint Adipose tissue-derived factors: impact on health and disease
    Maria E Trujillo
    Departments of Cell Biology and Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Endocr Rev 27:762-78. 2006
    ..Here, we briefly discuss some basic aspects of adipocyte physiology and the systemic impact of adipocyte-derived factors on energy homeostasis...
  58. pmc Role of extracellular signal-regulated kinase 5 in adipocyte signaling
    Hong Zhu
    From the Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461
    J Biol Chem 289:6311-22. 2014
    ..Reduced cAMP accumulation and increased phosphodiesterase activity are also found. Together, these results demonstrate integration of ERK5 with NFATc4 nucleo-cytoplasmic shuttling and PKA activation in adipocyte signaling. ..
  59. ncbi request reprint Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization
    Terry P Combs
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Endocrinology 143:998-1007. 2002
    ..Furthermore, Acrp30 is likely to be a biomarker of in vivo PPARgamma activation...
  60. ncbi request reprint The adipocyte as an important target cell for Trypanosoma cruzi infection
    Terry P Combs
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 280:24085-94. 2005
    ....
  61. pmc Trypanosoma cruzi utilizes the host low density lipoprotein receptor in invasion
    Fnu Nagajyothi
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    PLoS Negl Trop Dis 5:e953. 2011
    ....
  62. ncbi request reprint Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization
    Puneeth Iyengar
    Department of Cell Biology, Albert Einstein Cancer Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Oncogene 22:6408-23. 2003
    ..It promotes GSK3beta phosphorylation, beta-catenin stabilization, and increased beta-catenin activity in breast cancer cells and may critically contribute towards tumorigenesis when not counterbalanced by other factors...
  63. ncbi request reprint Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1
    Hyangkyu Lee
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Biol Chem 277:34556-67. 2002
    ..Furthermore, our co-immunoprecipitation experiments show that caveolin-2 and Ras-GAP are constitutively associated in c-Src expressing NIH-3T3 cells, but not in untransfected NIH-3T3 cells...
  64. ncbi request reprint Adipose tissue, inflammation, and cardiovascular disease
    Anders H Berg
    Department of Cell Biology, Bronx, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Circ Res 96:939-49. 2005
    ..The targeted suppression of various proinflammatory cascades in adipocytes specifically represents an exciting new therapeutic opportunity for the cardiovascular disease area...
  65. ncbi request reprint Phenotypic behavior of caveolin-3 R26Q, a mutant associated with hyperCKemia, distal myopathy, and rippling muscle disease
    Federica Sotgia
    Department of Molecular Pharmacology, The Albert Einstein Cancer Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Am J Physiol Cell Physiol 285:C1150-60. 2003
    ..We propose a haploinsufficiency model in which reduced levels of wild-type caveolin-3, although not rendered dysfunctional due to the caveolin-3 R26Q mutant protein, are insufficient for normal muscle cell function...
  66. ncbi request reprint Molecular cloning and developmental expression of the caveolin gene family in the amphibian Xenopus laevis
    Babak Razani
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Biochemistry 41:7914-24. 2002
    ..This report is the first detailed study of caveolin gene expression in a developing embryo...
  67. pmc Morphogenesis of the developing mammary gland: stage-dependent impact of adipocytes
    Shira Landskroner-Eiger
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Dev Biol 344:968-78. 2010
    ....
  68. pmc Perspectives on adipose tissue, chagas disease and implications for the metabolic syndrome
    Fnu Nagajyothi
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Interdiscip Perspect Infect Dis 2009:824324. 2009
    ..The T. cruzi-induced increase in macrophages in adipose tissue taken together with the reduction in adiponectin and the associated cardiomyopathy is reminiscent of the metabolic syndrome...
  69. ncbi request reprint JNK1 but not JNK2 promotes the development of steatohepatitis in mice
    Jörn M Schattenberg
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hepatology 43:163-72. 2006
    ..These findings also provide additional support for the critical mechanistic involvement of JNK1 overactivation in conditions associated with insulin resistance and the metabolic syndrome...
  70. ncbi request reprint Minireview: The adipocyte--at the crossroads of energy homeostasis, inflammation, and atherosclerosis
    Michael W Rajala
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Endocrinology 144:3765-73. 2003
    ....
  71. pmc Hepatocyte growth factor and the risk of ischemic stroke developing among postmenopausal women: results from the Women's Health Initiative
    Swapnil N Rajpathak
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Stroke 41:857-62. 2010
    ..However, there have been no prospective studies examining the relationship between HGF levels and risk of stroke...
  72. ncbi request reprint Within-individual stability of obesity-related biomarkers among women
    Robert C Kaplan
    Department of Epidemiology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Cancer Epidemiol Biomarkers Prev 16:1291-3. 2007
    ..However, this assumption is seldom tested...
  73. ncbi request reprint Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities
    Babak Razani
    Department of Molecular Pharmacology, The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 277:8635-47. 2002
    ..Our results show for the first time a clear role for caveolins in systemic lipid homeostasis in vivo and place caveolin-1/caveolae as major factors in hyperlipidemias and obesity...
  74. pmc Adipocyte, adipose tissue, and infectious disease
    Mahalia S Desruisseaux
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Infect Immun 75:1066-78. 2007
  75. ncbi request reprint Adiponectin, an adipocyte-derived hepatic insulin sensitizer regulation during development
    Ja Young Kim
    Department of Cell Biology, Albert Einstein College of Medicine, Morris Park Avenue, Bronx, NY 10461, USA
    Pediatr Endocrinol Rev 1:428-31. 2004
    ..Here we summarize the results from these recent findings in younger cohorts and discuss these results in context of the much vaster literature on adiponectin levels in lean, obese and diabetic adults...
  76. ncbi request reprint ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism
    Anders H Berg
    Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Trends Endocrinol Metab 13:84-9. 2002
    ..The current challenge is to understand the molecular mechanisms through which the protein exerts its multiple functions...
  77. ncbi request reprint Adiponectin, cardiovascular function, and hypertension
    Zhao V Wang
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA
    Hypertension 51:8-14. 2008
  78. ncbi request reprint Visceral fat adipokine secretion is associated with systemic inflammation in obese humans
    Luigi Fontana
    Washington University School of Medicine, Campus Box 8031, 660 South Euclid Ave, St Louis, MO 63110, USA
    Diabetes 56:1010-3. 2007
    ..These data suggest that visceral fat is an important site for IL-6 secretion and provide a potential mechanistic link between visceral fat and systemic inflammation in people with abdominal obesity...
  79. ncbi request reprint Peroxisome proliferator-activated receptor gamma agonists inhibit adipocyte expression of alpha1-acid glycoprotein
    Gino Castriota
    Department of Metabolic Disorders, RY80N C31, Merck Research Laboratories, 126 East Lincoln Avenue, P O Box 2000, Rahway, NJ 07065, USA
    Cell Biol Int 31:586-91. 2007
    ..These results suggest a potential novel adipocytic mechanism by which PPARgamma agonists may ameliorate T2DM-associated insulin resistance and cardiovascular disease...
  80. ncbi request reprint A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation
    Romel Somwar
    Programme in Cell Biology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Biol Chem 277:50386-95. 2002
    ..We propose that p38 contributes to enhancing GLUT4 activity, thereby increasing glucose uptake. In addition, the azaazulene class of inhibitors described will be useful to decipher cellular actions of p38 and JNK...
  81. ncbi request reprint A proteomic approach for identification of secreted proteins during the differentiation of 3T3-L1 preadipocytes to adipocytes
    Irina Kratchmarova
    Center for Experimental Bioinformatics, University of Southern Denmark, Odense M, DK 5230 Denmark
    Mol Cell Proteomics 1:213-22. 2002
    ..To our knowledge, this is the first study to identify several novel secreted proteins by adipocytes by a proteomic approach using mass spectrometry...
  82. pmc Obese mice lacking inducible nitric oxide synthase are sensitized to the metabolic actions of peroxisome proliferator-activated receptor-gamma agonism
    Patrice Dallaire
    Department of Anatomy and Physiology, Laval University, Quebec, Quebec, Canada
    Diabetes 57:1999-2011. 2008
    ..In this study, we tested whether targeted disruption of inducible nitric oxide (NO) synthase (iNOS), a key inflammatory mediator in obesity, modulates the metabolic effects of rosiglitazone in obese mice...
  83. ncbi request reprint A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome
    Claudia Menzaghi
    Research Division, Section on Genetics and Epidemiology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes 51:2306-12. 2002
    ....
  84. ncbi request reprint Keystone meeting summary: 'Adipogenesis, obesity, and inflammation' and 'Diabetes mellitus and the control of cellular energy metabolism, ' January 21-26, 2006, Vancouver, Canada
    Silvia Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genes Dev 20:2193-201. 2006
    ....
  85. ncbi request reprint Brain adipocytokine action and metabolic regulation
    Rexford S Ahima
    University of Pennsylvania School of Medicine, Division of Endocrinology, Diabetes and Metabolism, 764 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Diabetes 55:S145-54. 2006
    ..Understanding the actions of these "adipocytokines" will provide insight into the pathogenesis and treatment of obesity and related diseases...
  86. ncbi request reprint ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity
    Nabila Bouatia-Naji
    Centre National de la Recherche Scientifique UMR8090, Pasteur Institute of Lille, France
    Diabetes 55:545-50. 2006
    ..In summary, our study suggests that variations at the ACDC/adiponectin gene are associated with risk of severe forms of obesity. However, the mechanisms underlying these possible associations are not fully understood...
  87. ncbi request reprint Adiponectin resistance exacerbates insulin resistance in insulin receptor transgenic/knockout mice
    Hua V Lin
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Diabetes 56:1969-76. 2007
    ..Adiponectin increases insulin sensitivity and contributes to insulin's indirect effects on hepatic glucose production...
  88. pmc Evidence for enhanced adipogenesis in the orbits of patients with Graves' ophthalmopathy
    Seema Kumar
    Division of Pediatric Endocrinology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 89:930-5. 2004
    ....
  89. ncbi request reprint VGF ablation blocks the development of hyperinsulinemia and hyperglycemia in several mouse models of obesity
    Elizabeth Watson
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA
    Endocrinology 146:5151-63. 2005
    ..Modulation of VGF levels and/or VGF signaling may consequently represent an alternative means to regulate circulating glucose levels and insulin sensitivity...
  90. ncbi request reprint Consuming fructose-sweetened beverages increases body adiposity in mice
    Hella Jürgens
    Department of Pharmacology, German Institute of Human Nutrition, Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Obes Res 13:1146-56. 2005
    ....
  91. doi request reprint The adipokine SAA3 is induced by interleukin-1beta in mouse adipocytes
    Grit Sommer
    Department of Internal Medicine III, University of Leipzig, 04103 Leipzig, Germany
    J Cell Biochem 104:2241-7. 2008
    ..4-fold upregulation seen at 2 ng/ml effector. Moreover, IL-1beta-induced SAA3 expression was mediated by nuclear factor-kappaB and janus kinase 2. Taken together, our data show a potent upregulation of SAA3 by IL-1beta...
  92. pmc Plasma adiponectin complexes have distinct biochemical characteristics
    Todd Schraw
    Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8549, USA
    Endocrinology 149:2270-82. 2008
    ..The stability of adiponectin complexes highlights that the production and secretion of these forms from fat cells has a major influence on the circulating levels of each complex...
  93. ncbi request reprint Fat-cell mass, serum leptin and adiponectin changes during weight gain and loss in yellow-bellied marmots (Marmota flaviventris)
    Gregory L Florant
    Department of Biology, Colorado State University, Fort Collins, CO 80523, USA
    J Comp Physiol B 174:633-9. 2004
    ..Our data suggest that during autumn/winter animals have switched from a lipogenic condition to a lipolytic state, which may include leptin resistance...
  94. ncbi request reprint A CD36 nonsense mutation associated with insulin resistance and familial type 2 diabetes
    Frederic Lepretre
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Hum Mutat 24:104. 2004
    ..Furthermore, expression studies of the truncated protein showed a defective binding of acetylated-LDL. Thus, our findings suggest a possible role for CD36 in the pathogenesis of T2D associated with reduced insulin sensitivity...
  95. ncbi request reprint Disulfide-dependent multimeric assembly of resistin family hormones
    Saurabh D Patel
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Science 304:1154-8. 2004
    ..This result suggests that processing of the intertrimer disulfide bonds may reflect an obligatory step toward activation...
  96. ncbi request reprint Analysis of compensatory beta-cell response in mice with combined mutations of Insr and Irs2
    Jane J Kim
    Deparment of Pediatrics, University of California, San Diego, California, USA
    Am J Physiol Endocrinol Metab 292:E1694-701. 2007
    ..The eventual failure of compensatory insulin secretion suggests that a comprehensive treatment of beta-cell dysfunction in type 2 diabetes should positively affect both aspects of beta-cell physiology...
  97. ncbi request reprint Lipid metabolism and adipokine levels in fatty acid-binding protein null and transgenic mice
    Ann V Hertzel
    Dept of Biochemistry, Molecular Biology, and Biophysics, Univ of Minnesota, 321 Church St SE, Minneapolis, MN 55455, USA
    Am J Physiol Endocrinol Metab 290:E814-23. 2006
    ....
  98. ncbi request reprint Intracellular trafficking and secretion of adiponectin is dependent on GGA-coated vesicles
    Linglin Xie
    Division of Biology, Kansas State University, Manhattan, KS 66506, USA
    J Biol Chem 281:7253-9. 2006
    ..Interestingly, leptin secretion was unaffected by neither the wild type form or GGA1 mutant. Taken together these data demonstrate that the trafficking of adiponectin through its secretory pathway is dependent on GGA-coated vesicles...
  99. pmc The adipocyte as an endocrine cell
    Nils Halberg
    Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8549, USA
    Endocrinol Metab Clin North Am 37:753-68, x-xi. 2008
    ....