Research Topics
Genomes and Genes | E ScemesSummaryAffiliation: Albert Einstein College of Medicine Country: USA Publications
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Publications
Acute downregulation of Cx43 alters P2Y receptor expression levels in mouse spinal cord astrocytesSylvia O Suadicani
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA
Glia 42:160-71. 2003..On the basis of these results, we propose that Cx43 regulates both modes of ICW by altering P2Y receptor subtype expression in addition to providing intercellular coupling...- P2X7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2+ signalingSylvia O Suadicani
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Neurosci 26:1378-85. 2006.... 
Gap junction and purinergic P2 receptor proteins as a functional unit: insights from transcriptomicsDumitru A Iacobas
Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Membr Biol 217:83-91. 2007..It is proposed that coordination analysis of gene expression may provide a novel unbiased strategy for the identification of proteins belonging to supramolecular complexes...- Intercellular communication in spinal cord astrocytes: fine tuning between gap junctions and P2 nucleotide receptors in calcium wave propagationE Scemes
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Neurosci 20:1435-45. 2000..Intercellular communication via calcium waves therefore is sustained in Cx43 null mice by a finely tuned interaction between gap junction-dependent and independent mechanisms... - Modulation of astrocyte P2Y1 receptors by the carboxyl terminal domain of the gap junction protein Cx43Eliana Scemes
Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine Bronx, New York 10461, USA
Glia 56:145-53. 2008..Such modulation of P2Y1R is expected to influence several neural cell functions, especially under inflammation and neurodegenerative disorders where expression levels of Cx43 are decreased... - Astrocyte calcium waves: what they are and what they doEliana Scemes
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Glia 54:716-25. 2006.... - Connexin and pannexin mediated cell-cell communicationEliana Scemes
The Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, NY, 10461, USA
Neuron Glia Biol 3:199-208. 2007.... - Reduced expression of P2Y1 receptors in connexin43-null mice alters calcium signaling and migration of neural progenitor cellsEliana Scemes
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Neurosci 23:11444-52. 2003.... - Interleukin-1beta affects calcium signaling and in vitro cell migration of astrocyte progenitorsKatharine Striedinger
The Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Neuroimmunol 196:116-23. 2008..These results indicate that interleukin-1beta plays an important role during early stages of CNS development, modulating calcium signaling and cell migration... - Gap junction channels coordinate the propagation of intercellular Ca2+ signals generated by P2Y receptor activationS O Suadicani
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Glia 48:217-29. 2004..These data indicate that in 1321N1 cells gap junctional communication provides intercellular integration of Ca(2+) signals generated by P2YR activation, thus coordinating the propagation of intercellular calcium waves... - Human and mouse microglia express connexin36, and functional gap junctions are formed between rodent microglia and neuronsK Dobrenis
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Neurosci Res 82:306-15. 2005.... - Connexin43 null mice reveal that astrocytes express multiple connexinsR Dermietzel
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Brain Res Brain Res Rev 32:45-56. 2000.... - Exocytosis of ATP from astrocyte progenitors modulates spontaneous Ca2+ oscillations and cell migrationKatharine Striedinger
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York
Glia 55:652-62. 2007.... - P2X7 receptor-Pannexin1 complex: pharmacology and signalingR Iglesias
The Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA
Am J Physiol Cell Physiol 295:C752-60. 2008.... - The carboxyl-terminal domain of connexin43 is a negative modulator of neuronal differentiationMarcelo F Santiago
Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Biol Chem 285:11836-45. 2010..These results indicate that Cx43, and specifically its carboxyl terminus, is crucial for signaling mechanisms preventing premature neuronal differentiation during embryonic brain development... - Gene expression alterations in connexin null mice extend beyond the gap junctionDumitru A Iacobas
Department of Neuroscience, Albert Einstein College of Medicine, Kennedy Center, Room 915C, 1300 Morris Park Ave, Bronx, NY 10461, USA
Neurochem Int 45:243-50. 2004..Here we discuss those results in the context of the strategies and data analysis paradigms that we are using in such studies... - Pannexin 1: the molecular substrate of astrocyte "hemichannels"Rodolfo Iglesias
The Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Neurosci 29:7092-7. 2009..Moreover, quantification of the amount of ATP released from wild-type, Cx43-null, and Panx1-KD astrocytes indicates that downregulation of Panx1, but not of Cx43, prevented ATP release from these cells... - The TLR3 ligand polyI: C downregulates connexin 43 expression and function in astrocytes by a mechanism involving the NF-kappaB and PI3 kinase pathwaysYongmei Zhao
Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10464, USA
Glia 54:775-85. 2006..We conclude that activation of the innate immune response in astrocytes is associated with functional loss of GJIC through a pathway involving NF-kappaB and PI3 kinase... - The cytokine IL-1beta transiently enhances P2X7 receptor expression and function in human astrocytesLeontine Narcisse
Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Glia 49:245-58. 2005..These studies suggest that signaling via the P2X7R may modulate the astrocytic response to inflammation in the human central nervous system... - Array analysis of gene expression in connexin-43 null astrocytesDumitru A Iacobas
Department of Neuroscience, Albert Einstein College of Medicine, New York 10461, USA
Physiol Genomics 15:177-90. 2003..These data indicate a surprisingly high degree of impact of deletion of Cx43 on other astrocyte genes, implying that gap junction gene expression alters numerous processes in addition to intercellular communication... - A stochastic two-dimensional model of intercellular Ca2+ wave spread in gliaDumitru A Iacobas
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA
Biophys J 90:24-41. 2006..Such modeling is expected to be useful for testing phenomenological hypotheses and in understanding consequences of alteration of system components under experimental or pathological conditions... - Connexin43, the major gap junction protein of astrocytes, is down-regulated in inflamed white matter in an animal model of multiple sclerosisElimor Brand-Schieber
Department of Neurology, Albert Einstein College Medicine, Bronx, NY 10461, USA
J Neurosci Res 80:798-808. 2005..Our data support the notion that, in addition to damage of myelinating glia, altered astrocyte connectivity is a prominent feature of inflammatory demyelination... - Similar transcriptomic alterations in Cx43 knockdown and knockout astrocytesDumitru A Iacobas
Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cell Commun Adhes 15:195-206. 2008.... - The connexin43-dependent transcriptome during brain development: importance of genetic backgroundS Iacobas
Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1410, Pelham Parkway, Kennedy Center, Room 203, Bronx, NY 10461, USA
Brain Res 1487:131-9. 2012..This article is part of a Special Issue entitled Electrical Synapses... - Lack of "hemichannel" activity in insulin-producing cellsEliana Scemes
Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA
Cell Commun Adhes 15:143-54. 2008..Thus, insulin-producing cells are expected to provide a useful tool in the further characterization of hemichannel composition, properties, and physiological relevance... - Spatial and temporal control of cofilin activity is required for directional sensing during chemotaxisGhassan Mouneimne
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
Curr Biol 16:2193-205. 2006..We have tested this hypothesis by investigating whether activation of endogenous cofilin is spatially and temporally linked to sensing an EGF point source in carcinoma cells... - Mechanisms of glutamate release from astrocytes: gap junction "hemichannels", purinergic receptors and exocytotic releaseVladimir Parpura
Department of Cell Biology and Neuroscience, Center for Nanoscale Science and Engineering, University of California, Riverside, CA 92521, USA
Neurochem Int 45:259-64. 2004..In this review we limit our discussion to findings supporting the exocytotic release of glutamate, as well as two new pathways implicated in this release, the ionotropic (P2X) purinergic receptors and gap junction hemichannels... - Information processing and transmission in glia: calcium signaling and transmitter releaseJoachim W Deitmer
FB Biologie, TU, Kaiserslautern, Germany
Glia 54:639-41. 2006 - Modulation of intercellular communication in macrophages: possible interactions between GAP junctions and P2 receptorsFabio S A Fortes
Institute of Biophysics Carlos Chagas Filho, UFRJ, Cidade Universitaria, Ilha do Fundao, Rio de Janeiro, RJ 21941 590, Brazil
J Cell Sci 117:4717-26. 2004..Using confocal microscopy, it is shown here that, in ATP-s cells as well as in peritoneal macrophages, Cx43 and P2X(7) receptors are co-localized to the membrane of ATP-s cells and peritoneal macrophages... - Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complexSilviu Locovei
Department of Physiology and Biophysics, University of Miami School of Medicine, 1600 NW 10th Ave, Miami, FL 33136, USA
FEBS Lett 581:483-8. 2007..Thus, pannexin1 appears to be the molecular substrate for the permeabilization pore (or death receptor channel) recruited into the P2X(7)R signaling complex... - Electrophysiology of cardiac myocytes of Aplysia brasilianaMarta M Souza
Department of Physiology, Bioscience Institute, University of Sao Paulo, Sao Paulo, SP, Brazil
Comp Biochem Physiol A Mol Integr Physiol 133:161-8. 2002....
Research Grants
- Mechanisms of ATP Release from Glial ProgenitorsEliana Scemes; Fiscal Year: 2007..This identification is fundamental for the understanding of the signaling mechanisms ongoing during CNS development and repair. ..
- Glial Signaling:Interplay of Connexins and P2 ReceptorsEliana Scemes; Fiscal Year: 2006....
- Mechanisms of ATP Release from Glial ProgenitorsEliana Scemes; Fiscal Year: 2010..This identification is fundamental for the understanding of the signaling mechanisms ongoing during CNS development and repair. ..