Moshe Sadofsky

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc A WW-like module in the RAG1 N-terminal domain contributes to previously unidentified protein-protein interactions
    Radhashree Maitra
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, 10461, USA
    Nucleic Acids Res 37:3301-9. 2009
  2. ncbi request reprint Recombination-activating gene proteins: more regulation, please
    Moshe J Sadofsky
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Immunol Rev 200:83-9. 2004
  3. pmc The RAG1 N-terminal domain is an E3 ubiquitin ligase
    Vyacheslav Yurchenko
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Genes Dev 17:581-5. 2003
  4. ncbi request reprint Regulation of host cell cyclin D1 by Trypanosoma cruzi in myoblasts
    Boumediene Bouzahzah
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cell Cycle 7:500-3. 2008
  5. pmc SUMO modification of human XRCC4 regulates its localization and function in DNA double-strand break repair
    Vyacheslav Yurchenko
    Department of Pathology, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Mol Cell Biol 26:1786-94. 2006
  6. pmc Ku70 is stabilized by increased cellular SUMO
    Vyacheslav Yurchenko
    Department of Pathology, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Biochem Biophys Res Commun 366:263-8. 2008
  7. ncbi request reprint PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing
    Alexey V Ivanov
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Mol Cell 28:823-37. 2007
  8. pmc Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice
    Darryll D Dudley
    Howard Hughes Medical Institute, The Children s Hospital, The Center for Blood Research, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 198:1439-50. 2003

Research Grants

  1. Function of the RAG 1 Ring Finger
    Moshe Sadofsky; Fiscal Year: 2004
  2. DNA-BINDING AND COMPLEX FORMATION BY RAG PROTEINS
    Moshe Sadofsky; Fiscal Year: 2005

Collaborators

  • Richard G Pestell
  • Fnu Nagajyothi
  • David C Schultz
  • Vyacheslav Yurchenko
  • Zhu Xue
  • Radhashree Maitra
  • Boumediene Bouzahzah
  • Alexey V Ivanov
  • Darryll D Dudley
  • Michael P Lisanti
  • Chris Albanese
  • Shankar Mukherjee
  • Shigemi Matsuyama
  • James Hulit
  • Herbert B Tanowitz
  • Hannah Weiss
  • Vivian Gama
  • Vicki L Braunstein
  • Fabiana S Machado
  • Gerd G Maul
  • Elyse Psulkowski
  • Kyoko L Yap
  • Hongzhuang Peng
  • William J Fredericks
  • Ming Ming Zhou
  • Dmitri G Negorev
  • David E White
  • Frank J Rauscher
  • Jeffrey DeVido
  • Craig H Bassing
  • Chengming Zhu
  • Frederick W Alt
  • JoAnn Sekiguchi
  • Robert J Monroe
  • Scott Whitlow

Detail Information

Publications8

  1. pmc A WW-like module in the RAG1 N-terminal domain contributes to previously unidentified protein-protein interactions
    Radhashree Maitra
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, 10461, USA
    Nucleic Acids Res 37:3301-9. 2009
    ..Phylogenetic analysis shows the WW-like module to be highly conserved. The module contributes to protein-protein interactions that may also influence how RAG1 binds DNA targets...
  2. ncbi request reprint Recombination-activating gene proteins: more regulation, please
    Moshe J Sadofsky
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Immunol Rev 200:83-9. 2004
    ....
  3. pmc The RAG1 N-terminal domain is an E3 ubiquitin ligase
    Vyacheslav Yurchenko
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Genes Dev 17:581-5. 2003
    ..This finding suggests a new way in which V(D)J recombination can be regulated and coupled to other aspects of cell physiology...
  4. ncbi request reprint Regulation of host cell cyclin D1 by Trypanosoma cruzi in myoblasts
    Boumediene Bouzahzah
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cell Cycle 7:500-3. 2008
    ..Moreover, we demonstrated that the cyclin D1 protein was significantly stabilized after infection. Collectively, these data indicate that infection with T. cruzi increases cyclin D1 protein abundance post-translationally...
  5. pmc SUMO modification of human XRCC4 regulates its localization and function in DNA double-strand break repair
    Vyacheslav Yurchenko
    Department of Pathology, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Mol Cell Biol 26:1786-94. 2006
    ..The modification may serve a regulatory role. Our finding fits with an emerging literature associating SUMO modification with the control of the repair and recombination associated with DNA breaks...
  6. pmc Ku70 is stabilized by increased cellular SUMO
    Vyacheslav Yurchenko
    Department of Pathology, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Biochem Biophys Res Commun 366:263-8. 2008
    ..The same outcome was obtained by raising the expression of enzymes that promote SUMOylation. It is likely that many other proteins will be similarly regulated, providing a general control of cellular state...
  7. ncbi request reprint PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing
    Alexey V Ivanov
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Mol Cell 28:823-37. 2007
    ..These data provide a mechanistic explanation for the cooperation of PHD and bromodomains in gene regulation and describe a function of the PHD domain as an intramolecular E3 SUMO ligase...
  8. pmc Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice
    Darryll D Dudley
    Howard Hughes Medical Institute, The Children s Hospital, The Center for Blood Research, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 198:1439-50. 2003
    ..We discuss the potential implications of these findings for noncore RAG1 functions and for the ordered assembly of VH, DH, and JH segments...

Research Grants8

  1. Function of the RAG 1 Ring Finger
    Moshe Sadofsky; Fiscal Year: 2004
    ..If this can be achieved, I will test which of the family of E2 proteins best cooperate in the reaction, and pursue the identification of the natural targets in the cell. ..
  2. DNA-BINDING AND COMPLEX FORMATION BY RAG PROTEINS
    Moshe Sadofsky; Fiscal Year: 2005
    ..Understanding this mechanism will provide a valuable model for DNA recomb ination and additional highly ordered enzyme systems. ..