STEVEN RODERICK

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi The lac operon galactoside acetyltransferase
    Steven L Roderick
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    C R Biol 328:568-75. 2005
  2. ncbi Structure of human phosphatidylcholine transfer protein in complex with its ligand
    Steven L Roderick
    Department of Biochemistry, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nat Struct Biol 9:507-11. 2002
  3. ncbi A novel dimeric structure of the RimL Nalpha-acetyltransferase from Salmonella typhimurium
    Matthew W Vetting
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461 1602, USA
    J Biol Chem 280:22108-14. 2005
  4. ncbi Structure of the lac operon galactoside acetyltransferase
    Xing Guo Wang
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Structure 10:581-8. 2002
  5. ncbi Human phosphatidylcholine transfer protein: purification, crystallization and preliminary X-ray diffraction data
    Wayne W Chan
    Department of Medicine, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Biochim Biophys Acta 1596:1-5. 2002
  6. ncbi Structure and functions of the GNAT superfamily of acetyltransferases
    Matthew W Vetting
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Arch Biochem Biophys 433:212-26. 2005
  7. ncbi Structure of serine acetyltransferase in complexes with CoA and its cysteine feedback inhibitor
    Laurence R Olsen
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 43:6013-9. 2004
  8. ncbi Crystal structure of mycothiol synthase (Rv0819) from Mycobacterium tuberculosis shows structural homology to the GNAT family of N-acetyltransferases
    Matthew W Vetting
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Protein Sci 12:1954-9. 2003
  9. ncbi A bacterial acetyltransferase capable of regioselective N-acetylation of antibiotics and histones
    Matthew W Vetting
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461 USA
    Chem Biol 11:565-73. 2004
  10. ncbi Crystal structure of Vat(D): an acetyltransferase that inactivates streptogramin group A antibiotics
    Michele Sugantino
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 41:2209-16. 2002

Research Grants

  1. Structure and Function of Hexapeptide Acyltransferases
    STEVEN RODERICK; Fiscal Year: 2007
  2. STRUCTURE/FUNCTION OF HEXAPEPTIDE ACYLTRANSFERASE
    STEVEN RODERICK; Fiscal Year: 2002

Collaborators

  • Matthew W Vetting
  • D E Cohen
  • A Maxwell
  • Bin Huang
  • Corey M Johnson
  • Paul F Cook
  • Laurence R Olsen
  • Rong Guan
  • Keishi Kanno
  • John L Andreassi
  • Michele K Wu
  • Huei Ju Pan
  • Barbara Campanini
  • Subray S Hegde
  • John S Blanchard
  • Xing Guo Wang
  • Michele Sugantino
  • Todd W Beaman
  • Wayne W Chan
  • Thomas S Leyh
  • Patrick W Bilder
  • Erez F Scapa
  • Diana S Agate
  • Edward H Leiter
  • Benjamin L King
  • Huei-Ju Pan
  • Enea Salsi
  • Stefano Bettati
  • Howard E Takiff
  • Andrea Mozzarelli
  • Francesca Speroni
  • Lesley A Mitchenall
  • Dale G Drueckhammer
  • Xing-Guo Wang
  • Kurt W Vogel

Detail Information

Publications23

  1. ncbi The lac operon galactoside acetyltransferase
    Steven L Roderick
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    C R Biol 328:568-75. 2005
    ....
  2. ncbi Structure of human phosphatidylcholine transfer protein in complex with its ligand
    Steven L Roderick
    Department of Biochemistry, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nat Struct Biol 9:507-11. 2002
    ..The structures presented here provide a basis for rationalizing the specificity of PC-TP for PtdCho and may identify common features used by START proteins to bind their hydrophobic ligands...
  3. ncbi A novel dimeric structure of the RimL Nalpha-acetyltransferase from Salmonella typhimurium
    Matthew W Vetting
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461 1602, USA
    J Biol Chem 280:22108-14. 2005
    ....
  4. ncbi Structure of the lac operon galactoside acetyltransferase
    Xing Guo Wang
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Structure 10:581-8. 2002
    ..An extended loop projecting from the left-handed parallel beta helix domain contributes His115, which is in position to facilitate attack of the C6-hydroxyl group of the substrate on the thioester...
  5. ncbi Human phosphatidylcholine transfer protein: purification, crystallization and preliminary X-ray diffraction data
    Wayne W Chan
    Department of Medicine, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Biochim Biophys Acta 1596:1-5. 2002
    ..Both native and selenomethionyl PC-TP crystallized in two distinct space groups and diffracted X-rays to 2.4 A resolution...
  6. ncbi Structure and functions of the GNAT superfamily of acetyltransferases
    Matthew W Vetting
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Arch Biochem Biophys 433:212-26. 2005
    ....
  7. ncbi Structure of serine acetyltransferase in complexes with CoA and its cysteine feedback inhibitor
    Laurence R Olsen
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 43:6013-9. 2004
    ....
  8. ncbi Crystal structure of mycothiol synthase (Rv0819) from Mycobacterium tuberculosis shows structural homology to the GNAT family of N-acetyltransferases
    Matthew W Vetting
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Protein Sci 12:1954-9. 2003
    ..This is the first structure determined for an enzyme involved in the biosynthesis of mycothiol...
  9. ncbi A bacterial acetyltransferase capable of regioselective N-acetylation of antibiotics and histones
    Matthew W Vetting
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461 USA
    Chem Biol 11:565-73. 2004
    ....
  10. ncbi Crystal structure of Vat(D): an acetyltransferase that inactivates streptogramin group A antibiotics
    Michele Sugantino
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 41:2209-16. 2002
    ..These results reveal the molecular basis for a reaction by which Gram-positive cocci acquire resistance to a last resort antibiotic...
  11. ncbi Structure of the E. coli bifunctional GlmU acetyltransferase active site with substrates and products
    Laurence R Olsen
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Protein Sci 16:1230-5. 2007
    ..A superposition of these complex structures suggests that the 2-amino group of GlcN-1-PO(4) is positioned in proximity to the acetyl-CoA to facilitate direct attack on its thioester by a ternary complex mechanism...
  12. ncbi Acyl group specificity at the active site of tetrahydridipicolinate N-succinyltransferase
    Todd W Beaman
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Protein Sci 11:974-9. 2002
    ..These residues account at least in part for the substrate specificity that commits metabolic intermediates to either the succinylase or acetylase branches of the meso-diaminopimelate/lysine biosynthetic pathway...
  13. ncbi Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis in complex with coenzyme A and aminoglycoside substrates
    Matthew W Vetting
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nat Struct Biol 9:653-8. 2002
    ....
  14. ncbi The active site of O-acetylserine sulfhydrylase is the anchor point for bienzyme complex formation with serine acetyltransferase
    Bin Huang
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    J Bacteriol 187:3201-5. 2005
    ..These results explain the partial inhibition of OASS by SAT on complex formation as well as the competitive dissociation of the complex by O-acetylserine...
  15. ncbi A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA
    Subray S Hegde
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Science 308:1480-3. 2005
    ..This represents a form of DNA mimicry and explains both its inhibitory effect on DNA gyrase and fluoroquinolone resistance resulting from the protein's expression in vivo...
  16. ncbi Crystal structure of the Streptococcus pneumoniae mevalonate kinase in complex with diphosphomevalonate
    John L Andreassi
    DuPont Crop Protection, Stine Haskell Research Center, Newark, Delaware 19711, USA
    Protein Sci 16:983-9. 2007
    ..Features of the SpMK-binding pockets are discussed in the context of established mechanistic findings and inherited human diseases linked to MK deficiency...
  17. ncbi Structure and function of phosphatidylcholine transfer protein (PC-TP)/StarD2
    Keishi Kanno
    Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    Biochim Biophys Acta 1771:654-62. 2007
    ..Nevertheless, Pctp(-/-) mice exhibit interesting defects in lipid homeostasis, the understanding of which should elucidate the biological functions of PC-TP...
  18. ncbi The serine acetyltransferase reaction: acetyl transfer from an acylpantothenyl donor to an alcohol
    Corey M Johnson
    Department of Chemistry and Biochemistry, University of Oklahoma, 620 Parrington Oval, Norman, OK 73019, USA
    Arch Biochem Biophys 433:85-95. 2005
    ..The enzyme also associates with O-acetylserine sulfhydrylase, the final enzyme in the biosynthetic pathway, which contributes to stabilizing the acetyltransferase...
  19. ncbi Kinetic mechanism of the serine acetyltransferase from Haemophilus influenzae
    Corey M Johnson
    Department of Chemistry and Biochemistry, University of Oklahoma, 620 Parrington Oval, Norman, OK 73019, USA
    Arch Biochem Biophys 429:115-22. 2004
    ..As a dead-end inhibitor, L-cysteine is competitive against both substrates in both reaction directions. These results are discussed in terms of the mechanism of regulation...
  20. ncbi Roles of histidines 154 and 189 and aspartate 139 in the active site of serine acetyltransferase from Haemophilus influenzae
    Rong Guan
    Department of Chemistry and Biochemistry, University of Oklahoma, 620 Parrington Oval, Norman, Oklahoma 73019, USA
    Biochemistry 47:6322-8. 2008
    ..Aspartate 139, in dyad linkage with H154, likely facilitates catalysis by increasing the basicity of H154...
  21. ncbi Interaction of serine acetyltransferase with O-acetylserine sulfhydrylase active site: evidence from fluorescence spectroscopy
    Barbara Campanini
    Department of Biochemistry and Molecular Biology, Univeristy of Parma, 43100 Parma, Italy
    Protein Sci 14:2115-24. 2005
    ....
  22. ncbi A polymorphism in New Zealand inbred mouse strains that inactivates phosphatidylcholine transfer protein
    Huei Ju Pan
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    FEBS Lett 580:5953-8. 2006
    ..Consistent with the structure-based predictions, functional studies demonstrated that Arg120His PC-TP was inactive, suggesting that this mutation contributes to the deficiencies in phosphatidylcholine metabolism observed in NZO mice...
  23. ncbi Chemical mechanism of the serine acetyltransferase from Haemophilus influenzae
    Corey M Johnson
    Department of Chemistry and Biochemistry, University of Oklahoma, 620 Parrington Oval, Norman, Oklahoma 73072, USA
    Biochemistry 43:15534-9. 2004
    ..The rate-limiting step in the reaction at limiting l-serine levels is likely formation of the tetrahedral intermediate between serine and acetyl-CoA...

Research Grants10

  1. Structure and Function of Hexapeptide Acyltransferases
    STEVEN RODERICK; Fiscal Year: 2007
    ..abstract_text> ..
  2. STRUCTURE/FUNCTION OF HEXAPEPTIDE ACYLTRANSFERASE
    STEVEN RODERICK; Fiscal Year: 2002
    ..This information will be used to characterize the function of this newly recognized superfamily of enzymes and to provide a structural and mechanistic framework for the design of antibiotics directed against bacterial pathogens. ..