J W Pollard

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi request reprint A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors
    Jeffrey Wyckoff
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 64:7022-9. 2004
  2. ncbi request reprint Macrophages: obligate partners for tumor cell migration, invasion, and metastasis
    John Condeelis
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cell 124:263-6. 2006
  3. pmc Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy
    E Y Lin
    Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    J Exp Med 193:727-40. 2001
  4. pmc A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth
    Binzhi Qian
    Department of Developmental and Molecular Biology and the Department of Obstetrics Gynecology and Woman s Health, Center for the Study of Reproductive Biology and Woman s Health, Albert Einstein College of Medicine, Bronx, NY, USA
    PLoS ONE 4:e6562. 2009
  5. pmc Role of infiltrated leucocytes in tumour growth and spread
    E Y Lin
    Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Br J Cancer 90:2053-8. 2004
  6. pmc CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
    Bin Zhi Qian
    Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, New York, New York 10461, USA
    Nature 475:222-5. 2011
  7. pmc Requirement of macrophages and eosinophils and their cytokines/chemokines for mammary gland development
    Valerie Gouon-Evans
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 13000 Morris Park Avenue, Bronx, NY 10461, USA
    Breast Cancer Res 4:155-64. 2002
  8. ncbi request reprint Effect of the colony-stimulating factor-1 null mutation, osteopetrotic (csfm(op)), on the distribution of macrophages in the male mouse reproductive tract
    J W Pollard
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Biol Reprod 56:1290-300. 1997
  9. pmc Trophic macrophages in development and disease
    Jeffrey W Pollard
    Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Chanin 607, Bronx, New York 10461, USA
    Nat Rev Immunol 9:259-70. 2009
  10. pmc Tumour-stromal interactions. Transforming growth factor-beta isoforms and hepatocyte growth factor/scatter factor in mammary gland ductal morphogenesis
    J W Pollard
    Departments of Developmental and Molecular Biology, and OB GYN and Women s Health, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, New York, New York, USA
    Breast Cancer Res 3:230-7. 2001

Research Grants

  1. Hormonal Regulation of Roles of CSF-1 in Reproduction
    Jeffrey Pollard; Fiscal Year: 2003
  2. EINSTEIN TRANSGENIC AND GENE TARGETING COURSE
    Jeffrey Pollard; Fiscal Year: 2004
  3. PROGESTERONE, CELL CYCLE AND CANCER
    Jeffrey Pollard; Fiscal Year: 2002
  4. HORMONAL REGULATION AND ROLES OF CSF-1 IN REPRODUCTION
    Jeffrey Pollard; Fiscal Year: 2001
  5. PROGESTERONE, CELL CYCLE AND CANCER
    Jeffrey Pollard; Fiscal Year: 2005
  6. Hormonal Regulation of Roles of CSF-1 in Reproduction
    Jeffrey Pollard; Fiscal Year: 2005
  7. CSF-1 Macrophages & Mammary Gland Development and Cancer
    Jeffrey Pollard; Fiscal Year: 2005
  8. Hormonal Regulation of Roles of CSF-1 in Reproduction
    Jeffrey Pollard; Fiscal Year: 2006
  9. PROGESTERONE, CELL CYCLE AND CANCER
    Jeffrey Pollard; Fiscal Year: 2004
  10. CSF-1, MACROPHAGES AND MALE REPRODUCTIVE FUNCTION
    Jeffrey Pollard; Fiscal Year: 2001

Collaborators

Detail Information

Publications90

  1. ncbi request reprint A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors
    Jeffrey Wyckoff
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 64:7022-9. 2004
    ..This work provides the first direct evidence for a synergistic interaction between macrophages and tumor cells during cell migration in vivo and indicates a mechanism for how macrophages may contribute to metastasis...
  2. ncbi request reprint Macrophages: obligate partners for tumor cell migration, invasion, and metastasis
    John Condeelis
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cell 124:263-6. 2006
    ..Thus, macrophages are at the center of the invasion microenvironment and are an important drug target for cancer therapy...
  3. pmc Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy
    E Y Lin
    Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    J Exp Med 193:727-40. 2001
    ..Our data suggest that agents directed at CSF-1/CSF-1R activity could have important therapeutic effects...
  4. pmc A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth
    Binzhi Qian
    Department of Developmental and Molecular Biology and the Department of Obstetrics Gynecology and Woman s Health, Center for the Study of Reproductive Biology and Woman s Health, Albert Einstein College of Medicine, Bronx, NY, USA
    PLoS ONE 4:e6562. 2009
    ..However, at the metastatic site the role of these cells and their mechanism of actions for establishment and growth of metastases remain largely unknown...
  5. pmc Role of infiltrated leucocytes in tumour growth and spread
    E Y Lin
    Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Br J Cancer 90:2053-8. 2004
    ..Through the production of an array of growth factors, proteases and angiogenic mediators, leucocytes in the tumour microenvironment promote tumour growth, angiogenesis and metastasis...
  6. pmc CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
    Bin Zhi Qian
    Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, New York, New York 10461, USA
    Nature 475:222-5. 2011
    ..Our data provide the mechanistic link between these two clinical associations and indicate new therapeutic targets for treating metastatic breast cancer...
  7. pmc Requirement of macrophages and eosinophils and their cytokines/chemokines for mammary gland development
    Valerie Gouon-Evans
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 13000 Morris Park Avenue, Bronx, NY 10461, USA
    Breast Cancer Res 4:155-64. 2002
    ..These data emphasize the dual role of macrophages in the promotion of epithelial growth in normal and cancer states...
  8. ncbi request reprint Effect of the colony-stimulating factor-1 null mutation, osteopetrotic (csfm(op)), on the distribution of macrophages in the male mouse reproductive tract
    J W Pollard
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Biol Reprod 56:1290-300. 1997
    ..The absence of macrophages in the testis and epididymis of csfm(op)/csfm(op) mice correlates with dysfunction in these tissues, suggesting that macrophages play important nonimmunological roles in these tissues...
  9. pmc Trophic macrophages in development and disease
    Jeffrey W Pollard
    Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Chanin 607, Bronx, New York 10461, USA
    Nat Rev Immunol 9:259-70. 2009
    ..For example, macrophages enhance tumour progression and metastasis by affecting tumour-cell migration and invasion, as well as angiogenesis...
  10. pmc Tumour-stromal interactions. Transforming growth factor-beta isoforms and hepatocyte growth factor/scatter factor in mammary gland ductal morphogenesis
    J W Pollard
    Departments of Developmental and Molecular Biology, and OB GYN and Women s Health, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, New York, New York, USA
    Breast Cancer Res 3:230-7. 2001
    ..In addition, TGF-beta3 triggers apoptosis in the alveolar epithelia, which is a necessary component of mammary gland involution and return of the ductal structure to a virgin-like state after lactation...
  11. pmc Uterine DCs are essential for pregnancy
    Jeffrey W Pollard
    Department of Developmental and Molecular Biology, Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 118:3832-5. 2008
    ....
  12. pmc Macrophages define the invasive microenvironment in breast cancer
    Jeffrey W Pollard
    Dept Developmental and Molecular Biology, Center of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    J Leukoc Biol 84:623-30. 2008
    ..All of these activities suggest that macrophage functions are significant targets for the generation of novel therapeutics that should improve the current cytotoxic armamentarium...
  13. ncbi request reprint Tumour-educated macrophages promote tumour progression and metastasis
    Jeffrey W Pollard
    Center for the Study of Reproductive Biology and Women s Health and the Albert Einstein Cancer Center, Albert Einstein College of Medicine, New York, New York 10461, USA
    Nat Rev Cancer 4:71-8. 2004
  14. ncbi request reprint Complexity in uterine macrophage responses to cytokines in mice
    J W Pollard
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, New York 10461, USA
    Biol Reprod 58:1469-75. 1998
    ..Such molecules, together with CSF-1, may play a role in modulating the complexities of uterine macrophage dynamics in response to sex steroid hormones and mating...
  15. ncbi request reprint Absence of colony stimulating factor-1 in osteopetrotic (csfmop/csfmop) mice disrupts estrous cycles and ovulation
    P E Cohen
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Biol Reprod 56:110-8. 1997
    ..Thus, the major effect of CSF-1 on female reproductive function is on the frequency and rate of ovulation, indicating a major role for this growth factor in regulating follicular development and ovulation...
  16. pmc Progesterone inhibits estrogen-induced cyclin D1 and cdk4 nuclear translocation, cyclin E- and cyclin A-cdk2 kinase activation, and cell proliferation in uterine epithelial cells in mice
    W Tong
    Departments of Developmental and Molecular Biology and Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Cell Biol 19:2251-64. 1999
    ..This study showing a novel mechanism of cell cycle inhibition by P4 may provide the basis for the development of new antiestrogens...
  17. pmc Aberrant macrophage and neutrophil population dynamics and impaired Th1 response to Listeria monocytogenes in colony-stimulating factor 1-deficient mice
    I Guleria
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, New York 10461, USA
    Infect Immun 69:1795-807. 2001
    ..These data indicate that IL-6 occupies a central role in the CSF-1-regulated macrophage response to L. monocytogenes...
  18. ncbi request reprint Mammalian MutS homologue 5 is required for chromosome pairing in meiosis
    W Edelmann
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nat Genet 21:123-7. 1999
    ..We found that this meiotic failure leads to a diminution in testicular size and a complete loss of ovarian structures. Our results show that normal Msh5 function is essential for meiotic progression and, in females, gonadal maintenance...
  19. ncbi request reprint Colony-stimulating factor-1 plays a major role in the development of reproductive function in male mice
    P E Cohen
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Endocrinol 11:1636-50. 1997
    ..However, these males are responsive to GnRH and LH treatment. These studies have identified a novel role for CSF-1 in the development and/or regulation of the male hypothalamic-pituitary-gonadal axis...
  20. ncbi request reprint Postnatal mammary gland development requires macrophages and eosinophils
    V Gouon-Evans
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Development 127:2269-82. 2000
    ..Our data show that CSF1-regulated macrophages, in collaboration with eotaxin-regulated eosinophils, have essential and complementary functions in regulating the branching morphogenesis of the mammary gland...
  21. ncbi request reprint A pregnancy defect in the osteopetrotic (op/op) mouse demonstrates the requirement for CSF-1 in female fertility
    J W Pollard
    Department of Developmental Biology and Cancer, Albert Einstein College of Medicine AECOM, Bronx, New York 10461
    Dev Biol 148:273-83. 1991
    ..Further studies in the osteopetrotic mouse will be useful in delineating those functions required for pregnancy that are regulated by CSF-1...
  22. ncbi request reprint Role of colony-stimulating factor-1 in reproduction and development
    J W Pollard
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, New York 10461, USA
    Mol Reprod Dev 46:54-60; discussion 60-1. 1997
    ..The pleiotropic roles for CSF-1 in reproduction and in the brain suggest that CSF-1 exerts many of its action through the trophic activities of cells of the mononuclear phagocytic lineage...
  23. ncbi request reprint Rescue of the colony-stimulating factor 1 (CSF-1)-nullizygous mouse (Csf1(op)/Csf1(op)) phenotype with a CSF-1 transgene and identification of sites of local CSF-1 synthesis
    G R Ryan
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA
    Blood 98:74-84. 2001
    ....
  24. ncbi request reprint Absence of colony-stimulating factor-1 in osteopetrotic (csfmop/csfmop) mice results in male fertility defects
    P E Cohen
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Biol Reprod 55:310-7. 1996
    ....
  25. ncbi request reprint Mutation in the mismatch repair gene Msh6 causes cancer susceptibility
    W Edelmann
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cell 91:467-77. 1997
    ....
  26. ncbi request reprint Expression of colony-stimulating factor-1 (CSF-1) messenger RNA in human endometrial glands during the menstrual cycle: molecular cloning of a novel transcript that predicts a cell surface form of CSF-1
    S Pampfer
    Department of Developmental Biology and Cancer, Albert Einstein College of Medicine, New York, New York 10461
    Mol Endocrinol 5:1931-8. 1991
    ..These data raise the possibility that CSF-1 may be involved in both distant and cell to cell regulatory pathways of cell proliferation and differentiation in the human endometrium...
  27. pmc Temporal expression and location of colony-stimulating factor 1 (CSF-1) and its receptor in the female reproductive tract are consistent with CSF-1-regulated placental development
    R J Arceci
    Department of Developmental Biology and Cancer, Albert Einstein College of Medicine, Bronx, NY 10461
    Proc Natl Acad Sci U S A 86:8818-22. 1989
    ....
  28. ncbi request reprint Progesterone inhibits the estrogen-induced phosphoinositide 3-kinase-->AKT-->GSK-3beta-->cyclin D1-->pRB pathway to block uterine epithelial cell proliferation
    Bo Chen
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, New York, New York 10461, USA
    Mol Endocrinol 19:1978-90. 2005
    ..These data reveal a novel signaling pathway that links E2 and P4 action to growth factor-mediated signaling in the uterus...
  29. ncbi request reprint Eotaxin is required for eosinophil homing into the stroma of the pubertal and cycling uterus
    V Gouon-Evans
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, New York 10461, USA
    Endocrinology 142:4515-21. 2001
    ....
  30. pmc Colony stimulating factor 1 is required for mammary gland development during pregnancy
    J W Pollard
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461
    Proc Natl Acad Sci U S A 91:9312-6. 1994
    ..These data show that CSF-1 has a role in the development of the mammary gland during pregnancy...
  31. ncbi request reprint The trophoblast is a component of the innate immune system during pregnancy
    I Guleria
    Departments of Developmental and Molecular Biology and Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, New York, New York 10461, USA
    Nat Med 6:589-93. 2000
    ..This previously unknown function indicates that the trophoblast acts as a pregnancy-specific component of the innate immune system...
  32. ncbi request reprint Macrophages regulate the angiogenic switch in a mouse model of breast cancer
    Elaine Y Lin
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 66:11238-46. 2006
    ..Taken together, this study shows that tumor-associated macrophages play a key role in promoting tumor angiogenesis, an essential step in the tumor progression to malignancy...
  33. ncbi request reprint Normal sexual function in male mice lacking a functional type I interleukin-1 (IL-1) receptor
    P E Cohen
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Endocrinology 139:815-8. 1998
    ....
  34. pmc Positron emission tomography agent 2-deoxy-2-[18F]fluoro-D-glucose has a therapeutic potential in breast cancer
    Renee M Moadel
    Department of Nuclear Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, USA
    Breast Cancer Res 5:R199-205. 2003
    ..2-Deoxy-2-[18F]fluoro-D-glucose (18F-FDG) was evaluated as a potential radiomolecular therapy agent in breast cancer animal models and, retrospectively, in patients with metastatic breast cancer...
  35. pmc Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophages
    Elaine Y Lin
    Department of Developmental and Molecular Biology, Center of Reproductive Biology and Women s Health, Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Oncol 1:288-302. 2007
    ..This study suggests that macrophage-produced VEGF regulates malignant progression through stimulating tumor angiogenesis, leukocytic infiltration and tumor cell invasion...
  36. ncbi request reprint CSF-1 deficiency in mice results in abnormal brain development
    M D Michaelson
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Development 122:2661-72. 1996
    ..The effects of CSF-1 on cultured embryonic neural cells, the developmentally appropriate expression of CSF-1 and its receptor, and the neurological abnormalities in op/op mice suggest a role for CSF-1 in brain development...
  37. ncbi request reprint Meiotic pachytene arrest in MLH1-deficient mice
    W Edelmann
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York, USA
    Cell 85:1125-34. 1996
    ..The phenotypes of the mlh1 mutant mice are distinct from those deficient in msh2 and pms2. The different phenotypes of the three types of mutant mice suggest that these three genes may have independent functions in mammalian meiosis...
  38. ncbi request reprint Macrophages: modulators of breast cancer progression
    Elaine Y Lin
    Center for the Study of Reproductive Biology and Women s Health, Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park, New York, NY 10461, USA
    Novartis Found Symp 256:158-68; discussion 168-72, 259-69. 2004
    ..Macrophages might therefore be important targets for cancer therapies...
  39. pmc Progesterone blocks estrogen-induced DNA synthesis through the inhibition of replication licensing
    Haiyan Pan
    Department of Development and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 103:14021-6. 2006
    ..This reduced MCM binding resulted in the complete inhibition of E2-induced DNA synthesis by P4. These data reveal mechanisms not only for female sex steroid hormone action but also in the regulation of DNA replication licensing...
  40. pmc Estradiol-17beta regulates mouse uterine epithelial cell proliferation through insulin-like growth factor 1 signaling
    Liyin Zhu
    Department of Developmental and Molecular Biology, Center of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 104:15847-51. 2007
    ..Exposure to E(2) is the major risk factor for endometrial cancer, suggesting that downstream activation of this IGF1-mediated pathway by mutation could be causal in the progression to ER-independent tumors...
  41. pmc The EGF/CSF-1 paracrine invasion loop can be triggered by heregulin beta1 and CXCL12
    Lorena Hernandez
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10801, USA
    Cancer Res 69:3221-7. 2009
    ..Our results identify a stromal/tumor interaction that acts as an engine underlying invasion induced by multiple ligands...
  42. ncbi request reprint Colony stimulating factor-1 is required to recruit macrophages into the mammary gland to facilitate mammary ductal outgrowth
    Andrew Van Nguyen
    Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, 1300 Morris Park, New York, New York, 10461, USA
    Dev Biol 247:11-25. 2002
    ..These data show that macrophages acting locally are required for branching morphogenesis of the mammary gland...
  43. pmc Gene expression analysis of macrophages that facilitate tumor invasion supports a role for Wnt-signaling in mediating their activity in primary mammary tumors
    Laureen S Ojalvo
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 184:702-12. 2010
    ..Taken together, we conjecture that invasive TAMs link angiogenesis and tumor invasion and that Wnt-signaling plays a role in mediating their activity...
  44. ncbi request reprint Colony stimulating factor-1 in human follicular fluid
    B R Witt
    Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Fertil Steril 68:259-64. 1997
    ..To evaluate colony stimulating factor-1 (CSF-1) concentrations in serum and follicular fluid (FF) at the time of oocyte retrieval and to test for presence of messenger RNA (mRNA) for CSF-1 and its receptor, c-fms, in FF cells...
  45. pmc Genetic evidence for the interactions of cyclin D1 and p27(Kip1) in mice
    W Tong
    Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, New York, New York 10461, USA
    Mol Cell Biol 21:1319-28. 2001
    ..It also supports the suggestion that the cyclin E/Cdk2 pathway can largely bypass Rb in regulating the cell cycle in vivo...
  46. ncbi request reprint Treatment with rhenium-188-perrhenate and iodine-131 of NIS-expressing mammary cancer in a mouse model remarkably inhibited tumor growth
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Nucl Med Biol 32:695-700. 2005
    ..We report the results of a therapy study with (131)I(-) and (188)ReO(4)(-) of breast cancer in polyoma middle T oncoprotein (PyMT) transgenic mice endogenously expressing the Na(+)/I(-) symporter (NIS)...
  47. ncbi request reprint Microarray analysis of uterine epithelial gene expression during the implantation window in the mouse
    Haiyan Pan
    Department of Developmental and Molecular Biology and Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Endocrinology 147:4904-16. 2006
    ..The identification of these genes showing a cell type hormonally regulated pattern of expression in the uterus suggests novel functions for them during implantation...
  48. pmc Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors
    Evanthia T Roussos
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Breast Cancer Res 12:R101. 2010
    ..Whether Mena is required for tumor progression is still unknown. Here we report the effects of Mena deficiency on tumor progression, metastasis and on normal mammary gland development...
  49. ncbi request reprint Macrophage diversity enhances tumor progression and metastasis
    Bin Zhi Qian
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cell 141:39-51. 2010
    ..Specialized subpopulations of macrophages may represent important new therapeutic targets...
  50. ncbi request reprint Macrophages promote collagen fibrillogenesis around terminal end buds of the developing mammary gland
    Wendy V Ingman
    Department of Molecular and Developmental Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Dev Dyn 235:3222-9. 2006
    ..Macrophage deficiency also caused terminal end buds to be rounder and shorter. These studies reveal a role for macrophages in collagen fibrillogenesis and in organization of the structure of terminal end buds...
  51. pmc Lithium chloride treatment induces epithelial cell proliferation in xenografted human endometrium
    Alex J Polotsky
    Department of Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, Bronx, NY, USA
    Hum Reprod 24:1960-7. 2009
    ..We developed a functional model of xenografted human endometrium to test whether similar mechanisms are operative in the human by using Lithium chloride (LiCl), an inhibitor of GSK3beta...
  52. ncbi request reprint Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors
    Jeffrey B Wyckoff
    Gruss Lipper Center for Biophotonics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 67:2649-56. 2007
    ..These results show that the interaction between macrophages and tumor cells lying in close proximity defines a microenvironment that is directly involved in the intravasation of cancer cells in mammary tumors...
  53. ncbi request reprint Tumor-associated macrophages press the angiogenic switch in breast cancer
    Elaine Y Lin
    Department of Developmental and Molecular Biology, Center of Reproductive Biology and Women s Health, Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 67:5064-6. 2007
    ..These findings establish a causal linkage to explain well-documented clinical correlations between macrophages, microvessel density, and poor prognosis in breast tumors...
  54. pmc Insulin-like growth factor 2 receptor is an IFNgamma-inducible microglial protein that facilitates intracellular HIV replication: implications for HIV-induced neurocognitive disorders
    Hyeon Sook Suh
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Am J Pathol 177:2446-58. 2010
    ..Mice with the Csf1r- driven Igf2r knockout should be useful for the investigation of macrophage-specific IGF2R function...
  55. pmc Colony-stimulating factor-1-dependent macrophage functions regulate the maternal decidua immune responses against Listeria monocytogenes infections during early gestation in mice
    Xuan Qiu
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Infect Immun 77:85-97. 2009
    ..monocytogenes infection. These data suggest that the anti-Listeria responses in the maternal decidual tissue are dependent on CSF-1-regulated macrophages...
  56. ncbi request reprint Cyclin D2 compensates for the loss of cyclin D1 in estrogen-induced mouse uterine epithelial cell proliferation
    Bo Chen
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, New York 10461, USA
    Mol Endocrinol 17:1368-81. 2003
    ..Our data show that in vivo cyclin D2 can completely compensate for the loss of cyclin D1 and reinforces the conclusions that cyclin Ds are the central regulatory point in the proliferative responses of epithelial cells to estrogens...
  57. ncbi request reprint Progesterone regulation of the mammalian ortholog of methylcitrate dehydratase (immune response gene 1) in the uterine epithelium during implantation through the protein kinase C pathway
    Bo Chen
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, New York 10461, USA
    Mol Endocrinol 17:2340-54. 2003
    ....
  58. ncbi request reprint The molecular basis of tamoxifen induction of mouse uterine epithelial cell proliferation
    Haifan Zhang
    Center for the Study for Reproductive Biology and Women s Health, Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    J Endocrinol 184:129-40. 2005
    ....
  59. pmc Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases
    Elaine Y Lin
    Center for Study of Reproductive Biology and Women s Health, Departments of Developmental and Molecular Biology Obstetrics and Gynecology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Am J Pathol 163:2113-26. 2003
    ..An increased leukocytic infiltration was also closely associated with the malignant transition. This study demonstrates that the PyMT mouse model is an excellent one to understand the biology of tumor progression in humans...
  60. ncbi request reprint Genetic analysis of chromosome pairing, recombination, and cell cycle control during first meiotic prophase in mammals
    P E Cohen
    Department of Molecular Genetics, Center for the Study of Reproduction and Women s Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Endocr Rev 27:398-426. 2006
    ..This review provides a comprehensive analysis of the use of genetic manipulation, particularly in mice, but also of the analysis of mutations in humans, to elucidate the mechanisms that are required for traverse through prophase I...
  61. ncbi request reprint Regulation of meiotic recombination and prophase I progression in mammals
    P E Cohen
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Bioessays 23:996-1009. 2001
    ....
  62. ncbi request reprint Intranuclear endoplasmic reticulum induced by Nopp140 mimics the nucleolar channel system of human endometrium
    C Isaac
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Cell Sci 114:4253-64. 2001
    ..Therefore, the nucleolar channel system appears to be identical to the R-rings, suggesting a role for Nopp140 in human reproduction...
  63. ncbi request reprint Characterization and expression of uterine and placental alkaline phosphatases in the mouse
    J W Pollard
    Department of Developmental Biology and Cancer, Albert Einstein College of Medicine, Bronx, NY 10461
    J Reprod Fertil 89:735-42. 1990
    ..abstract truncated at 250 words)..
  64. ncbi request reprint GFP expression in the mammary gland for imaging of mammary tumor cells in transgenic mice
    Fayyaz Ahmed
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 62:7166-9. 2002
    ..These animals provide a range of expression of GFP that is suitable for analysis of transgenic mammary tumors and metastases in vivo at the single cell level of resolution...
  65. pmc High-density gene expression analysis of tumor-associated macrophages from mouse mammary tumors
    Laureen S Ojalvo
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Am J Pathol 174:1048-64. 2009
    ....
  66. pmc Microenvironmental regulation of metastasis
    Johanna A Joyce
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, USA
    Nat Rev Cancer 9:239-52. 2009
    ..This Review describes experimental data demonstrating the role of the microenvironment in metastasis, identifies areas for future research and suggests possible new therapeutic avenues...
  67. pmc Proangiogenic contribution of adiponectin toward mammary tumor growth in vivo
    Shira Landskroner-Eiger
    Department of Cell Biology, Center of Reproductive Biology and Womens Health, Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Clin Cancer Res 15:3265-76. 2009
    ..To explore the association of APN with breast cancer and tumor angiogenesis, we took an in vivo approach aiming to study its role in the mouse mammary tumor virus (MMTV)-polyoma middle T antigen (PyMT) mammary tumor model...
  68. pmc A novel mouse model of inflammatory bowel disease links mammalian target of rapamycin-dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesis
    Lin Deng
    Department of Medicine, Oncology Division, Albert Einstein Cancer Center, Bronx, NY 10467, USA
    Am J Pathol 176:952-67. 2010
    ....
  69. ncbi request reprint Colony-stimulating factor-1-dependent macrophages are responsible for IVIG protection in antibody-induced autoimmune disease
    Pierre Bruhns
    Laboratory of Molecular Genetics and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Immunity 18:573-81. 2003
    ....
  70. ncbi request reprint Mining the mouse transcriptome of receptive endometrium reveals distinct molecular signatures for the luminal and glandular epithelium
    Andrea L Niklaus
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Endocrinology 147:3375-90. 2006
    ..The data show that each epithelial compartment has a distinct molecular signature and that they act differentially and synergistically to permit blastocyst implantation...
  71. ncbi request reprint Assessment of the proliferative status of epithelial cell types in the endometrium of young and menopausal transition women
    Andrea L Niklaus
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Hum Reprod 22:1778-88. 2007
    ....
  72. ncbi request reprint Differential mRNA expression of the phosphoprotein p19/SCG10 gene family in mouse preimplantation embryos, uterus, and placenta
    S Pampfer
    Department of Developmental Biology and Cancer, Albert Einstein College of Medicine, New York 10461
    Reprod Fertil Dev 4:205-11. 1992
    ..The expression of both genes in preimplantation embryos suggests distinct but possibly overlapping roles for p19 and SCG10 in early mammalian development...
  73. pmc Caeruloplasmin biosynthesis by the human uterus
    M L Schilsky
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY
    Biochem J 288:657-61. 1992
    ....
  74. ncbi request reprint Colony-stimulating factor 1 regulation of neuroendocrine pathways that control gonadal function in mice
    Paula E Cohen
    Center for the Study of Reproductive Biology and Women s Health, Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Endocrinology 143:1413-22. 2002
    ..These data suggest a role for CSF-1 and its target cells, microglia, in establishing the feedback sensitivity to circulating steroid hormones in the hypothalamus of mice...
  75. pmc Fcgamma receptor cross-linking stimulates cell proliferation of macrophages via the ERK pathway
    Yong Luo
    Departments of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 285:4232-42. 2010
    ..In addition, our results suggest the possibility of new treatment options for certain infectious diseases, chronic inflammatory diseases, and leukemias based on interference with FcgammaR-stimulated macrophage cell proliferation...
  76. ncbi request reprint The macrophage growth factor CSF-1 in mammary gland development and tumor progression
    Elaine Y Lin
    Center for Study of Reproductive Biology and Women s Health, Departments of Developmental and Molecular Biology and Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Mammary Gland Biol Neoplasia 7:147-62. 2002
    ....
  77. ncbi request reprint Conditional deletion of the colony stimulating factor-1 receptor (c-fms proto-oncogene) in mice
    Jia Li
    Department of Development and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Genesis 44:328-35. 2006
    ..This conditional allele will prove extremely valuable to study the spatial and temporal roles of CSF-1R...
  78. ncbi request reprint Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization
    Puneeth Iyengar
    Department of Cell Biology, Albert Einstein Cancer Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Oncogene 22:6408-23. 2003
    ..It promotes GSK3beta phosphorylation, beta-catenin stabilization, and increased beta-catenin activity in breast cancer cells and may critically contribute towards tumorigenesis when not counterbalanced by other factors...
  79. ncbi request reprint The uterine NK cell population requires IL-15 but these cells are not required for pregnancy nor the resolution of a Listeria monocytogenes infection
    Ellen M Barber
    Center for the Study of Reproductive Biology and Women s Health, Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 171:37-46. 2003
    ..These results show that uNK cells are not required for successful pregnancy and that NK cells are not essential for an adequate immune response to L. monocytogenes in either pregnant or nonpregnant mice...
  80. ncbi request reprint Unexpected deposition of brown fat in mammary gland during postnatal development
    Valerie Gouon-Evans
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, New York 10461, USA
    Mol Endocrinol 16:2618-27. 2002
    ..Our data suggest that BAT negatively regulates the differentiation of mammary epithelial cells in a systemic manner during prepubertal ductal outgrowth...
  81. pmc Genomic profiling of microRNAs and messenger RNAs reveals hormonal regulation in microRNA expression in human endometrium
    Satu Kuokkanen
    Department of Obstetrics and Gynecology and Women s Health, Cooperative Center for the Study of Reproduction and Infertility Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Biol Reprod 82:791-801. 2010
    ..Thus, our findings suggest a role for miRNAs in down-regulating the expression of some cell cycle genes in the secretory-phase endometrial epithelium, thereby suppressing cell proliferation...
  82. pmc Selective depletion of eosinophils or neutrophils in mice impacts the efficiency of apoptotic cell clearance in the thymus
    Hye Jung Kim
    Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 5:e11439. 2010
    ..These results suggested that there is crosstalk between cells of the innate immune system that is necessary for maximizing the efficiency of apoptotic cell removal...
  83. pmc Morphogenesis of the developing mammary gland: stage-dependent impact of adipocytes
    Shira Landskroner-Eiger
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Dev Biol 344:968-78. 2010
    ....
  84. ncbi request reprint Indoleamine 2,3-dioxygenase is regulated by IFN-gamma in the mouse placenta during Listeria monocytogenes infection
    Ari M Mackler
    Center for the Study of Reproductive Biology and Women s Health, Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 170:823-30. 2003
    ..These data suggest that IDO plays a role in resolving bacterial infection in the placenta while at the same time maintaining a barrier to T cells whose presence might result in fetal rejection...
  85. pmc Th1 cytokines are essential for placental immunity to Listeria monocytogenes
    Ellen M Barber
    Department of Developmental and Molecular Biology and Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Infect Immun 73:6322-31. 2005
    ..These data show a requirement for Th1 cytokines during pregnancy for effective immunity and indicate that a bias away from Th1 cytokine synthesis is not a necessary prerequisite of pregnancy...
  86. ncbi request reprint Insulin cell mass is altered in Csf1op/Csf1op macrophage-deficient mice
    Linda Banaei-Bouchareb
    INSERM U457, Paris, France
    J Leukoc Biol 76:359-67. 2004
    ..The demonstration of the colony-stimulating factor 1-dependent macrophage involvement in life-time pancreas development/remodeling allows us to pinpoint the tissue-modeling and remodeling functions of this leukocyte lineage...
  87. ncbi request reprint Distinct role of macrophages in different tumor microenvironments
    Claire E Lewis
    Academic Unit of Pathology, Division of Genomic Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, United Kingdom
    Cancer Res 66:605-12. 2006
    ..This review will discuss the evidence for differential regulation of TAMs in these microenvironments and provide an overview of current attempts to target or use TAMs for therapeutic purposes...
  88. ncbi request reprint GSK-3beta mediates in the progesterone inhibition of estrogen induced cyclin D2 nuclear localization and cell proliferation in cyclin D1-/- mouse uterine epithelium
    Yuxiang Wang
    School of Life Science and National Key Laboratory of Genetic Engineering, Fudan University, Shanghai 200433, PR China
    FEBS Lett 581:3069-75. 2007
    ..Our results indicate that GSK-3beta is a major target of E(2) and P(4) in regulation of cyclin D2 localization in the mouse uterine epithelium...
  89. ncbi request reprint A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse
    R Tedjo Sasmono
    Institute for Molecular Bioscience and ARC Special Research Centre for Functional and Applied Genomics, University of Queensland, Brisbane, Australia
    Blood 101:1155-63. 2003
    ..We have therefore defined the elements required to generate myeloid- and trophoblast-specific transgenes as well as a model system for the study of mononuclear phagocyte development and function...
  90. ncbi request reprint Dynamic regulation of expression of colony-stimulating factor 1 in the reproductive tract of cattle during the estrous cycle and in pregnancy
    Rita S F Lee
    Reproductive Technologies Group, AgResearch, Ruakura Research Centre, Hamilton 2001, New Zealand
    Biol Reprod 69:518-28. 2003
    ..The high level of CSF-1 expression during bovine pregnancy in uteroplacental tissues is consistent with its proposed role in placental physiology...

Research Grants33

  1. Hormonal Regulation of Roles of CSF-1 in Reproduction
    Jeffrey Pollard; Fiscal Year: 2003
    ..Elucidation of these mechanisms should have profound consequences for the understanding of significant problems in women's health, menstrual cycle dysfunction, and the fetal morbidity and mortality as a result of placental infections. ..
  2. EINSTEIN TRANSGENIC AND GENE TARGETING COURSE
    Jeffrey Pollard; Fiscal Year: 2004
    ..Considerable emphasis in placed upon these interactions so that experimental procedures can be developed by the students in the future that address specific human diseases particularly cancer. ..
  3. PROGESTERONE, CELL CYCLE AND CANCER
    Jeffrey Pollard; Fiscal Year: 2002
    ..abstract_text> ..
  4. HORMONAL REGULATION AND ROLES OF CSF-1 IN REPRODUCTION
    Jeffrey Pollard; Fiscal Year: 2001
    ..Since L. monocytogenes causes significant fetal morbidity and mortality during pregnancy in humans, such studies might also point to areas for therapeutic intervention in this infection during pregnancy. ..
  5. PROGESTERONE, CELL CYCLE AND CANCER
    Jeffrey Pollard; Fiscal Year: 2005
    ..abstract_text> ..
  6. Hormonal Regulation of Roles of CSF-1 in Reproduction
    Jeffrey Pollard; Fiscal Year: 2005
    ..Elucidation of these mechanisms should have profound consequences for the understanding of significant problems in women's health, menstrual cycle dysfunction, and the fetal morbidity and mortality as a result of placental infections. ..
  7. CSF-1 Macrophages & Mammary Gland Development and Cancer
    Jeffrey Pollard; Fiscal Year: 2005
    ..Understanding the mechanistic basis of the macrophage enhancement of metastasis could result in the development of novel therapeutics aimed at to prevent this step. ..
  8. Hormonal Regulation of Roles of CSF-1 in Reproduction
    Jeffrey Pollard; Fiscal Year: 2006
    ..Elucidation of these mechanisms should have profound consequences for the understanding of significant problems in women's health, menstrual cycle dysfunction, and the fetal morbidity and mortality as a result of placental infections. ..
  9. PROGESTERONE, CELL CYCLE AND CANCER
    Jeffrey Pollard; Fiscal Year: 2004
    ..abstract_text> ..
  10. CSF-1, MACROPHAGES AND MALE REPRODUCTIVE FUNCTION
    Jeffrey Pollard; Fiscal Year: 2001
    ..This should significantly enhance our understanding of some aspects of human infertility and will provide important insight into the mechanism by which infection can affect fertility in healthy human males. ..
  11. CSF-1 Macrophages & Mammary Gland Development and Cancer
    Jeffrey Pollard; Fiscal Year: 2006
    ..Understanding the mechanistic basis of the macrophage enhancement of metastasis could result in the development of novel therapeutics aimed at to prevent this step. ..
  12. 2006 Reproductive Tract Biology Gordon Research Conference
    Jeffrey Pollard; Fiscal Year: 2006
    ....
  13. Macrophages and Tumor Angiogenesis
    Jeffrey Pollard; Fiscal Year: 2009
    ..In part, this is through the regulation of blood vessel formation (angiogenesis), essential for tumor survival. This proposal will define the mechanism of macrophage action that should indicate novel therapeutic strategies. ..
  14. CSF-1 Macrophages & Mammary Gland Development and Cancer
    Jeffrey Pollard; Fiscal Year: 2003
    ..Understanding the mechanistic basis of the macrophage enhancement of metastasis could result in the development of novel therapeutics aimed at to prevent this step. ..
  15. CSF-1, MACROPHAGES AND MALE REPRODUCTIVE FUNCTION
    Jeffrey Pollard; Fiscal Year: 1999
    ..This should significantly enhance our understanding of some aspects of human infertility and will provide important insight into the mechanism by which infection can affect fertility in healthy human males. ..
  16. CSF-1, MACROPHAGES AND MALE REPRODUCTIVE FUNCTION
    Jeffrey Pollard; Fiscal Year: 2000
    ..This should significantly enhance our understanding of some aspects of human infertility and will provide important insight into the mechanism by which infection can affect fertility in healthy human males. ..
  17. HORMONAL REGULATION AND ROLES OF CSF-1 IN REPRODUCTION
    Jeffrey Pollard; Fiscal Year: 2000
    ..Since L. monocytogenes causes significant fetal morbidity and mortality during pregnancy in humans, such studies might also point to areas for therapeutic intervention in this infection during pregnancy. ..
  18. CSF-1 Macrophages & Mammary Gland Development and Cancer
    Jeffrey Pollard; Fiscal Year: 2004
    ..Understanding the mechanistic basis of the macrophage enhancement of metastasis could result in the development of novel therapeutics aimed at to prevent this step. ..
  19. CSF-1 Macrophages & Mammary Gland Development and Cancer
    Jeffrey Pollard; Fiscal Year: 2002
    ..Understanding the mechanistic basis of the macrophage enhancement of metastasis could result in the development of novel therapeutics aimed at to prevent this step. ..
  20. PROGESTERONE, CELL CYCLE AND CANCER
    Jeffrey Pollard; Fiscal Year: 2001
    ..abstract_text> ..
  21. HORMONAL REGULATION AND ROLES OF CSF-1 IN REPRODUCTION
    Jeffrey Pollard; Fiscal Year: 2002
    ..Since L. monocytogenes causes significant fetal morbidity and mortality during pregnancy in humans, such studies might also point to areas for therapeutic intervention in this infection during pregnancy. ..
  22. HORMONAL REGULATION AND ROLES OF CSF-1 IN REPRODUCTION
    Jeffrey Pollard; Fiscal Year: 1999
    ..Since L. monocytogenes causes significant fetal morbidity and mortality during pregnancy in humans, such studies might also point to areas for therapeutic intervention in this infection during pregnancy. ..
  23. Hormonal Regulation of Roles of CSF-1 in Reproduction
    Jeffrey Pollard; Fiscal Year: 2004
    ..Elucidation of these mechanisms should have profound consequences for the understanding of significant problems in women's health, menstrual cycle dysfunction, and the fetal morbidity and mortality as a result of placental infections. ..
  24. Hormonal Regulation of Roles of CSF-1 in Reproduction
    Jeffrey Pollard; Fiscal Year: 2007
    ..Elucidation of these mechanisms should have profound consequences for the understanding of significant problems in women's health, menstrual cycle dysfunction, and the fetal morbidity and mortality as a result of placental infections. ..
  25. PROGESTERONE, CELL CYCLE AND CANCER
    Jeffrey Pollard; Fiscal Year: 2003
    ..abstract_text> ..