Jonathan U Peled

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. doi request reprint The biochemistry of somatic hypermutation
    Jonathan U Peled
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Annu Rev Immunol 26:481-511. 2008
  2. pmc Do electronic health records help or hinder medical education?
    Jonathan U Peled
    Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS Med 6:e1000069. 2009
  3. pmc MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites
    Sergio Roa
    Department of Cell Biology, Albert Einstein College of Medicine, New York, New York, USA
    PLoS ONE 5:e11182. 2010
  4. ncbi request reprint A role for Mlh3 in somatic hypermutation
    Ziqiang Li
    Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    DNA Repair (Amst) 5:675-82. 2006
  5. ncbi request reprint Targeting AID to the Ig genes
    Ziqiang Li
    Department of Cell Biology, Albert Einstein College of Medicine, New York, New York 10461, USA
    Adv Exp Med Biol 596:93-109. 2007
  6. pmc Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression
    Sergio Roa
    Departments of Cell Biology and Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 105:16248-53. 2008
  7. pmc Msh6 protects mature B cells from lymphoma by preserving genomic stability
    Jonathan U Peled
    Cell Biology Department, Chanin 403, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Am J Pathol 177:2597-608. 2010
  8. pmc Requirement for cyclin D3 in germinal center formation and function
    Jonathan U Peled
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cell Res 20:631-46. 2010
  9. pmc Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification
    Ziqiang Li
    Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Chanin 403, Bronx, NY 10461, USA
    J Exp Med 200:47-59. 2004

Collaborators

Detail Information

Publications9

  1. doi request reprint The biochemistry of somatic hypermutation
    Jonathan U Peled
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Annu Rev Immunol 26:481-511. 2008
    ..Both AID and these components of an emerging error-prone mutasome are regulated on many levels by complex mechanisms that are only beginning to be elucidated...
  2. pmc Do electronic health records help or hinder medical education?
    Jonathan U Peled
    Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS Med 6:e1000069. 2009
    ..Many countries worldwide are digitizing patients' medical records. What impact will these electronic health records have upon medical education? This debate examines the threats and opportunities...
  3. pmc MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites
    Sergio Roa
    Department of Cell Biology, Albert Einstein College of Medicine, New York, New York, USA
    PLoS ONE 5:e11182. 2010
    ..We propose a model for the role of MutSalpha at the immunoglobulin locus where the local balance of error-free and error-prone repair has an impact in the spectrum of mutations introduced during Phase 2 of SHM...
  4. ncbi request reprint A role for Mlh3 in somatic hypermutation
    Ziqiang Li
    Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    DNA Repair (Amst) 5:675-82. 2006
    ..This is the first instance where a loss of a DNA repair protein has a positive impact on the rate of SHM, suggesting that Mlh3 normally inhibits the accumulation of mutations in SHM...
  5. ncbi request reprint Targeting AID to the Ig genes
    Ziqiang Li
    Department of Cell Biology, Albert Einstein College of Medicine, New York, New York 10461, USA
    Adv Exp Med Biol 596:93-109. 2007
  6. pmc Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression
    Sergio Roa
    Departments of Cell Biology and Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 105:16248-53. 2008
    ....
  7. pmc Msh6 protects mature B cells from lymphoma by preserving genomic stability
    Jonathan U Peled
    Cell Biology Department, Chanin 403, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Am J Pathol 177:2597-608. 2010
    ..We conclude that MSH6 protects B cells from neoplastic transformation by preserving genomic stability...
  8. pmc Requirement for cyclin D3 in germinal center formation and function
    Jonathan U Peled
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cell Res 20:631-46. 2010
    ..This is the first demonstration that cyclin D3 plays an important and unique role at the GC stage of B cell development...
  9. pmc Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification
    Ziqiang Li
    Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Chanin 403, Bronx, NY 10461, USA
    J Exp Med 200:47-59. 2004
    ..Together, our data suggest that MutS homologues Msh2, Msh3, and Msh6 play overlapping and distinct roles during antibody diversification processes...