JOSHUA NOSANCHUK

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi request reprint Current status and future of antifungal therapy for systemic mycoses
    Joshua D Nosanchuk
    Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Recent Pat Antiinfect Drug Discov 1:75-84. 2006
  2. pmc Fatty acid synthase impacts the pathobiology of Candida parapsilosis in vitro and during mammalian infection
    Long Nam Nguyen
    Department of Medicine Division of Infectious Diseases, Albert Einstein College of Medicine, New York, New York, USA
    PLoS ONE 4:e8421. 2009
  3. pmc Biological function and molecular mapping of M antigen in yeast phase of Histoplasma capsulatum
    Allan Jefferson Guimarães
    Division of Infectious Diseases, Department of Medicine and Microbiology and Immunology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, USA
    PLoS ONE 3:e3449. 2008
  4. pmc Effects of disrupting the polyketide synthase gene WdPKS1 in Wangiella [Exophiala] dermatitidis on melanin production and resistance to killing by antifungal compounds, enzymatic degradation, and extremes in temperature
    William F Paolo
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
    BMC Microbiol 6:55. 2006
  5. ncbi request reprint Protective antibodies and endemic dimorphic fungi
    J D Nosanchuk
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Curr Mol Med 5:435-42. 2005
  6. pmc Histoplasma capsulatum at the host-pathogen interface
    Joshua D Nosanchuk
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Microbes Infect 10:973-7. 2008
  7. ncbi request reprint Blastomyces dermatitidis produces melanin in vitro and during infection
    Joshua D Nosanchuk
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    FEMS Microbiol Lett 239:187-93. 2004
  8. pmc Impact of melanin on microbial virulence and clinical resistance to antimicrobial compounds
    Joshua D Nosanchuk
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Antimicrob Agents Chemother 50:3519-28. 2006
  9. ncbi request reprint Fungal myocarditis
    Joshua Daniel Nosanchuk
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Front Biosci 7:d1423-38. 2002
  10. pmc Antibodies to a cell surface histone-like protein protect against Histoplasma capsulatum
    Joshua D Nosanchuk
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 112:1164-75. 2003

Research Grants

  1. MELANOGENESIS IN CRYPTOCOCCUS NEOFORMANS
    JOSHUA NOSANCHUK; Fiscal Year: 2002
  2. Antibody Protection in Histoplamosis
    JOSHUA NOSANCHUK; Fiscal Year: 2006
  3. Antibody Protection in Histoplamosis
    JOSHUA NOSANCHUK; Fiscal Year: 2007
  4. Antibody Protection in Histoplamosis
    JOSHUA NOSANCHUK; Fiscal Year: 2009
  5. Antibody Protection in Histoplamosis
    JOSHUA NOSANCHUK; Fiscal Year: 2009

Collaborators

Detail Information

Publications54

  1. ncbi request reprint Current status and future of antifungal therapy for systemic mycoses
    Joshua D Nosanchuk
    Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Recent Pat Antiinfect Drug Discov 1:75-84. 2006
    ..This review discusses the antifungal drugs that are clinically in use and summarizes interesting new applications and patents from the US Patent and Trademark Office...
  2. pmc Fatty acid synthase impacts the pathobiology of Candida parapsilosis in vitro and during mammalian infection
    Long Nam Nguyen
    Department of Medicine Division of Infectious Diseases, Albert Einstein College of Medicine, New York, New York, USA
    PLoS ONE 4:e8421. 2009
    ..parapsilosis growth in the absence of exogenous fatty acids, is involved in unsaturated fatty acid production, influences fungal virulence, and represents a promising antifungal drug target...
  3. pmc Biological function and molecular mapping of M antigen in yeast phase of Histoplasma capsulatum
    Allan Jefferson Guimarães
    Division of Infectious Diseases, Department of Medicine and Microbiology and Immunology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, USA
    PLoS ONE 3:e3449. 2008
    ....
  4. pmc Effects of disrupting the polyketide synthase gene WdPKS1 in Wangiella [Exophiala] dermatitidis on melanin production and resistance to killing by antifungal compounds, enzymatic degradation, and extremes in temperature
    William F Paolo
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
    BMC Microbiol 6:55. 2006
    ..Cell wall pigmentation in W. dermatitidis depends on the WdPKS1 gene, which encodes a polyketide synthase required for generating the key precursor for dihydroxynaphthalene melanin biosynthesis...
  5. ncbi request reprint Protective antibodies and endemic dimorphic fungi
    J D Nosanchuk
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Curr Mol Med 5:435-42. 2005
    ..This paper reviews the recent data on protective antibody in histoplasmosis and previous data supporting a role for antibody in protective responses in other dimorphic fungi...
  6. pmc Histoplasma capsulatum at the host-pathogen interface
    Joshua D Nosanchuk
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Microbes Infect 10:973-7. 2008
    ..capsulatum virulence and numerous recent advances have been made regarding the pathogenesis of this fungus that will improve our capacity to combat disease...
  7. ncbi request reprint Blastomyces dermatitidis produces melanin in vitro and during infection
    Joshua D Nosanchuk
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    FEMS Microbiol Lett 239:187-93. 2004
    ..Melanization reduced susceptibility to amphotericin B, but not to itraconazole or voriconazole. Since melanin is an important virulence factor in other pathogenic fungi, this pigment may affect the pathogenesis of blastomycosis...
  8. pmc Impact of melanin on microbial virulence and clinical resistance to antimicrobial compounds
    Joshua D Nosanchuk
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Antimicrob Agents Chemother 50:3519-28. 2006
  9. ncbi request reprint Fungal myocarditis
    Joshua Daniel Nosanchuk
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Front Biosci 7:d1423-38. 2002
    ..The major fungal pathogens responsible for myocardial infection and the clinical settings in which they occur are reviewed...
  10. pmc Antibodies to a cell surface histone-like protein protect against Histoplasma capsulatum
    Joshua D Nosanchuk
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 112:1164-75. 2003
    ....
  11. ncbi request reprint Coccidioides posadasii produces melanin in vitro and during infection
    Joshua D Nosanchuk
    Department of Medicine Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Fungal Genet Biol 44:517-20. 2007
    ..Since melanin is an important virulence factor in other pathogenic fungi, it may affect the pathogenesis of coccidioidomycosis...
  12. pmc Histoplasma capsulatum synthesizes melanin-like pigments in vitro and during mammalian infection
    Joshua D Nosanchuk
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 70:5124-31. 2002
    ..Since melanin is an important virulence factor in other pathogenic fungi, this pigment may have a similar role to play in the pathogenesis of histoplasmosis...
  13. ncbi request reprint Budding of melanized Cryptococcus neoformans in the presence or absence of L-dopa
    Joshua D Nosanchuk
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
    Microbiology 149:1945-51. 2003
    ..These results imply that melanin remodelling occurs during cell growth in a process that involves degradation and synthesis at sites of budding...
  14. pmc Effects of voriconazole on Cryptococcus neoformans
    David van Duin
    Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Antimicrob Agents Chemother 48:2014-20. 2004
    ..The high activity of voriconazole against both melanized and nonmelanized cells results suggest that voriconazole may be a particularly valuable drug for cryptococcosis...
  15. pmc Monoclonal antibodies to heat shock protein 60 alter the pathogenesis of Histoplasma capsulatum
    Allan J Guimaraes
    Department of Medicine Division of Infectious Diseases and Microbiology and Immunology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
    Infect Immun 77:1357-67. 2009
    ..Hence, IgG1 and IgG2a MAbs to Hsp60 can modify H. capsulatum pathogenesis in part by altering the intracellular fate of the fungus and inducing the production of Th1-associated cytokines...
  16. pmc A monoclonal antibody to Histoplasma capsulatum alters the intracellular fate of the fungus in murine macrophages
    Li Shi
    Division of Infectious Diseases, Departments of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Eukaryot Cell 7:1109-17. 2008
    ..The MAb alters the intracellular fate of H. capsulatum by affecting the ability of the fungus to regulate the milieu of the phagosome...
  17. pmc Melanization of Cryptococcus neoformans and Histoplasma capsulatum reduces their susceptibilities to amphotericin B and caspofungin
    David van Duin
    Department of Medicine, Division of Infectious Diseases Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Antimicrob Agents Chemother 46:3394-400. 2002
    ..Furthermore, the results indicate that fungal melanins protect C. neoformans and H. capsulatum from the activities of amphotericin B and caspofungin and that this protection is not demonstrable by standard broth macrodilution assays...
  18. pmc Interaction of Blastomyces dermatitidis, Sporothrix schenckii, and Histoplasma capsulatum with Acanthamoeba castellanii
    Judith N Steenbergen
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 72:3478-88. 2004
    ..These results are consistent with the view that soil amoebae may contribute to the selection and maintenance of certain traits in pathogenic dimorphic fungi that confer on these microbes the capacity for virulence in mammals...
  19. pmc Voriconazole inhibits melanization in Cryptococcus neoformans
    Luis R Martinez
    Department of Medicine Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Antimicrob Agents Chemother 51:4396-400. 2007
    ..Hence, voriconazole affects melanization in C. neoformans by interacting directly with laccase, which may increase the efficacy of this potent antifungal against certain pigmented fungi...
  20. ncbi request reprint Phage display library derived peptides that bind to human tumor melanin as potential vehicles for targeted radionuclide therapy of metastatic melanoma
    Robertha C Howell
    Department of Nuclear Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    Bioconjug Chem 18:1739-48. 2007
    ..Thus, these heptapeptides appear to have potentially significant advantages for targeted therapy of melanoma relative to existing melanin-binding peptides...
  21. ncbi request reprint The contribution of melanin to microbial pathogenesis
    Joshua D Nosanchuk
    Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Cell Microbiol 5:203-23. 2003
    ..The process of melanization poses fascinating problems in cell biology and provides a type of pathogenic strategy that is common to highly diverse pathogens...
  22. pmc Melanization of Cryptococcus neoformans affects lung inflammatory responses during cryptococcal infection
    Aron J Mednick
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Infect Immun 73:2012-9. 2005
    ..The results provide strong evidence that cryptococcal melanization can influence the immune response to infection and suggest that immunomodulation is an additional mechanism by which the pigment contributes to virulence...
  23. pmc Cryptococcus neoformans responds to mannitol by increasing capsule size in vitro and in vivo
    Allan Jefferson Guimarães
    Department of Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA
    Cell Microbiol 12:740-53. 2010
    ..Our results demonstrate the capacity of carbohydrate source and concentration to modify the expression of a major virulence factor of C. neoformans. These findings may impact the clinical management of cryptococcosis...
  24. doi request reprint Radioimmunotherapy of experimental human metastatic melanoma with melanin-binding antibodies and in combination with dacarbazine
    Ekaterina Revskaya
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Clin Cancer Res 15:2373-9. 2009
    ....
  25. pmc The use of chitosan to damage Cryptococcus neoformans biofilms
    Luis R Martinez
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Biomaterials 31:669-79. 2010
    ..Our results indicate that cryptococcal biofilms are susceptible to treatment with chitosan, suggesting an option for the prevention or treatment of fungal biofilms on indwelling medical devices...
  26. doi request reprint Methamphetamine enhances histoplasmosis by immunosuppression of the host
    Luis R Martinez
    Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Infect Dis 200:131-41. 2009
    ..With use of a murine model of histoplasmosis, this study establishes that methamphetamine may alter the immune system of the host and enhance fungal pathogenesis...
  27. doi request reprint The radioprotective properties of fungal melanin are a function of its chemical composition, stable radical presence and spatial arrangement
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
    Pigment Cell Melanoma Res 21:192-9. 2008
    ..Melanin protected fungi against ionizing radiation and its radioprotective properties were a function of its chemical composition, free radical quenching, and spherical spatial arrangement...
  28. pmc The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum
    Eszter Lazar-Molnar
    Departments of Microbiology and Immunology, Albert Einstein College of Medicine, Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 105:2658-63. 2008
    ..The results show that the PD-1/PD-L pathway has a key role in the regulation of antifungal immunity, and suggest that manipulation of this pathway represents a strategy of immunotherapy for histoplasmosis...
  29. doi request reprint Demonstration of antibiofilm and antifungal efficacy of chitosan against candidal biofilms, using an in vivo central venous catheter model
    Luis R Martinez
    Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, 1300Morris Park Ave, Bronx, NY 10461, USA
    J Infect Dis 201:1436-40. 2010
    ..Chitosan should be considered for the prevention or treatment of fungal biofilms on central venous catheters and perhaps other medical devices...
  30. doi request reprint Vesicular transport across the fungal cell wall
    Arturo Casadevall
    Departments of Microbiology and Immunology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Trends Microbiol 17:158-62. 2009
    ..The discovery of vesicular transport in fungi opens many new avenues for investigation in basic cell biology and pathogenesis...
  31. pmc Dead cells in melanoma tumors provide abundant antigen for targeted delivery of ionizing radiation by a mAb to melanin
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 101:14865-70. 2004
    ....
  32. ncbi request reprint Susceptibility of the human pathogenic fungi Cryptococcus neoformans and Histoplasma capsulatum to gamma-radiation versus radioimmunotherapy with alpha- and beta-emitting radioisotopes
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, 1695A Eastchester Road, Bronx, NY 10461, USA
    J Nucl Med 45:313-20. 2004
    ....
  33. ncbi request reprint Microstructure of cell wall-associated melanin in the human pathogenic fungus Cryptococcus neoformans
    Helene C Eisenman
    Division of Infectious Diseases of the Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 44:3683-93. 2005
    ..We propose a model of cryptococcal melanin structure whereby the melanin granules are held together in layers. This structural model has implications for cell division, cell wall remodeling, and antifungal drug discovery...
  34. pmc Effect of amphotericin B on capsule and cell size in Cryptococcus neoformans during murine infection
    Oscar Zaragoza
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Antimicrob Agents Chemother 49:4358-61. 2005
    ..We examined the effects of amphotericin B on C. neoformans during murine infection. The antifungal reduced capsule size and serum polysaccharide, which suggests an additional mechanism for amphotericin B's efficacy in cryptococcosis...
  35. ncbi request reprint Comparative analysis of Cryptococcus neoformans acid-resistant particles generated from pigmented cells grown in different laccase substrates
    Javier Garcia-Rivera
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Fungal Genet Biol 42:989-98. 2005
    ..neoformans in different substrates affected cell and capsule size but not capsule induction. Hence, the type of pigment produced by C. neoformans is dependent on the substrate and not all pigments meet the criteria for melanins...
  36. ncbi request reprint 'Ready made' virulence and 'dual use' virulence factors in pathogenic environmental fungi--the Cryptococcus neoformans paradigm
    Arturo Casadevall
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York 10461, USA
    Curr Opin Microbiol 6:332-7. 2003
    ..The findings with C. neoformans may provide a paradigm for understanding the origin and maintenance of virulence in other pathogenic environmental fungi...
  37. ncbi request reprint Radiolabeled melanin-binding peptides are safe and effective in treatment of human pigmented melanoma in a mouse model of disease
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    Cancer Biother Radiopharm 21:117-29. 2006
    ..These results indicate that radiolabeled melanin-binding peptides are efficient and safe in treatment of melanoma and could be potentially useful against this tumor...
  38. ncbi request reprint Efficacy of voriconazole in experimental Cryptococcus neoformans infection
    Nikolaos Mavrogiorgos
    Department of Microbiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mycopathologia 162:111-4. 2006
    ..The antifungal reduced serum polysaccharide and significantly prolonged the survival of lethally infected animals...
  39. ncbi request reprint Experimental murine cryptococcal infection results in contamination of bedding with Cryptococcus neoformans
    Joshua D Nosanchuk
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Contemp Top Lab Anim Sci 42:9-12. 2003
    ..This result suggests that precautions may be warranted when disposing bedding from cages that housed mice with pulmonary C. neoformans infection...
  40. pmc Ionizing radiation changes the electronic properties of melanin and enhances the growth of melanized fungi
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 2:e457. 2007
    ..We hypothesized that ionizing radiation could change the electronic properties of melanin and might enhance the growth of melanized microorganisms...
  41. pmc Lipase 8 affects the pathogenesis of Candida albicans
    Attila Gacser
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Infect Immun 75:4710-8. 2007
    ..Mutants deficient in the LIP8 gene were significantly less virulent in a murine intravenous infection model. The results clearly indicate that Lip8p is an important virulence factor of C. albicans...
  42. pmc Targeted gene deletion in Candida parapsilosis demonstrates the role of secreted lipase in virulence
    Attila Gacser
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Yeshiva University, New York, New York, USA
    J Clin Invest 117:3049-58. 2007
    ..This efficient system for targeted gene deletion holds great promise for rapidly enhancing our knowledge of the biology and virulence of this increasingly common invasive fungal pathogen...
  43. pmc Cryptococcus neoformans virulence is enhanced after growth in the genetically malleable host Dictyostelium discoideum
    Judith N Steenbergen
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Infect Immun 71:4862-72. 2003
    ..neoformans virulence in the environment and suggest that D. discoideum promises to be an extremely useful system for studying the interaction of C. neoformans with phagocytic cells...
  44. pmc Melanin-covered nanoparticles for protection of bone marrow during radiation therapy of cancer
    Andrew D Schweitzer
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Int J Radiat Oncol Biol Phys 78:1494-502. 2010
    ....
  45. pmc Acetylsalicylic acid (aspirin) reduces damage to reconstituted human tissues infected with Candida species by inhibiting extracellular fungal lipases
    David Trofa
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, 1300 Morris Park Avenue, NY 10461, USA
    Microbes Infect 11:1131-9. 2009
    ..parapsilosis in complex with ASA. The results suggest that development of inhibitors of fungal lipases could result in broad-spectrum therapeutics, especially since fungal lipases are not homologous to their human analogues...
  46. ncbi request reprint Caspofungin reduces the incidence of fungal contamination in cell culture
    Luis R Martinez
    Department of Medicine Division of Infectious Diseases, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Mycopathologia 164:279-86. 2007
    ..16 cells, although modest increases in IL-4 and IFN-gamma occurred upon LPS stimulation. Hence, echinocandins appear to be relatively non-toxic, and protect against fungal contamination in cell culture...
  47. pmc Methamphetamine inhibits antigen processing, presentation, and phagocytosis
    Zsolt Talloczy
    Department of Neurology, Columbia University, New York, New York, United States of America
    PLoS Pathog 4:e28. 2008
    ..Meth exerts previously unreported direct immunosuppressive effects that contribute to increased risk of infection and exacerbate AIDS pathology...
  48. pmc A histoplasma capsulatum-specific IgG1 isotype monoclonal antibody, H1C, to a 70-kilodalton cell surface protein is not protective in murine histoplasmosis
    Livia Cristina Liporagi Lopes
    Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Clin Vaccine Immunol 17:1155-8. 2010
    ..This further demonstrates the complexities of host-pathogen interactions...
  49. pmc Candida parapsilosis, an emerging fungal pathogen
    David Trofa
    Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Clin Microbiol Rev 21:606-25. 2008
    ..parapsilosis virulence. The emerging information will provide a deeper understanding of C. parapsilosis pathogenesis and facilitate the development of new therapeutic approaches for treating C. parapsilosis infections...
  50. pmc Aggregation of Streptococcus pneumoniae by a pneumococcal capsular polysaccharide-specific human monoclonal IgM correlates with antibody efficacy in vivo
    Kevin Fabrizio
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Clin Vaccine Immunol 17:713-21. 2010
    ..These findings suggest that A7-mediated aggregation enhances resistance to ST3, most likely by enhancing C3 deposition on the ST3 capsule, thereby promoting host antipneumococcal activity in vivo...
  51. ncbi request reprint Virulence of Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis in reconstituted human tissue models
    Attila Gacser
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Fungal Genet Biol 44:1336-41. 2007
    ..Our data show that reconstituted human tissues are extremely useful for modeling host interactions with C. parapsilosis and for studying fungal virulence factors...
  52. doi request reprint Antimicrobial and healing efficacy of sustained release nitric oxide nanoparticles against Staphylococcus aureus skin infection
    Luis R Martinez
    Division of Infectious Diseases, Departments of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Invest Dermatol 129:2463-9. 2009
    ..Together, these data suggest that these NO-releasing nanoparticles have the potential to serve as a novel class of topically applied antimicrobials for the treatment of cutaneous infections and wounds...
  53. ncbi request reprint Tuberculosis in New York city: recent lessons and a look ahead
    William F Paolo
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York, USA
    Lancet Infect Dis 4:287-93. 2004
    ..However, given the presence of a large reservoir of latently infected individuals in the city and an ongoing tuberculosis pandemic, New York city continues to face significant challenges from this persistent pathogen...
  54. pmc Nitric oxide releasing nanoparticles are therapeutic for Staphylococcus aureus abscesses in a murine model of infection
    George Han
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY, USA
    PLoS ONE 4:e7804. 2009
    ..These data suggest that NO-np may be useful therapeutics for microbial abscesses...

Research Grants6

  1. MELANOGENESIS IN CRYPTOCOCCUS NEOFORMANS
    JOSHUA NOSANCHUK; Fiscal Year: 2002
    ..To explore the structure of melanin using biochemistry, phage display peptide libraries and mAbs; and 4. To use peptides and mAbs to study C. neoformans melanogenesis in vivo and in vitro. ..
  2. Antibody Protection in Histoplamosis
    JOSHUA NOSANCHUK; Fiscal Year: 2006
    ..These studies are expected to lead to insights into H. capsulatum pathogenesis and initiate the development of new therapeutic and diagnostic reagents. ..
  3. Antibody Protection in Histoplamosis
    JOSHUA NOSANCHUK; Fiscal Year: 2007
    ..These studies are expected to lead to insights into H. capsulatum pathogenesis and initiate the development of new therapeutic and diagnostic reagents. ..
  4. Antibody Protection in Histoplamosis
    JOSHUA NOSANCHUK; Fiscal Year: 2009
    ..These studies are expected to lead to insights into H. capsulatum pathogenesis and initiate the development of new therapeutic and diagnostic reagents. ..
  5. Antibody Protection in Histoplamosis
    JOSHUA NOSANCHUK; Fiscal Year: 2009
    ..These studies are expected to lead to insights into H. capsulatum pathogenesis and initiate the development of new therapeutic and diagnostic reagents. ..