Fnu Nagajyothi

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc Curcumin treatment provides protection against Trypanosoma cruzi infection
    Fnu Nagajyothi
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, NY, USA
    Parasitol Res 110:2491-9. 2012
  2. pmc Response of adipose tissue to early infection with Trypanosoma cruzi (Brazil strain)
    Fnu Nagajyothi
    Department of Pathology, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY, USA
    J Infect Dis 205:830-40. 2012
  3. pmc Trypanosoma cruzi utilizes the host low density lipoprotein receptor in invasion
    Fnu Nagajyothi
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    PLoS Negl Trop Dis 5:e953. 2011
  4. pmc Trypanosoma cruzi infection of cultured adipocytes results in an inflammatory phenotype
    Fnu Nagajyothi
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    Obesity (Silver Spring) 16:1992-7. 2008
  5. pmc Crucial role of the central leptin receptor in murine Trypanosoma cruzi (Brazil strain) infection
    Fnu Nagajyothi
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    J Infect Dis 202:1104-13. 2010
  6. pmc Chagas disease, adipose tissue and the metabolic syndrome
    Fnu Nagajyothi
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mem Inst Oswaldo Cruz 104:219-25. 2009
  7. pmc Alterations in glucose homeostasis in a murine model of Chagas disease
    Fnu Nagajyothi
    Division of Parasitology and Tropical Medicine, Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Pathol 182:886-94. 2013
  8. ncbi request reprint Cell cycle regulatory proteins in the liver in murine Trypanosoma cruzi infection
    Boumediene Bouzahzah
    Department of Pathology at Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cell Cycle 5:2396-400. 2006
  9. pmc Adipose tissue, diabetes and Chagas disease
    Herbert B Tanowitz
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    Adv Parasitol 76:235-50. 2011
  10. pmc Alterations in myocardial gene expression associated with experimental Trypanosoma cruzi infection
    Shankar Mukherjee
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Genomics 91:423-32. 2008

Collaborators

Detail Information

Publications22

  1. pmc Curcumin treatment provides protection against Trypanosoma cruzi infection
    Fnu Nagajyothi
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, NY, USA
    Parasitol Res 110:2491-9. 2012
    ..These data suggest that curcumin and its derivatives could be a suitable drug for the amelioration of chagasic heart disease...
  2. pmc Response of adipose tissue to early infection with Trypanosoma cruzi (Brazil strain)
    Fnu Nagajyothi
    Department of Pathology, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY, USA
    J Infect Dis 205:830-40. 2012
    ..The mRNA levels of cytokines, chemokines, and their receptors were increased. Nuclear Factor Kappa B levels were increased in BAT, whereas Iκκ-γ levels increased in WAT. Adipose tissue is an early target of T. cruzi infection...
  3. pmc Trypanosoma cruzi utilizes the host low density lipoprotein receptor in invasion
    Fnu Nagajyothi
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    PLoS Negl Trop Dis 5:e953. 2011
    ....
  4. pmc Trypanosoma cruzi infection of cultured adipocytes results in an inflammatory phenotype
    Fnu Nagajyothi
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    Obesity (Silver Spring) 16:1992-7. 2008
    ..cruzi-infected adipocytes. Overall, these data implicate the adipocyte as an important target of T. cruzi, and one which contributes significantly to the inflammatory response observed in Chagas disease...
  5. pmc Crucial role of the central leptin receptor in murine Trypanosoma cruzi (Brazil strain) infection
    Fnu Nagajyothi
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    J Infect Dis 202:1104-13. 2010
    ..These findings suggest that leptin resistance in individuals with obesity and diabetes mellitus may have adverse consequences in T. cruzi infection...
  6. pmc Chagas disease, adipose tissue and the metabolic syndrome
    Fnu Nagajyothi
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mem Inst Oswaldo Cruz 104:219-25. 2009
    ..Adipose tissue is an important target tissue of T. cruzi and the infection of this tissue is associated with a profound impact on systemic metabolism, increasing the risk of metabolic syndrome...
  7. pmc Alterations in glucose homeostasis in a murine model of Chagas disease
    Fnu Nagajyothi
    Division of Parasitology and Tropical Medicine, Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Pathol 182:886-94. 2013
    ..cruzi-induced hypoglycemia, despite reduced insulin, but elevated glucagon levels. The data establishes a complex, multi-tissue relationship between T. cruzi infection, Chagas disease, and host glucose homeostasis...
  8. ncbi request reprint Cell cycle regulatory proteins in the liver in murine Trypanosoma cruzi infection
    Boumediene Bouzahzah
    Department of Pathology at Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cell Cycle 5:2396-400. 2006
    ..Thus infection caused a reversion to a fetal/neonatal phenotype. These data provide a molecular basis for cell proliferation in the liver following T. cruzi infection...
  9. pmc Adipose tissue, diabetes and Chagas disease
    Herbert B Tanowitz
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    Adv Parasitol 76:235-50. 2011
    ..The adipocyte is both a target of infection and a reservoir for the parasite during the chronic phase from which recrudescence of the infection may occur during periods of immunosuppression...
  10. pmc Alterations in myocardial gene expression associated with experimental Trypanosoma cruzi infection
    Shankar Mukherjee
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Genomics 91:423-32. 2008
    ..These data may provide insight into the pathogenesis of chagasic cardiomyopathy and provide new targets for intervention...
  11. ncbi request reprint Regulation of host cell cyclin D1 by Trypanosoma cruzi in myoblasts
    Boumediene Bouzahzah
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cell Cycle 7:500-3. 2008
    ..Moreover, we demonstrated that the cyclin D1 protein was significantly stabilized after infection. Collectively, these data indicate that infection with T. cruzi increases cyclin D1 protein abundance post-translationally...
  12. pmc Immune dysfunction in caveolin-1 null mice following infection with Trypanosoma cruzi (Tulahuen strain)
    Freddy A Medina
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Microbes Infect 9:325-33. 2007
    ..These results suggest that Cav-1 may play an important role in the normal development of immune responses...
  13. pmc Mechanisms of Trypanosoma cruzi persistence in Chagas disease
    Fnu Nagajyothi
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
    Cell Microbiol 14:634-43. 2012
    ..Ongoing and future research will continue to help refining the models of T. cruzi invasion and persistence in diverse tissues and organs in the host...
  14. ncbi request reprint Chagas disease, adipose tissue and the metabolic syndrome
    Fnu Nagajyothi
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA
    Mem Inst Oswaldo Cruz 104:219-25. 2009
    ..Adipose tissue is an important target tissue of T. cruzi and the infection of this tissue is associated with a profound impact on systemic metabolism, increasing the risk of metabolic syndrome...
  15. pmc Transcriptomic alterations in Trypanosoma cruzi-infected cardiac myocytes
    Regina Coeli Dos Santos Goldenberg
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
    Microbes Infect 11:1140-9. 2009
    ....
  16. pmc Trypanosoma cruzi infection induces proliferation of vascular smooth muscle cells
    Ghada S Hassan
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Infect Immun 74:152-9. 2006
    ..Taken together, these data suggest that T. cruzi infection stimulates smooth muscle cell proliferation and is likely a result of the upregulation of the ERK-cyclin D1-endothelin-1 pathway...
  17. ncbi request reprint Microarray technology in the investigation of diseases of myocardium with special reference to infection
    Shankar Mukherjee
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Front Biosci 11:1802-13. 2006
    ..This paper provides an overview of microarray technology and its recent developments followed by its usage in studies of cardiovascular disease and how it pertains to viral and parasitic infections of the heart...
  18. ncbi request reprint Cyclin and caveolin expression in an acute model of murine Chagasic myocarditis
    Fnu Nagajyothi
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cell Cycle 5:107-12. 2006
    ....
  19. pmc Perspectives on adipose tissue, chagas disease and implications for the metabolic syndrome
    Fnu Nagajyothi
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Interdiscip Perspect Infect Dis 2009:824324. 2009
    ..The T. cruzi-induced increase in macrophages in adipose tissue taken together with the reduction in adiponectin and the associated cardiomyopathy is reminiscent of the metabolic syndrome...
  20. pmc Interactions of Encephalitozoon cuniculi polar tube proteins
    Boumediene Bouzahzah
    Department of Pathology, Division of Tropical Medicine and Parasitology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Infect Immun 78:2745-53. 2010
    ..Further studies of polar tube proteins and their structural interactions may help elucidate the formation of the polar tube during the invasion process...
  21. ncbi request reprint Molecular cloning and characterization of the protein kinase A regulatory subunit of Trypanosoma cruzi
    Huan Huang
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Mol Biochem Parasitol 149:242-5. 2006
  22. pmc Trypanosoma cruzi infection results in an increase in intracellular cholesterol
    Christopher Johndrow
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
    Microbes Infect 16:337-44. 2014
    ..The observed changes in intracellular lipids and associated oxidative stress due to these elevated lipids may contribute to the development of Chagasic cardiomyopathy. ..