Radhika H Muzumdar

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell
    Regina Kuliawat
    2Department of Pediatrics, Golding Bldg 705, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    FASEB J 27:4890-8. 2013
  2. pmc Acute humanin therapy attenuates myocardial ischemia and reperfusion injury in mice
    Radhika H Muzumdar
    Department of Pediatrics, Children s Hospital at Montefiore, Diabetes Research and Training Center, Bronx, NY, USA 10461
    Arterioscler Thromb Vasc Biol 30:1940-8. 2010
  3. pmc Humanin: a novel central regulator of peripheral insulin action
    Radhika H Muzumdar
    Department of Pediatrics, Children s Hospital at Montefiore, Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY, USA
    PLoS ONE 4:e6334. 2009
  4. pmc Enhanced activation of a "nutrient-sensing" pathway with age contributes to insulin resistance
    Francine H Einstein
    Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA
    FASEB J 22:3450-7. 2008
  5. pmc Aging per se increases the susceptibility to free fatty acid-induced insulin resistance
    Francine H Einstein
    Department of Obstetrics and Gynecology and Women s Health at Montefiore Medical Center, Bronx, New York, USA
    J Gerontol A Biol Sci Med Sci 65:800-8. 2010
  6. ncbi request reprint Resistance to leptin action is the major determinant of hepatic triglyceride accumulation in vivo
    Sigal Fishman
    Institute for Aging Research, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    FASEB J 21:53-60. 2007
  7. ncbi request reprint Accretion of visceral fat and hepatic insulin resistance in pregnant rats
    Francine H Einstein
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology and Women s Health, The Albert Einstein College of Medicine Montefiore Medical Center, 1825 Eastchester Road, Bronx, NY 10461, USA
    Am J Physiol Endocrinol Metab 294:E451-5. 2008
  8. ncbi request reprint Central and opposing effects of IGF-I and IGF-binding protein-3 on systemic insulin action
    Radhika H Muzumdar
    Division of Pediatric Endocrinology, Children s Hospital at Montefiore, New York, USA
    Diabetes 55:2788-96. 2006
  9. pmc The critical role of metabolic pathways in aging
    Nir Barzilai
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
    Diabetes 61:1315-22. 2012
  10. doi request reprint Epigenetic genome-wide association methylation in aging and longevity
    Danny Ben-Avraham
    Department of Medicine, 1300 Morris Park Ave, Golding 502b, Bronx, NY 10461, USA
    Epigenomics 4:503-9. 2012

Collaborators

Detail Information

Publications12

  1. pmc Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell
    Regina Kuliawat
    2Department of Pediatrics, Golding Bldg 705, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    FASEB J 27:4890-8. 2013
    ..The glucose-dependent effects on insulin secretion along with the established effects on insulin action suggest potential for HN and its analogs in the treatment of diabetes...
  2. pmc Acute humanin therapy attenuates myocardial ischemia and reperfusion injury in mice
    Radhika H Muzumdar
    Department of Pediatrics, Children s Hospital at Montefiore, Diabetes Research and Training Center, Bronx, NY, USA 10461
    Arterioscler Thromb Vasc Biol 30:1940-8. 2010
    ..We evaluated the effects of a potent analog of HN (HNG) in an in vivo murine model of myocardial ischemia and reperfusion...
  3. pmc Humanin: a novel central regulator of peripheral insulin action
    Radhika H Muzumdar
    Department of Pediatrics, Children s Hospital at Montefiore, Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY, USA
    PLoS ONE 4:e6334. 2009
    ..A novel mitochondria-associated peptide, Humanin (HN), has a neuroprotective role against AD-related neurotoxicity. Considering the association between insulin resistance and AD, we investigated if HN influences insulin sensitivity...
  4. pmc Enhanced activation of a "nutrient-sensing" pathway with age contributes to insulin resistance
    Francine H Einstein
    Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA
    FASEB J 22:3450-7. 2008
    ..These results suggest that altered nutrient sensing by HBP with age may be the link among nutrients, insulin resistance, and age-related diabetes...
  5. pmc Aging per se increases the susceptibility to free fatty acid-induced insulin resistance
    Francine H Einstein
    Department of Obstetrics and Gynecology and Women s Health at Montefiore Medical Center, Bronx, New York, USA
    J Gerontol A Biol Sci Med Sci 65:800-8. 2010
    ..Thus, aging per se increases the inflammatory response to excess nutrients and vulnerability to FFA-induced insulin resistance with aging...
  6. ncbi request reprint Resistance to leptin action is the major determinant of hepatic triglyceride accumulation in vivo
    Sigal Fishman
    Institute for Aging Research, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    FASEB J 21:53-60. 2007
    ..By dissociating action of leptin from that of insulin, we suggest that the failure of leptin action is the major physiological mechanism for hepatic steatosis...
  7. ncbi request reprint Accretion of visceral fat and hepatic insulin resistance in pregnant rats
    Francine H Einstein
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology and Women s Health, The Albert Einstein College of Medicine Montefiore Medical Center, 1825 Eastchester Road, Bronx, NY 10461, USA
    Am J Physiol Endocrinol Metab 294:E451-5. 2008
    ..05). Accretion of visceral fat is an important component in the development of hepatic IR in pregnancy, and accumulation of hepatic triglycerides is a mechanism by which visceral fat may modulate insulin action in pregnancy...
  8. ncbi request reprint Central and opposing effects of IGF-I and IGF-binding protein-3 on systemic insulin action
    Radhika H Muzumdar
    Division of Pediatric Endocrinology, Children s Hospital at Montefiore, New York, USA
    Diabetes 55:2788-96. 2006
    ..Marked, opposing, and independent physiological effects of IGF-I and IGFBP-3 through central mechanisms may have implications on potential strategies in specific modulation of peripheral insulin action...
  9. pmc The critical role of metabolic pathways in aging
    Nir Barzilai
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
    Diabetes 61:1315-22. 2012
    ..Although life span has been the major outcome of interest in the laboratory, a special focus is made in this study on healthspan, as improved quality of life is the goal when translated to humans...
  10. doi request reprint Epigenetic genome-wide association methylation in aging and longevity
    Danny Ben-Avraham
    Department of Medicine, 1300 Morris Park Ave, Golding 502b, Bronx, NY 10461, USA
    Epigenomics 4:503-9. 2012
    ..This article systematically highlights the advances made in the field of epigenomics and their contribution to the understanding of the complex physiology of aging, lifespan and age-associated diseases...
  11. ncbi request reprint Central resistance to the inhibitory effects of leptin on stimulated insulin secretion with aging
    Radhika H Muzumdar
    Division of Pediatric Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neurobiol Aging 27:1308-14. 2006
    ..0+/-2.0 in young versus old, respectively) suggesting that part of the leptin resistance was beyond the BBB. Resistance to the effects of leptin on insulin secretion in aging may protect against the onset of diabetes in old subjects...
  12. pmc Pancreatic function, type 2 diabetes, and metabolism in aging
    Zhenwei Gong
    Department of Pediatrics, Divisions of Endocrinology and Geriatrics, Children s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Int J Endocrinol 2012:320482. 2012
    ....