Genomes and Genes
Radhika H Muzumdar
Affiliation: Albert Einstein College of Medicine
- Pancreatic function, type 2 diabetes, and metabolism in agingZhenwei Gong
Department of Pediatrics, Divisions of Endocrinology and Geriatrics, Children s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Int J Endocrinol 2012:320482. 2012....
- Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cellRegina Kuliawat
2Department of Pediatrics, Golding Bldg 705, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
FASEB J 27:4890-8. 2013..The glucose-dependent effects on insulin secretion along with the established effects on insulin action suggest potential for HN and its analogs in the treatment of diabetes...
- Acute humanin therapy attenuates myocardial ischemia and reperfusion injury in miceRadhika H Muzumdar
Department of Pediatrics, Children s Hospital at Montefiore, Diabetes Research and Training Center, Bronx, NY, USA 10461
Arterioscler Thromb Vasc Biol 30:1940-8. 2010..We evaluated the effects of a potent analog of HN (HNG) in an in vivo murine model of myocardial ischemia and reperfusion...
- Humanin: a novel central regulator of peripheral insulin actionRadhika H Muzumdar
Department of Pediatrics, Children s Hospital at Montefiore, Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY, USA
PLoS ONE 4:e6334. 2009..A novel mitochondria-associated peptide, Humanin (HN), has a neuroprotective role against AD-related neurotoxicity. Considering the association between insulin resistance and AD, we investigated if HN influences insulin sensitivity...
- Enhanced activation of a "nutrient-sensing" pathway with age contributes to insulin resistanceFrancine H Einstein
Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA
FASEB J 22:3450-7. 2008..These results suggest that altered nutrient sensing by HBP with age may be the link among nutrients, insulin resistance, and age-related diabetes...
- Aging per se increases the susceptibility to free fatty acid-induced insulin resistanceFrancine H Einstein
Department of Obstetrics and Gynecology and Women s Health at Montefiore Medical Center, Bronx, New York, USA
J Gerontol A Biol Sci Med Sci 65:800-8. 2010..Thus, aging per se increases the inflammatory response to excess nutrients and vulnerability to FFA-induced insulin resistance with aging...
- Resistance to leptin action is the major determinant of hepatic triglyceride accumulation in vivoSigal Fishman
Institute for Aging Research, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
FASEB J 21:53-60. 2007..By dissociating action of leptin from that of insulin, we suggest that the failure of leptin action is the major physiological mechanism for hepatic steatosis...
- Accretion of visceral fat and hepatic insulin resistance in pregnant ratsFrancine H Einstein
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology and Women s Health, The Albert Einstein College of Medicine Montefiore Medical Center, 1825 Eastchester Road, Bronx, NY 10461, USA
Am J Physiol Endocrinol Metab 294:E451-5. 2008..05). Accretion of visceral fat is an important component in the development of hepatic IR in pregnancy, and accumulation of hepatic triglycerides is a mechanism by which visceral fat may modulate insulin action in pregnancy...
- Central and opposing effects of IGF-I and IGF-binding protein-3 on systemic insulin actionRadhika H Muzumdar
Division of Pediatric Endocrinology, Children s Hospital at Montefiore, New York, USA
Diabetes 55:2788-96. 2006..Marked, opposing, and independent physiological effects of IGF-I and IGFBP-3 through central mechanisms may have implications on potential strategies in specific modulation of peripheral insulin action...
- The critical role of metabolic pathways in agingNir Barzilai
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
Diabetes 61:1315-22. 2012..Although life span has been the major outcome of interest in the laboratory, a special focus is made in this study on healthspan, as improved quality of life is the goal when translated to humans...
- Epigenetic genome-wide association methylation in aging and longevityDanny Ben-Avraham
Department of Medicine, 1300 Morris Park Ave, Golding 502b, Bronx, NY 10461, USA
Epigenomics 4:503-9. 2012..This article systematically highlights the advances made in the field of epigenomics and their contribution to the understanding of the complex physiology of aging, lifespan and age-associated diseases...
- Reductions in serum IGF-1 during aging impair health spanZhenwei Gong
Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, 10461, USA
Aging Cell 13:408-18. 2014..We conclude that an intact GH/IGF-1 axis is essential to maintain health span and that elevated GH, even late in life, associates with increased pathology...
- Central resistance to the inhibitory effects of leptin on stimulated insulin secretion with agingRadhika H Muzumdar
Division of Pediatric Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Neurobiol Aging 27:1308-14. 2006..0+/-2.0 in young versus old, respectively) suggesting that part of the leptin resistance was beyond the BBB. Resistance to the effects of leptin on insulin secretion in aging may protect against the onset of diabetes in old subjects...