John W Murray

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc Single vesicle analysis of endocytic fission on microtubules in vitro
    John W Murray
    Marion Bessin Liver Research Center and Department of Medicine, and Division of Hepatology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Traffic 9:833-47. 2008
  2. pmc Kif5B and Kifc1 interact and are required for motility and fission of early endocytic vesicles in mouse liver
    Sangeeta Nath
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Biol Cell 18:1839-49. 2007
  3. ncbi request reprint In vitro motility system to study the role of motor proteins in receptor-ligand sorting
    John W Murray
    Marion Bessin Liver Research Center, Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY, USA
    Methods Mol Biol 392:143-58. 2007
  4. pmc Oatp1a1 requires PDZK1 to traffic to the plasma membrane by selective recruitment of microtubule-based motor proteins
    Wen Jun Wang
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Division of Gastroenterology and Liver Diseases, Albert Einstein College of Medicine, Bronx, New York
    Drug Metab Dispos 42:62-9. 2014
  5. pmc PDZK1 binding and serine phosphorylation regulate subcellular trafficking of organic anion transport protein 1a1
    Jo H Choi
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Am J Physiol Gastrointest Liver Physiol 300:G384-93. 2011
  6. pmc Microtubule-dependent movement of late endocytic vesicles in vitro: requirements for Dynein and Kinesin
    Eustratios Bananis
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Biol Cell 15:3688-97. 2004
  7. ncbi request reprint PKCzeta is required for microtubule-based motility of vesicles containing the ntcp transporter
    Souvik Sarkar
    Marion Bessin Liver Research Center, Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Traffic 7:1078-91. 2006
  8. doi request reprint Topological assessment of oatp1a1: a 12-transmembrane domain integral membrane protein with three N-linked carbohydrate chains
    Pijun Wang
    Department of Medicine, Division of Hepatology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1052-9. 2008
  9. pmc Proteomic analysis of endocytic vesicles: Rab1a regulates motility of early endocytic vesicles
    Aparna Mukhopadhyay
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Sci 124:765-75. 2011
  10. pmc In vitro motility of liver connexin vesicles along microtubules utilizes kinesin motors
    Alfredo G Fort
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 286:22875-85. 2011

Collaborators

Detail Information

Publications18

  1. pmc Single vesicle analysis of endocytic fission on microtubules in vitro
    John W Murray
    Marion Bessin Liver Research Center and Department of Medicine, and Division of Hepatology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Traffic 9:833-47. 2008
    ..A single round of fission resulted in 6.5-fold purification of ntcp from ASOR, and 25% of the resulting vesicles were completely depleted of the endocytic ligand...
  2. pmc Kif5B and Kifc1 interact and are required for motility and fission of early endocytic vesicles in mouse liver
    Sangeeta Nath
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Biol Cell 18:1839-49. 2007
    ..However, the present study shows that coordinated activity of these kinesins is essential for motility and processing of early endocytic vesicles...
  3. ncbi request reprint In vitro motility system to study the role of motor proteins in receptor-ligand sorting
    John W Murray
    Marion Bessin Liver Research Center, Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY, USA
    Methods Mol Biol 392:143-58. 2007
    ..Cultured cells and other organelles can also be examined, and many important biological questions concerning intracellular traffic and organelle composition can be studied by creative adaptation of the protocols that are presented...
  4. pmc Oatp1a1 requires PDZK1 to traffic to the plasma membrane by selective recruitment of microtubule-based motor proteins
    Wen Jun Wang
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Division of Gastroenterology and Liver Diseases, Albert Einstein College of Medicine, Bronx, New York
    Drug Metab Dispos 42:62-9. 2014
    ..Whether this is a result of direct interaction of the Oatp1a1 cytoplasmic domain with dynein or with a dynein-containing protein complex remains to be established. ..
  5. pmc PDZK1 binding and serine phosphorylation regulate subcellular trafficking of organic anion transport protein 1a1
    Jo H Choi
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Am J Physiol Gastrointest Liver Physiol 300:G384-93. 2011
    ..Identification of the proteins and motor molecules that mediate these trafficking events represents an important area for future study...
  6. pmc Microtubule-dependent movement of late endocytic vesicles in vitro: requirements for Dynein and Kinesin
    Eustratios Bananis
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Biol Cell 15:3688-97. 2004
    ..Flow cytometric purification should ultimately facilitate detailed proteomic analysis and mapping of endocytic vesicle-associated proteins...
  7. ncbi request reprint PKCzeta is required for microtubule-based motility of vesicles containing the ntcp transporter
    Souvik Sarkar
    Marion Bessin Liver Research Center, Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Traffic 7:1078-91. 2006
    ..These data indicate that PKCzeta is required specifically for the intracellular movement of vesicles that contain the ntcp transporter...
  8. doi request reprint Topological assessment of oatp1a1: a 12-transmembrane domain integral membrane protein with three N-linked carbohydrate chains
    Pijun Wang
    Department of Medicine, Division of Hepatology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1052-9. 2008
    ..This was in accord with the finding that fully unglycosylated oatp1a1 was well expressed but located intracellularly with limited transport ability as a consequence of its reduced cell surface expression...
  9. pmc Proteomic analysis of endocytic vesicles: Rab1a regulates motility of early endocytic vesicles
    Aparna Mukhopadhyay
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Sci 124:765-75. 2011
    ....
  10. pmc In vitro motility of liver connexin vesicles along microtubules utilizes kinesin motors
    Alfredo G Fort
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 286:22875-85. 2011
    ....
  11. ncbi request reprint Regulation of early endocytic vesicle motility and fission in a reconstituted system
    Eustratios Bananis
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Sci 116:2749-61. 2003
    ....
  12. pmc Heterogeneous accumulation of fluorescent bile acids in primary rat hepatocytes does not correlate with their homogenous expression of ntcp
    John W Murray
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol Gastrointest Liver Physiol 301:G60-8. 2011
    ..These studies indicate that single-cell imaging can provide insight into previously unrecognized details of anion transport in the complex environment of polarized hepatocytes...
  13. ncbi request reprint Roles of the cytoskeleton and motor proteins in endocytic sorting
    John W Murray
    Marion Bessin Liver Research Center and Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 517 Ullmann Building, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Adv Drug Deliv Rev 55:1385-403. 2003
    ..A mechanistic understanding of how organelles control motor protein activity to allow for endocytic sorting presents an exciting avenue for future research...
  14. pmc Reconstitution of herpes simplex virus microtubule-dependent trafficking in vitro
    Grace E Lee
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    J Virol 80:4264-75. 2006
    ..This simple, minimal reconstitution of microtubule-mediated anterograde traffic should facilitate and complement molecular analysis of HSV egress in vivo...
  15. ncbi request reprint Interaction with PDZK1 is required for expression of organic anion transporting protein 1A1 on the hepatocyte surface
    Pijun Wang
    Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 280:30143-9. 2005
    ..Because its ability to transport substances into the cell requires surface expression, this must be considered in any assessment of physiologic function...
  16. pmc The Na(+) -Taurocholate Cotransporting Polypeptide Traffics with the Epidermal Growth Factor Receptor
    Xintao Wang
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, 10461, USA
    Traffic 17:230-44. 2016
    ..ntcp-containing vesicles that are not associated with EGFR have reduced microtubule-based motility, consistent with intracellular accumulation and reduced surface expression of ntcp in cells following EGFR knockdown. ..
  17. pmc Hepatocytes maintain greater fluorescent bile acid accumulation and greater sensitivity to drug-induced cell death in three-dimensional matrix culture
    John W Murray
    Department of Anatomy and Structural Biology, Division of Gastroenterology and Liver Diseases, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York
    Physiol Rep 2:. 2014
    ..Overall, the studies suggest that high accumulation of FBA can indicate the sensitivity of cultured hepatocytes to hydrophobic bile acids and other toxins...
  18. ncbi request reprint Assay of Rab4-dependent trafficking on microtubules
    John W Murray
    Methods Enzymol 403:92-107. 2005
    ..We review measurements of microtubule-based motility as well as measurements for protein localization and protein segregation in vitro...