G A Morrill

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi request reprint Mg2+ modulates membrane lipids in vascular smooth muscle: a link to atherogenesis
    G A Morrill
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    FEBS Lett 408:191-4. 1997
  2. pmc Progesterone binding to the alpha1-subunit of the Na/K-ATPase on the cell surface: insights from computational modeling
    Gene A Morrill
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Steroids 73:27-40. 2008
  3. ncbi request reprint Gonadotropin stimulation of steroid synthesis and metabolism in the Rana pipiens ovarian follicle: sequential changes in endogenous steroids during ovulation, fertilization and cleavage stages
    Gene A Morrill
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Steroid Biochem Mol Biol 99:129-38. 2006
  4. ncbi request reprint The steroid-binding subunit of the Na/K-ATPase as a progesterone receptor on the amphibian oocyte plasma membrane
    Gene A Morrill
    Department of Physiology and Biophysics, Yeshiva University, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Steroids 70:933-45. 2005
  5. ncbi request reprint Interaction between ferric ions, phospholipid hydroperoxides, and the lipid phosphate moiety at physiological pH
    Gene A Morrill
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Lipids 39:881-9. 2004
  6. ncbi request reprint Molecular species analysis of 1,2-diacylglycerol released in response to progesterone binding to the amphibian oocyte plasma membrane
    G A Morrill
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, 10461, Bronx, NY, USA
    Cell Signal 12:787-96. 2000
  7. ncbi request reprint Progesterone induces meiotic division in the amphibian oocyte by releasing lipid second messengers from the plasma membrane
    G A Morrill
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Steroids 64:157-67. 1999
  8. pmc Progesterone-induced changes in the phosphoryl potential during the meiotic divisions in amphibian oocytes: role of Na/K-ATPase
    Gene A Morrill
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    BMC Dev Biol 11:67. 2011
  9. ncbi request reprint The first product of phospholipid N-methylation, phosphatidylmonomethylethanolamine, is a lipid mediator for progesterone action at the amphibian oocyte plasma membrane
    A B Kostellow
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Steroids 66:849-56. 2001
  10. doi request reprint Progesterone and subsequent polar metabolites are essential for completion of the first meiotic division in amphibian oocytes
    Adele B Kostellow
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Mol Cell Endocrinol 291:50-6. 2008

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Mg2+ modulates membrane lipids in vascular smooth muscle: a link to atherogenesis
    G A Morrill
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    FEBS Lett 408:191-4. 1997
    ..A decrease in lipid oxidation in the presence of elevated Mg2+ could contribute to the apparent protective role of increased Mg2+ intake on vascular function in humans...
  2. pmc Progesterone binding to the alpha1-subunit of the Na/K-ATPase on the cell surface: insights from computational modeling
    Gene A Morrill
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Steroids 73:27-40. 2008
    ..Peptide flexibility undergoes a maximal transition near the midway point in the M1-M2 loop, suggesting that folding occurs within the loop, which further stabilizes progesterone binding...
  3. ncbi request reprint Gonadotropin stimulation of steroid synthesis and metabolism in the Rana pipiens ovarian follicle: sequential changes in endogenous steroids during ovulation, fertilization and cleavage stages
    Gene A Morrill
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Steroid Biochem Mol Biol 99:129-38. 2006
    ..The progesterone metabolites formed during meiosis are largely released at fertilization...
  4. ncbi request reprint The steroid-binding subunit of the Na/K-ATPase as a progesterone receptor on the amphibian oocyte plasma membrane
    Gene A Morrill
    Department of Physiology and Biophysics, Yeshiva University, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Steroids 70:933-45. 2005
    ..Progesterone may thus act in part through the plasma membrane Na/K-ATPase signaling system...
  5. ncbi request reprint Interaction between ferric ions, phospholipid hydroperoxides, and the lipid phosphate moiety at physiological pH
    Gene A Morrill
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Lipids 39:881-9. 2004
    ..These PC-derived products have been shown to activate components of the inflammatory system. This suggests that the episodic release of ferric ions may play a significant role in generating inflammatory mediators...
  6. ncbi request reprint Molecular species analysis of 1,2-diacylglycerol released in response to progesterone binding to the amphibian oocyte plasma membrane
    G A Morrill
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, 10461, Bronx, NY, USA
    Cell Signal 12:787-96. 2000
    ....
  7. ncbi request reprint Progesterone induces meiotic division in the amphibian oocyte by releasing lipid second messengers from the plasma membrane
    G A Morrill
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Steroids 64:157-67. 1999
    ..We conclude that the initial action of progesterone at its plasma membrane receptor triggers a series of enzyme activations that modify the membrane and release multiple DAG species...
  8. pmc Progesterone-induced changes in the phosphoryl potential during the meiotic divisions in amphibian oocytes: role of Na/K-ATPase
    Gene A Morrill
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    BMC Dev Biol 11:67. 2011
    ..This is followed by internalization of specific membrane proteins, plasma membrane depolarization and nuclear membrane breakdown, culminating in arrest at second metaphase...
  9. ncbi request reprint The first product of phospholipid N-methylation, phosphatidylmonomethylethanolamine, is a lipid mediator for progesterone action at the amphibian oocyte plasma membrane
    A B Kostellow
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Steroids 66:849-56. 2001
    ....
  10. doi request reprint Progesterone and subsequent polar metabolites are essential for completion of the first meiotic division in amphibian oocytes
    Adele B Kostellow
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Mol Cell Endocrinol 291:50-6. 2008
    ..However, meiosis does occur if 4-MA is followed by a polar steroid. Thus, progesterone binding at the oocyte surface initiates a process which requires polar progesterone metabolites for completion of the first meiotic division...
  11. pmc Progesterone modulation of transmembrane helix-helix interactions between the alpha-subunit of Na/K-ATPase and phospholipid N-methyltransferase in the oocyte plasma membrane
    Gene A Morrill
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    BMC Struct Biol 10:12. 2010
    ..We have characterized this site, using a low affinity ouabain binding isoform of the alpha1-subunit...
  12. ncbi request reprint Iron-catalyzed lipid peroxidation in aortic cells in vitro: protective effect of extracellular magnesium
    Adele B Kostellow
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Atherosclerosis 175:15-22. 2004
    ..The results indicate that Mg2+ protects aortic cell plasma membranes from ferric iron-catalyzed lipid peroxidation and that this is a contributing factor in the protective action of ionized Mg2+ on the cardiovascular system...