MARK MEHLER

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc Profiling RE1/REST-mediated histone modifications in the human genome
    Deyou Zheng
    Institute for Brain Disorders and Neural Regeneration, Department of Neurology, Rose F Kennedy Center for the Study of Intellectual and Developmental Disabilities, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Genome Biol 10:R9. 2009
  2. pmc Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation
    Tim R Mercer
    Institute for Molecular Bioscience, University of Queensland, 306 Carmody Road, Brisbane, QLD 4072, Australia
    BMC Neurosci 11:14. 2010
  3. ncbi request reprint Brain dystrophin, neurogenetics and mental retardation
    M F Mehler
    Departments of Neurology, Neuroscience and Psychiatry, the Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Brain Res Brain Res Rev 32:277-307. 2000
  4. ncbi request reprint Developmental changes in progenitor cell responsiveness to bone morphogenetic proteins differentially modulate progressive CNS lineage fate
    M F Mehler
    Department of Neurology, the Rose F Kennedy Center for Research in Mental Retardation and Developmental Disabilities, Albert Einstein College of Medicine, Bronx, N Y, USA
    Dev Neurosci 22:74-85. 2000
  5. ncbi request reprint Noncoding RNAs and RNA editing in brain development, functional diversification, and neurological disease
    Mark F Mehler
    Institute for Brain Disorders and Neural Regeneration, Department of Neurology, Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Physiol Rev 87:799-823. 2007
  6. pmc Epigenetic principles and mechanisms underlying nervous system functions in health and disease
    Mark F Mehler
    Institute for Brain Disorders and Neural Regeneration, Albert Einstein College of Medicine, Rose F Kennedy Center 401, 1410 Pelham Parkway South, Bronx, NY 10461, USA
    Prog Neurobiol 86:305-41. 2008
  7. ncbi request reprint Postnatal cerebral cortical multipotent progenitors: regulatory mechanisms and potential role in the development of novel neural regenerative strategies
    M F Mehler
    Department of Neurology, Rose F Kennedy Center for Research in Mental Retardation and Developmental Disabilities, Albert Einstein Coll of Medicine, Bronx, New York 10461, USA
    Brain Pathol 9:515-26. 1999
  8. pmc Autism, fever, epigenetics and the locus coeruleus
    Mark F Mehler
    Institute for Brain Disorders and Neural Regeneration, The Saul R Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Brain Res Rev 59:388-92. 2009
  9. doi request reprint Epigenetics and the nervous system
    Mark F Mehler
    Institute for Brain Disorders and Neural Regeneration, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Ann Neurol 64:602-17. 2008
  10. ncbi request reprint Developmental mechanisms in the pathogenesis of neurodegenerative diseases
    M F Mehler
    Laboratory of Developmental and Molecular Neuroscience, Department of Neurology, Rose F Kennedy Center for Research in Mental Retardation and Developmental Disabilities, Albert Einstein College of Medicine, Bronx 10461, NY, USA
    Prog Neurobiol 63:337-63. 2001

Collaborators

Detail Information

Publications23

  1. pmc Profiling RE1/REST-mediated histone modifications in the human genome
    Deyou Zheng
    Institute for Brain Disorders and Neural Regeneration, Department of Neurology, Rose F Kennedy Center for the Study of Intellectual and Developmental Disabilities, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Genome Biol 10:R9. 2009
    ....
  2. pmc Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation
    Tim R Mercer
    Institute for Molecular Bioscience, University of Queensland, 306 Carmody Road, Brisbane, QLD 4072, Australia
    BMC Neurosci 11:14. 2010
    ..Long non-protein-coding RNAs (ncRNAs) are emerging as important regulators of cellular differentiation and are widely expressed in the brain...
  3. ncbi request reprint Brain dystrophin, neurogenetics and mental retardation
    M F Mehler
    Departments of Neurology, Neuroscience and Psychiatry, the Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Brain Res Brain Res Rev 32:277-307. 2000
    ....
  4. ncbi request reprint Developmental changes in progenitor cell responsiveness to bone morphogenetic proteins differentially modulate progressive CNS lineage fate
    M F Mehler
    Department of Neurology, the Rose F Kennedy Center for Research in Mental Retardation and Developmental Disabilities, Albert Einstein College of Medicine, Bronx, N Y, USA
    Dev Neurosci 22:74-85. 2000
    ....
  5. ncbi request reprint Noncoding RNAs and RNA editing in brain development, functional diversification, and neurological disease
    Mark F Mehler
    Institute for Brain Disorders and Neural Regeneration, Department of Neurology, Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Physiol Rev 87:799-823. 2007
    ....
  6. pmc Epigenetic principles and mechanisms underlying nervous system functions in health and disease
    Mark F Mehler
    Institute for Brain Disorders and Neural Regeneration, Albert Einstein College of Medicine, Rose F Kennedy Center 401, 1410 Pelham Parkway South, Bronx, NY 10461, USA
    Prog Neurobiol 86:305-41. 2008
    ....
  7. ncbi request reprint Postnatal cerebral cortical multipotent progenitors: regulatory mechanisms and potential role in the development of novel neural regenerative strategies
    M F Mehler
    Department of Neurology, Rose F Kennedy Center for Research in Mental Retardation and Developmental Disabilities, Albert Einstein Coll of Medicine, Bronx, New York 10461, USA
    Brain Pathol 9:515-26. 1999
    ....
  8. pmc Autism, fever, epigenetics and the locus coeruleus
    Mark F Mehler
    Institute for Brain Disorders and Neural Regeneration, The Saul R Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Brain Res Rev 59:388-92. 2009
    ....
  9. doi request reprint Epigenetics and the nervous system
    Mark F Mehler
    Institute for Brain Disorders and Neural Regeneration, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Ann Neurol 64:602-17. 2008
    ....
  10. ncbi request reprint Developmental mechanisms in the pathogenesis of neurodegenerative diseases
    M F Mehler
    Laboratory of Developmental and Molecular Neuroscience, Department of Neurology, Rose F Kennedy Center for Research in Mental Retardation and Developmental Disabilities, Albert Einstein College of Medicine, Bronx 10461, NY, USA
    Prog Neurobiol 63:337-63. 2001
    ....
  11. ncbi request reprint Basic and clinical neuroscience applications of embryonic stem cells
    S Gokhan
    Department of Neurology, Albert Einstein School of Medicine, Bronx, NY 10461, USA
    Anat Rec 265:142-56. 2001
    ....
  12. ncbi request reprint Temporal expression of neuronal connexins during hippocampal ontogeny
    R Rozental
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Brain Res Brain Res Rev 32:57-71. 2000
    ..In addition, we describe the functional properties and expression pattern of the newly discovered neuronal-specific gap junctional protein, Cx36, in the developing mouse fetal hippocampus and in the rat retina and brain...
  13. ncbi request reprint Developmental changes in progenitor cell responsiveness to cytokines
    G Zhu
    Departments of Neurology and Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA
    J Neurosci Res 56:131-45. 1999
    ....
  14. ncbi request reprint Cytokine regulation of neuronal differentiation of hippocampal progenitor cells
    M F Mehler
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461
    Nature 362:62-5. 1993
    ..Further, they define an in vitro model system that may facilitate molecular analysis of graded stages of mammalian neuronal differentiation...
  15. ncbi request reprint Sonic hedgehog and BMP2 exert opposing actions on proliferation and differentiation of embryonic neural progenitor cells
    G Zhu
    Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, 10461, USA
    Dev Biol 215:118-29. 1999
    ..Our observations suggest that Shh-N selectively promotes the elaboration of both neuronal and oligodendroglial lineage species and inhibits the effects of BMP2 on progenitor cell proliferation and astroglial differentiation...
  16. ncbi request reprint Interleukin-7 is trophic for embryonic neurons and is expressed in developing brain
    M D Michaelson
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Dev Biol 179:251-63. 1996
    ....
  17. ncbi request reprint Development of bone morphogenetic protein receptors in the nervous system and possible roles in regulating trkC expression
    D Zhang
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 18:3314-26. 1998
    ....
  18. ncbi request reprint CSF-1 deficiency in mice results in abnormal brain development
    M D Michaelson
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Development 122:2661-72. 1996
    ..The effects of CSF-1 on cultured embryonic neural cells, the developmentally appropriate expression of CSF-1 and its receptor, and the neurological abnormalities in op/op mice suggest a role for CSF-1 in brain development...
  19. pmc Non-coding RNAs in the nervous system
    Mark F Mehler
    ARC Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD 4072, Australia
    J Physiol 575:333-41. 2006
    ..Non-coding RNAs may provide the key to understanding the multi-tiered links between neural development, nervous system function, and neurological diseases...
  20. pmc Specific expression of long noncoding RNAs in the mouse brain
    Tim R Mercer
    Australian Research Council Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD 4072, Australia
    Proc Natl Acad Sci U S A 105:716-21. 2008
    ..Our results show that the majority of ncRNAs are expressed in the brain and provide strong evidence that the majority of processed transcripts with no protein-coding capacity function intrinsically as RNAs...
  21. pmc Differential modulation of BMP signaling promotes the elaboration of cerebral cortical GABAergic neurons or oligodendrocytes from a common sonic hedgehog-responsive ventral forebrain progenitor species
    Shau Yu Yung
    Departments of Neuroscience, Rose F Kennedy Center for Research in Mental Retardation and Developmental Disabilities, Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 99:16273-8. 2002
    ....
  22. ncbi request reprint Regional forebrain patterning and neural subtype specification: implications for cerebral cortical functional connectivity and the pathogenesis of neurodegenerative diseases
    Mark F Mehler
    Departments of Neurology, Neuroscience and Psychiatry, Rose F Kennedy Center for Research in Mental Retardation and Developmental Disabilities, Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Results Probl Cell Differ 39:157-78. 2002
  23. doi request reprint RNA editing, DNA recoding and the evolution of human cognition
    John S Mattick
    ARC Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD 4072, Australia
    Trends Neurosci 31:227-33. 2008
    ....

Research Grants10

  1. Neurodegenerative Diseases: A New Class of Primary Developmental Disorders?
    Mark F Mehler; Fiscal Year: 2010
    ..abstract_text> ..
  2. Mechanisms Regulating Astroglial Lineage Development
    MARK MEHLER; Fiscal Year: 2006
    ..These studies will further our understandingof the molecular mechanisms governing the changing profiles of neural lineage elaboration during embryonic cerebralcortical neurogenesis and gliogenesis. ..
  3. REGULATION OF POSTNATAL CORTICAL MULTIPOTENT PROGENITORS
    MARK MEHLER; Fiscal Year: 2002
    ....