Research Topics
| Hayley M McDaidSummaryAffiliation: Albert Einstein College of Medicine Country: USA Publications
| Collaborators
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Detail Information
Publications
Enhancement of the therapeutic efficacy of taxol by the mitogen-activated protein kinase kinase inhibitor CI-1040 in nude mice bearing human heterotransplantsHayley M McDaid
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cancer Res 65:2854-60. 2005..These findings are significant and indicate that this combination may have broad therapeutic applications in a diverse range of lung tumors with different intrinsic chemosensitivities...
Resistance to discodermolide, a microtubule-stabilizing agent and senescence inducer, is 4E-BP1-dependentSuzan K Chao
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Proc Natl Acad Sci U S A 108:391-6. 2011..Furthermore, the stability of p53 was enhanced in AD32 cells. Our studies propose a role for 4E-BP1 as a regulator of discodermolide-induced accelerated senescence...
Potentiation of taxol efficacy and by discodermolide in ovarian carcinoma xenograft-bearing miceGloria S Huang
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Clin Cancer Res 12:298-304. 2006..These data confirm the potency of this combination and support the use of concurrent low doses of Taxol and discodermolide for potential use in cancer therapeutics...
Targeting protein translation in human non small cell lung cancer via combined MEK and mammalian target of rapamycin suppressionMarie Emmanuelle Legrier
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cancer Res 67:11300-8. 2007..These data (a) provide evidence that both pathways converge on factors that regulate translation initiation and (b) support therapeutic strategies in lung cancer that simultaneously suppress the RAS and AKT signaling network...
Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescenceSuzan K Chao
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Oncotarget 2:89-98. 2011..This research perspective will address these somewhat contradictory findings and summarize recent research regarding senescence and mTORC1 signaling...
Characterization of a human βV-tubulin antibody and expression of this isotype in normal and malignant human tissueSuzan K Chao
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Cytoskeleton (Hoboken) 69:566-76. 2012..Thus, βV-tubulin expression is a potentially promising prognostic marker of malignancy...
