Sean M J McBride
Affiliation: Albert Einstein College of Medicine
- Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndromeSean M J McBride
Section of Molecular Cardiology, Department of Medicine, Medical Scientist Training Program, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Neuron 45:753-64. 2005..They also raise the possibility that compounds having similar effects on metabotropic glutamate receptors may ameliorate cognitive and behavioral defects observed in Fragile X patients...
- Pharmacological and genetic reversal of age-dependent cognitive deficits attributable to decreased presenilin functionSean M J McBride
Section of Molecular Cardiology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Neurosci 30:9510-22. 2010..They also indicate that enhanced mGluR signaling and calcium release regulated by InsP(3)R as underlying causes of the age-dependent cognitive phenotypes observed when psn activity is reduced...
- Age-dependent cognitive impairment in a Drosophila fragile X model and its pharmacological rescueCatherine H Choi
Section of Molecular Cardiology and Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Biogerontology 11:347-62. 2010....
- The Drosophila DmGluRA is required for social interaction and memoryBrian P Schoenfeld
Section of Molecular Cardiology, Department of Molecular Pharmacology and Medicine, Albert Einstein College of Medicine Bronx, NY, USA Department of Genetics, University of Pennsylvania School of Medicine Philadelphia, PA, USA
Front Pharmacol 4:64. 2013..This work demonstrates a role for mGluR activity in both social behavior and memory in Drosophila...
- Pharmacological reversal of synaptic plasticity deficits in the mouse model of fragile X syndrome by group II mGluR antagonist or lithium treatmentCatherine H Choi
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Brain Res 1380:106-19. 2011....
- Individual carboxypeptidase D domains have both redundant and unique functions in Drosophila development and behaviorGalyna Sidyelyeva
Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Cell Mol Life Sci 67:2991-3004. 2010..These findings suggest that CPD domains-1 and -2 have largely redundant functions in the processing of growth factors, hormones, and neuropeptides...
- Validation of a 2-day water maze protocol in miceMaria Gulinello
Behavioral Core Facility, Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Behav Brain Res 196:220-7. 2009..A further benefit of this method is that large numbers of animals can be tested in a short time...
- Flies as the ointment: Drosophila modeling to enhance drug discoveryAaron J Bell
Department of Molecular Pharmacology, Division of Molecular Cardiology, Albert Einstein College of Medicine, Bronx, New York, USA
Fly (Austin) 3:39-49. 2009..Together, these factors may contribute towards savings in time and cost during the drug discovery process...
- Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interestThomas C Dockendorff
Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Neuron 34:973-84. 2002..Morphological analysis of neurons required for normal circadian behavior reveals subtle abnormalities, suggesting that defects in axonal pathfinding or synapse formation may cause the observed behavioral defects...