Sean M J McBride

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi request reprint Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndrome
    Sean M J McBride
    Section of Molecular Cardiology, Department of Medicine, Medical Scientist Training Program, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neuron 45:753-64. 2005
  2. pmc Pharmacological and genetic reversal of age-dependent cognitive deficits attributable to decreased presenilin function
    Sean M J McBride
    Section of Molecular Cardiology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 30:9510-22. 2010
  3. pmc Age-dependent cognitive impairment in a Drosophila fragile X model and its pharmacological rescue
    Catherine H Choi
    Section of Molecular Cardiology and Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Biogerontology 11:347-62. 2010
  4. pmc The Drosophila DmGluRA is required for social interaction and memory
    Brian P Schoenfeld
    Section of Molecular Cardiology, Department of Molecular Pharmacology and Medicine, Albert Einstein College of Medicine Bronx, NY, USA Department of Genetics, University of Pennsylvania School of Medicine Philadelphia, PA, USA
    Front Pharmacol 4:64. 2013
  5. pmc Pharmacological reversal of synaptic plasticity deficits in the mouse model of fragile X syndrome by group II mGluR antagonist or lithium treatment
    Catherine H Choi
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Brain Res 1380:106-19. 2011
  6. pmc Individual carboxypeptidase D domains have both redundant and unique functions in Drosophila development and behavior
    Galyna Sidyelyeva
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Cell Mol Life Sci 67:2991-3004. 2010
  7. doi request reprint Validation of a 2-day water maze protocol in mice
    Maria Gulinello
    Behavioral Core Facility, Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Behav Brain Res 196:220-7. 2009
  8. ncbi request reprint Flies as the ointment: Drosophila modeling to enhance drug discovery
    Aaron J Bell
    Department of Molecular Pharmacology, Division of Molecular Cardiology, Albert Einstein College of Medicine, Bronx, New York, USA
    Fly (Austin) 3:39-49. 2009
  9. ncbi request reprint Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest
    Thomas C Dockendorff
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuron 34:973-84. 2002

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndrome
    Sean M J McBride
    Section of Molecular Cardiology, Department of Medicine, Medical Scientist Training Program, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neuron 45:753-64. 2005
    ..They also raise the possibility that compounds having similar effects on metabotropic glutamate receptors may ameliorate cognitive and behavioral defects observed in Fragile X patients...
  2. pmc Pharmacological and genetic reversal of age-dependent cognitive deficits attributable to decreased presenilin function
    Sean M J McBride
    Section of Molecular Cardiology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 30:9510-22. 2010
    ..They also indicate that enhanced mGluR signaling and calcium release regulated by InsP(3)R as underlying causes of the age-dependent cognitive phenotypes observed when psn activity is reduced...
  3. pmc Age-dependent cognitive impairment in a Drosophila fragile X model and its pharmacological rescue
    Catherine H Choi
    Section of Molecular Cardiology and Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Biogerontology 11:347-62. 2010
    ....
  4. pmc The Drosophila DmGluRA is required for social interaction and memory
    Brian P Schoenfeld
    Section of Molecular Cardiology, Department of Molecular Pharmacology and Medicine, Albert Einstein College of Medicine Bronx, NY, USA Department of Genetics, University of Pennsylvania School of Medicine Philadelphia, PA, USA
    Front Pharmacol 4:64. 2013
    ..This work demonstrates a role for mGluR activity in both social behavior and memory in Drosophila...
  5. pmc Pharmacological reversal of synaptic plasticity deficits in the mouse model of fragile X syndrome by group II mGluR antagonist or lithium treatment
    Catherine H Choi
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Brain Res 1380:106-19. 2011
    ....
  6. pmc Individual carboxypeptidase D domains have both redundant and unique functions in Drosophila development and behavior
    Galyna Sidyelyeva
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Cell Mol Life Sci 67:2991-3004. 2010
    ..These findings suggest that CPD domains-1 and -2 have largely redundant functions in the processing of growth factors, hormones, and neuropeptides...
  7. doi request reprint Validation of a 2-day water maze protocol in mice
    Maria Gulinello
    Behavioral Core Facility, Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Behav Brain Res 196:220-7. 2009
    ..A further benefit of this method is that large numbers of animals can be tested in a short time...
  8. ncbi request reprint Flies as the ointment: Drosophila modeling to enhance drug discovery
    Aaron J Bell
    Department of Molecular Pharmacology, Division of Molecular Cardiology, Albert Einstein College of Medicine, Bronx, New York, USA
    Fly (Austin) 3:39-49. 2009
    ..Together, these factors may contribute towards savings in time and cost during the drug discovery process...
  9. ncbi request reprint Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest
    Thomas C Dockendorff
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuron 34:973-84. 2002
    ..Morphological analysis of neurons required for normal circadian behavior reveals subtle abnormalities, suggesting that defects in axonal pathfinding or synapse formation may cause the observed behavioral defects...